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Anshu, A., Mannan, M. A.-U., Chakraborty, A., Chakrabarti, S., & Dey, M. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00981-14 · Cited by 21 · see citing works

Limited Portability of G-Patch Domains in Regulators of the Prp43 RNA Helicase Required for Pre-mRNA Splicing and Ribosomal RNA Maturation in Saccharomyces cerevisiae

Banerjee, D., McDaniel, P. M., & Rymond, B. C. (2015) · Genetics · doi:10.1534/genetics.115.176461 · Cited by 19 · see citing works

Interactions Between the Kinetochore Complex and the Protein Kinase A Pathway in Saccharomyces cerevisiae

Ma, L., Ho, K. L., Piggott, N., Luo, Z., & Measday, V. (2012) · G3 Genes Genomes Genetics · doi:10.1534/g3.112.002675 · Cited by 17 · see citing works

Screens, maps & networks: from genome sequences to personalized medicine

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A genome wide dosage suppressor network reveals genomic robustness

Patra, B. N., Kon, Y., Yadav, G., Sevold, A., Frumkin, J. P., Vallabhajosyula, R. R., Hintze, A., Østman, B., Schossau, J., Bhan, A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1148 · Cited by 17 · see citing works

Genome-wide haploinsufficiency screen reveals a novel role for γ-TuSC in spindle organization and genome stability

Choy, J. S., O'Toole, E. T., Schuster, B. M., Crisp, M. J., Karpova, T., McNally, J. G., Winey, M., Gardner, M. K., & Basrai, M. A. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-12-0902 · Cited by 16 · see citing works

Genetic suppression: Extending our knowledge from lab experiments to natural populations

Matsui, T., Lee, J. T., & Ehrenreich, I. M. (2017) · BioEssays · doi:10.1002/bies.201700023 · Cited by 15 · see citing works

Yeast as a model eukaryote in toxinology: a functional genomics approach to studying the molecular basis of action of pharmacologically active molecules.

Mattiazzi, M., Petrovič, U., & Križaj, I. (2012) · Toxicon · doi:10.1016/j.toxicon.2012.03.014 · Cited by 18 · see citing works

Chemical genomic guided engineering of gamma-valerolactone tolerant yeast

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A Candida parapsilosis Overexpression Collection Reveals Genes Required for Pathogenesis

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Promotion of Cell Viability and Histone Gene Expression by the Acetyltransferase Gcn5 and the Protein Phosphatase PP2A in Saccharomyces cerevisiae

Petty, E. L., Lafon, A., Tomlinson, S. L., Mendelsohn, B. A., & Pillus, L. (2016) · Genetics · doi:10.1534/genetics.116.189506 · Cited by 12 · see citing works

Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress

Harreman, M. T., Walker, J., Temcinaite, K., Herlihy, A. E., Taschner, M., Berger, A. C., Corbett, A. H., Dirac-Svejstrup, A. B., & Svejstrup, J. Q. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111536 · Cited by 12 · see citing works

A single-cell resolved genotype-phenotype map using genome-wide genetic and environmental perturbations

Nadal‐Ribelles, M., Solé, C., Díez-Villanueva, A., Attolini, C. S., Matas, Y., Steinmetz, L. M., de Nadal, E., & Posas, F. (2025) · Nature Communications · doi:10.1038/s41467-025-57600-4 · Cited by 11 · see citing works

Selective functional inhibition of a tumor-derived p53 mutant by cytosolic chaperones identified using split-YFP in budding yeast

Denney, A. S., Weems, A. D., & McMurray, M. A. (2021) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkab230 · Cited by 11 · see citing works

Link Clustering Reveals Structural Characteristics and Biological Contexts in Signed Molecular Networks

Lin, C., Lee, C.-H., Fuh, C., Juan, H., & Huang, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067089 · Cited by 11 · see citing works

Gene Suppressor: An added phase toward solving large scale optimization problems in genetic algorithm

Manicassamy, J., Kumar, S. S., Rangan, M., Ananth, V., Vengattaraman, T., & Dhavachelvan, P. (2015) · Applied Soft Computing · doi:10.1016/j.asoc.2015.06.017 · Cited by 11 · see citing works

Evidence that conserved essential genes are enriched for pro-longevity factors

Oz, N., Vayndorf, E. M., Tsuchiya, M., McLean, S., Turcios-Hernandez, L., Pitt, J. N., Blue, B. W., Muir, M., Kiflezghi, M. G., Tyshkovskiy, A., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00604-5 · Cited by 10 · see citing works

Suppression Analysis ofesa1Mutants inSaccharomyces cerevisiaeLinksNAB3to Transcriptional Silencing and Nucleolar Functions

Chang, C., Clarke, A. S., & Pillus, L. (2012) · G3 Genes Genomes Genetics · doi:10.1534/g3.112.003558 · Cited by 10 · see citing works

The budding yeast RSC complex maintains ploidy by promoting spindle pole body insertion

Sing, T. L., Hung, M. P., Ohnuki, S., Suzuki, G., Luis, B.-J. S., McClain, M. L., Unruh, J. R., Yu, Z., Ou, J., Marshall-Sheppard, J., et al. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201709009 · Cited by 10 · see citing works

