Viral error catastrophe by mutagenic nucleosides

Anderson, Jon P.; Daifuku, Richard; Loeb, Lawrence A.

doi:10.1146/annurev.micro.58.030603.123649

Cited by 221Evolution and Genetic DynamicsHepatitis C virus researchMathematical and Theoretical Epidemiology and Ecology Models

Viral error catastrophe by mutagenic nucleosides

Anderson, Jon P., Daifuku, Richard, Loeb, Lawrence A.·2004·Annual Review of Microbiology

DOI 10.1146/annurev.micro.58.030603.123649

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Abstract

▪ Abstract Riboviruses and retroviruses have the highest rates of mutations of any known organism. Increasing the mutation rate of these viruses could exceed the error threshold for viability of a viral population within a host. Recent experiments with mutagenic nucleoside analogs validate this new approach to treating infection of RNA viruses. Lethal mutagenesis with HIV-infected cells in culture has been documented and has been postulated to be the mechanism for treatment of hepatitis C with ribavirin. We consider the viral dynamics involved in the formation of a quasispecies, the choice of mutagenic nucleoside analogs, and the studies that have demonstrated the feasibility of lethal mutagenesis.

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A moderate artificial increase in mutation rates of RNA viruses can lead to complete extinction of virus populations.
“a moderate artificial increase in mutation rates of viruses can lead to a complete extinction of virus populations.”
From Thermodynamic Basis for the Emergence of Genomes during Prebiotic Evolution (2012) · cites this paper as [26]
Increasing the mutation rate to precipitate an error catastrophe appears to be a practical anti-retroviral strategy.
“Indeed, increasing the mutation rate to precipitate an error catastrophe appears to be a practical anti-retroviral strategy (14–16).”
From The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA (2011) · cites this paper as [15]

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Stochastic Simulations Suggest that HIV-1 Survives Close to Its Error Threshold
Tripathi, K., Balagam, R., Vishnoi, N. K., & Dixit, N. M. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002684 · Cited by 34 · see citing works

Authors: Anderson, J. P., Daifuku, R., & Loeb, L. A.
Affiliations: University of Washington (US)
Koronis Pharmaceuticals, Redmond, Washington 98052;
ORCID: Daifuku, Richard
Loeb, Lawrence A.
Venue: Annual Review of Microbiology
Publisher: Annual Reviews
Published: 2004-10-01
Volume: 58
Issue: 1
Pages: 183-205
ISSN: 0066-4227 (ISSN-L)
1545-3251
DOI: 10.1146/annurev.micro.58.030603.123649
OpenAlex: W2124692557
Cited by: 221
References: 84
Citations by year: 2025: 1 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 9 · 2020: 2 · 2019: 2 · 2018: 8 · 2017: 11 · 2016: 4 · 2015: 10 · 2014: 17 · 2013: 19 · 2012: 26
FWCI: 1.48
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute for Health and Care Research
National Institutes of Health (1r13ai042579-01, 5r21ca078883-02)
National Cancer Institute (CA-102029, R01CA102029, CA78883)
National Institute of Allergy and Infectious Diseases (AI42579)
National Institute of Environmental Health Sciences (P30 ES-07033, T32ES0032, T32ES007032, P30ES007033)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Health Sciences › Medicine › Hepatology › Hepatitis C virus research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mathematical and Theoretical Epidemiology and Ecology Models
Keywords: error catastrophe, lethal mutagenesis, ribavirin, hepatitis C, HIV, RNA viruses, retroviruses, quasispecies, error threshold, viral mutation rate, antiviral therapy
MeSH terms: Antiviral Agents, Hepatitis C, HIV, Humans, Models, Genetic, Nucleosides, Ribavirin, RNA Viruses, HIV Infections, Hepacivirus, Mutagenesis

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Viral error catastrophe by mutagenic nucleosides

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