Kelly, Jeffery W.

Adapting Proteostasis for Disease Intervention

Balch, W. E., Morimoto, R. I., Dillin, A., & Kelly, J. W. (2008) · Science

Heat shock proteins researchGenetics, Aging, and Longevity in Model Organisms

Cited by 2,495

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

Powers, E. T., Morimoto, R. I., Dillin, A., Kelly, J. W., & Balch, W. E. (2009) · Annual Review of Biochemistry

Heat shock proteins researchEndoplasmic Reticulum Stress and Disease

Cited by 1,149

Opposing activities protect against age-onset proteotoxicity

Cohen, E., Bieschke, J., Perciavalle, R. M., Kelly, J. W., & Dillin, A. (2006) · Science

Genetics, Aging, and Longevity in Model OrganismsAlzheimer's disease research and treatments

Cited by 843

Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

Talantova, M., Sanz-Blasco, S., Zhang, X., Xia, P., Akhtar, M. W., Okamoto, S.-I., Dziewczapolski, G., Nakamura, T., Cao, G., Pratt, A. E., et al. (2013) · Proceedings of the National Academy of Sciences

Neuroscience and Neuropharmacology ResearchAlzheimer's disease research and treatments

Cited by 600

Reduced IGF-1 signaling delays age-associated proteotoxicity in mice

Cohen, E., Paulsson, J. F., Blinder, P., Burstyn-Cohen, T., Du, D., Estepa, G., Adame, A., Pham, H. M., Holzenberger, M., Kelly, J. W., et al. (2009) · Cell

Alzheimer's disease research and treatmentsGenetics, Aging, and Longevity in Model Organisms

Cited by 488

A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function

Araya, C. L., Fowler, D. M., Chen, W., Muniez, I., Kelly, J. W., & Fields, S. (2012) · Proceedings of the National Academy of Sciences

Protein Structure and Dynamicsthermodynamics and calorimetric analyses

Cited by 230

Protein Native-State Stabilization by Placing Aromatic Side Chains in N-Glycosylated Reverse Turns

Culyba, E. K., Price, J. L., Hanson, S. R., Dhar, A., Wong, C.-H., Gruebele, M., Powers, E. T., & Kelly, J. W. (2011) · Science

Glycosylation and Glycoproteins ResearchProtein purification and stability

Cited by 171

An Adaptable Standard for Protein Export from the Endoplasmic Reticulum

Wiseman, R. L., Powers, E. T., Buxbaum, J. N., Kelly, J. W., & Balch, W. E. (2007) · Cell

Endoplasmic Reticulum Stress and DiseaseHeat shock proteins research

Cited by 155

α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss

Trudler, D., Sanz-Blasco, S., Eisele, Y. S., Ghatak, S., Bodhinathan, K., Akhtar, M. W., Lynch, W. P., Piña-Crespo, J. C., Talantova, M., Kelly, J. W., et al. (2021) · The Journal of Neuroscience

Parkinson's Disease Mechanisms and TreatmentsNeuroscience and Neuropharmacology Research

Cited by 104

Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease

Chou, C.-C., Vest, R., Prado, M. A., Wilson-Grady, J., Paulo, J. A., Shibuya, Y., Moran-Losada, P., Lee, T.-T., Luo, J., Gygi, S. P., et al. (2025) · Nature Cell Biology

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 94

Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma

Choi, S., Connelly, S., Reixach, N., Wilson, I. A., & Kelly, J. W. (2010) · Nature Chemical Biology

Amyloidosis: Diagnosis, Treatment, OutcomesAlzheimer's disease research and treatments

Cited by 90

Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer’s Disease-like Pathology

Savas, J. N., Wang, Y.-Z., DeNardo, L. A., Martinez-Bartolome, S., McClatchy, D. B., Hark, T. J., Shanks, N. F., Cozzolino, K. A., Lavallée-Adam, M., Smukowski, S. N., et al. (2017) · Cell Reports

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 66