Walther, Tobias C.

Lysine acetylation targets protein complexes and co-regulates major cellular functions

Choudhary, C., Kumar, C., Gnad, F., Nielsen, M. L., Rehman, M., Walther, T. C., Olsen, J. V., & Mann, M. (2009) · Science

Advanced Proteomics Techniques and ApplicationsGenomics and Chromatin Dynamics

Cited by 4,040

Cellular Fatty Acid Metabolism and Cancer

Currie, E., Schulze, A., Zechner, R., Walther, T. C., & Farese, R. V. (2013) · Cell Metabolism

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 2,123

The biophysics and cell biology of lipid droplets

Thiam, A. R., Farese Jr, R. V., & Walther, T. C. (2013) · Nature Reviews Molecular Cell Biology

Lipid metabolism and biosynthesisCancer, Lipids, and Metabolism

Cited by 986

Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast

de Godoy, L. M. F., Olsen, J. V., Cox, J., Nielsen, M. L., Hubner, N. C., Fröhlich, F., Walther, T. C., & Mann, M. (2008) · Nature

Advanced Proteomics Techniques and ApplicationsFungal and yeast genetics research

Cited by 873

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

Wilfling, F., Wang, H., Haas, J. T., Krahmer, N., Gould, T. J., Uchida, A., Cheng, J.-X., Graham, M., Christiano, R., Fröhlich, F., et al. (2013) · Developmental Cell

Lipid metabolism and biosynthesisLipid metabolism and disorders

Cited by 806

The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria

Stone, S. J., Levin, M. C., Zhou, P., Han, J., Walther, T. C., & Farese, R. V. (2009) · Journal of Biological Chemistry

Lipid metabolism and biosynthesisCancer, Lipids, and Metabolism

Cited by 390

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

Fanning, S., Haque, A., Imberdis, T., Baru, V., Barrasa, M. I., Nuber, S., Termine, D., Ramalingam, N., Ho, G. P. H., Noble, T., et al. (2019) · Molecular Cell

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 285

Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

Piccolis, M., Bond, L. M., Kampmann, M., Pulimeno, P., Chitraju, C., Jayson, C. B. K., Vaites, L. P., Boland, S., Lai, Z. W., Gabriel, K. R., et al. (2019) · Molecular Cell

Lipid metabolism and biosynthesisCancer, Lipids, and Metabolism

Cited by 269

Global Proteome Turnover Analyses of the Yeasts S. cerevisiae and S. pombe

Christiano, R., Nagaraj, N., Fröhlich, F., & Walther, T. C. (2014) · Cell Reports

Ubiquitin and proteasome pathwaysFungal and yeast genetics research

Cited by 268

Proteome-wide Analysis of Lysine Acetylation Suggests its Broad Regulatory Scope in Saccharomyces cerevisiae

Henriksen, P., Wagner, S. A., Weinert, B. T., Sharma, S., Bačinskaja, G., Rehman, M., Juffer, A. H., Walther, T. C., Lisby, M., & Choudhary, C. (2012) · Molecular & Cellular Proteomics

Advanced Proteomics Techniques and ApplicationsUbiquitin and proteasome pathways

Cited by 246

The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes

Chitraju, C., Walther, T. C., & Farese, R. V. (2019) · Journal of Lipid Research

Lipid metabolism and biosynthesisLipid metabolism and disorders

Cited by 206

Organellar proteomics and phospho-proteomics reveal subcellular reorganization in diet-induced hepatic steatosis

Krahmer, N., Najafi, B., Schueder, F., Quagliarini, F., Steger, M., Seitz, S., Kasper, R., Salinas, F., Cox, J., Uhlenhaut, N. H., et al. (2018) · Developmental Cell

Liver Disease Diagnosis and TreatmentLipid metabolism and biosynthesis

Cited by 188

Partitioning of MLX-family transcription factors to lipid droplets regulates metabolic gene expression

Mejhert, N., Kuruvilla, L., Gabriel, K. R., Elliott, S. D., Guie, M.-A., Wang, H., Lai, Z. W., Lane, E. A., Christiano, R., Danial, N. N., et al. (2020) · Molecular Cell

Lipid metabolism and biosynthesisLipid metabolism and disorders

Cited by 121

Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme

Sui, X., Wang, K., Gluchowski, N. L., Elliott, S. D., Liao, M., Walther, T. C., & Farese, R. V. (2020) · Nature

Lipid metabolism and biosynthesisLipid metabolism and disorders

Cited by 120

Seipin forms a flexible cage at lipid droplet formation sites

Arlt, H., Sui, X., Folger, B., Adams, C., Chen, X., Remme, R., Hamprecht, F. A., DiMaio, F., Liao, M., Goodman, J. M., et al. (2022) · Nature Structural & Molecular Biology

Lipid metabolism and biosynthesisProtein Structure and Dynamics

Cited by 107

Seipin forms a flexible cage at lipid droplet formation sites

Arlt, H., Sui, X., Folger, B., Adams, C., Chen, X., Remme, R., Hamprecht, F. A., DiMaio, F., Liao, M., Goodman, J. M., et al. (2021) · Nature Structural & Molecular Biology

Lipid metabolism and biosynthesisProtein Structure and Dynamics

Cited by 107

Identification of two pathways mediating protein targeting from ER to lipid droplets

Song, J., Mizrak, A., Lee, C.-W., Cicconet, M., Lai, Z. W., Tang, W.-C., Lu, C.-H., Mohr, S. E., Farese, R. V., & Walther, T. C. (2022) · Nature Cell Biology

Cellular transport and secretionLipid metabolism and biosynthesis

Cited by 106

Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis

Boland, S., Swarup, S., Ambaw, Y. A., Malia, P. C., Richards, R. C., Fischer, A. W., Singh, S., Aggarwal, G., Spina, S., Nana, A. L., et al. (2022) · Nature Communications

Lysosomal Storage Disorders ResearchGlycogen Storage Diseases and Myoclonus

Cited by 97

The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology

Mejhert, N., Gabriel, K. R., Frendo-Cumbo, S., Krahmer, N., Song, J., Kuruvilla, L., Chitraju, C., Boland, S., Jang, D.-K., von Grotthuss, M., et al. (2022) · Developmental Cell

Lipid metabolism and biosynthesisLipid metabolism and disorders

Cited by 79

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway

Naguib, S., Lopez-Lee, C., Torres, E. R., Lee, S.-I., Zhu, J., Zhu, D., Ye, P., Norman, K., Zhao, M., Wong, M. Y., et al. (2025) · Immunity

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 32

APOE3 - R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition

Naguib, S., Lopez-Lee, C., Torres, E. R., Lee, S.-I., Zhu, J., Zhu, D., Ye, P., Norman, K., Zhao, M., Wong, M. Y., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory)

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 25

Progranulin in the hematopoietic compartment protects mice from atherosclerosis

Nguyen, A. D., Nguyen, T. A., Singh, R. K., Eberlé, D., Zhang, J., Abate, J. P., Robles, A., Koliwad, S., Huang, E. J., Maxfield, F. R., et al. (2018) · Atherosclerosis

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 23