Chemical Genetic Modifier Screens

Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection.

Li, C., & Wong, W. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.31 · Cited by 3,133 · see citing works

HDAC6 is a microtubule-associated deacetylase

Hubbert, C., Guardiola, A., Shao, R., Kawaguchi, Y., Ito, A., Nixon, A., Yoshida, M., Wang, X.-F., & Yao, T.-P. (2002) · Nature · doi:10.1038/417455a · Cited by 2,403 · see citing works

Histone deacetylases and cancer: causes and therapies

Marks, P. A., Rifkind, R. A., Richon, V. M., Breslow, R., Miller, T., & Kelly, W. K. (2001) · Nature reviews. Cancer · doi:10.1038/35106079 · Cited by 1,866 · see citing works

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

Yoshida, M., Kijima, M., Akita, M., & Beppu, T. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44885-x · Cited by 1,856 · see citing works

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

Taunton, J., Hassig, C. A., & Schreiber, S. L. (1996) · Science · doi:10.1126/science.272.5260.408 · Cited by 1,829 · see citing works

"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells

Ramalho‐Santos, M., Yoon, S., Matsuzaki, Y., Mulligan, R. C., & Melton, D. A. (2002) · Science · doi:10.1126/science.1072530 · Cited by 1,711 · see citing works

Retinoblastoma protein recruits histone deacetylase to repress transcription

Brehm, A., Miska, E. A., McCance, D. J., Reid, J. L., Bannister, A. J., & Kouzarides, T. (1998) · Nature · doi:10.1038/35404 · Cited by 1,231 · see citing works

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

Haggarty, S. J., Koeller, K. M., Wong, J. C., Grozinger, C. M., & Schreiber, S. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0430973100 · Cited by 1,066 · see citing works

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases

Richon, V. M., Emiliani, S., Verdin, E., Webb, Y., Breslow, R., Rifkind, R. A., & Marks, P. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3003 · Cited by 914 · see citing works

Microtubules containing acetylated alpha-tubulin in mammalian cells in culture.

Piperno, G., LeDizet, M., & Chang, X. J. (1987) · The Journal of cell biology · doi:10.1083/jcb.104.2.289 · Cited by 873 · see citing works

Untitled work

(2002) · PubMed · Cited by 732 · see citing works

A common mechanism of action for three mood-stabilizing drugs

Williams, R. S. B., Cheng, L., Mudge, A. W., & Harwood, A. J. (2002) · Nature · doi:10.1038/417292a · Cited by 617 · see citing works

HDAC4 deacetylase associates with and represses the MEF2 transcription factor

Miska, E. A., Karlsson, C., Langley, E., Nielsen, S. J., Pines, J., & Kouzarides, T. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.5099 · Cited by 551 · see citing works

Deacetylase Enzymes

Grozinger, C. M., & Schreiber, S. L. (2002) · Chemistry & Biology · doi:10.1016/s1074-5521(02)00092-3 · Cited by 537 · see citing works

Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase.

Kijima, M., Yoshida, M., Sugita, K., Horinouchi, S., & Beppu, T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41547-5 · Cited by 516 · see citing works

Small molecule developmental screens reveal the logic and timing of vertebrate development

Peterson, R. T., Link, B. A., Dowling, J. E., & Schreiber, S. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.24.12965 · Cited by 486 · see citing works

FR901228, a Potent Antitumor Antibiotic, Is a Novel Histone Deacetylase Inhibitor

Nakajima, H., Kim, Y. B., Terano, H., Yoshida, M., & Horinouchi, S. (1998) · Experimental Cell Research · doi:10.1006/excr.1998.4027 · Cited by 484 · see citing works

Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report

Piekarz, R., Robey, R. W., Sandor, V. A., Bakke, S., Wilson, W. H., Dahmoush, L., Kingma, D. M., Turner, M. L. C., Altemus, R., & Bates, S. E. (2001) · Blood · doi:10.1182/blood.v98.9.2865 · Cited by 445 · see citing works

Genomewide studies of histone deacetylase function in yeast

Bernstein, B., Tong, J. K., & Schreiber, S. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250477697 · Cited by 419 · see citing works

Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin

Furumai, R., Komatsu, Y., Nishino, N., Khochbin, S., Yoshida, M., & Horinouchi, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.87 · Cited by 412 · see citing works

Signaling Network Model of Chromatin

Schreiber, S. L., & Bernstein, B. (2002) · Cell · doi:10.1016/s0092-8674(02)01196-0 · Cited by 395 · see citing works

Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer.

