Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works

Gout-associated uric acid crystals activate the NALP3 inflammasome

Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326 · see citing works

Type 2 diabetes as an inflammatory disease

Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737 · see citing works

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708 · see citing works

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655 · see citing works

The Inflammasomes: Guardians of the Body

Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436 · see citing works

GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428 · see citing works

Inflammasomes in health and disease

Strowig, T., Henao-Mejia, J., Elinav, E., & Flavell, R. (2012) · Nature · doi:10.1038/nature10759 · Cited by 2,230 · see citing works

The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells

Endres, S., Ghorbani, R., Kelley, V. E., Georgilis, K., Lonnemann, G., van der Meer, J. W. M., Cannon, J. G., Rogers, T. S., Klempner, M. S., Weber, P. C., et al. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902023200501 · Cited by 1,898 · see citing works

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

Wen, H., Gris, D., Lei, Y. L., Jha, S., Zhang, L., Huang, M. T.-H., Brickey, W. J., & Ting, J. P. ‐. (2011) · Nature Immunology · doi:10.1038/ni.2022 · Cited by 1,814 · see citing works

Islet cell failure in type 2 diabetes

Prentki, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29103 · Cited by 1,690 · see citing works

Resolvins

Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., & Moussignac, R.-L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020760 · Cited by 1,650 · see citing works

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

Davis, B. K., Wen, H., & Ting, J. P.-Y. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101405 · Cited by 1,618 · see citing works

Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

Hirasawa, A., Tsumaya, K., Awaji, T., Katsuma, S., Adachi, T., Yamada, M., Sugimoto, Y., Miyazaki, S., & Tsujimoto, G. (2004) · Nature Medicine · doi:10.1038/nm1168 · Cited by 1,551 · see citing works

Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

Itoh, Y., Kawamata, Y., Harada, M., Kobayashi, M., Fujii, R., Fukusumi, S., Ogi, K., Hosoya, M., Tanaka, Y., Uejima, H., et al. (2003) · Nature · doi:10.1038/nature01478 · Cited by 1,538 · see citing works

Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes

Spranger, J., Kroke, A., Möhlig, M., Hoffmann, K., Bergmann, M. M., Ristow, M., Boeing, H., & Pfeiffer, A. F. H. (2003) · Diabetes · doi:10.2337/diabetes.52.3.812 · Cited by 1,493 · see citing works

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Masters, S. L., Dunne, A., Subramanian, S. L., Hull, R. L., Tannahill, G. M., Sharp, F. A., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., et al. (2010) · Nature Immunology · doi:10.1038/ni.1935 · Cited by 1,330 · cited 5× · see citing works

Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular Processing

Serhan, C. N., Clish, C. B., Brannon, J., Colgan, S. P., Chiang, N., & Gronert, K. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.8.1197 · Cited by 1,189 · see citing works

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

Schroder, K., Zhou, R., & Tschopp, J. (2010) · Science · doi:10.1126/science.1184003 · Cited by 1,131 · see citing works

Five stages of evolving beta-cell dysfunction during progression to diabetes

Weir, G. C., & Bonner-Weir, S. (2004) · Diabetes · doi:10.2337/diabetes.53.suppl_3.s16 · Cited by 1,126 · cited 10× · see citing works

Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2

Bohn, L., Lefkowitz, R. J., Gainetdinov, R. R., Peppel, K., Caron, M. G., & Lin, F. (1999) · Science · doi:10.1126/science.286.5449.2495 · Cited by 1,079 · see citing works

Nutrient sensing and inflammation in metabolic diseases

Hotamisligil, G. S., & Erbay, E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2449 · Cited by 1,040 · see citing works

HÆMOSTATIC FUNCTION AND PLATELET POLYUNSATURATED FATTY ACIDS IN ESKIMOS

Dyerberg, J., & Bang, H. O. (1979) · The Lancet · doi:10.1016/s0140-6736(79)91490-9 · Cited by 1,005 · see citing works

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

Guarda, G., Braun, M., Staehli, F., Tardivel, A., Mattmann, C., Förster, I., Farlik, M., Decker, T., Pasquier, R. D., Romero, P. J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.02.006 · Cited by 924 · see citing works

β-Cell Glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes.

