Prives, Carol

Blinded by the Light: The Growing Complexity of p53

Vousden, K. H., & Prives, C. (2009) · Cell

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 3,163

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

Shieh, S.-Y., Ikeda, M., Taya, Y., & Prives, C. (1997) · Cell

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 2,100

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

Banin, S., Moyal, L., Shieh, S.-Y., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., et al. (1998) · Science

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 1,797

A role for ATR in the DNA damage-induced phosphorylation of p53

Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S.-Y., Taya, Y., Prives, C., & Abraham, R. T. (1999) · Genes & Development

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 1,046

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

Shieh, S.-Y., Ahn, J., Tamai, K., Taya, Y., & Prives, C. (2000) · Genes & Development

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 972

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

Freed-Pastor, W. A., Mizuno, H., Zhao, X., Langerød, A., Moon, S.-H., Rodriguez-Barrueco, R., Barsotti, A., Chicas, A., Li, W., Polotskaia, A., et al. (2012) · Cell

Cancer, Lipids, and MetabolismCancer-related Molecular Pathways

Cited by 865

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

Chen, X., Ko, L. J., Jayaraman, L., & Prives, C. (1996) · Genes & Development

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 735

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

Suzuki, S., Tanaka, T., Poyurovsky, M. V., Nagano, H., Mayama, T., Ohkubo, S., Lokshin, M., Hosokawa, H., Nakayama, T., Suzuki, Y., et al. (2010) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismCancer-related Molecular Pathways

Cited by 705

Signaling to p53

Prives, C. (1998) · Cell

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 623

Wild-type p53 activates transcription in vitro

Farmer, G., Bargonetti, J., Zhu, H., Friedman, P., Prywes, R., & Prives, C. (1992) · Nature

Cancer-related Molecular PathwaysGenomics and Chromatin Dynamics

Cited by 579

Transcriptional Regulation by P53

Beckerman, R., & Prives, C. (2010) · Cold Spring Harbor Perspectives in Biology

Cancer-related Molecular PathwaysGenomics and Chromatin Dynamics

Cited by 569

PML is induced by oncogenic ras and promotes premature senescence

Ferbeyre, G., de Stanchina, E., Querido, E., Baptiste, N., Prives, C., & Lowe, S. W. (2000) · Genes & Development

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 536

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

Weissmueller, S., Manchado, E., Saborowski, M., Morris, J. P., Wagenblast, E., Davis, C. A., Moon, S.-H., Pfister, N. T., Tschaharganeh, D. F., Kitzing, T., et al. (2014) · Cell

Cancer-related Molecular PathwaysPancreatic and Hepatic Oncology Research

Cited by 466

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

Gaiddon, C., Lokshin, M., Ahn, J., Zhang, T., & Prives, C. (2001) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 464

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

Wang, Y., & Prives, C. (1995) · Nature

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 336

Cyclin G Recruits PP2A to Dephosphorylate Mdm2

Okamoto, K., Li, H., Jensen, M. R., Zhang, T., Taya, Y., Thorgeirsson, S. S., & Prives, C. (2002) · Molecular Cell

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 215

Relevance of the p53–MDM2 axis to aging

Wu, D., & Prives, C. (2018) · Cell Death & Differentiation

Cancer-related Molecular PathwaysGenetics, Aging, and Longevity in Model Organisms

Cited by 215

The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity

Poyurovsky, M. V., Priest, C., Kentsis, A., Borden, K. L., Pan, Z., Pavletich, N., & Prives, C. (2007) · The EMBO Journal

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 203

p53 accumulates but is functionally impaired when DNA synthesis is blocked

Gottifredi, V., Shieh, S.-Y., Taya, Y., & Prives, C. (2001) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 147

DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation

Okamoto, K., Kashima, K., Pereg, Y., Ishida, M., Yamazaki, S., Nota, A., Teunisse, A., Migliorini, D., Kitabayashi, I., Marine, J.-C., et al. (2005) · Molecular and Cellular Biology

Cancer-related Molecular Pathways14-3-3 protein interactions

Cited by 129

Discovery of Mdm2-MdmX E3 Ligase Inhibitors Using a Cell-Based Ubiquitination Assay

Herman, A. G., Hayano, M., Poyurovsky, M. V., Shimada, K., Skouta, R., Prives, C., & Stockwell, B. R. (2011) · Cancer Discovery

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 100

Questioning the Role of Checkpoint Kinase 2 in the p53 DNA Damage Response

Ahn, J., Urist, M., & Prives, C. (2003) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 99

p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation

Soria, G., Speroni, J., Podhajcer, O. L., Prives, C., & Gottifredi, V. (2008) · Journal of Cell Science

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 94

Decreased p21 levels are required for efficient restart of DNA synthesis after S phase block

Gottifredi, V., McKinney, K., Poyurovsky, M. V., & Prives, C. (2004) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 76