Mariadason, J. M., Corner, G. A., & Augenlicht, L. H. (2000) · PubMed · Cited by 375 · see citing works

A role for histone deacetylase activity in HDAC1-mediated transcriptional repression

Hassig, C. A., Tong, J. K., Fleischer, T. C., Owa, T., Grable, P. G., Ayer, D. E., & Schreiber, S. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3519 · Cited by 365 · see citing works

Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia

He, L.-Z., Tolentino, T., Grayson, P. C., Zhong, S., Warrell, R. P., Rifkind, R. A., Marks, P. A., Richon, V. M., & Pandolfi, P. P. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200111537 · Cited by 303 · see citing works

Histone Deacetylase Inhibitor Activates the WAF1/Cip1 Gene Promoter through the Sp1 Sites

Sowa, Y., Orita, T., Minamikawa, S., Nakano, K., Mizuno, T., Nomura, H., & Sakai, T. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7786 · Cited by 289 · see citing works

Molecular Cloning and Characterization of a Novel Histone Deacetylase HDAC10

Guardiola, A. R., & Yao, T.-P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109861200 · Cited by 253 · see citing works

Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis

Haggarty, S. J., Mayer, T. U., Miyamoto, D. T., Fathi, R., King, R. W., Mitchison, T. J., & Schreiber, S. L. (2000) · Chemistry & Biology · doi:10.1016/s1074-5521(00)00101-0 · Cited by 251 · see citing works

Histone Deacetylase Inhibitors Trigger a G2 Checkpoint in Normal Cells That Is Defective in Tumor Cells

Qiu, L., Burgess, A., Fairlie, D. P., Leonard, H. P., Parsons, P. G., & Gabrielli, B. G. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.6.2069 · Cited by 249 · see citing works

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

Fan, Z., Beresford, P. J., Zhang, D., Xu, Z., Novina, C. D., Yoshida, A., Pommier, Y. G., & Lieberman, J. (2003) · Nature Immunology · doi:10.1038/ni885 · Cited by 240 · see citing works

High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications

Stockwell, B. R., Haggarty, S. J., & Schreiber, S. L. (1999) · Chemistry & Biology · doi:10.1016/s1074-5521(99)80004-0 · Cited by 203 · see citing works

Multidimensional Chemical Genetic Analysis of Diversity-Oriented Synthesis-Derived Deacetylase Inhibitors Using Cell-Based Assays

Haggarty, S. J., Koeller, K. M., Wong, J. C., Butcher, R. A., & Schreiber, S. L. (2003) · Chemistry & Biology · doi:10.1016/s1074-5521(03)00095-4 · Cited by 201 · see citing works

Retinoic acid alters photoreceptor development in vivo

Hyatt, G. A., Schmitt, E. A., Fadool, J. M., & Dowling, J. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13298 · Cited by 189 · see citing works

Synthesis of 7200 Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors Trichostatin and Trapoxin

Sternson, S. M., Wong, J. C., Grozinger, C. M., & Schreiber, S. L. (2001) · Organic Letters · doi:10.1021/ol016915f · Cited by 139 · see citing works

Human mesenchymal stem cells support megakaryocyte and pro-platelet formation from CD34+ hematopoietic progenitor cells

Cheng, L., Qasba, P., Vanguri, P., & Thiede, M. A. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200007)184:1 · Cited by 136 · see citing works

Mechanism of Cell Cycle Arrest Caused by Histone Deacetylase Inhibitors in Human Carcinoma Cells.