Robertson, R. P., Harmon, J., Tran, P. O. T., & Poitout, V. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s119 · Cited by 914 · see citing works

The inflammasome: an integrated view

Gross, O., Thomas, C. J., Guarda, G., & Tschopp, J. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01046.x · Cited by 778 · see citing works

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

Spite, M., Norling, L. V., Summers, L., Yang, R., Cooper, D., Petasis, N. A., Flower, R. J., Perretti, M., & Serhan, C. N. (2009) · Nature · doi:10.1038/nature08541 · Cited by 695 · see citing works

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

Ichimura, A., Hirasawa, A., Poulain‐Godefroy, O., Bonnefond, A., Hara, T., Yengo, L., Kimura, I., Leloire, A., Liu, N., Iida, K., et al. (2012) · Nature · doi:10.1038/nature10798 · Cited by 663 · see citing works

Resolvin E1 Selectively Interacts with Leukotriene B4 Receptor BLT1 and ChemR23 to Regulate Inflammation

Arita, M., Ohira, T., Sun, Y., Elangovan, S., Chiang, N., & Serhan, C. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3912 · Cited by 636 · see citing works

Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β

Mishra, B. B., Rathinam, V. A. K., Martens, G. W., Martinot, A. J., Kornfeld, H., Fitzgerald, K. A., & Sassetti, C. M. (2013) · Nature Immunology · doi:10.1038/ni.2474 · Cited by 571 · see citing works

Fat-1 mice convert n-6 to n-3 fatty acids

Kang, J. X., Wang, J., Wu, L., & Kang, Z. B. (2004) · Nature · doi:10.1038/427504a · Cited by 545 · see citing works

Effects of an Engineered Human Anti–TNF-α Antibody (CDP571) on Insulin Sensitivity and Glycemic Control in Patients With NIDDM

Ofei, F., Hurel, S. J., Newkirk, J., Sopwith, M., & Taylor, R. (1996) · Diabetes · doi:10.2337/diab.45.7.881 · Cited by 510 · see citing works

Endoplasmic Reticulum Stress and the Development of Diabetes

Harding, H. P., & Ron, D. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s455 · Cited by 465 · see citing works

Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules

Briscoe, C. P., Peat, A. J., McKeown, S. C., Corbett, D. F., Goetz, A. S., Littleton, T. R., McCoy, D. C., Kenakin, T., Andrews, J. L., Ämmälä, C., et al. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706770 · Cited by 401 · see citing works

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

Mao, K., Chen, S., Chen, M., Ma, Y., Wang, Y., Huang, B., He, Z., Zeng, Y., Hu, Y., Sun, S., et al. (2013) · Cell Research · doi:10.1038/cr.2013.6 · Cited by 397 · see citing works

Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity

Cintra, D. E., Ropelle, E. R., Moraes, J. C., Pauli, J. R., Morari, J., de Souza, C. T., Grimaldi, R., Stahl, M., Carvalheira, J. B., Saad, M. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030571 · Cited by 381 · see citing works

Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis

Hudert, C. A., Weylandt, K. H., Lü, Y., Wang, J., Hong, S., Dignass, A. U., Serhan, C. N., & Kang, J. X. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601280103 · Cited by 379 · see citing works

Peroxisome proliferator-activated receptors and inflammation

Moraes, L. A., Piqueras, L., & Bishop‐Bailey, D. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.08.007 · Cited by 377 · see citing works

Fatty Acids as Modulators of the Immune Response

Fritsche, K. L. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.25.050304.092610 · Cited by 316 · see citing works

The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1β processing

Papin, S., Cuenin, S., Agostini, L., Martinon, F., Werner, S., Beer, H., Grütter, C., Grütter, M. G., & Tschopp, J. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402142 · Cited by 313 · see citing works

Metabolic and Vascular Effects of Tumor Necrosis Factor-α Blockade with Etanercept in Obese Patients with Type 2 Diabetes

Dominguez, H., Storgaard, H., Rask-Madsen, C., Steffen Hermann, T., Ihlemann, N., Baunbjerg Nielsen, D., Spohr, C., Kober, L., Vaag, A., & Torp-Pedersen, C. (2005) · Journal of Vascular Research · doi:10.1159/000088261 · Cited by 286 · see citing works

The G-Protein−Coupled Receptor GPR40 Directly Mediates Long-Chain Fatty Acid−Induced Secretion of Cholecystokinin

Liou, A. P., Lu, X., Sei, Y., Zhao, X., Pechhold, S. B., Carrero, R. J., Raybould, H. E., & Wank, S. A. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.10.012 · Cited by 276 · see citing works

