Gygi, Steven P.

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers

Jirawatnotai, S., Hu, Y., Michowski, W., Elias, J. E., Becks, L., Bienvenu, F., Zagozdzon, A., Goswami, T., Wang, Y. E., Clark, A. B., et al. (2011) · Nature

DNA Repair MechanismsCancer-related Molecular Pathways

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Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer

Petralia, F., Tignor, N., Reva, B., Koptyra, M., Chowdhury, S., Rykunov, D., Krek, A., Ma, W., Zhu, Y., Ji, J., et al. (2020) · Cell

Glioma Diagnosis and TreatmentCancer Genomics and Diagnostics

Cited by 317

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

Biancur, D. E., Paulo, J. A., Małachowska, B., Quiles Del Rey, M., Sousa, C. M., Wang, X., Sohn, A. S. W., Chu, G. C., Gygi, S. P., Harper, J. W., et al. (2017) · Nature Communications

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 315

Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries

Kuljanin, M., Mitchell, D. C., Schweppe, D. K., Gikandi, A. S., Nusinow, D. P., Bulloch, N. J., Vinogradova, E. V., Wilson, D. L., Kool, E. T., Mancias, J. D., et al. (2021) · Nature Biotechnology

Click Chemistry and ApplicationsAdvanced Proteomics Techniques and Applications

Cited by 305

A Stress-Responsive System for Mitochondrial Protein Degradation

Heo, J.-M., Livnat-Levanon, N., Taylor, E. B., Jones, K. T., Dephoure, N., Ring, J., Xie, J., Brodsky, J. L., Madeo, F., Gygi, S. P., et al. (2010) · Molecular Cell

Ubiquitin and proteasome pathwaysMitochondrial Function and Pathology

Cited by 304

Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells

Coloff, J. L., Murphy, J. P., Braun, C. R., Harris, I. S., Shelton, L. M., Kami, K., Gygi, S. P., Selfors, L. M., & Brugge, J. S. (2016) · Cell Metabolism

Amino Acid Enzymes and MetabolismCancer, Hypoxia, and Metabolism

Cited by 288

pH-gated succinate secretion regulates muscle remodeling in response to exercise

Reddy, A., Bozi, L. H. M., Yaghi, O. K., Mills, E. L., Xiao, H., Nicholson, H. E., Paschini, M., Paulo, J. A., Garrity, R., Laznik-Bogoslavski, D., et al. (2020) · Cell

Muscle Physiology and DisordersAdipose Tissue and Metabolism

Cited by 279

Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen

Bienvenu, F., Jirawatnotai, S., Elias, J. E., Meyer, C. A., Mizeracka, K., Marson, A., Frampton, G. M., Cole, M. F., Odom, D. T., Odajima, J., et al. (2010) · Nature

Cancer-related Molecular PathwaysDevelopmental Biology and Gene Regulation

Cited by 276

Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopenia

Ibebunjo, C., Chick, J. M., Kendall, T., Eash, J. K., Li, C., Zhang, Y., Vickers, C., Wu, Z., Clarke, B. A., Shi, J., et al. (2013) · Molecular and Cellular Biology

Muscle Physiology and DisordersNutrition and Health in Aging

Cited by 267

The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria

Long, J. Z., Svensson, K. J., Bateman, L. A., Lin, H., Kamenecka, T., Lokurkar, I. A., Lou, J., Rao, R. R., Chang, M. R., Jedrychowski, M. P., et al. (2016) · Cell

Adipose Tissue and MetabolismLipid metabolism and biosynthesis

Cited by 257

Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics

Liu, G., Papa, A., Katchman, A. N., Zakharov, S. I., Roybal, D., Hennessey, J. A., Kushner, J., Yang, L., Chen, B.-X., Kushnir, A., et al. (2020) · Nature

Ion channel regulation and functionCardiac electrophysiology and arrhythmias

Cited by 243

Characterization and optimization of multiplexed quantitative analyses using high-field asymmetric-waveform ion mobility mass spectrometry

Schweppe, D. K., Prasad, S., Belford, M. W., Navarrete-Perea, J., Bailey, D. J., Huguet, R., Jedrychowski, M. P., Rad, R., McAlister, G., Abbatiello, S. E., et al. (2019) · Analytical Chemistry