Kim, Y. B., Ki, S. W., YOSNIDA, M., & Horinouchi, S. (2000) · The Journal of Antibiotics · doi:10.7164/antibiotics.53.1191 · Cited by 117 · see citing works

Transgenic expression of a GFP-rhodopsin COOH-terminal fusion protein in zebrafish rod photoreceptors

Perkins, B. D., Kainz, P. M., O’Malley, D. M., & Dowling, J. E. (2002) · Visual Neuroscience · doi:10.1017/s0952523802192030 · Cited by 41 · see citing works

Photoaffinity Labeling and Mass Spectrometry Identify Ribosomal Protein S3 as a Potential Target for Hybrid Polar Cytodifferentiation Agents

Webb, Y., Zhou, X., Ngo, L., Cornish, V. W., Stahl, J., Erdjument‐Bromage, H., Tempst, P., Rifkind, R. A., Marks, P. A., Breslow, R., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.20.14280 · Cited by 36 · see citing works

Polyglutamine Disease: Acetyltransferases Awry

Hughes, R. E. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00709-1 · Cited by 35 · see citing works

The Pit-1β Domain Dictates Active Repression and Alteration of Histone Acetylation of the Proximal Prolactin Promoter

Diamond, S. E., & Gutierrez‐Hartmann, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006048200 · Cited by 29 · see citing works

Repression of the mouse M-lysozyme gene involves both hindrance of enhancer factor binding to the methylated enhancer and histone deacetylation

Ammerpohl, O., Schmitz, A., Steinmüller, L., & Renkawitz, R. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.23.5256 · Cited by 24 · see citing works

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

Haggarty, S. J., Koeller, K. M., Wong, J. C., Grozinger, C. M., & Schreiber, S. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0430973100 · Cited by 1,066 · see citing works

Microtubule Acetylation Promotes Kinesin-1 Binding and Transport

Reed, N. A., Cai, D., Blasius, T. L., Jih, G. T., Meyhofer, E., Gaertig, J., & Verhey, K. J. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.014 · Cited by 919 · see citing works

ER sliding dynamics and ER-mitochondrial contacts occur on acetylated microtubules

Friedman, J. R., Webster, B. M., Mastronarde, D. N., Verhey, K. J., & Voeltz, G. K. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200911024 · Cited by 393 · see citing works

New approaches to molecular cancer therapeutics

Collins, I., & Workman, P. (2006) · Nature Chemical Biology · doi:10.1038/nchembio840 · Cited by 390 · see citing works

Histone deacetylase inhibitors

Monneret, C. (2004) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2004.10.001 · Cited by 337 · see citing works

Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains

Chung, C., Coste, H., White, J. H. M., Mirguet, O., Wilde, J. I., Gosmini, R. L., Delves, C. J., Magny, S. D., Woodward, R., Hughes, S. A., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200108t · Cited by 334 · see citing works

Identification of Direct Protein Targets of Small Molecules

Lomenick, B., Olsen, R. W., & Huang, J. (2010) · ACS Chemical Biology · doi:10.1021/cb100294v · Cited by 300 · see citing works

Chemical Genetics

Walsh, D. P., & Chang, Y. (2006) · Chemical Reviews · doi:10.1021/cr0404141 · Cited by 296 · see citing works

Histone Acetylation Regulates Intracellular pH

McBrian, M. A., Behbahan, I. S., Ferrari, R., Su, T., Huang, T.-W., Li, K., Hong, C. S., Christofk, H. R., Vogelauer, M., Seligson, D. B., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.025 · Cited by 272 · see citing works

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

Shaw, A. T., Winslow, M. M., Magendantz, M., Ouyang, C., Dowdle, J. A., Subramanian, A., Lewis, T. A., Maglathin, R. L., Tolliday, N. J., & Jacks, T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105941108 · Cited by 229 · see citing works

p21^WAF1/Cip1 is a negative transcriptional regulator of <i>Wnt4</i> expression downstream of Notch1 activation

Devgan, V., Mammucari, C., Millar, S. E., Brisken, C., & Dotto, G. P. (2005) · Genes &amp; Development · doi:10.1101/gad.341405 · Cited by 209 · see citing works

Multidimensional Chemical Genetic Analysis of Diversity-Oriented Synthesis-Derived Deacetylase Inhibitors Using Cell-Based Assays

