Tabas, Ira

Mitochondrial fission promotes the continued clearance of apoptotic cells by macrophages

Wang, Y., Subramanian, M., Yurdagul, A., Barbosa-Lorenzi, V. C., Cai, B., de Juan-Sanz, J., Ryan, T. A., Nomura, M., Maxfield, F. R., & Tabas, I. (2017) · Cell

Phagocytosis and Immune RegulationCell death mechanisms and regulation

Cited by 364

Efferocytosis induces macrophage proliferation to help resolve tissue injury

Gerlach, B. D., Ampomah, P. B., Yurdagul, A., Liu, C., Lauring, M. C., Wang, X., Kasikara, C., Kong, N., Shi, J., Tao, W., et al. (2021) · Cell Metabolism

Phagocytosis and Immune RegulationCell death mechanisms and regulation

Cited by 360

Mertk Receptor Mutation Reduces Efferocytosis Efficiency and Promotes Apoptotic Cell Accumulation and Plaque Necrosis in Atherosclerotic Lesions of Apoe −/− Mice

Thorp, E., Cui, D., Schrijvers, D. M., Kuriakose, G., & Tabas, I. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology

Phagocytosis and Immune RegulationAtherosclerosis and Cardiovascular Diseases

Cited by 357

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

Filliol, A., Saito, Y., Nair, A., Dapito, D. H., Yu, L.-X., Ravichandra, A., Bhattacharjee, S., Affo, S., Fujiwara, N., Su, H., et al. (2022) · Nature

Liver physiology and pathologyHepatocellular Carcinoma Treatment and Prognosis

Cited by 349

Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis

Yurdagul, A., Doran, A. C., Cai, B., Fredman, G., & Tabas, I. A. (2018) · Frontiers in Cardiovascular Medicine

Phagocytosis and Immune RegulationAtherosclerosis and Cardiovascular Diseases

Cited by 300

Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK)

Thorp, E., Vaisar, T., Subramanian, M., Mautner, L., Blobel, C., & Tabas, I. (2011) · Journal of Biological Chemistry

Phagocytosis and Immune RegulationImmune Response and Inflammation

Cited by 298

Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

Cai, B., Dongiovanni, P., Corey, K. E., Wang, X., Shmarakov, I. O., Zheng, Z., Kasikara, C., Davra, V., Meroni, M., Chung, R. T., et al. (2020) · Cell Metabolism

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 266

The role of non-resolving inflammation in atherosclerosis

Kasikara, C., Doran, A. C., Cai, B., & Tabas, I. (2018) · Journal of Clinical Investigation

Atherosclerosis and Cardiovascular DiseasesFatty Acid Research and Health

Cited by 266

MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis

Cai, B., Thorp, E. B., Doran, A. C., Sansbury, B. E., Daemen, M. J. A. P., Dorweiler, B., Spite, M., Fredman, G., & Tabas, I. (2017) · Journal of Clinical Investigation

Phagocytosis and Immune RegulationAtherosclerosis and Cardiovascular Diseases

Cited by 262

Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 V617F Mice

Wang, W., Liu, W., Fidler, T., Wang, Y., Tang, Y., Woods, B., Welch, C., Cai, B., Silvestre-Roig, C., Ai, D., et al. (2018) · Circulation Research

Atherosclerosis and Cardiovascular DiseasesMyeloproliferative Neoplasms: Diagnosis and Treatment

Cited by 262

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

Zhu, C., Kim, K., Wang, X., Bartolome, A., Salomao, M., Dongiovanni, P., Meroni, M., Graham, M. J., Yates, K. P., Diehl, A. M., et al. (2018) · Science Translational Medicine

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 250

Mechanisms and consequences of efferocytosis in advanced atherosclerosis

Thorp, E., & Tabas, I. (2009) · Journal of Leukocyte Biology

Phagocytosis and Immune RegulationAtherosclerosis and Cardiovascular Diseases

Cited by 231

microRNA-33 regulates macrophage autophagy in atherosclerosis

Ouimet, M., Ediriweera, H., Afonso, M. S., Ramkhelawon, B., Singaravelu, R., Liao, X., Bandler, R. C., Rahman, K., Fisher, E. A., Rayner, K. J., et al. (2017) · Arteriosclerosis, Thrombosis, and Vascular Biology

