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Cited by 684Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

An overview of APP processing enzymes and products.

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Chow, Vivian W., Mattson, Mark P., Wong, Philip C., Gleichmann, Marc·2010·NeuroMolecular Medicine
DOI 10.1007/s12017-009-8104-zPMC PMC2889200
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Abstract

The generation of amyloid beta-peptide (A beta) by enzymatic cleavages of the beta-amyloid precursor protein (APP) has been at the center of Alzheimer's disease (AD) research. While the basic process of beta- and gamma-secretase-mediated generation of A beta is text book knowledge, new aspects of A beta and other cleavage products have emerged in recent years. Also our understanding of the enzymes involved in APP proteolysis has increased dramatically. All of these discoveries contribute to a more complete understanding of APP processing and the physiologic and pathologic roles of its secreted and intracellular protein products. Understanding APP processing is important for any therapeutic strategy aimed at reducing A beta levels in AD. In this review, we provide a concise description of the current state of understanding the enzymes involved in APP processing, the cleavage products generated by different processing patterns, and the potential functions of those cleavage products.

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  • Increased Aβ production can contribute substantially to extracellular Aβ accumulation and the amyloid cascade underlying Alzheimer's disease pathology, but impaired turnover and clearance can also promote Aβ accumulation.

    “Increased Aβ production can contribute substantially to extracellular Aβ accumulation and the amyloid cascade underlying Alzheimer’s disease pathology (Chow et al., 2010; Zhang et al., 2011) but impaired turnover and clearance can also promote Aβ accumulation.”

    From Isogenic human stem cell models reveal mutation-dependent protective mechanisms of APOE3 Christchurch (2026) · cites this paper as Chow et al., 2010

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Authors
Chow, V. W., Mattson, M. P., Wong, P. C., & Gleichmann, M.
Affiliations
  • Johns Hopkins University (US)
  • National Institute on Aging (US)
Corresponding author
Gleichmann, Marc
ORCID
Venue
NeuroMolecular Medicine
Publisher
Springer Science and Business Media LLC
Published
2009-11-24
Volume
12
Issue
1
Pages
1-12
ISSN
  • 1535-1084 (ISSN-L)
  • 1559-1174
DOI
10.1007/s12017-009-8104-z
PMC
PMC2889200
OpenAlex
W1973026127
Cited by
684
References
10
Citations by year
2026: 33 · 2025: 38 · 2024: 61 · 2023: 55 · 2022: 60 · 2021: 75 · 2020: 66 · 2019: 57 · 2018: 46 · 2017: 31 · 2016: 31 · 2015: 22 · 2014: 18 · 2013: 16 · 2012: 26
FWCI
2.77
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • NeuroMolecular Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (Z01AG000312, T32AG027668, Z01AG000314)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
amyloid-beta, amyloid precursor protein, APP processing, beta-secretase, gamma-secretase, APP proteolysis, Alzheimer's disease
MeSH terms
Alzheimer Disease, Amino Acid Sequence, Animals, Humans, Molecular Sequence Data, Signal Transduction, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Amyloid Precursor Protein Secretases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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