Glucose Signaling Is Connected to Chromosome Segregation Through Protein Kinase A Phosphorylation of the Dam1 Kinetochore Subunit inSaccharomyces cerevisiae

Shah, S. B., Parmiter, D., Constantine, C., Elizalde, P., Naldrett, M. J., Karpova, T., & Choy, J. S. (2018) · Genetics · doi:10.1534/genetics.118.301727 · Cited by 10 · see citing works

‘Domino’ systems biology and the ‘A’ of ATP

Verma, M., Zakhartsev, M. V., Reuß, M., & Westerhoff, H. V. (2012) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.09.014 · Cited by 9 · see citing works

Functional genomics in the study of yeast cell polarity: moving in the right direction

Styles, E. B., Youn, J., Ušaj, M. M., & Andrews, B. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0118 · Cited by 9 · see citing works

Resurrection from lethal knockouts: Bypass of gene essentiality

Du, L. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.05.207 · Cited by 9 · see citing works

If a Bull Were a Cow, How Much Milk Would He Give?

Soller, M. (2014) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-022114-110751 · Cited by 9 · see citing works

Deletion of yeast TPK1 reduces the efficiency of non-homologous end joining DNA repair

Hooshyar, M., Jessulat, M., Burnside, D. J., Kluew, A., Babu, M., & Golshani, A. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.09.083 · Cited by 9 · see citing works

The IQGAP-related RasGAP IqgC regulates cell–substratum adhesion in Dictyostelium discoideum

Mijanović, L., Putar, D., Mimica, L., Klajn, S., Filić, V., & Weber, I. T. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00678-3 · Cited by 8 · see citing works

Autophagy gene overexpression in Saccharomyces cerevisiae perturbs subcellular organellar function and accumulates ROS to accelerate cell death with relevance to sparkling wine production

Preiss, R., Tyrawa, C., & van der Merwe, G. K. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9304-y · Cited by 8 · see citing works

High-throughput synthetic rescue for exhaustive characterization of suppressor mutations in human genes

Kobaisi, F., Fayyad, N., Sulpice, E., Badran, B. M., Fayyad‐Kazan, H., Rachidi, W., & Gidrol, X. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03519-6 · Cited by 7 · see citing works

Yeast Phenomics—Large-scale Mapping of the Genetic Basis for Organismal Traits

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Navigating yeast genome maintenance with functional genomics

Measday, V., & Stirling, P. C. (2015) · Briefings in Functional Genomics · doi:10.1093/bfgp/elv033 · Cited by 5 · see citing works

Actin Dosage Lethality Screening in Yeast Mediated by Selective Ploidy Ablation Reveals Links to Urmylation/Wobble Codon Recognition and Chromosome Stability

Haarer, B. K., Mi‐Mi, L., Cho, J. S., Cortese, M. J., Viggiano, S. C., Burke, D. J., & Amberg, D. C. (2013) · G3 Genes Genomes Genetics · doi:10.1534/g3.113.005579 · Cited by 6 · see citing works

Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions

Talavera, D., Kershaw, C. J., Costello, J. L., Castelli, L. M., Rowe, W., Sims, P. F. G., Ashe, M., Grant, C. M., Pavitt, G. D., & Hubbard, S. J. (2018) · Scientific Reports · doi:10.1038/s41598-018-26170-5 · Cited by 6 · see citing works

Dosage sensitivity of JDPs, a valuable tool for understanding their function: a case study on Caj1 overexpression-mediated filamentous growth in budding yeast

Sagarika, P., Dobriyal, N., & Sahi, C. (2021) · Current Genetics · doi:10.1007/s00294-021-01153-8 · Cited by 6 · see citing works

Premature Aging in Aneuploid Yeast is Caused in Part by Aneuploidy-Induced Defects in Ribosome Quality ControlPreprint

Escalante, L. E., Hose, J., Howe, H., Paulsen, N., Place, M., & Gasch, A. P. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.22.600216 · Cited by 6 · see citing works

Overexpression profiling reveals cellular requirements in the context of genetic backgrounds and environments

Saeki, N., Yamamoto, C., Eguchi, Y., Sekito, T., Shigenobu, S., Yoshimura, M., Yashiroda, Y., Boone, C. M., & Moriya, H. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010732 · Cited by 5 · see citing works

Genetic Networks

Costanzo, M., Baryshnikova, A., VanderSluis, B., Andrews, B., Myers, C. L., & Boone, C. M. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-385944-0.00006-x · Cited by 5 · see citing works

Utilizing functional genomics in Saccharomyces cerevisiae to characterize food preservative compounds: A pilot study

Smith, J. R., Martini, A., & Gibney, P. A. (2024) · Journal of Food Science · doi:10.1111/1750-3841.16906 · Cited by 4 · see citing works

Chemogenomic Profiling

Lee, A. Y., Bader, G. D., Nislow, C., & Giaever, G. N. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-385944-0.00008-3 · Cited by 4 · see citing works

GPS: a constraint-based gene position procurement in chromosome for solving large-scale multiobjective multiple knapsack problems

