Yong, V. Wee

Multiple sclerosis progression: time for a new mechanism-driven framework

Kuhlmann, T., Moccia, M., Coetzee, T., Cohen, J. A., Correale, J., Graves, J., Marrie, R. A., Montalban, X., Yong, V. W., Thompson, A. J., et al. (2023) · The Lancet Neurology

Multiple Sclerosis Research StudiesPsoriasis: Treatment and Pathogenesis

Cited by 667

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

Lampron, A., Larochelle, A., Laflamme, N., Préfontaine, P., Plante, M.-M., Sánchez, M. G., Yong, V. W., Stys, P. K., Tremblay, M.-È., & Rivest, S. (2015) · Journal of Experimental Medicine

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 595

Metalloproteinases: Mediators of Pathology and Regeneration in the CNS

Yong, V. W. (2005) · Nature Reviews Neuroscience

Protease and Inhibitor MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 582

Pathophysiology of the brain extracellular matrix: a new target for remyelination

Lau, L. W., Cua, R., Keough, M. B., Haylock-Jacobs, S., & Yong, V. W. (2013) · Nature reviews. Neuroscience

Proteoglycans and glycosaminoglycans researchMultiple Sclerosis Research Studies

Cited by 549

The Promise of Minocycline in Neurology

Yong, V. W., Wells, J., Giuliani, F., Casha, S., Power, C., & Metz, L. M. (2004) · The Lancet Neurology

Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments

Cited by 518

Pro‐regenerative properties of cytokine‐activated astrocytes

Liberto, C. M., Albrecht, P. J., Herx, L. M., Yong, V. W., & Levison, S. W. (2004) · Journal of Neurochemistry

Neuroinflammation and Neurodegeneration MechanismsSpinal Cord Injury Research

Cited by 464

Progressive multiple sclerosis: from pathophysiology to therapeutic strategies

Faissner, S., Plemel, J. R., Gold, R., & Yong, V. W. (2019) · Nature Reviews Drug Discovery

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 459

Human endogenous retrovirus glycoprotein–mediated induction of redox reactants causes oligodendrocyte death and demyelination

Antony, J. M., van Marle, G., Opii, W., Butterfield, D. A., Mallet, F., Yong, V. W., Wallace, J. L., Deacon, R. M., Warren, K., & Power, C. (2004) · Nature Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 388

Immunosenescence of microglia and macrophages: impact on the ageing central nervous system

Rawji, K. S., Mishra, M. K., Michaels, N. J., Rivest, S., Stys, P. K., & Yong, V. W. (2016) · Brain

Neuroinflammation and Neurodegeneration MechanismsGenetics, Aging, and Longevity in Model Organisms

Cited by 252

Locus for severity implicates CNS resilience in progression of multiple sclerosis

International Multiple Sclerosis Genetics Consortium, Harroud, A., Stridh, P., McCauley, J. L., Saarela, J., van den Bosch, A. M. R., Engelenburg, H. J., Beecham, A. H., Alfredsson, L., Alikhani, K., et al. (2023) · Nature

Multiple Sclerosis Research StudiesGenetic Associations and Epidemiology

Cited by 243

Mechanisms of lysophosphatidylcholine‐induced demyelination: A primary lipid disrupting myelinopathy

Plemel, J. R., Michaels, N. J., Weishaupt, N., Caprariello, A. V., Keough, M. B., Rogers, J. A., Yukseloglu, A., Lim, J., Patel, V. V., Rawji, K. S., et al. (2018) · Glia

Multiple Sclerosis Research StudiesSphingolipid Metabolism and Signaling

Cited by 220

The benefits and detriments of macrophages/microglia in models of multiple sclerosis

Rawji, K. S., & Yong, V. W. (2013) · Clinical and Developmental Immunology

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 217

Cortical remyelination: A new target for repair therapies in multiple sclerosis

Chang, A., Staugaitis, S. M., Dutta, R., Batt, C. E., Easley, K. E., Chomyk, A. M., Yong, V. W., Fox, R. J., Kidd, G. J., & Trapp, B. D. (2012) · Annals of Neurology

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 216

Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion

Plemel, J. R., Stratton, J. A., Michaels, N. J., Rawji, K. S., Zhang, E., Sinha, S., Baaklini, C. S., Dong, Y., Ho, M., Thorburn, K., et al. (2020) · Science Advances

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 208

Determinants of Human B Cell Migration Across Brain Endothelial Cells

Alter, A., Duddy, M., Hebert, S., Biernacki, K., Prat, A., Antel, J. P., Yong, V. W., Nuttall, R. K., Pennington, C. J., Edwards, D. R., et al. (2003) · The Journal of Immunology

Barrier Structure and Function StudiesCell Adhesion Molecules Research

Cited by 195

Central Nervous System-Initiated Inflammation and Neurotrophism in Trauma: IL-1β Is Required for the Production of Ciliary Neurotrophic Factor

Herx, L. M., Rivest, S., & Yong, V. W. (2000) · The Journal of Immunology

Neuroinflammation and Neurodegeneration MechanismsTraumatic Brain Injury and Neurovascular Disturbances

Cited by 190

The benefits of neuroinflammation for the repair of the injured central nervous system

Yong, H. Y. F., Rawji, K. S., Ghorbani, S., Xue, M., & Yong, V. W. (2019) · Cellular & Molecular Immunology

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 190

Microglia in multiple sclerosis: protectors turn destroyers

Yong, V. W. (2022) · Neuron

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 185

Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia

Dong, Y., D’Mello, C., Pinsky, W., Lozinski, B. M., Kaushik, D. K., Ghorbani, S., Moezzi, D., Brown, D., Melo, F. C., Zandee, S., et al. (2021) · Nature Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 181

Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system

Rawji, K. S., Young, A. M. H., Ghosh, T., Michaels, N. J., Mirzaei, R., Kappen, J., Kolehmainen, K. L., Alaeiilkhchi, N., Lozinski, B., Mishra, M. K., et al. (2020) · Acta Neuropathologica

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 153

Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis

Kaushik, D. K., Bhattacharya, A., Mirzaei, R., Rawji, K. S., Ahn, Y., Rho, J. M., & Yong, V. W. (2019) · Journal of Clinical Investigation

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 136

The clinical response to minocycline in multiple sclerosis is accompanied by beneficial immune changes: a pilot study

Zabad, R. K., Metz, L. M., Todoruk, T. R., Zhang, Y., Mitchell, J. R., Yeung, M., Patry, D. G., Bell, R. B., & Yong, V. W. (2007) · Multiple Sclerosis Journal

Multiple Sclerosis Research StudiesPsoriasis: Treatment and Pathogenesis

Cited by 120

Unique spectral signatures of the nucleic acid dye acridine orange can distinguish cell death by apoptosis and necroptosis

Plemel, J. R., Caprariello, A. V., Keough, M. B., Henry, T. J., Tsutsui, S., Chu, T. H., Schenk, G. J., Klaver, R., Yong, V. W., & Stys, P. K. (2017) · Journal of Cell Biology

Cell death mechanisms and regulationAdvanced Fluorescence Microscopy Techniques

Cited by 97

Oxidized phospholipids as novel mediators of neurodegeneration

Dong, Y., & Yong, V. W. (2022) · Trends in Neurosciences

Antioxidant Activity and Oxidative StressNeuroinflammation and Neurodegeneration Mechanisms

Cited by 69