Haggarty, S. J., Koeller, K. M., Wong, J. C., Butcher, R. A., & Schreiber, S. L. (2003) · Chemistry & Biology · doi:10.1016/s1074-5521(03)00095-4 · Cited by 201 · see citing works

Epigenetic Information and Estrogen Receptor Alpha Expression in Breast Cancer

Giacinti, L., Claudio, P. P., Lopez, M., & Giordano, A. (2006) · The Oncologist · doi:10.1634/theoncologist.11-1-1 · Cited by 183 · see citing works

Inadequate histone deacetylation during oocyte meiosis causes aneuploidy and embryo death in mice

Akiyama, T., Nagata, M., & Aoki, F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510946103 · Cited by 180 · see citing works

Crystal Structure of a Bacterial Class 2 Histone Deacetylase Homologue

Nielsen, T. K., Hildmann, C., Dickmanns, A., Schwienhorst, A., & Ficner, R. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.09.065 · Cited by 157 · see citing works

Diverse small-molecule modulators of SMN expression found by high-throughput compound screening: early leads towards a therapeutic for spinal muscular atrophy

Jarecki, J., Chen, X., Bernardino, A., Coovert, D. D., Whitney, M., Burghes, A. H. M., Stack, J. H., & Pollok, B. A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi205 · Cited by 150 · see citing works

Relationship of Stereochemical and Skeletal Diversity of Small Molecules to Cellular Measurement Space

Kim, Y.-K., Arai, M. A., Arai, T., Lamenzo, J. O., Dean, E. F., Patterson, N. J., Clemons, P. A., & Schreiber, S. L. (2004) · Journal of the American Chemical Society · doi:10.1021/ja048170p · Cited by 130 · see citing works

Complex phenotypic assays in high-throughput screening

Clemons, P. A. (2004) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2004.04.002 · Cited by 101 · see citing works

From large networks to small molecules

Sharom, J. R., Bellows, D. S., & Tyers, M. (2003) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2003.12.007 · Cited by 96 · see citing works

Activation of the Growth-Differentiation Factor 11 Gene by the Histone Deacetylase (HDAC) Inhibitor Trichostatin A and Repression by HDAC3

Zhang, X. M., Wharton, W., Yuan, Z., Tsai, S., Olashaw, N., & Seto, E. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.12.5106-5118.2004 · Cited by 94 · see citing works

Activity of the histone deacetylase inhibitor belinostat (PXD101) in preclinical models of prostate cancer

Qian, X., Ara, G., Mills, E., LaRochelle, W. J., Lichenstein, H. S., & Jeffers, M. (2007) · International Journal of Cancer · doi:10.1002/ijc.23243 · Cited by 93 · see citing works

R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies

Arts, J., Angibaud, P. R., Mariën, A., Floren, W., Janssens, B., King, P., Dun, J. V., Janssen, L., Geerts, T., Tuman, R. W., et al. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6604025 · Cited by 89 · see citing works

Identification and Characterization of Small Molecule Inhibitors of a Class I Histone Deacetylase from Plasmodium falciparum

Patel, V. P., Mazitschek, R., Coleman, B. I., Nguyen, C., Urgaonkar, S., Cortese, J. F., Barker, R. H., Greenberg, E. F., Tang, W., Bradner, J. E., et al. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm801654y · Cited by 87 · see citing works

Synthesis and Biological Evaluation of Analogues of AKT (Protein Kinase B) Inhibitor-IV

Sun, Q., Wu, R., Cai, S., Lin, Y., Sellers, L., Sakamoto, K., He, B., & Peterson, B. R. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm100912b · Cited by 79 · see citing works

Substrate and inhibitor specificity of class 1 and class 2 histone deacetylases

Hildmann, C., Wegener, D., Riester, D., Hempel, R., Schober, A., Merana, J., Giurato, L., Guccione, S., Nielsen, T. K., Ficner, R., et al. (2006) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2006.01.030 · Cited by 78 · see citing works

The principle of complementarity: chemical versus biological space

Haggarty, S. J. (2005) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2005.04.006 · Cited by 72 · see citing works