Elevated Levels of the Anti-Inflammatory Interleukin-1 Receptor Antagonist Precede the Onset of Type 2 Diabetes

Herder, C., Brunner, E. J., Rathmann, W., Straßburger, K., Tabák, Á. G., Schloot, N. C., & Witte, D. R. (2008) · Diabetes Care · doi:10.2337/dc08-1161 · Cited by 207 · see citing works

Tollip Regulates Proinflammatory Responses to Interleukin-1 and Lipopolysaccharide

Didierlaurent, A. M., Brissoni, B., Velin, D., Aebi, N., Tardivel, A., Käslin, E., Sirard, J., Angelov, G. S., Tschopp, J., & Burns, K. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.3.735-742.2006 · Cited by 195 · see citing works

Resolvins: Anti-Inflammatory and Proresolving Mediators Derived from Omega-3 Polyunsaturated Fatty Acids

Zhang, M. J., & Spite, M. R. (2012) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071811-150726 · Cited by 170 · see citing works

Insulin resistance in patients with rheumatoid arthritis: effect of anti‐TNFα therapy

Rosenvinge, A., Krogh‐Madsen, R., Baslund, B., & Pedersen, B. K. (2007) · Scandinavian Journal of Rheumatology · doi:10.1080/03009740601179605 · Cited by 112 · see citing works

Effects of TNF-α neutralization on adipocytokines and skeletal muscle adiposity in the metabolic syndrome

Lo, J., Bernstein, L. E., Hron, B. M., Torriani, M., Jackson, M. B., Ahima, R. S., & Grinspoon, S. K. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00089.2007 · Cited by 106 · see citing works

Dietary marine lipids suppress continuous expression of interleukin‐1β gene transcription1

Robinson, D. R., Urakaze, M., Huang, R., Taki, H., Sugiyama, E., Knoell, C. T., Xu, L.-L., Yeh, E. T. H., & Auron, P. E. (1996) · Lipids · doi:10.1007/bf02637046 · Cited by 83 · see citing works

Inflammasomes: mechanism of action, role in disease, and therapeutics

Guo, H., Callaway, J. B., & Ting, J. P.-Y. (2015) · Nature Medicine · doi:10.1038/nm.3893 · Cited by 3,340 · see citing works

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

Esser, N., Legrand-Poels, S., Piette, J., Scheen, A. J., & Paquot, N. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.04.006 · Cited by 1,981 · see citing works

The intestinal microbiota fuelling metabolic inflammation

Tilg, H., Zmora, N., Adolph, T. E., & Elinav, E. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0198-4 · Cited by 1,089 · see citing works

Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome

Yan, Y., Jiang, W., Liu, L., Wang, X., Ding, C., Tian, Z., & Zhou, R. (2015) · Cell · doi:10.1016/j.cell.2014.11.047 · Cited by 1,014 · see citing works

Inflammaging and ‘Garb-aging’

Franceschi, C., Garagnani, P., Vitale, G., Capri, M., & Salvioli, S. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.09.005 · Cited by 997 · see citing works

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

Grebe, A., Hoss, F., & Latz, E. (2018) · Circulation Research · doi:10.1161/circresaha.118.311362 · Cited by 926 · see citing works

Diet, metabolites, and “western-lifestyle” inflammatory diseases

Thorburn, A. N., Macia, L., & Mackay, C. R. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.014 · Cited by 879 · see citing works

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

He, H., Jiang, H., Chen, Y., Ye, J., Wang, A., Wang, C., Liu, Q., Liang, G., Deng, X., Jiang, W., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04947-6 · Cited by 827 · see citing works

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

Jiang, H., He, H., Chen, Y., Huang, W., Cheng, J., Ye, J., Wang, A., Tao, J., Wang, C., Liu, Q., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20171419 · Cited by 771 · see citing works

Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms

Tosti, V., Bertozzi, B., & Fontana, L. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx227 · Cited by 762 · see citing works

Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease

Cao, X. (2015) · Nature reviews. Immunology · doi:10.1038/nri.2015.8 · Cited by 661 · see citing works

Diverging inflammasome signals in tumorigenesis and potential targeting

Karki, R., & Kanneganti, T. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0123-y · Cited by 641 · see citing works

Inflammasomes in the CNS

Walsh, J. G., Muruve, D. A., & Power, C. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3638 · Cited by 637 · see citing works

Inflammation in gout: mechanisms and therapeutic targets

So, A. K.-L., & Martinon, F. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.155 · Cited by 619 · see citing works

