Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults
Open accessAbstract
Background: Recent experimental approaches have unraveled essential migratory and functional differences of monocyte subpopulations in mice. In order to possibly translate these findings into human physiology and pathophysiology, human monocyte subsets need to be carefully revisited in health and disease. In analogy to murine studies, we hypothesized that human monocyte subsets dynamically change during ageing, potentially influencing their functionality and contributing to immunosenescence. Results: Circulating monocyte subsets, surface marker and chemokine receptor expression were analyzed in 181 healthy volunteers (median age 42, range 18-88). Unlike the unaffected total leukocyte or total monocyte counts, non-classical CD14 + CD16 + monocytes significantly increased with age, but displayed reduced HLA-DR and CX 3 CR1 surface expression in the elderly. Classical CD14 ++ CD16 - monocyte counts did not vary dependent on age. Serum MCP-1 (CCL2), but not MIP1α (CCL3), MIP1β (CCL4) or fractalkine (CX 3 CL1) concentrations increased with age. Monocyte-derived macrophages from old or young individuals did not differ with respect to cytokine release in vitro at steady state or upon LPS stimulation. Conclusions: Our study demonstrates dynamic changes of circulating monocytes during ageing in humans. The expansion of the non-classical CD14 + CD16 + subtype, alterations of surface protein and chemokine receptor expression as well as circulating monocyte-related chemokines possibly contribute to the preserved functionality of the monocyte pool throughout adulthood.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Monocyte populations shift in elderly people, with accumulation of non-classical monocytes that downregulate HLA-DR.
“Monocyte populations shift in the elderly, and there is an accumulation of non-classical monocytes that significantly downregulate HLA-DR123.”
From SARS-CoV-2, COVID-19 and the aging immune system (2021) · cites this paper as [123]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,366 · see citing works
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049 · see citing works
Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682 · see citing works
Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300 · see citing works
Identification of splenic reservoir monocytes and their deployment to inflammatory sites
Swirski, F. K., Nahrendorf, M., Etzrodt, M., Wildgruber, M., Cortez-Retamozo, V., Panizzi, P., Figueiredo, J.-L., Kohler, R. H., Chudnovskiy, A., Waterman, P., et al. (2009) · Science · doi:10.1126/science.1175202 · Cited by 2,221 · see citing works
Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior
Auffray, C., Fogg, D., Garfa, M., Elain, G., Join-Lambert, O., Kayal, S., Sarnacki, S., Cumano, A., Lauvau, G., & Geissmann, F. (2007) · Science · doi:10.1126/science.1142883 · Cited by 1,973 · see citing works
Serbina, N. V., & Pamer, E. G. (2006) · Nature Immunology · doi:10.1038/ni1309 · Cited by 1,658 · see citing works
Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells
Auffray, C., Sieweke, M. H., & Geissmann, F. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132557 · Cited by 1,647 · see citing works
Tacke, F., Alvarez, D., Kaplan, T. J., Jakubzick, C., Spanbroek, R., Llodra, J., Garin, A., Liu, J., Mack, M., van Rooijen, N., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28549 · Cited by 1,323 · see citing works
Self-citationTsou, C.-L., Peters, W., Si, Y., Slaymaker, S., Aslanian, A. M., Weisberg, S. P., Mack, M., & Charo, I. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29919 · Cited by 1,152 · see citing works
Identification and characterization of a novel monocyte subpopulation in human peripheral blood
Passlick, B., Flieger, D., & Ziegler‐Heitbrock, H. W. L. (1989) · Blood · doi:10.1182/blood.v74.7.2527.2527 · Cited by 1,032 · see citing works
Karlmark, K. R., Weiskirchen, R., Zimmermann, H. W., Gassler, N., Ginhoux, F., Weber, C., Merad, M., Luedde, T., Trautwein, C., & Tacke, F. (2009) · Hepatology · doi:10.1002/hep.22950 · Cited by 782 · see citing works
Self-citationAdmission criteria for immunogerontological studies in man: The senieur protocol
Ligthart, G. J., Corberand, J. X., Fournier, C., Galanaud, P., Hijmans, W., Kennes, B., Müller-Hermelink, H. K., & Steinmann, G. G. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90152-0 · Cited by 754 · cited 1× · see citing works
“Using these efforts, all participants, including the persons above 65 years of age, could be considered "healthy" based on admission criteria of the extensively validated 'senieur protocol' [17,18].”
