Hochedlinger, Konrad

Disease-Specific Induced Pluripotent Stem Cells.

Park, I.-H., Arora, N., Huo, H., Maherali, N., Ahfeldt, T., Shimamura, A., Lensch, M. W., Cowan, C., Hochedlinger, K., & Daley, G. Q. (2008) · Cell

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

Cited by 2,196

Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution

Maherali, N., Sridharan, R., Xie, W., Utikal, J., Eminli, S., Arnold, K., Stadtfeld, M., Yachechko, R., Tchieu, J., Jaenisch, R., et al. (2007) · Cell stem cell

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 1,725

Induced pluripotent stem cells generated without viral integration

Stadtfeld, M., Nagaya, M., Utikal, J., Weir, G., & Hochedlinger, K. (2008) · Science

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

Cited by 1,683

A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells

Polo, J. M., Anderssen, E., Walsh, R. M., Schwarz, B. A., Nefzger, C. M., Lim, S. M., Borkent, M., Apostolou, E., Alaei, S., Cloutier, J., et al. (2012) · Cell

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 861

Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming

Schiebinger, G., Shu, J., Tabaka, M., Cleary, B., Subramanian, V., Solomon, A., Gould, J., Liu, S., Lin, S., Berube, P., et al. (2019) · Cell

Single-cell and spatial transcriptomicsPluripotent Stem Cells Research

Cited by 829

Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse

Stadtfeld, M., Maherali, N., Breault, D. T., & Hochedlinger, K. (2008) · Cell stem cell

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 823

Reprogramming to recover youthful epigenetic information and restore vision

Lu, Y., Brommer, B., Tian, X., Krishnan, A., Meer, M., Wang, C., Vera, D. L., Zeng, Q., Yu, D., Bonkowski, M. S., et al. (2020) · Nature

Epigenetics and DNA MethylationPluripotent Stem Cells Research

Cited by 820

Induced Pluripotent Stem Cell Generation Using a Single Lentiviral Stem Cell Cassette

Sommer, C. A., Stadtfeld, M., Murphy, G. J., Hochedlinger, K., Kotton, D. N., & Mostoslavsky, G. (2009) · Stem Cells

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

Cited by 676

Human iPSC-Derived Oligodendrocyte Progenitor Cells Can Myelinate and Rescue a Mouse Model of Congenital Hypomyelination

Wang, S., Bates, J., Li, X., Schanz, S., Chandler-Militello, D., Levine, C., Maherali, N., Studer, L., Hochedlinger, K., Windrem, M., et al. (2013) · Cell Stem Cell

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 586

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

Foudi, A., Hochedlinger, K., Van Buren, D., Schindler, J. W., Jaenisch, R., Carey, V., & Hock, H. (2009) · Nature Biotechnology

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 586

A High-Efficiency System for the Generation and Study of Human Induced Pluripotent Stem Cells

Maherali, N., Ahfeldt, T., Rigamonti, A., Utikal, J., Cowan, C., & Hochedlinger, K. (2008) · Cell Stem Cell

Pluripotent Stem Cells ResearchMesenchymal stem cell research

Cited by 563

Tgfβ Signal Inhibition Cooperates in the Induction of iPSCs and Replaces Sox2 and cMyc

Maherali, N., & Hochedlinger, K. (2009) · Current Biology

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 348

α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells

TeSlaa, T., Chaikovsky, A. C., Lipchina, I., Escobar, S. L., Hochedlinger, K., Huang, J., Graeber, T. G., Braas, D., & Teitell, M. A. (2016) · Cell Metabolism

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 287

Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming

Schiebinger, G., Shu, J., Tabaka, M., Cleary, B., Subramanian, V., Solomon, A., Gould, J., Liu, S., Lin, S., Berube, P., et al. (2019) · Cell

Single-cell and spatial transcriptomicsGene Regulatory Network Analysis

Cited by 139

Local Genome Topology Can Exhibit an Incompletely Rewired 3D-Folding State during Somatic Cell Reprogramming

Beagan, J. A., Gilgenast, T. G., Kim, J., Plona, Z., Norton, H. K., Hu, G., Hsu, S. C., Shields, E. J., Lyu, X., Apostolou, E., et al. (2016) · Cell Stem Cell

Pluripotent Stem Cells ResearchGenomics and Chromatin Dynamics

Cited by 134

Chromatin-state barriers enforce an irreversible mammalian cell fate decision

Blanco, M. A., Sykes, D. B., Gu, L., Wu, M., Petroni, R., Karnik, R., Wawer, M., Rico, J., Li, H., Jacobus, W. D., et al. (2021) · Cell Reports

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

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Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming

Lu, Y., Krishnan, A., Brommer, B., Tian, X., Meer, M., Vera, D. L., Wang, C., Zeng, Q., Yu, D., Bonkowski, M. S., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory)

Epigenetics and DNA MethylationRetinal Development and Disorders

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