Effects of Omega-3 Fatty Acids on Immune Cells

Gutiérrez, S., Svahn, S. L., & Johansson, M. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205028 · Cited by 588 · see citing works

Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor– and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity

Hoque, R., Farooq, A., Ghani, A., Gorelick, F. S., & Mehal, W. Z. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.03.014 · Cited by 576 · see citing works

Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases

Huang, Y., Jiang, H., Chen, Y., Wang, X., Yang, Y., Tao, J., Deng, X., Liang, G., Zhang, H., Jiang, W., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201708689 · Cited by 521 · see citing works

Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity

Tilg, H., Adolph, T., Dudek, M., & Knolle, P. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00501-9 · Cited by 495 · see citing works

NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation

Song, N., Liu, Z.-S., Xue, W., Bai, Z., Wang, Q., Dai, J., Liu, X., Huang, Y.-J., Cai, H., Zhan, X., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.08.017 · Cited by 494 · see citing works

The Intestinal Immune System in Obesity and Insulin Resistance

Winer, D. A., Luck, H., Tsai, S. J., & Winer, S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.003 · Cited by 476 · see citing works

Adipose tissue as an immunological organ

Grant, R. W., & Dixit, V. D. (2015) · Obesity · doi:10.1002/oby.21003 · Cited by 453 · see citing works

Cardioprotective mechanism of omega-3 polyunsaturated fatty acids

Endo, J., & Arita, M. (2016) · Journal of Cardiology · doi:10.1016/j.jjcc.2015.08.002 · Cited by 369 · see citing works

The microbiota–gut–brain axis and neurodevelopmental disorders

Wang, Q., Yang, Q., & Liu, X. (2023) · Protein & Cell · doi:10.1093/procel/pwad026 · Cited by 407 · see citing works

CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation

Tang, T., Lang, X., Xu, C., Wang, X., Gong, T., Yang, Y., Cui, J., Bai, L., Wang, J., Jiang, W., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00227-x · Cited by 364 · see citing works

A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia

Kaliannan, K., Wang, B., Li, X., Kim, K., & Kang, J. X. (2015) · Scientific Reports · doi:10.1038/srep11276 · Cited by 362 · see citing works

Omega-3 fatty acids in obesity and metabolic syndrome: A mechanistic update

Albracht-Schulte, K., Kalupahana, N. S., Ramalingam, L., Wang, S., Rahman, S. M., Robert-McComb, J., & Moustaid-Moussa, N. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.02.012 · Cited by 355 · see citing works

Omega−3 Polyunsaturated Fatty Acids (PUFAs): Emerging Plant and Microbial Sources, Oxidative Stability, Bioavailability, and Health Benefits—A Review

Saini, R. K., Prasad, P., Sreedhar, R. V., Akhilender Naidu, K., Shang, X., & Keum, Y.-S. (2021) · Antioxidants · doi:10.3390/antiox10101627 · Cited by 337 · see citing works

Pathogenesis of acute stroke and the role of inflammasomes

Fann, D. Y., Lee, S.-Y., Manzanero, S., Chunduri, P., Sobey, C. G., & Arumugam, T. V. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.09.004 · Cited by 334 · see citing works

Mediterranean Diet Effects on Type 2 Diabetes Prevention, Disease Progression, and Related Mechanisms. A Review

Martín-Peláez, S., Fito, M., & Castaner, O. (2020) · Nutrients · doi:10.3390/nu12082236 · Cited by 330 · see citing works

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

Wang, X., Jiang, W., Yan, Y., Gong, T., Han, J., Tian, Z., & Zhou, R. (2014) · Nature Immunology · doi:10.1038/ni.3015 · Cited by 323 · see citing works

Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages

Guo, C., Chi, Z., Jiang, D., Xu, T., Yu, W., Wang, Z., Chen, S., Zhang, L., Liu, Q., Guo, X., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.08.021 · Cited by 319 · see citing works

The Influence of Dietary Fatty Acids on Immune Responses

Radzikowska, U., Rinaldi, A. O., Çelebi Sözener, Z., Karaguzel, D., Wojcik, M., Cypryk, K., Akdis, M., Akdis, C. A., & Sokolowska, M. (2019) · Nutrients · doi:10.3390/nu11122990 · Cited by 306 · see citing works

Inflammasomes in the gastrointestinal tract: infection, cancer and gut microbiota homeostasis

Man, S. M. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0054-1 · Cited by 305 · see citing works

Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control

Próchnicki, T., & Latz, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.018 · Cited by 297 · see citing works

NLRP3 at the interface of metabolism and inflammation

Haneklaus, M., & O'Neill, L. A. J. (2015) · Immunological Reviews · doi:10.1111/imr.12285 · Cited by 294 · see citing works

Focus on the Role of NLRP3 Inflammasome in Diseases

Fusco, R., Siracusa, R., Genovese, T., Cuzzocrea, S., & Paola, R. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124223 · Cited by 292 · see citing works

Current role of the NLRP3 inflammasome on obesity and insulin resistance: A systematic review

Rheinheimer, J., de Souza, B. M., Cardoso, N. S., Bauer, A. C., & Crispim, D. (2017) · Metabolism · doi:10.1016/j.metabol.2017.06.002 · Cited by 275 · see citing works

Drivers of age‐related inflammation and strategies for healthspan extension

Goldberg, E. L., & Dixit, V. D. (2015) · Immunological Reviews · doi:10.1111/imr.12295 · Cited by 274 · see citing works

NLRP3: A promising therapeutic target for autoimmune diseases

Shen, H., Yang, Y., Meng, X. L., Luo, X., Li, X., Shuai, Z., Ye, D., & Pan, H. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.01.020 · Cited by 272 · see citing works

Complex Pharmacology of Free Fatty Acid Receptors

Milligan, G., Shimpukade, B., Ulven, T., & Hudson, B. D. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00056 · Cited by 267 · see citing works

Metabolic and Vascular Effect of the Mediterranean Diet

Tuttolomondo, A., Simonetta, I., Daidone, M., Mogavero, A., Ortello, A., & Pinto, A. V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194716 · Cited by 269 · see citing works

The impact of diet on asthma and allergic diseases

Julia, V., Macia, L., & Dombrowicz, D. (2015) · Nature reviews. Immunology · doi:10.1038/nri3830 · Cited by 253 · see citing works

An overview of the inflammatory signalling mechanisms in the myocardium underlying the development of diabetic cardiomyopathy

Frati, G., Schirone, L., Chimenti, I., Yee, D., Biondi‐Zoccai, G., Volpe, M., & Sciarretta, S. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx011 · Cited by 245 · see citing works

Inflammasome-Mediated Secretion of IL-1β in Human Monocytes through TLR2 Activation; Modulation by Dietary Fatty Acids

Snodgrass, R. G., Huang, S., Choi, I.-W., Rutledge, J. C., & Hwang, D. H. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300298 · Cited by 243 · see citing works

Metabolism meets immunity: The role of free fatty acid receptors in the immune system

Alvarez‐Curto, E., & Milligan, G. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.03.017 · Cited by 242 · see citing works

Molecular Pathophysiology of Gout

Desai, J., Steiger, S., & Anders, H. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.06.005 · Cited by 240 · see citing works

Omega-3 Fatty Acids and Insulin Resistance: Focus on the Regulation of Mitochondria and Endoplasmic Reticulum Stress

Lepretti, M., Martucciello, S., Burgos Aceves, M., Putti, R., & Lionetti, L. (2018) · Nutrients · doi:10.3390/nu10030350 · Cited by 232 · see citing works

Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells

Pizato, N., Luzete, B. C., Kiffer, L. F. M. V., Corrêa, L. H., Santos, I. D. O., Assumpção, J. A. F., Ito, M., & Magalhães, K. G. (2018) · Scientific Reports · doi:10.1038/s41598-018-20422-0 · Cited by 224 · see citing works

Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis

Ishihara, T., Yoshida, M., & Arita, M. (2019) · International Immunology · doi:10.1093/intimm/dxz001 · Cited by 218 · see citing works

Omega-3 Free Fatty Acids Suppress Macrophage Inflammasome Activation by Inhibiting NF-κB Activation and Enhancing Autophagy

Williams-Bey, Y., Boularan, C., Vural, A., Huang, N.-N., Hwang, I.-Y., Shan-Shi, C., & Kehrl, J. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097957 · Cited by 215 · see citing works

Curcumin Suppresses IL-1β Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome

Yin, H., Guo, Q., Li, X., Tang, T., Li, C., Wang, H., Sun, Y., Feng, Q., Ma, C., Gao, C., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701495 · Cited by 210 · see citing works

Regulator of Fatty Acid Metabolism, Acetyl Coenzyme A Carboxylase 1, Controls T Cell Immunity