Differential protein acetylation induced by novel histone deacetylase inhibitors

Glaser, K. B., Li, J., Pease, L. J., Staver, M. J., Marcotte, P. A., Guo, J., Frey, R. R., Garland, R. B., Heyman, H. R., Wada, C. K., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.10.082 · Cited by 66 · see citing works

A Phenotypic Small-Molecule Screen Identifies an Orphan Ligand-Receptor Pair that Regulates Neural Stem Cell Differentiation

Saxe, J. P., Wu, H., Kelly, T. K., Phelps, M. E., Sun, Y. E., Kornblum, H. I., & Huang, J. (2007) · Chemistry & Biology · doi:10.1016/j.chembiol.2007.07.016 · Cited by 66 · see citing works

ADVANCES IN CHEMICAL GENETICS

Smukste, I., & Stockwell, B. R. (2005) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.6.080604.162136 · Cited by 65 · see citing works

Breast cancer chemotherapy induces vascular dysfunction and hypertension through a NOX4-dependent mechanism

Szczepaniak, P., Siedliński, M., Hodorowicz-Zaniewska, D. M., Nosalski, R., Mikolajczyk, T. P., Dobosz, A. M., Dikalova, A., Dikalov, S., Streb, J., Gara, K., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci149117 · Cited by 52 · see citing works

A kinesin-1 variant reveals motor-induced microtubule damage in cells

Budaitis, B. G., Badieyan, S., Yue, Y., Blasius, T. L., Reinemann, D. N., Lang, M. J., Cianfrocco, M. A., & Verhey, K. J. (2022) · Current Biology · doi:10.1016/j.cub.2022.04.020 · Cited by 49 · see citing works

Carbohydrates in diversity-oriented synthesis: challenges and opportunities

Lenci, E., Menchi, G., & Trabocchi, A. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob02253c · Cited by 48 · see citing works

Introduction: Cell-Based Assays for High-Throughput Screening

An, W. F., & Tolliday, N. J. (2009) · Methods in molecular biology · doi:10.1007/978-1-60327-545-3_1 · Cited by 44 · see citing works

Identification of Agents that Induce Apoptosis of Multicellular Tumour Spheroids: Enrichment for Mitotic Inhibitors with Hydrophobic Properties

Fayad, W., Rickardson, L., Haglund, C., Olofsson, M. H., D’Arcy, P., Larsson, R. L., Linder, S. T., & Fryknäs, M. (2011) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2011.01170.x · Cited by 41 · see citing works

Recent progress in the development of assays suited for histone deacetylase inhibitor screening

Wegener, D., Hildmann, C., & Schwienhorst, A. (2003) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2003.08.008 · Cited by 41 · see citing works

A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression

Johnson, R. L., Huang, W., Jadhav, A., Austin, C. P., Inglese, J., & Martínez, E. D. (2007) · Analytical Biochemistry · doi:10.1016/j.ab.2007.12.028 · Cited by 36 · see citing works

One-pot synthesis of tetrahydrobenzo[a]xanthen-11-one derivatives catalyzed by ruthenium chloride hydrate as a homogeneous catalyst

Tabatabaeian, K., Khorshidi, A., Mamaghani, M., Dadashi, A., & Khoshnood, M. (2011) · Canadian Journal of Chemistry · doi:10.1139/v11-042 · Cited by 33 · see citing works

Contribution of reactivated RUNX3 to inhibition of gastric cancer cell growth following suberoylanilide hydroxamic acid (vorinostat) treatment

Huang, C., Ida, H., Ito, K., Zhang, H., & Ito, Y. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.12.013 · Cited by 33 · see citing works

Pterostilbene improves neurological dysfunction and neuroinflammation after ischaemic stroke via HDAC3/Nrf1-mediated microglial activation

Chen, Y., He, W., Qiu, J., Luo, Y., Jiang, C., Zhao, F., Wei, H., Jiao, M., Long, T., Zhang, X., et al. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00634-1 · Cited by 32 · see citing works

