Willson, Timothy M.

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature

Peroxisome Proliferator-Activated ReceptorsFatty Acid Research and Health

Cited by 3,525

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D., et al. (1999) · Science

Cholesterol and Lipid MetabolismDrug Transport and Resistance Mechanisms

Cited by 2,274

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences

Peroxisome Proliferator-Activated ReceptorsFatty Acid Research and Health

Cited by 2,164

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C., & Lehmann, J. M. (1995) · Cell

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 2,028

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell

Drug Transport and Resistance MechanismsCholesterol and Lipid Metabolism

Cited by 1,940

The PPARs: From Orphan Receptors to Drug Discovery

Willson, T. M., Brown, P. J., Sternbach, D. D., & Henke, B. R. (2000) · Journal of Medicinal Chemistry

Peroxisome Proliferator-Activated ReceptorsNuclear Receptors and Signaling

Cited by 1,816

Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway

Lehmann, J. M., Kliewer, S. A., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J.-L., Sundseth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A., et al. (1997) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismSteroid Chemistry and Biochemistry

Cited by 1,233

Molecular recognition of fatty acids by peroxisome proliferator-activated receptors

Xu, H. E., Lambert, M. H., Montana, V. G., Parks, D. J., Blanchard, S. G., Brown, P. J., Sternbach, D. D., Lehmann, J. M., Wisely, G. B., Willson, T. M., et al. (1999) · Molecular Cell

Peroxisome Proliferator-Activated ReceptorsProtein Structure and Dynamics

Cited by 1,169

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

Kast, H. R., Goodwin, B., Tarr, P. T., Jones, S. A., Anisfeld, A. M., Stoltz, C. M., Tontonoz, P., Kliewer, S., Willson, T. M., & Edwards, P. A. (2002) · Journal of Biological Chemistry

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 916

ApoE Promotes the Proteolytic Degradation of Aβ

Jiang, Q., Lee, C. Y. D., Mandrekar, S., Wilkinson, B., Cramer, P., Zelcer, N., Mann, K., Lamb, B., Willson, T. M., Collins, J. L., et al. (2008) · Neuron

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 876

The promise and peril of chemical probes

Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., Bountra, C., Brennan, P. E., Brown, P. J., Bunnage, M. E., et al. (2015) · Nature Chemical Biology

Click Chemistry and ApplicationsComputational Drug Discovery Methods

Cited by 839

Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition

Bledsoe, R. K., Montana, V. G., Stanley, T. B., Delves, C. J., Apolito, C. J., McKee, D. D., Consler, T. G., Parks, D. J., Stewart, E. L., Willson, T. M., et al. (2002) · Cell

Estrogen and related hormone effectsReceptor Mechanisms and Signaling

Cited by 818

6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity

Pellicciari, R., Fiorucci, S., Camaioni, E., Clerici, C., Costantino, G., Maloney, P. R., Morelli, A., Parks, D. J., & Willson, T. M. (2002) · Journal of Medicinal Chemistry

Drug Transport and Resistance MechanismsCholesterol and Lipid Metabolism

Cited by 743

Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity

Guerre-Millo, M., Gervois, P., Raspé, E., Madsen, L., Poulain, P., Derudas, B., Herbert, J.-M., Winegar, D. A., Willson, T. M., Fruchart, J.-C., et al. (2000) · Journal of Biological Chemistry

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 605

Functional Consequences of Cysteine Modification in the Ligand Binding Sites of Peroxisome Proliferator Activated Receptors by GW9662

Leesnitzer, L. M., Parks, D. J., Bledsoe, R. K., Cobb, J. E., Collins, J. L., Consler, T. G., Davis, R. G., Hull-Ryde, E. A., Lenhard, J. M., Patel, L., et al. (2002) · Biochemistry

Peroxisome Proliferator-Activated ReceptorsEstrogen and related hormone effects

Cited by 566

Parallel SUMOylation-Dependent Pathways Mediate Gene- and Signal-Specific Transrepression by LXRs and PPARγ

Ghisletti, S., Huang, W., Ogawa, S., Pascual, G., Lin, M.-E., Willson, T. M., Rosenfeld, M. G., & Glass, C. K. (2007) · Molecular Cell

Peroxisome Proliferator-Activated ReceptorsNuclear Receptors and Signaling

Cited by 561

Orphan Nuclear Receptors: Shifting Endocrinology into Reverse

Kliewer, S. A., Lehmann, J. M., & Willson, T. M. (1999) · Science

Nuclear Receptors and SignalingEstrogen and related hormone effects

Cited by 499

Peroxisome proliferator-activated receptors and hepatic stellate cell activation

Miyahara, T., Schrum, L., Rippe, R., Xiong, S., Yee, H. F., Motomura, K., Anania, F. A., Willson, T. M., & Tsukamoto, H. (2000) · Journal of Biological Chemistry

Peroxisome Proliferator-Activated ReceptorsLiver physiology and pathology

Cited by 473

Too many roads not taken

Edwards, A. M., Isserlin, R., Bader, G. D., Frye, S. V., Willson, T. M., & Yu, F. H. (2011) · Nature

Bioinformatics and Genomic NetworksGenomics and Phylogenetic Studies

Cited by 411

Tapinarof is a natural AhR agonist that resolves skin inflammation in mice and humans.

Smith, S. H., Jayawickreme, C., Rickard, D. J., Nicodeme, E., Bui, T., Simmons, C., Coquery, C. M., Neil, J., Pryor, W. M., Mayhew, D., et al. (2017) · Journal of Investigative Dermatology

Psoriasis: Treatment and PathogenesisDermatology and Skin Diseases

Cited by 387

Comprehensive characterization of the Published Kinase Inhibitor Set

Elkins, J. M., Fedele, V., Szklarz, M., Abdul Azeez, K. R., Salah, E., Mikolajczyk, J., Romanov, S., Sepetov, N., Huang, X.-P., Roth, B. L., et al. (2016) · Nature Biotechnology

Computational Drug Discovery MethodsProtein Kinase Regulation and GTPase Signaling

Cited by 323

Polyunsaturated Fatty Acids Including Docosahexaenoic and Arachidonic Acid Bind to the Retinoid X Receptor α Ligand-binding Domain

Lengqvist, J., Mata de Urquiza, A., Bergman, A.-C., Willson, T. M., Sjövall, J., Perlmann, T., & Griffiths, W. J. (2004) · Molecular & Cellular Proteomics

Fatty Acid Research and HealthRetinoids in leukemia and cellular processes

Cited by 323

Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

Wisely, G. B., Miller, A. B., Davis, R. G., Thornquest, A. D., Johnson, R., Spitzer, T., Sefler, A., Shearer, B., Moore, J. T., Miller, A. B., et al. (2002) · Structure

Protein Structure and DynamicsPeroxisome Proliferator-Activated Receptors

Cited by 311

Target Genes of Peroxisome Proliferator-activated Receptor γ in Colorectal Cancer Cells

Gupta, R. A., Brockman, J. A., Sarraf, P., Willson, T. M., & DuBois, R. N. (2001) · Journal of Biological Chemistry

Peroxisome Proliferator-Activated ReceptorsCancer, Lipids, and Metabolism

Cited by 215