Lee, J., Walsh, M. C., Hoehn, K. L., James, D. E., Wherry, E. J., & Choi, Y. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302985 · Cited by 207 · see citing works

Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

Chaudhary, M. R., Chaudhary, S., Sharma, Y., Singh, T. A., Mishra, A. K., Sharma, S. G., & Mehdi, M. M. (2023) · Biogerontology · doi:10.1007/s10522-023-10050-1 · Cited by 210 · see citing works

Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance

Yu, J., & Lee, M. (2016) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0827-4 · Cited by 207 · see citing works

The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging

Meyers, A. K., & Zhu, X. (2020) · Cells · doi:10.3390/cells9081808 · Cited by 203 · see citing works

Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes

Legrand-Poels, S., Esser, N., L’homme, L., Scheen, A., Paquot, N., & Piette, J. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.08.013 · Cited by 194 · see citing works

Acne vulgaris: The metabolic syndrome of the pilosebaceous follicle

Melnik, B. C. (2017) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2017.09.006 · Cited by 197 · see citing works

Importance of propionate for the repression of hepatic lipogenesis and improvement of insulin sensitivity in high‐fat diet‐induced obesity

Weitkunat, K., Schumann, S., Nickel, D., Kappo, K. A., Petzke, K. J., Kipp, A. P., Blaut, M., & Klaus, S. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600305 · Cited by 183 · see citing works

Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation

Primiano, M. J., Lefker, B. A., Bowman, M. R., Bree, A. G., Hubeau, C., Bonin, P. D., Mangan, M., Dower, K., Monks, B. G., Cushing, L., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600035 · Cited by 180 · see citing works

Eicosapentaenoic acid reduces membrane fluidity, inhibits cholesterol domain formation, and normalizes bilayer width in atherosclerotic-like model membranes

Mason, R. P., Jacob, R. F., Shrivastava, S., Sherratt, S. C. R., & Chattopadhyay, A. (2016) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2016.10.002 · Cited by 179 · see citing works

TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity

Lang, X., Tang, T., Jin, T., Ding, C., Zhou, R., & Jiang, W. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20160592 · Cited by 177 · see citing works

Coordinated Modulation of Energy Metabolism and Inflammation by Branched-Chain Amino Acids and Fatty Acids

Ye, Z., Wang, S., Zhang, C., & Zhao, Y. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00617 · Cited by 173 · see citing works

Dopamine D2 receptor restricts astrocytic NLRP3 inflammasome activation via enhancing the interaction of β-arrestin2 and NLRP3

Zhu, J., Hu, Z., Han, X., Wang, D., Jiang, Q., Ding, J., Xiao, M., Wang, C., Lu, M., & Hu, G. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0127-2 · Cited by 174 · see citing works

Impact of intracellular innate immune receptors on immunometabolism

Chou, W.-C., Rampanelli, E., Li, X., & Ting, J. P. ‐. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00780-y · Cited by 170 · see citing works

Free Fatty Acid (FFA) and Hydroxy Carboxylic Acid (HCA) Receptors

Offermanns, S. (2013) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135945 · Cited by 171 · see citing works

Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages

Sokołowska, M., Chen, L., Liu, Y., Martínez‐Antón, A., Qi, H., Logun, C., Alsaaty, S., Park, Y. H., Kastner, D. L., Chae, J. J., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401343 · Cited by 169 · see citing works

Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages

L’homme, L., Esser, N., Riva, L., Scheen, A. J., Paquot, N., Piette, J. G., & Legrand-Poels, S. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m037861 · Cited by 169 · see citing works

The IL-1 Pathway in Type 2 Diabetes and Cardiovascular Complications

Herder, C., Dalmas, É., Böni‐Schnetzler, M., & Donath, M. Y. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.08.001 · Cited by 169 · see citing works

Inflammasomes link vascular disease with neuroinflammation and brain disorders

Lénárt, N., Brough, D., & Dénes, Á. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16662043 · Cited by 169 · see citing works

Fatty acid metabolism in the progression and resolution of CNS disorders

Bogie, J. F. J., Haidar, M., Kooij, G., & Hendriks, J. J. A. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.01.004 · Cited by 167 · see citing works

Protective role of oleic acid against cardiovascular insulin resistance and in the early and late cellular atherosclerotic process

Perdomo, L., Beneit, N., Otero, Y. F., Escribano, Ó., Díaz-Castroverde, S., Gómez‐Hernández, A., & Benito, M. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0237-9 · Cited by 166 · see citing works

Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications

Checa-Ros, A., Jeréz-Calero, A., Molina-Carballo, A., Campoy, C., & Muñoz-Hoyos, A. (2021) · Nutrients · doi:10.3390/nu13010249 · Cited by 164 · see citing works

The Imbalance between n-6/n-3 Polyunsaturated Fatty Acids and Inflammatory Bowel Disease: A Comprehensive Review and Future Therapeutic Perspectives

Scaioli, E., Liverani, E., & Belluzzi, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122619 · Cited by 163 · see citing works

Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages

Karasawa, T., Kawashima, A., Usui-Kawanishi, F., Watanabe, S., Kimura, H., Kamata, R., Shirasuna, K., Koyama, Y., Sato-Tomita, A., Matsuzaka, T., et al. (2018) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.117.310581 · Cited by 162 · see citing works

Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice

Ellenbroek, J. H., van Dijck, L., Töns, H. A. M., Rabelink, T. J., Carlotti, F., Ballieux, B. E. P. B., & de Koning, E. J. P. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00453.2013 · Cited by 154 · see citing works

ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation

Zheng, S., Que, X., Wang, S., Zhou, Q., Xing, X., Liang, C., Hou, C., Ma, J., An, P., Peng, Y., et al. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.11.015 · Cited by 156 · see citing works

Rosuvastatin Alleviates Diabetic Cardiomyopathy by Inhibiting NLRP3 Inflammasome and MAPK Pathways in a Type 2 Diabetes Rat Model

Luo, B., Li, B., Wang, W., Liu, X., Liu, X., Xia, Y., Zhang, C., Zhang, Y., Zhang, M., & An, F. (2013) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-013-6498-1 · Cited by 150 · see citing works

Environmental factors in autoimmune diseases and their role in multiple sclerosis

Haase, S., Grohme, D. A., Erzler, M., Binsfeld, M., Haghikia, A., Müller, D. N., Linker, R. A., & Kleinewietfeld, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2311-1 · Cited by 152 · see citing works

Therapeutic Options Targeting Oxidative Stress, Mitochondrial Dysfunction and Inflammation to Hinder the Progression of Vascular Complications of Diabetes

Teodoro, J. S., Nunes, S., Rolo, A. P., Reis, F., & Palmeira, C. M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01857 · Cited by 149 · see citing works

Stress induced microglial activation contributes to depression

Li, B., Yang, W., Ge, T., Wang, Y., & Cui, R. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106145 · Cited by 147 · see citing works

Diet in Parkinson’s Disease: Critical Role for the Microbiome

Jackson, A., Forsyth, C. B., Shaikh, M., Voigt, R. M., Engen, P. A., Ramirez, V., & Keshavarzian, A. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01245 · Cited by 145 · see citing works

Echinatin effectively protects against NLRP3 inflammasome–driven diseases by targeting HSP90

Xu, G., Fu, S., Zhan, X., Wang, Z., Zhang, P., Shi, W., Qin, N., Chen, Y., Wang, C., Niu, M., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.134601 · Cited by 143 · see citing works

GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects

Moraes‐Vieira, P. M., Saghatelian, A., & Kahn, B. B. (2016) · Diabetes · doi:10.2337/db16-0221 · Cited by 143 · see citing works

The gut microbiome connects nutrition and human health

Sanz, Y., Cryan, J. F., Deschasaux, M., Elinav, E., Lambrecht, R., & Veiga, P. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01077-5 · Cited by 142 · see citing works

Epidermal fatty acid binding protein promotes skin inflammation induced by high-fat diet

Zhang, Y., Li, Q., Rao, E., Sun, Y., Grossmann, M. E., Morris, R. J., Cleary, M. P., & Li, B. (2015) · Immunity · doi:10.1016/j.immuni.2015.04.016 · Cited by 137 · see citing works

The Role of Diet and Nutritional Intervention for the Management of Patients with NAFLD

Francisco Barrera, M., & George, J. (2013) · Clinics in Liver Disease · doi:10.1016/j.cld.2013.09.009 · Cited by 136 · see citing works

NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes

Hong, P., Gu, R., Li, F., Xiong, X., Liang, W., You, Z.-J., & Zhang, H. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1498-0 · Cited by 136 · see citing works

Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination

Xu, M., Jiang, Z., Wang, C., Li, N., Bo, L., Zha, Y., Bian, J., Zhang, Y., & Deng, X. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0276-5 · Cited by 135 · see citing works

