Haggarty, Stephen J.

Human iPSC-derived neuronal model of Tau-A152T frontotemporal dementia reveals tau-mediated mechanisms of neuronal vulnerability

Silva, M. C., Cheng, C., Mair, W., Almeida, S., Fong, H., Biswas, M. H. U., Zhang, Z., Huang, Y., Temple, S., Coppola, G., et al. (2016) · Stem Cell Reports

Alzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

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Chemical Genetic Modifier Screens

Koeller, K. M., Haggarty, S. J., Perkins, B. D., Leykin, I., Wong, J. C., Kao, M.-C. J., & Schreiber, S. L. (2003) · Chemistry & Biology

Histone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics

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Chemical Genomic Profiling of Biological Networks Using Graph Theory and Combinations of Small Molecule Perturbations

Haggarty, S. J., Clemons, P. A., & Schreiber, S. L. (2003) · Journal of the American Chemical Society

Bioinformatics and Genomic NetworksGene Regulatory Network Analysis

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Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery

Bernard-Gauthier, V., Mossine, A. V., Knight, A., Patnaik, D., Zhao, W.-N., Cheng, C., Krishnan, H. S., Xuan, L. L., Chindavong, P. S., Reis, S. A., et al. (2019) · Journal of Medicinal Chemistry

Alzheimer's disease research and treatmentsWnt/β-catenin signaling in development and cancer

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WNT/β-Catenin Pathway and Epigenetic Mechanisms Regulate the Pitt-Hopkins Syndrome and Schizophrenia Risk Gene TCF4

Hennig, K. M., Fass, D. M., Zhao, W.-N., Sheridan, S. D., Fu, T., Erdin, S., Stortchevoi, A., Lucente, D., Cody, J. D., Sweetser, D., et al. (2017) · Complex Psychiatry

Genetics and Neurodevelopmental DisordersWnt/β-catenin signaling in development and cancer

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Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory

Zhao, W.-N., Ghosh, B., Tyler, M., Lalonde, J., Joseph, N. F., Kosaric, N., Fass, D. M., Tsai, L.-H., Mazitschek, R., & Haggarty, S. J. (2018) · ACS Chemical Neuroscience

Histone Deacetylase Inhibitors ResearchNeuroscience and Neuropharmacology Research

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Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression

Moreno-Yruela, C., Fass, D. M., Cheng, C., Herz, J., Olsen, C. A., & Haggarty, S. J. (2019) · ACS Chemical Neuroscience

Histone Deacetylase Inhibitors ResearchAlzheimer's disease research and treatments

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Advancing drug discovery for schizophrenia

Marder, S. R., Roth, B., Sullivan, P. F., Scolnick, E. M., Nestler, E. J., Geyer, M. A., Welnberger, D. R., Karayiorgou, M., Guidotti, A., Gingrich, J., et al. (2011) · Annals of the New York Academy of Sciences

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

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Human iPSC Models in Drug Discovery: Opportunities and Challenges

Silva, M. C., Cross, A., Brandon, N. J., & Haggarty, S. J. (2017) · Comprehensive Medicinal Chemistry III

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

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