Marcotte, Edward M.

Insights into the regulation of protein abundance from proteomic and transcriptomic analyses

Vogel, C., & Marcotte, E. M. (2012) · Nature Reviews Genetics

Advanced Proteomics Techniques and ApplicationsRNA and protein synthesis mechanisms

Cited by 4,195

Detecting Protein Function and Protein-Protein Interactions from Genome Sequences

Marcotte, E. M., Pellegrini, M., Ng, H.-L., Rice, D. W., Yeates, T. O., & Eisenberg, D. (1999) · Science

Bioinformatics and Genomic NetworksGenomics and Phylogenetic Studies

Cited by 1,670

Global signatures of protein and mRNA expression levels

de Sousa Abreu, R., Penalva, L. O., Marcotte, E. M., & Vogel, C. (2009) · Molecular BioSystems

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 1,248

Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation

Lu, P., Vogel, C., Wang, R., Yao, X., & Marcotte, E. M. (2007) · Nature Biotechnology

Advanced Proteomics Techniques and ApplicationsFungal and yeast genetics research

Cited by 1,139

Genome evolution in the allotetraploid frog Xenopus laevis

Session, A. M., Uno, Y., Kwon, T., Chapman, J. A., Toyoda, A., Takahashi, S., Fukui, A., Hikosaka, A., Suzuki, A., Kondo, M., et al. (2016) · Nature

Chromosomal and Genetic VariationsGenomics and Phylogenetic Studies

Cited by 949

Sequence signatures and mRNA concentration can explain two‐thirds of protein abundance variation in a human cell line

Vogel, C., de Sousa Abreu, R., Ko, D., Le, S., Shapiro, B. A., Burns, S. C., Sandhu, D., Boutz, D. R., Marcotte, E. M., & Penalva, L. O. (2010) · Molecular Systems Biology

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 608

A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans

Lee, I., Lehner, B., Crombie, C., Wong, W., Fraser, A. G., & Marcotte, E. M. (2008) · Nature Genetics

Bioinformatics and Genomic NetworksGene Regulatory Network Analysis

Cited by 281

A critical assessment of Mus musculusgene function prediction using integrated genomic evidence

Peña-Castillo, L., Tasan, M., Myers, C. L., Lee, H., Joshi, T., Zhang, C., Guan, Y., Leone, M., Pagnani, A., Kim, W. K., et al. (2008) · Genome Biology

Bioinformatics and Genomic NetworksGenomics and Phylogenetic Studies

Cited by 248

HumanNet v2: human gene networks for disease research

Hwang, S., Kim, C. Y., Yang, S., Kim, E., Hart, T., Marcotte, E. M., & Lee, I. (2019) · Nucleic Acids Research

Bioinformatics and Genomic NetworksBiomedical Text Mining and Ontologies

Cited by 210

Protein abundances are more conserved than mRNA abundances across diverse taxa

Laurent, J. M., Vogel, C., Kwon, T., Craig, S. A., Boutz, D. R., Huse, H. K., Nozue, K., Walia, H., Whiteley, M., Ronald, P. C., et al. (2010) · PROTEOMICS

Genomics and Phylogenetic StudiesRNA and protein synthesis mechanisms

Cited by 156

Protein Expression Regulation under Oxidative Stress

Vogel, C., Silva, G. M., & Marcotte, E. M. (2011) · Molecular & Cellular Proteomics

Redox biology and oxidative stressFungal and yeast genetics research

Cited by 144

Native doublet microtubules from Tetrahymena thermophila reveal the importance of outer junction proteins

Kubo, S., Black, C. S., Joachimiak, E., Yang, S. K., Legal, T., Peri, K., Khalifa, A. A. Z., Ghanaeian, A., McCafferty, C. L., Valente-Paterno, M., et al. (2023) · Nature Communications

Genetic and Kidney Cyst DiseasesCystic Fibrosis Research Advances

Cited by 93

A map of human protein interactions derived from co‐expression of human mRNAs and their orthologs

Ramani, A. K., Li, Z., Hart, G. T., Carlson, M. W., Boutz, D. R., & Marcotte, E. M. (2008) · Molecular Systems Biology

Bioinformatics and Genomic NetworksAdvanced Proteomics Techniques and Applications

Cited by 78

Integrative modeling reveals the molecular architecture of the intraflagellar transport A (IFT-A) complex

McCafferty, C. L., Papoulas, O., Jordan, M. A., Hoogerbrugge, G., Nichols, C., Pigino, G., Taylor, D. W., Wallingford, J. B., & Marcotte, E. M. (2022) · eLife

Genetic and Kidney Cyst DiseasesCystic Fibrosis Research Advances

Cited by 40

Does AlphaFold2 model proteins’ intracellular conformations? An experimental test using cross-linking mass spectrometry of endogenous ciliary proteins

McCafferty, C. L., Pennington, E. L., Papoulas, O., Taylor, D. W., & Marcotte, E. M. (2022) · Communications Biology

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 35

Does AlphaFold2 model proteins’ intracellular conformations? An experimental test using cross-linking mass spectrometry of endogenous ciliary proteins

McCafferty, C. L., Pennington, E. L., Papoulas, O., Taylor, D. W., & Marcotte, E. M. (2023) · Communications Biology

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 35

Structure and organization of full-length epidermal growth factor receptor in extracellular vesicles by cryo-electron tomography

Gonzalez-Magaldi, M., Gullapalli, A., Papoulas, O., Liu, C., Leung, A. Y.-H., Guo, L., Brilot, A. F., Marcotte, E. M., Ke, Z., & Leahy, D. J. (2025) · Proceedings of the National Academy of Sciences

Extracellular vesicles in diseaseAdvanced Electron Microscopy Techniques and Applications

Cited by 17

Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography

Gonzalez-Magaldi, M., Gullapalli, A., Papoulas, O., Liu, C., Leung, A. Y.-H., Guo, L., Brilot, A., Marcotte, E. M., Ke, Z., & Leahy, D. J. (2024) · Proceedings of the National Academy of Sciences

Extracellular vesicles in diseaseAdvanced Electron Microscopy Techniques and Applications

Cited by 17

Effects of Functional Bias on Supervised Learning of a Gene Network Model

Lee, I., & Marcotte, E. M. (2009) · Methods in Molecular Biology

Gene Regulatory Network AnalysisBioinformatics and Genomic Networks

Cited by 14

Alternative proteoforms and proteoform-dependent assemblies in humans and plants

McWhite, C. D., Sae-Lee, W., Yuan, Y., Mallam, A. L., Gort-Freitas, N. A., Ramundo, S., Onishi, M., & Marcotte, E. M. (2024) · Molecular Systems Biology

Advanced Proteomics Techniques and ApplicationsProtein Structure and Dynamics

Cited by 10