Comparison of gene expression profiles between human and mouse monocyte subsets
Ingersoll, M. A., Spanbroek, R., Lottaz, C., Gautier, E. L., Frankenberger, M., Hoffmann, R. F. G., Lang, R., Haniffa, M. A., Collin, M. P., Tacke, F., et al. (2009) · Blood · doi:10.1182/blood-2009-07-235028 · Cited by 731 · see citing works
Self-citationIncreased cytokine production in mononuclear cells of healthy elderly people
Fagiolo, U., Cossarizza, A., Scala, E., Fanales‐Belasio, E., Ortolani, C., Cozzi, E., Monti, D., Franceschi, C., & Paganelli, R. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230950 · Cited by 665 · see citing works
Migratory fate and differentiation of blood monocyte subsets
Tacke, F., & Randolph, G. J. (2006) · Immunobiology · doi:10.1016/j.imbio.2006.05.025 · Cited by 528 · see citing works
Self-citationHuman innate immunosenescence: causes and consequences for immunity in old age
Panda, A., Arjona, A., Sapey, E., Bai, F., Fikrig, E., Montgomery, R. R., Lord, J. M., & Shaw, A. C. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.05.004 · Cited by 502 · see citing works
CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival
Landsman, L., Bar‐On, L., Zernecke, A., Kim, K.-W., Krauthgamer, R., Shagdarsuren, E., Lira, S. A., Weissman, I. L., Weber, C., & Jung, S. (2008) · Blood · doi:10.1182/blood-2008-07-170787 · Cited by 490 · see citing works
Auffray, C., Fogg, D. K., Narni-Mancinelli, E., Senechal, B., Trouillet, C., Saederup, N., Leemput, J., Bigot, K., Campisi, L., Abitbol, M., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081385 · Cited by 422 · see citing works
Inflammatory Pathways in Liver Homeostasis and Liver Injury
Tacke, F., Luedde, T., & Trautwein, C. (2009) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-008-8091-0 · Cited by 393 · see citing works
Self-citationImmunosenescence: what does it mean to health outcomes in older adults?
McElhaney, J. E., & Effros, R. B. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.023 · Cited by 340 · see citing works
Obstfeld, A. E., Sugaru, E., Thearle, M. S., Francisco, A.-M., Gayet, C., Ginsberg, H. N., Ables, E. V., & Ferrante, A. W. (2010) · Diabetes · doi:10.2337/db09-1403 · Cited by 314 · see citing works
Zimmermann, H. W., Seidler, S., Nattermann, J., Gaßler, N., Hellerbrand, C., Zernecke, A., Tischendorf, J. J. W., Luedde, T., Weiskirchen, R., Trautwein, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011049 · Cited by 311 · see citing works
Self-citationJakubzick, C. V., Tacke, F., Ginhoux, F., Wagers, A., van Rooijen, N., Mack, M., Merad, M., & Randolph, G. (2008) · Journal of Immunology · doi:10.4049/jimmunol.180.5.3019 · Cited by 263 · see citing works
Self-citationGautier, E. L., Jakubzick, C., & Randolph, G. J. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.180505 · Cited by 216 · see citing works
Raff, H. V., Picker, L. J., & Stobo, J. D. (1980) · The Journal of Experimental Medicine · doi:10.1084/jem.152.3.581 · Cited by 197 · see citing works
Grage‐Griebenow, E., Lorenzen, D. R., Fetting, R., Flad, H., & Ernst, M. (1993) · European Journal of Immunology · doi:10.1002/eji.1830231213 · Cited by 150 · see citing works
Phenotypic and functional characteristics of circulating monocytes of elderly persons☆
Sadeghi, H. M., Schnelle, J. F., Thomas, J. K., Nishanian, P., & Fahey, J. L. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00065-0 · Cited by 146 · see citing works
Increase in Circulating Levels of Monocyte Chemoattractant Protein-1 with Aging
Inadera, H., Egashira, K., Takemoto, M., Ouchi, Y., & Matsushima, K. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099313127 · Cited by 120 · see citing works