Effects of Omega-3 Fatty Acid Supplementation on Glucose Control and Lipid Levels in Type 2 Diabetes: A Meta-Analysis

Chen, C., Yu, X., & Shao, S. (2015) · PLOS ONE · doi:10.1371/journal.pone.0139565 · Cited by 133 · see citing works

Unsaturated bond recognition leads to biased signal in a fatty acid receptor

Mao, C., Xiao, P., Tao, X.-N., Qin, J., He, Q., Zhang, C., Guo, S., Du, Y., Chen, L.-N., Shen, D., et al. (2023) · Science · doi:10.1126/science.add6220 · Cited by 128 · see citing works

Therapeutic potential of garlic chive-derived vesicle-like nanoparticles in NLRP3 inflammasome-mediated inflammatory diseases

Liu, B., Li, X., Yu, H. V., Shi, X., Zhou, Y., Alvarez, S., Naldrett, M. J., Kachman, S. D., Ro, S., Sun, X., et al. (2021) · Theranostics · doi:10.7150/thno.60265 · Cited by 133 · see citing works

Inflammasomes and intestinal inflammation

Zmora, N., Levy, M., Pevsner-Fishcer, M., & Elinav, E. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.19 · Cited by 125 · see citing works

Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma

Harun-Or-Rashid, M., & Inman, D. M. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1346-7 · Cited by 121 · see citing works

Cellular metabolism of myeloid cells in sepsis

Arts, R. J. W., Gresnigt, M. S., Joosten, L. A. B., & Netea, M. G. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.4mr0216-066r · Cited by 120 · see citing works

Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke

Xu, Q., Zhao, B., Ye, Y., Li, Y., Zhang, Y., Xiong, X., & Gu, L. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02137-8 · Cited by 118 · see citing works

Procyanidin B2 inhibits NLRP3 inflammasome activation in human vascular endothelial cells

Yang, H., Xiao, L., Yuan, Y., Luo, X., Jiang, M., Ni, J., & Wang, N. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.10.001 · Cited by 118 · see citing works

Autoinflammatory Features in Gouty Arthritis

Galozzi, P., Bindoli, S., Doria, A., Oliviero, F., & Sfriso, P. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10091880 · Cited by 116 · see citing works

The fish oil ingredient, docosahexaenoic acid, activates cytosolic phospholipase A2via GPR120 receptor to produce prostaglandin E2and plays an anti‐inflammatory role in macrophages

Liu, Y., Chen, L., Sokołowska, M., Eberlein, M. H., Alsaaty, S., Martínez‐Antón, A., Logun, C., Qi, H., & Shelhamer, J. H. (2014) · Immunology · doi:10.1111/imm.12296 · Cited by 114 · see citing works

Immunomodulatory Effects of Omega‐3 Fatty Acids: Mechanistic Insights and Health Implications

Bodur, M., Yılmaz, B., Ağagündüz, D., & Özoğul, Y. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400752 · Cited by 124 · see citing works

Dietary Fatty Acids and Their Potential for Controlling Metabolic Diseases Through Activation of FFA4/GPR120

Ulven, T., & Christiansen, E. (2015) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071714-034410 · Cited by 114 · see citing works

Fish Oil Cools the Inflammasome

Polage, C. R. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006920

(De-) Oiling Inflammasomes

Marty-Roix, R., & Lien, E. (2013) · Immunity · doi:10.1016/j.immuni.2013.06.006 · Cited by 8 · see citing works

Dietary fatty acid composition is sensed by the NLRP3 inflammasome: omega-3 fatty acid (DHA) prevents NLRP3 activation in human macrophages

Martínez-Micaelo, N., González‐Abuín, N., Pinent, M., Ardèvol, A., & Blay, M. (2016) · Food & Function · doi:10.1039/c6fo00477f · Cited by 48 · see citing works

Omega-3 Free Fatty Acids Suppress Macrophage Inflammasome Activation by Inhibiting NF-κB Activation and Enhancing Autophagy

Williams-Bey, Y., Boularan, C., Vural, A., Huang, N.-N., Hwang, I.-Y., Shan-Shi, C., & Kehrl, J. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097957 · Cited by 215 · see citing works

Fishing for anti-inflammatory mechanisms

Minton, K. (2013) · Nature reviews. Immunology · doi:10.1038/nri3498 · Cited by 2 · see citing works