Gygi, Steven P.
Harvard University
90 papers on CoChatORCID 0000-0001-7626-0034
Most cited papers
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Hierarchical phosphorylation of the translation inhibitor 4E-BP1
Gingras, A.-C., Raught, B., Gygi, S. P., Niedzwiecka, A., Miron, M., Burley, S. K., Polakiewicz, R. D., Wyslouch-Cieszynska, A., Aebersold, R., & Sonenberg, N. (2001) · Genes & Development
PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanisms
Cited by 883
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A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila , and Humans
Bricker, D. K., Taylor, E. B., Schell, J. C., Orsak, T., Boutron, A., Chen, Y.-C., Cox, J. E., Cardon, C. M., Van Vranken, J. G., Dephoure, N., et al. (2012) · Science
Mitochondrial Function and PathologyMetabolism and Genetic Disorders
Cited by 843
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The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
Chantranupong, L., Scaria, S. M., Saxton, R. A., Gygi, M. P., Shen, K., Wyant, G. A., Wang, T., Harper, J. W., Gygi, S. P., & Sabatini, D. M. (2016) · Cell
PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy
Cited by 843
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Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
Quirós, P. M., Prado, M. A., Zamboni, N., D’Amico, D., Williams, R. W., Finley, D., Gygi, S. P., & Auwerx, J. (2017) · Journal of Cell Biology
Endoplasmic Reticulum Stress and DiseaseMitochondrial Function and Pathology
Cited by 832
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An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans
Greer, E. L., Dowlatshahi, D., Banko, M. R., Villen, J., Hoang, K., Blanchard, D., Gygi, S. P., & Brunet, A. (2007) · Current Biology
Genetics, Aging, and Longevity in Model OrganismsFOXO transcription factor regulation
Cited by 801
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Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity
Ringel, A. E., Drijvers, J. M., Baker, G. J., Catozzi, A., García-Cañaveras, J. C., Gassaway, B. M., Miller, B. C., Juneja, V. R., Nguyen, T. H., Joshi, S., et al. (2020) · Cell
Cancer Immunotherapy and BiomarkersImmune cells in cancer
Cited by 780
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Large-scale phosphorylation analysis of mouse liver
Villén, J., Beausoleil, S. A., Gerber, S. A., & Gygi, S. P. (2007) · Proceedings of the National Academy of Sciences
Advanced Proteomics Techniques and ApplicationsBioinformatics and Genomic Networks
Cited by 730
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Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis
Morita, E., Sandrin, V., Chung, H., Morham, S. G., Gygi, S. P., Rodesch, C. K., & Sundquist, W. I. (2007) · The EMBO Journal
Cellular transport and secretionMicrotubule and mitosis dynamics
Cited by 724
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BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
Danial, N. N., Gramm, C. F., Scorrano, L., Zhang, C.-Y., Krauss, S., Ranger, A. M., Robert Datta, S., Greenberg, M. E., Licklider, L. J., Lowell, B. B., et al. (2003) · Nature
Cell death mechanisms and regulationMitochondrial Function and Pathology
Cited by 705
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Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex
Kajimura, S., Seale, P., Kubota, K., Lunsford, E., Frangioni, J. V., Gygi, S. P., & Spiegelman, B. M. (2009) · Nature
Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors
Cited by 703
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SDH5 , a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma
Hao, H.-X., Khalimonchuk, O., Schraders, M., Dephoure, N., Bayley, J.-P., Kunst, H., Devilee, P., Cremers, C. W. R. J., Schiffman, J. D., Bentz, B. G., et al. (2009) · Science
Adrenal and Paraganglionic TumorsMitochondrial Function and Pathology
Cited by 702
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Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response
Wang, B., Matsuoka, S., Ballif, B. A., Zhang, D., Smogorzewska, A., Gygi, S. P., & Elledge, S. J. (2007) · Science
DNA Repair MechanismsBRCA gene mutations in cancer
Cited by 695
