Rock, Kenneth L.

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature

Inflammasome and immune disordersAtherosclerosis and Cardiovascular Diseases

Cited by 4,026

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 3,065

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules.

Rock, K. L., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D., & Goldberg, A. L. (1994) · Cell

Ubiquitin and proteasome pathwaysProtease and Inhibitor Mechanisms

Cited by 2,524

How dying cells alert the immune system to danger

Kono, H., & Rock, K. L. (2008) · Nature Reviews Immunology

Immune Response and InflammationCell death mechanisms and regulation

Cited by 1,737

Molecular identification of a danger signal that alerts the immune system to dying cells

Shi, Y., Evans, J. E., & Rock, K. L. (2003) · Nature

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 1,684

Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation

Dhatchinamoorthy, K., Colbert, J. D., & Rock, K. L. (2021) · Frontiers in Immunology

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 1,077

A Phagosome-to-Cytosol Pathway for Exogenous Antigens Presented on MHC Class I Molecules

Kovacsovics-Bankowski, M., & Rock, K. L. (1995) · Science

Immunotherapy and Immune Responsesvaccines and immunoinformatics approaches

Cited by 884

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

Chen, C.-J., Kono, H., Golenbock, D., Reed, G., Akira, S., & Rock, K. L. (2007) · Nature Medicine

Immune Response and InflammationInflammasome and immune disorders

Cited by 876

The Sterile Inflammatory Response

Rock, K. L., Latz, E., Ontiveros, F., & Kono, H. (2010) · Annual Review of Immunology

Immune Response and InflammationInflammasome and immune disorders

Cited by 865

Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.

Shen, Z., Reznikoff, G., Dranoff, G., & Rock, K. L. (1997) · The Journal of Immunology

Immunotherapy and Immune ResponsesT-cell and B-cell Immunology

Cited by 846

Present yourself! by MHC class I and MHC class II molecules

Rock, K. L., Reits, E., & Neefjes, J. (2016) · Trends in Immunology

Immunotherapy and Immune Responsesvaccines and immunoinformatics approaches

Cited by 814

Uric acid promotes an acute inflammatory response to sterile cell death in mice

Kono, H., Chen, C.-J., Ontiveros, F., & Rock, K. L. (2010) · Journal of Clinical Investigation

Gout, Hyperuricemia, Uric AcidImmune Response and Inflammation

Cited by 337

Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7

Gaczynska, M., Rock, K. L., Spies, T., & Goldberg, A. L. (1994) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysProtease and Inhibitor Mechanisms

Cited by 312

Multiple cathepsins promote pro-IL-1β synthesis and NLRP3-mediated IL-1β activation

Orlowski, G. M., Colbert, J. D., Sharma, S., Bogyo, M., Robertson, S. A., & Rock, K. L. (2015) · The Journal of Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 268

Cross-presentation of exogenous antigens on MHC I molecules

Colbert, J. D., Cruz, F. M., & Rock, K. L. (2020) · Current Opinion in Immunology

Immunotherapy and Immune ResponsesT-cell and B-cell Immunology

Cited by 150

Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression

Kriegsman, B. A., Vangala, P., Chen, B. J., Meraner, P., Brass, A. L., Garber, M., & Rock, K. L. (2019) · The Journal of Immunology

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 114

Identification of the Cellular Sensor That Stimulates the Inflammatory Response to Sterile Cell Death

Kono, H., Karmarkar, D., Iwakura, Y., & Rock, K. L. (2010) · The Journal of Immunology

Immune Response and InflammationInflammasome and immune disorders

Cited by 101

Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury

Lai, J.-J., Cruz, F. M., & Rock, K. L. (2020) · Immunity

Immune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 85

The combined deficiency of immunoproteasome subunits affects both the magnitude and quality of Pathogen- and genetic vaccination- induced CD8+ T Cell responses to the human Protozoan parasite Trypanosoma cruzi

Ersching, J., Vasconcelos, J. R., Ferreira, C. P., Caetano, B. C., Machado, A. V., Bruna–Romero, O., Baron, M. A., Ferreira, L. R. P., Cunha-Neto, E., Rock, K. L., et al. (2016) · PLOS Pathogens

Trypanosoma species research and implicationsvaccines and immunoinformatics approaches

Cited by 18