ATP‐induced osteoclast function: the formation of sealing‐zone like structure and the secretion of lytic granules via microtubule‐deacetylation under the control of Syk

Hazama, R., Qu, X., Kunio, Y., Tanaka, C., Kinoshita, E., He, J., Takahashi, S., Tohyama, K., Yamamura, H., & Tohyama, Y. (2009) · Genes to Cells · doi:10.1111/j.1365-2443.2009.01317.x · Cited by 32 · see citing works

1,2,3-Triazoles

Rachwał, S., & KATRITZKY, A. R. (2008) · Elsevier eBooks · doi:10.1016/b978-008044992-0.00501-0 · Cited by 31 · see citing works

Histone deacetylase inhibitor assay based on fluorescence resonance energy transfer

Riester, D., Hildmann, C., Schwienhorst, A., & Meyer‐Almes, F. (2007) · Analytical Biochemistry · doi:10.1016/j.ab.2006.12.019 · Cited by 29 · see citing works

The contributions of microtubule stability and dynamic instability to adenovirus nuclear localization efficiency

Warren, J. C., & Cassimeris, L. (2007) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20215 · Cited by 27 · see citing works

Small molecule intervention in microtubule-associated human disease

Gerdes, J. M. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi269 · Cited by 27 · see citing works

A Dual-Mode Fluorescence Strategy for Screening HAT Modulators

Xie, N., Elangwe, E. N., Asher, S., & Zheng, Y. G. (2009) · Bioconjugate Chemistry · doi:10.1021/bc800467a · Cited by 26 · see citing works

Using High-Throughput Screening Data To Discriminate Compounds with Single-Target Effects from Those with Side Effects

Klekota, J., Brauner, E., Roth, F. P., & Schreiber, S. L. (2006) · Journal of Chemical Information and Modeling · doi:10.1021/ci050495h · Cited by 26 · see citing works

Clinically Applicable Inhibitors Impacting Genome Stability

Prakash, A., García-Moreno, J. F., Brown, J. A. L., & Bourke, E. (2018) · Molecules · doi:10.3390/molecules23051166 · Cited by 24 · see citing works

Recent Advances in Medicinal Chemistry of Histone Deacetylase Inhibitors

Weinmann, H., & Ottow, E. (2004) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(04)39015-9 · Cited by 25 · see citing works

Histone deacetylase inhibitor pharmacodynamic analysis by multiparameter flow cytometry.

Chung, E. J., Lee, S., Sausville, E. A., Ryan, Q. C., Karp, J. E., Gojo, I., Telford, W. G., Lee, M. J., Kong, H. S., & Trepel, J. B. (2005) · PubMed · Cited by 24 · see citing works

Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability

Shen, Z., Liao, X., Shao, Z., Feng, M., Yuan, J., Wang, S., Gan, S., Ha, Y., He, Z., & Jie, W. (2019) · BMC Cancer · doi:10.1186/s12885-019-5482-y · Cited by 24 · see citing works

Small Molecule Modulation of the Human Chromatid Decatenation Checkpoint

Haggarty, S. J., Koeller, K. M., Kau, T. R., Silver, P. A., Roberge, M., & Schreiber, S. L. (2003) · Chemistry & Biology · doi:10.1016/j.chembiol.2003.11.014 · Cited by 24 · see citing works

The Discovery of Anticancer Drugs From Natural Sources

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The Missing Linker

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Processing of DNA double strand breaks by alternative non-homologous end-joining in hyperacetylated chromatin

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Dynamic protein deacetylation is a limited carbon source for acetyl-CoA–dependent metabolism

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Chemical Genetics and Orphan Genetic Diseases

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Maintenance of HDACs and H3K9me3 Prevents Arterial Flow-Induced Venous Endothelial Damage

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Facile and Efficient Method for the Synthesis of 14-Substituted-14-H-dibenzo[a,j]xanthenes Catalyzed by Ruthenium Chloride Hydrate as a Homogeneous Catalyst

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Anticancer/Antiviral Agent Akt Inhibitor-IV Massively Accumulates in Mitochondria and Potently Disrupts Cellular Bioenergetics