Ahluwalia, N., Mastro, A. M., Ball, R., Miles, M. P., Rajendra, R., & Handte, G. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00266-4 · Cited by 82 · see citing works
Increase of CXC chemokine CXCL10 and CC chemokine CCL2 serum levels in normal ageing
Antonelli, A., Rotondi, M., Fallahi, P., Ferrari, S. M., Paolicchi, A., Romagnani, P., Serio, M., & Ferrannini, E. (2006) · Cytokine · doi:10.1016/j.cyto.2006.03.012 · Cited by 78 · see citing works
Insulin Resistance in Liver Cirrhosis Is Not Associated With Circulating Retinol-Binding Protein 4
Yagmur, E., Weiskirchen, R., Gressner, A. M., Trautwein, C., & Tacke, F. (2007) · Diabetes Care · doi:10.2337/dc06-2323 · Cited by 63 · see citing works
Self-citationVolumetric and functional heterogeneity of human monocytes.
Arenson, E. B., Epstein, M., & Seeger, R. C. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109706 · Cited by 60 · see citing works
The role of chemokines and their receptors in dendritic cell biology
Lukacs‐Kornek, V. (2007) · Frontiers in bioscience · doi:10.2741/2838 · Cited by 57 · see citing works
The SENIEUR Protocol after 16 years: a need for a paradigm shift?
Castle, S. C., Uyemura, K., & Makinodan, T. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00238-4 · Cited by 25 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Age-dependent dysregulation of innate immunity
Shaw, A. C., Goldstein, D. R., & Montgomery, R. R. (2013) · Nature Reviews Immunology · doi:10.1038/nri3547 · Cited by 1,061 · see citing works
Developmental and Functional Heterogeneity of Monocytes
Guilliams, M., Mildner, A., & Yona, S. (2018) · Immunity · doi:10.1016/j.immuni.2018.10.005 · Cited by 973 · see citing works
Immunology of age-related macular degeneration
Ambati, J., Atkinson, J. P., & Gelfand, B. D. (2013) · Nature reviews. Immunology · doi:10.1038/nri3459 · Cited by 591 · see citing works
Hearps, A. C., Martin, G. E., Angelovich, T. A., Cheng, W., Maisa, A., Landay, A. L., Jaworowski, A., & Crowe, S. M. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00851.x · Cited by 547 · see citing works
Calder, P. C., Bosco, N., Bourdet‐Sicard, R., Capuron, L., Delzenne, N. M., Dore, J. M., Franceschi, C., Lehtinen, M. J., Recker, T., Salvioli, S., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.001 · Cited by 498 · see citing works
Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study
Puzianowska-Kuźnicka, M., Owczarz, M., Wieczorowska-Tobis, K., Nadrowski, P., Chudek, J., Slusarczyk, P., Skalska, A., Jonas, M., Franek, E., & Mossakowska, M. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0076-x · Cited by 445 · see citing works
A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies
Calder, P. C., Ahluwalia, N., Albers, R., Bosco, N., Bourdet-Sicard, R., Haller, D., Holgate, S. T., Jönsson, L. S., Latulippe, M. E., Marcos, A., et al. (2013) · British Journal of Nutrition · doi:10.1017/s0007114512005119 · Cited by 425 · see citing works
Immune ageing at single-cell resolution
Mogilenko, D. A., Shchukina, I., & Artyomov, M. N. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00646-4 · Cited by 392 · see citing works
SARS-CoV-2, COVID-19 and the aging immune system
Bartleson, J. M., Radenkovic, D., Covarrubias, A. J., Furman, D., Winer, D. A., & Verdin, E. (2021) · Nature Aging · doi:10.1038/s43587-021-00114-7 · Cited by 359 · see citing works
Interconnections between Inflammageing and Immunosenescence during Ageing
Teissier, T., Boulanger, É., & Cox, L. S. (2022) · Cells · doi:10.3390/cells11030359 · Cited by 310 · see citing works
Aging, inflammation, immunity and periodontal disease
