Gygi, Steven P.

O-GlcNAc regulates gene expression by controlling detained intron splicing

Tan, Z.-W., Fei, G., Paulo, J. A., Bellaousov, S., Martin, S. E. S., Duveau, D. Y., Thomas, C. J., Gygi, S. P., Boutz, P. L., & Walker, S. (2020) · Nucleic Acids Research

RNA Research and SplicingGlycosylation and Glycoproteins Research

Cited by 119

O-GlcNAc regulates gene expression by controlling detained intron splicing

Tan, Z.-W., Fei, G., Paulo, J. A., Bellaousov, S., Martin, S. E. S., Duveau, D. Y., Thomas, C. J., Gygi, S. P., Boutz, P. L., & Walker, S. (2020) · Nucleic Acids Research

RNA Research and SplicingGlycosylation and Glycoproteins Research

Cited by 119

Ribosome binding of a single copy of the SecY complex: implications for protein translocation.

Ménétret, J.-F., Schaletzky, J., Clemons, W. M., Osborne, A. R., Skånland, S. S., Denison, C., Gygi, S. P., Kirkpatrick, D. S., Park, E., Ludtke, S. J., et al. (2007) · Molecular Cell

RNA and protein synthesis mechanismsBacterial Genetics and Biotechnology

Cited by 108

Trim32 reduces PI3K–Akt–FoxO signaling in muscle atrophy by promoting plakoglobin–PI3K dissociation

Cohen, S., Lee, D., Zhai, B., Gygi, S. P., & Goldberg, A. L. (2014) · Journal of Cell Biology

Muscle Physiology and DisordersFOXO transcription factor regulation

Cited by 103

Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease

Chou, C.-C., Vest, R., Prado, M. A., Wilson-Grady, J., Paulo, J. A., Shibuya, Y., Moran-Losada, P., Lee, T.-T., Luo, J., Gygi, S. P., et al. (2025) · Nature Cell Biology

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 94

A multi-scale map of cell structure fusing protein images and interactions

Qin, Y., Huttlin, E. L., Winsnes, C. F., Gosztyla, M. L., Wacheul, L., Kelly, M. R., Blue, S. M., Zheng, F., Chen, M., Schaffer, L. V., et al. (2021) · Nature

Bioinformatics and Genomic NetworksAdvanced Proteomics Techniques and Applications

Cited by 82

Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation

Brubaker, D. K., Paulo, J. A., Sheth, S., Poulin, E. J., Popow, O., Joughin, B. A., Strasser, S. D., Starchenko, A., Gygi, S. P., Lauffenburger, D. A., et al. (2019) · Cell Systems

Protein Kinase Regulation and GTPase SignalingBioinformatics and Genomic Networks

Cited by 57

Regulation of microtubule-based transport by MAP4

Semenova, I., Ikeda, K., Resaul, K., Kraikivski, P., Aguiar, M., Gygi, S., Zaliapin, I., Cowan, A., & Rodionov, V. (2014) · Molecular Biology of the Cell

Microtubule and mitosis dynamicsGenetic and Kidney Cyst Diseases

Cited by 44

Targeting oncoproteins with a positive selection assay for protein degraders

Koduri, V., Duplaquet, L., Lampson, B. L., Wang, A. C., Sabet, A. H., Ishoey, M., Paulk, J., Teng, M., Harris, I. S., Endress, J. E., et al. (2021) · Science Advances

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 44

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

Mitchell, W., Goeminne, L. J., Tyshkovskiy, A., Zhang, S., Chen, J. Y., Paulo, J. A., Pierce, K. A., Choy, A. H., Clish, C. B., Gygi, S. P., et al. (2024) · eLife

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 33

Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma

Nardone, C., Gao, J., Seo, H.-S., Mintseris, J., Ort, L., Yip, M. C. J., Negasi, M., Besschetnova, A. K., Kamitaki, N., Gygi, S. P., et al. (2025) · Molecular Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 22

Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma

Nardone, C., Gao, J., Seo, H.-S., Mintseris, J., Ort, L., Yip, M. C. J., Negasi, M., Besschetnova, A. K., Kamitaki, N., Gygi, S. P., et al. (2025) · Molecular Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 22

Erratum: Corrigendum: Identification of a unique TGF-β–dependent molecular and functional signature in microglia

Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsTGF-β signaling in diseases

Cited by 19

A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform

Jain, S. U., Williamson, K. E., Ying, A. W., Turner, A. M., Jiang, R. J., Raval, S., So, K., Allison, M. J., Sankar, A., Sáme Guerra, D. D., et al. (2026) · Science

Chromatin Remodeling and CancerGenomics and Chromatin Dynamics

Cited by 11

Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity

Wassarman, D. R., Pfaff, P., Paulo, J. A., Gygi, S. P., Shokat, K. M., & Kranzusch, P. J. (2025) · Science

interferon and immune responsesBacteriophages and microbial interactions

Cited by 9

Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity

Wassarman, D. R., Pfaff, P., Paulo, J. A., Gygi, S. P., Shokat, K. M., & Kranzusch, P. J. (2025) · Science

interferon and immune responsesBacteriophages and microbial interactions

Cited by 9

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

Mitchell, W., Goeminne, L. J. E., Tyshkovskiy, A., Zhang, S., Chen, J. Y., Paulo, J. A., Pierce, K. A., Choy, A. H., Clish, C. B., Gygi, S. P., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory)

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 2

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

Mitchell, W., Goeminne, L. J. E., Tyshkovskiy, A., Zhang, S., Chen, J. Y., Paulo, J. A., Pierce, K. A., Choy, A. H., Clish, C. B., Gygi, S. P., et al. (2024) · eLife

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 0