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Histone Acetyltransferases

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Identifying Biologically Active Compound Classes Using Phenotypic Screening Data and Sampling Statistics

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Energy Stress–Induced circEPB41(2) Promotes Lipogenesis in Hepatocellular Carcinoma

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Catalyst-free tandem aldol condensation/Michael addition of 1,3-cyclohexanediones with enolizable aldehydes

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The Effect of miR-140-5p with HDAC4 towards Growth and Differentiation Signaling of Chondrocytes in Thiram-Induced Tibial Dyschondroplasia

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Melatonin Prevents Thioacetamide–Induced Gut Leakiness and Liver Fibrosis Through the Gut–Liver Axis via Modulating Sirt1‐Related Deacetylation of Gut Junctional Complex and Hepatic Proteins

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Upregulation of cyclin-dependent kinase inhibitors CDKN1B and CDKN1C in hepatocellular carcinoma-derived cells via goniothalamin-mediated protein stabilization and epigenetic modifications

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Trps1 acts as a regulator of Sf-1 transcription and testosterone synthesis in mouse Leydig cells

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The Bicyclic Depsipeptide Family of Histone Deacetylase Inhibitors

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Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

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Recent Development in Novel Anticancer Therapies

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Chemical genetics: An evolving toolbox for target identification and lead optimization

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(Epi)genetic control of secondary seed dormancy depth and germination in Capsella bursa-pastoris

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Expression characterization and the promoter activity analysis of zebrafish hdac4

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Forward Chemical Genetics

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Terpyridine Zn(II) Complexes with Azide Units for Visualization of Histone Deacetylation in Living Cells under STED Nanoscopy

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Dissecting cell biology with chemical scalpels

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Emerging challenges in ligand discovery: new opportunities for chromatographic assay

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CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the treatment of Alzheimer's disease

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The gE/gI complex is necessary for kinesin-1 recruitment during alphaherpesvirus egress from neurons

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PLCD1-Induced DNA Damage Inhibits the Tumor Growth via Downregulating CDKs in Chondrosarcoma

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8 Chemical genetics

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Rational Drug Design of Small Molecule Anticancer Agents: Preclinical Discovery

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Is level of acetylation directly correlated to radiation sensitivity of cancer cell?

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Combinatorial Chemistry and Multiple Parallel Synthesis

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3-Hydroxy-2-[(2E)-1-(2-hydroxy-6-oxocyclohex-1-en-1-yl)-3-(2-methoxyphenyl)prop-2-en-1-yl]cyclohex-2-en-1-one

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Effect of histone deacetylase inhibitor trichostatin A (TSA) on the microtubular system ofTetrahymena

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The Effect of Tubulin Acetylation and Detyrosination on the in vitro Motility of Kinesin-1.

Kaul, N. (2012) · Deep Blue (University of Michigan)

Additional file 1 of Pterostilbene improves neurological dysfunction and neuroinflammation after ischaemic stroke via HDAC3/Nrf1-mediated microglial activation

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Trichostatin A Inhibits Cytokines Released in LPS-Induced THP-1 Cells via Downregulating Deacetylated-Syntaxin 17 and Promoting Autophagosome-Lysosome Fusion

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BindingDB Entry 50032218: New approaches to molecular cancer therapeutics.

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BindingDB Entry 3230: Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.

BindingDB (2009) · UC San Diego · doi:10.7270/q26h4frd

BindingDB Entry 50040366: Discovery and characterization of small molecule inhibitors of the BET family bromodomains.

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From Discovery to the Coming Generation of Histone Deacetylase Inhibitors

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Trichostatin A - like Hydroxamate Histone Deacetylase Inhibitors as Therapeutic Agents: Toxicological Point of View

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A Mechanistic Approach to Anticancer Therapy: Targeting the Cell Cycle with Histone Deacetylase Inhibitors

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Novel Hydroxamate and Anilide Derivatives as Potent Histone Deacetylase Inhibitors: Synthesis and Antiproliferative Evaluation

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Structurally Simple Trichostatin A-Like Straight Chain Hydroxamates as Potent Histone Deacetylase Inhibitors

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