Ebersole, J. L., Graves, C. L., González, O. A., Dawson, D. R., Morford, L. A., Emecen‐Huja, P., Hartsfield, J. K., Huja, S. S., Pandruvada, S. N. M., & Wallet, S. M. (2016) · Periodontology 2000 · doi:10.1111/prd.12135 · Cited by 308 · see citing works
Chronic Kidney Disease: A Clinical Model of Premature Aging
Stenvinkel, P., & Larsson, T. E. (2013) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2012.11.051 · Cited by 298 · see citing works
Franceschi, C., Salvioli, S., Garagnani, P., de Eguileor, M., Monti, D., & Capri, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00982 · Cited by 290 · see citing works
DNA damage response and metabolic disease
Shimizu, I., Yoshida, Y., Suda, M., & Minamino, T. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.10.008 · Cited by 286 · see citing works
Zimmermann, H. W., Seidler, S., Gaßler, N., Nattermann, J., Luedde, T., Trautwein, C., & Tacke, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021381 · Cited by 277 · see citing works
Self-citationThe Confluence of Sex Hormones and Aging on Immunity
Gubbels Bupp, M. R., Potluri, T., Fink, A. L., & Klein, S. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01269 · Cited by 277 · see citing works
The impact of ageing on monocytes and macrophages
De Maeyer, R. P. H., & Chambers, E. S. (2021) · Immunology Letters · doi:10.1016/j.imlet.2020.12.003 · Cited by 275 · see citing works
Oh, S. J., Lee, J. K., & Shin, O. S. (2019) · Immune Network · doi:10.4110/in.2019.19.e37 · Cited by 261 · see citing works
Ageing and the immune system: focus on macrophages
Linehan, E., & Fitzgerald, D. (2015) · European Journal of Microbiology and Immunology · doi:10.1556/eujmi-d-14-00035 · Cited by 228 · see citing works
Immune senescence, epigenetics and autoimmunity
Ray, D., & Yung, R. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.04.002 · Cited by 219 · see citing works
Terekhova, M., Swain, A., Bohacova, P., Aladyeva, E., Arthur, L., Laha, A., Mogilenko, D. A., Burdess, S., Sukhov, V., Kleverov, D., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.10.013 · Cited by 199 · see citing works
Petričević, B., Laengle, J., Singer, J., Sachet, M., Fazekas, J., Steger, G. G., Bartsch, R., Jensen‐Jarolim, E., & Bergmann, M. M. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-307 · Cited by 196 · see citing works
Metcalf, T. U., Cubas, R. A., Ghneim, K., Cartwright, M. J., Grevenynghe, J. V., Richner, J. M., Olagnier, D. P., Wilkinson, P. A., Cameron, M. J., Park, B. S., et al. (2015) · Aging Cell · doi:10.1111/acel.12320 · Cited by 189 · see citing works
Teissier, T., & Boulanger, É. (2019) · Biogerontology · doi:10.1007/s10522-019-09808-3 · Cited by 177 · see citing works
Heymann, F., Hammerich, L., Storch, D., Bartneck, M., Huss, S., Rüsseler, V., Gaßler, N., Lira, S. A., Luedde, T., Trautwein, C., et al. (2011) · Hepatology · doi:10.1002/hep.24764 · Cited by 175 · see citing works
Self-citationTNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity
Puchta, A., Naidoo, A., Verschoor, C. P., Loukov, D., Thevaranjan, N., Mandur, T. S., Nguyen, P.-S., Jordana, M., Loeb, M. B., Xing, Z., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005368 · Cited by 173 · see citing works
Pacinella, G., Ciaccio, A. M., & Tuttolomondo, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415722 · Cited by 172 · see citing works
Aging, inflammation and cancer
Bottazzi, B., Ríboli, E., & Mantovani, A. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.10.011 · Cited by 167 · see citing works
Immunosenescence and inflammaging: Mechanisms and role in diseases