Manicassamy, J., Karunanidy, D., Pothula, S., Thirumal, V., Ponnurangam, D., & Ramalingam, S. (2017) · Frontiers of Computer Science · doi:10.1007/s11704-016-5195-1 · Cited by 4 · see citing works

Genetic suppression interactions are highly conserved across genetically diverse yeast isolates

Paltenghi, C., & van Leeuwen, J. S. (2025) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkaf047 · Cited by 3 · see citing works

Vacuolar pH regulates clathrin-mediated endocytosis through TORC1 signaling during replicative aging

Antenor, K. G., Lee-Dadswell, J., Salahshour, N., Grishchenko, N., Swaleh, S., Makhija, G., Spangaro, A., & Ušaj, M. M. (2025) · The Journal of Cell Biology · doi:10.1083/jcb.202412064 · Cited by 3 · see citing works

Systematic Phenotyping of Plant Development in Arabidopsis thaliana

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Gain- and loss-of-function alleles within signaling pathways lead to phenotypic diversity among individuals

Vandermeulen, M. D., Khaiwal, S., Rubio, G., Liti, G., & Cullen, P. J. (2024) · iScience · doi:10.1016/j.isci.2024.110860 · Cited by 2 · see citing works

Yeast: a microbe with macro-implications to antimicrobial drug discovery

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EXOSC3 G191 Variants Trigger System-Wide Recalibration of RNA Processing Machinery

Wijeratne, H. R. S., Runnebohm, A. M., Barron, M. P., Hampton, A. J., Li, R., Peck Justice, S. A., Lenceski, S. H., Rooney, J. D., Smith-Kinnaman, W. R., Chang, G. S., et al. (2026) · doi:10.64898/2026.01.26.701775 · Cited by 1 · see citing works

Chromosome duplication causes premature aging via defects in ribosome quality control

Escalante, L. E., Hose, J., Ahrens, J. M., Howe, H., Paulsen, N., Liss, S. J., Place, M., & Gasch, A. P. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003509 · Cited by 1 · see citing works

Analysis of Genetic Interaction Networks Shows That Alternatively Spliced Genes Are Highly Versatile

Talavera, D., Sheoran, R., & Lovell, S. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055671 · Cited by 1 · see citing works

A genome wide dosage suppressor network reveals genetic robustness and a novel mechanism for Huntington’s diseasePreprint

Patra, B. N., Kon, Y., Yadav, G., Sevold, A., Frumkin, J. P., Vallabhajosyula, R. R., Hintze, A., Østman, B., Schossau, J., Bhan, A., et al. (2013) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/000265 · Cited by 2 · see citing works

Identification and characterization of novel genes involved in DNA double strand break repair process in the yeast Saccharomyces cerevisiae

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Dosage adds new dimension

Casci, T. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3019

Phosphoregulation of Sfi1 is Required for Yeast Centrosome Duplication and Separation

Avena, J. S. (2014) · CU Scholar (University of Colorado Boulder)

Exploring Mechanisms Underlying Retinitis Pigmentosa by Using Temperature Sensitive Alleles in Yeast

Naghdigheshlaghi, Z. (2014) · TSpace (University of Toronto)

Mapping Genetic Interaction Networks in Yeast

Baryshnikova, A. (2013) · TSpace (University of Toronto)

Systematic Analysis of Suppressor Mutations in S. cerevisiae Strains with Deleted Genome Integrity Genes

Yamaguchi, T. N. (2013) · Library and Archives Canada (Government of Canada)

Yeast: A Model Organism for Antimicrobial Drug Discovery

Sharma, P. (2020) · Springer eBooks · doi:10.1007/978-981-15-1695-5_28

Current World Literature

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Diverse innate immune factors protect yeast from lethal viral pathogenesisPreprint

Chau, S., Gao, J., Diao, A. J., Cao, S. B., Azhieh, A., Davidson, A. R., & Meneghini, M. D. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.14.480455

Prediction and Investigation of Novel Proteins in DNA Double Stranded Break Repair

Hooshyar, M. (2016) · doi:10.22215/etd/2016-11472

Faculty Opinions recommendation of Rewired cellular signaling coordinates sugar and hypoxic responses for anaerobic xylose fermentation in yeast.

Kumar, A. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735304940.793558138

Identifying Endogenous Cellular Proteins Destabilizing the Propagation of Swi1 Prion upon Overproduction

Du, Z., Cho, B., & Li, L. (2022) · Viruses · doi:10.3390/v14071366

Dosage adds new dimension

Casci, T. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3019

A Novel gene overexpression plasmid library and its application in mapping genetic networks by systematic dosage suppression

Magtanong, L. (2012) · TSpace (University of Toronto)

Exploring genetic suppression interactions on a global scale

van Leeuwen, J. S., Pons, C., Mellor, J. C., Yamaguchi, T. N., Friesen, H., Koschwanez, J. H., Ušaj, M. M., Pechlaner, M., Takar, M., Ušaj, M., et al. (2016) · Science · doi:10.1126/science.aag0839 · Cited by 176 · see citing works

A global genetic suppression network

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Data from: A global genetic interaction network maps a wiring diagram of cellular function

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