Cholesterol and Lipid MetabolismAutophagy in Disease and Therapy

Cited by 221

ABCA1 and ABCG1 Protect Against Oxidative Stress–Induced Macrophage Apoptosis During Efferocytosis

Yvan-Charvet, L., Pagler, T. A., Seimon, T. A., Thorp, E., Welch, C. L., Witztum, J. L., Tabas, I., & Tall, A. R. (2010) · Circulation Research

Cholesterol and Lipid MetabolismPhagocytosis and Immune Regulation

Cited by 217

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

Wang, X., Cai, B., Yang, X., Sonubi, O. O., Zheng, Z., Ramakrishnan, R., Shi, H., Valenti, L., Pajvani, U. B., Sandhu, J., et al. (2020) · Cell Metabolism

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 204

MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity

Cai, B., Kasikara, C., Doran, A. C., Ramakrishnan, R., Birge, R. B., & Tabas, I. (2018) · Science Signaling

Fatty Acid Research and HealthPhagocytosis and Immune Regulation

Cited by 175

Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase

Chandak, P. G., Radović, B., Aflaki, E., Kolb, D., Buchebner, M., Fröhlich, E., Magnes, C., Sinner, F., Haemmerle, G., Zechner, R., et al. (2010) · Journal of Biological Chemistry

Lipid metabolism and biosynthesisLipid metabolism and disorders

Cited by 163

Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis

Yu, J., Zhu, C., Wang, X., Kim, K., Bartolome, A., Dongiovanni, P., Yates, K. P., Valenti, L., Carrer, M., Sadowski, T., et al. (2021) · Science Translational Medicine

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 132

The UPR in atherosclerosis

Zhou, A. X., & Tabas, I. (2013) · Seminars in Immunopathology

Endoplasmic Reticulum Stress and DiseaseAtherosclerosis and Cardiovascular Diseases

Cited by 121

Maladaptive regeneration - the reawakening of developmental pathways in NASH and fibrosis

Zhu, C., Tabas, I., Schwabe, R. F., & Pajvani, U. B. (2021) · Nature Reviews Gastroenterology & Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 112

The role of macrophages and dendritic cells in the clearance of apoptotic cells in advanced atherosclerosis

Thorp, E., Subramanian, M., & Tabas, I. (2011) · European Journal of Immunology

Phagocytosis and Immune RegulationAtherosclerosis and Cardiovascular Diseases

Cited by 107

The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver

Mederacke, I., Filliol, A., Affo, S., Nair, A., Hernandez, C., Sun, Q., Hamberger, F., Brundu, F., Chen, Y., Ravichandra, A., et al. (2022) · Science Translational Medicine

Adenosine and Purinergic SignalingLiver physiology and pathology

Cited by 103

CD47-SIRPα axis blockade in NASH promotes necroptotic hepatocyte clearance by liver macrophages and decreases hepatic fibrosis

Shi, H., Wang, X., Li, F., Gerlach, B. D., Yurdagul, A., Moore, M. P., Zeldin, S., Zhang, H., Cai, B., Zheng, Z., et al. (2022) · Science Translational Medicine

Phagocytosis and Immune RegulationLiver Disease Diagnosis and Treatment

Cited by 85

Efferocytosis drives a tryptophan metabolism pathway in macrophages to promote tissue resolution

Sukka, S. R., Ampomah, P. B., Darville, L. N. F., Ngai, D., Wang, X., Kuriakose, G., Xiao, Y., Shi, J., Koomen, J. M., McCusker, R. H., et al. (2024) · Nature Metabolism

Phagocytosis and Immune RegulationAtherosclerosis and Cardiovascular Diseases

Cited by 82