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 229

An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. Elegans and Cancer

Wu, L., Zhou, B., Oshiro-Rapley, N., Li, M., Paulo, J. A., Webster, C. M., Mou, F., Kacergis, M. C., Talkowski, M. E., Carr, C. E., et al. (2016) · Cell

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 227

Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics

Kirkpatrick, D. S., Denison, C., & Gygi, S. P. (2005) · Nature Cell Biology

Ubiquitin and proteasome pathwaysAdvanced Proteomics Techniques and Applications

Cited by 209

Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy

Cohen, S., Zhai, B., Gygi, S. P., & Goldberg, A. L. (2012) · Journal of Cell Biology

Muscle Physiology and DisordersUbiquitin and proteasome pathways

Cited by 205

Tissue-Specific Oncogenic Activity of KRASA146T

Poulin, E. J., Bera, A. K., Lu, J., Lin, Y.-J., Strasser, S. D., Paulo, J. A., Huang, T. Q., Morales, C., Yan, W., Cook, J., et al. (2019) · Cancer Discovery

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 197

Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation

Wang, L. W., Shen, H., Nobre, L., Ersing, I., Paulo, J. A., Trudeau, S., Wang, Z., Smith, N. A., Ma, Y., Reinstadler, B., et al. (2019) · Cell Metabolism

Viral-associated cancers and disordersCancer, Hypoxia, and Metabolism

Cited by 190

Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs

Wang, Y., Dix, M. M., Bianco, G., Remsberg, J. R., Lee, H.-Y., Kalocsay, M., Gygi, S. P., Forli, S., Vite, G., Lawrence, R. M., et al. (2019) · Nature Chemistry

Click Chemistry and ApplicationsAdvanced Proteomics Techniques and Applications

Cited by 179

Selective alanine transporter utilization creates a targetable metabolic niche in pancreatic cancer

Parker, S. J., Amendola, C. R., Hollinshead, K. E. R., Yu, Q., Yamamoto, K., Encarnación-Rosado, J., Rose, R. E., LaRue, M. M., Sohn, A. S. W., Biancur, D. E., et al. (2020) · Cancer Discovery

Amino Acid Enzymes and MetabolismPancreatic and Hepatic Oncology Research

Cited by 175

PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2

German, N. J., Yoon, H., Yusuf, R. Z., Murphy, J. P., Finley, L. W. S., Laurent, G., Haas, W., Satterstrom, F. K., Guarnerio, J., Zaganjor, E., et al. (2016) · Molecular Cell

Cancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism

Cited by 156

Hyperplexing: a method for higher-order multiplexed quantitative proteomics provides a map of the dynamic response to rapamycin in yeast

Dephoure, N., & Gygi, S. P. (2012) · Science Signaling

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 153

Latency-Associated Degradation of the MRP1 Drug Transporter During Latent Human Cytomegalovirus Infection

Weekes, M. P., Tan, S. Y. L., Poole, E., Talbot, S., Antrobus, R., Smith, D. L., Montag, C., Gygi, S. P., Sinclair, J. H., & Lehner, P. J. (2013) · Science

Cytomegalovirus and herpesvirus researchDrug Transport and Resistance Mechanisms

Cited by 131

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

White, J. P., Wrann, C. D., Rao, R. R., Nair, S. K., Jedrychowski, M. P., You, J.-S., Martínez-Redondo, V., Gygi, S. P., Ruas, J. L., Hornberger, T. A., et al. (2014) · Proceedings of the National Academy of Sciences

Muscle Physiology and DisordersAdipose Tissue and Metabolism

Cited by 123

A Genome-wide Camptothecin Sensitivity Screen Identifies a Mammalian MMS22L-NFKBIL2 Complex Required for Genomic Stability

O'Connell, B. C., Adamson, B., Lydeard, J. R., Sowa, M. E., Ciccia, A., Bredemeyer, A. L., Schlabach, M., Gygi, S. P., Elledge, S. J., & Harper, J. W. (2010) · Molecular Cell

DNA Repair MechanismsCancer therapeutics and mechanisms

Cited by 122