Peeper, Daniel S.

B cells and tertiary lymphoid structures promote immunotherapy response

Helmink, B. A., Reddy, S. M., Gao, J., Zhang, S., Basar, R., Thakur, R., Yizhak, K., Sade-Feldman, M., Blando, J., Han, G., et al. (2020) · Nature

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 2,731

The human tumor microbiome is composed of tumor type–specific intracellular bacteria

Nejman, D., Livyatan, I., Fuks, G., Gavert, N., Zwang, Y., Geller, L. T., Rotter-Maskowitz, A., Weiser, R., Mallel, G., Gigi, E., et al. (2020) · Science

Gut microbiota and healthBacterial Cancer Therapy

Cited by 2,464

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature

Telomeres, Telomerase, and SenescenceMelanoma and MAPK Pathways

Cited by 2,160

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 2,086

The essence of senescence: Figure 1.

Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 2,038

Senescence-messaging secretome: SMS-ing cellular stress

Kuilman, T., & Peeper, D. S. (2009) · Nature Reviews Cancer

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 909

Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma

Blank, C. U., Rozeman, E. A., Fanchi, L. F., Sikorska, K., van de Wiel, B., Kvistborg, P., Krijgsman, O., van den Braber, M., Philips, D., Broeks, A., et al. (2018) · Nature Medicine

Cancer Immunotherapy and BiomarkersCutaneous Melanoma Detection and Management

Cited by 880

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

Müller, J., Krijgsman, O., Tsoi, J., Robert, L., Hugo, W., Song, C., Kong, X., Possik, P. A., Cornelissen-Steijger, P. D. M., Foppen, M. H. G., et al. (2014) · Nature Communications

Melanoma and MAPK PathwaysLung Cancer Treatments and Mutations

Cited by 639

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

Kaplon, J., Zheng, L., Meissl, K., Chaneton, B., Selivanov, V. A., Mackay, G., van der Burg, S. H., Verdegaal, E. M. E., Cascante, M., Shlomi, T., et al. (2013) · Nature

Telomeres, Telomerase, and SenescenceCancer, Hypoxia, and Metabolism

Cited by 633

Identification of the optimal combination dosing schedule of neoadjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma (OpACIN-neo): a multicentre, phase 2, randomised, controlled trial

Rozeman, E. A., Menzies, A. M., van Akkooi, A. C. J., Adhikari, C., Bierman, C., van de Wiel, B. A., Scolyer, R. A., Krijgsman, O., Sikorska, K., Eriksson, H., et al. (2019) · The Lancet Oncology

Cancer Immunotherapy and BiomarkersCutaneous Melanoma Detection and Management

Cited by 537

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases

Weeber, F., van de Wetering, M., Hoogstraat, M., Dijkstra, K. K., Krijgsman, O., Kuilman, T., Gadellaa-van Hooijdonk, C. G. M., van der Velden, D. L., Peeper, D. S., Cuppen, E. P. J. G., et al. (2015) · Proceedings of the National Academy of Sciences

Cancer Genomics and DiagnosticsCancer Cells and Metastasis

Cited by 482

Oncogene-Induced Cell Senescence — Halting on the Road to Cancer

Mooi, W. J., & Peeper, D. S. (2006) · New England Journal of Medicine

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 371

Cellular senescence in vivo: a barrier to tumorigenesis

Prieur, A., & Peeper, D. S. (2008) · Current Opinion in Cell Biology

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 260

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

Vredevoogd, D. W., Kuilman, T., Ligtenberg, M. A., Boshuizen, J., Stecker, K. E., de Bruijn, B., Krijgsman, O., Huang, X., Kenski, J. C. N., Lacroix, R., et al. (2019) · Cell

Cancer Immunotherapy and BiomarkersCell death mechanisms and regulation

Cited by 259

Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors

Boshuizen, J., Koopman, L. A., Krijgsman, O., Shahrabi, A., van den Heuvel, E. G., Ligtenberg, M. A., Vredevoogd, D. W., Kemper, K., Kuilman, T., Song, J.-Y., et al. (2018) · Nature Medicine

Melanoma and MAPK PathwaysCancer Immunotherapy and Biomarkers

Cited by 229

Phenotype Switching: Tumor Cell Plasticity as a Resistance Mechanism and Target for Therapy

Kemper, K., de Goeje, P. L., Peeper, D. S., & van Amerongen, R. (2014) · Cancer Research

Melanoma and MAPK PathwaysCancer Cells and Metastasis

Cited by 216

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

Yu, Y., Schleich, K., Yue, B., Ji, S., Lohneis, P., Kemper, K., Silvis, M. R., Qutob, N., van Rooijen, E., Werner-Klein, M., et al. (2018) · Cancer Cell

Melanoma and MAPK PathwaysEpigenetics and DNA Methylation

Cited by 156

Integrative epigenetic taxonomy of primary prostate cancer

Stelloo, S., Nevedomskaya, E., Kim, Y., Schuurman, K., Valle-Encinas, E., Lobo, J., Krijgsman, O., Peeper, D. S., Chang, S. L., Feng, F. Y.-C., et al. (2018) · Nature Communications

Prostate Cancer Treatment and ResearchChromatin Remodeling and Cancer

Cited by 154

E2F transcriptional repressor complexes are critical downstream targets of p19ARF/p53-induced proliferative arrest

Rowland, B. D., Denissov, S. G., Douma, S., Stunnenberg, H. G., Bernards, R., & Peeper, D. S. (2002) · Cancer Cell

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 120

Massive reshaping of genome-nuclear lamina interactions during oncogene-induced senescence.

Lenain, C., de Graaf, C. A., Pagie, L., Visser, N. L., de Haas, M., de Vries, S. S., Peric-Hupkes, D., van Steensel, B., & Peeper, D. S. (2017) · Genome Research

Nuclear Structure and FunctionTelomeres, Telomerase, and Senescence

Cited by 89

Evidence of oncogene-induced senescence in thyroid carcinogenesis

Vizioli, M. G., Possik, P. A., Tarantino, E., Meissl, K., Borrello, M. G., Miranda, C., Anania, M. C., Pagliardini, S., Seregni, E., Pierotti, M. A., et al. (2011) · Endocrine-Related Cancer

Telomeres, Telomerase, and SenescenceThyroid Cancer Diagnosis and Treatment

Cited by 47

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

Yu, Y., Schleich, K., Yue, B., Ji, S., Lohneis, P., Kemper, K., Silvis, M. R., Qutob, N., van Rooijen, E., Werner-Klein, M., et al. (2018) · Cancer Cell

Telomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

Cited by 46

Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell-cycle machinery

Peeper, D. S., & Bernards, R. (1997) · FEBS Letters

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 36