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Target-Decoy Search Strategy for Mass Spectrometry-Based Proteomics
Elias, J. E., & Gygi, S. P. (2010) · Methods in Molecular Biology
Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications
Cited by 644
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Increasing the Multiplexing Capacity of TMTs Using Reporter Ion Isotopologues with Isobaric Masses
McAlister, G. C., Huttlin, E. L., Haas, W., Ting, L., Jedrychowski, M. P., Rogers, J. C., Kuhn, K., Pike, I., Grothe, R. A., Blethrow, J. D., et al. (2012) · Analytical Chemistry
Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications
Cited by 605
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Accumulation of succinate controls activation of adipose tissue thermogenesis
Mills, E. L., Pierce, K. A., Jedrychowski, M. P., Garrity, R., Winther, S., Vidoni, S., Yoneshiro, T., Spinelli, J. B., Lu, G. Z., Kazak, L., et al. (2018) · Nature
Adipose Tissue and MetabolismLipid metabolism and biosynthesis
Cited by 539
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A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage
Chou, D. M., Adamson, B., Dephoure, N. E., Tan, X., Nottke, A. C., Hurov, K. E., Gygi, S. P., Colaiácovo, M. P., & Elledge, S. J. (2010) · Proceedings of the National Academy of Sciences
DNA Repair MechanismsPARP inhibition in cancer therapy
Cited by 529
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Semiquantitative Proteomic Analysis of Rat Forebrain Postsynaptic Density Fractions by Mass Spectrometry
Peng, J., Kim, M. J., Cheng, D., Duong, D. M., Gygi, S. P., & Sheng, M. (2004) · Journal of Biological Chemistry
Advanced Proteomics Techniques and ApplicationsNeuroscience and Neuropharmacology Research
Cited by 473
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The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1
Chantranupong, L., Wolfson, R. L., Orozco, J. M., Saxton, R. A., Scaria, S. M., Bar-Peled, L., Spooner, E., Isasa, M., Gygi, S. P., & Sabatini, D. M. (2014) · Cell Reports
PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy
Cited by 466
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A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics
Si, L., Bai, H., Rodas, M., Cao, W., Oh, C. Y., Jiang, A., Moller, R., Hoagland, D., Oishi, K., Horiuchi, S., et al. (2021) · Nature Biomedical Engineering
3D Printing in Biomedical ResearchSARS-CoV-2 and COVID-19 Research
Cited by 440
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Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation
Ron-Harel, N., Santos, D., Ghergurovich, J. M., Sage, P. T., Reddy, A., Lovitch, S. B., Dephoure, N., Satterstrom, F. K., Sheffer, M., Spinelli, J. B., et al. (2016) · Cell Metabolism
Mitochondrial Function and PathologyT-cell and B-cell Immunology
Cited by 429
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Proteomics of Primary Cilia by Proximity Labeling
Mick, D. U., Rodrigues, R. B., Leib, R. D., Adams, C. M., Chien, A. S., Gygi, S. P., & Nachury, M. V. (2015) · Developmental Cell
Genetic and Kidney Cyst DiseasesBiotin and Related Studies
Cited by 409
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Defining the consequences of genetic variation on a proteome-wide scale
Chick, J. M., Munger, S. C., Simecek, P., Huttlin, E. L., Choi, K., Gatti, D. M., Raghupathy, N., Svenson, K. L., Churchill, G. A., & Gygi, S. P. (2016) · Nature
Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals
Cited by 361
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Targeting mi R‐155 restores abnormal microglia and attenuates disease in SOD 1 mice
Butovsky, O., Jedrychowski, M. P., Cialic, R., Krasemann, S., Murugaiyan, G., Fanek, Z., Greco, D. J., Wu, P. M., Doykan, C. E., Kiner, O., et al. (2015) · Annals of Neurology
Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration Mechanisms
Cited by 358
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The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival
Wang, H., Nicolay, B. N., Chick, J. M., Gao, X., Geng, Y., Ren, H., Gao, H., Yang, G., Williams, J. A., Suski, J. M., et al. (2017) · Nature
Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer
Cited by 347
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