Ajoolabady, A., Praticò, D., Tang, D., Zhou, S., Franceschi, C., & Ren, J. T. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102540 · Cited by 160 · see citing works
Frailty, aging, and periodontal disease: Basic biologic considerations
Clark, D. L., Kotronia, E., & Ramsay, S. E. (2021) · Periodontology 2000 · doi:10.1111/prd.12380 · Cited by 159 · see citing works
Immunosenescence: signaling pathways, diseases and therapeutic targets
Fu, Y., Wang, B., Alu, A., Hong, W., Hong, L., He, X., Shi, H., Cheng, P., & Yang, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02371-z · Cited by 157 · see citing works
Chemokines in CNS injury and repair
Järve, A., & Müller, H. W. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1427-3 · Cited by 155 · see citing works
Age‐associated elevation in TLR5 leads to increased inflammatory responses in the elderly
Qian, F., Wang, X., Zhang, L., Chen, S., Piecychna, M., Allore, H., Bockenstedt, L., Malawista, S., Bucala, R., Shaw, A. C., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2011.00759.x · Cited by 154 · see citing works
Tsao, F.-Y., Wu, M., Chang, Y., Wu, C., & Ho, H. (2017) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2017.03.011 · Cited by 148 · see citing works
Zhong, W., Rao, Z., Rao, J., Han, G., Wang, P., Jiang, T., Pan, X., Zhou, S., Zhou, H., & Wang, X. (2020) · Aging Cell · doi:10.1111/acel.13186 · Cited by 147 · see citing works
Crooke, S. N., Ovsyannikova, I. G., Poland, G. A., & Kennedy, R. B. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110632 · Cited by 143 · see citing works
Dynamics of human monocytes and airway macrophages during healthy aging and after transplant
Byrne, A. J., Powell, J. E., O’Sullivan, B., Ogger, P. P., Hoffland, A., Cook, J., Bonner, K., Hewitt, R. J., Wolf, S., Ghai, P., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20191236 · Cited by 136 · see citing works
Immunosenescence and pneumococcal disease: an imbalance in host-pathogen interactions.
Krone, C. L., van de Groep, K., Trzciński, K., Sanders, E. A. M., & Bogaert, D. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70165-6 · Cited by 134 · see citing works
Severe COVID-19 and aging: are monocytes the key?
Pence, B. D. (2020) · GeroScience · doi:10.1007/s11357-020-00213-0 · Cited by 133 · see citing works
A distinct innate immune signature marks progression from mild to severe COVID-19
Chevrier, S., Zurbuchen, Y., Cervia, C., Adamo, S., Raeber, M. E., de Souza, N., Sivapatham, S., Jacobs, A., Bächli, E., Rudiger, A., et al. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100166 · Cited by 131 · see citing works
Hallmarks and detection techniques of cellular senescence and cellular ageing in immune cells
Zhou, D., Borsa, M., & Simon, A. K. (2021) · Aging Cell · doi:10.1111/acel.13316 · Cited by 129 · see citing works
The Impact of Immunosenescence on Pulmonary Disease
Murray, M., & Chotirmall, S. H. (2015) · Mediators of Inflammation · doi:10.1155/2015/692546 · Cited by 124 · see citing works
A deficiency in CCR2+ monocytes: the hidden side of Alzheimer’s disease
Naert, G., & Rivest, S. (2013) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt028 · Cited by 123 · see citing works
Martin, G. E., Gouillou, M., Hearps, A. C., Angelovich, T. A., Cheng, A. C., Lynch, F., Cheng, W., Paukovics, G., Palmer, C. S., Novak, R. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055279 · Cited by 120 · see citing works
Macrophage metabolic reprogramming during chronic lung disease
Ogger, P. P., & Byrne, A. J. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-00356-5 · Cited by 120 · see citing works
Bongen, E., Lucian, H. J., Khatri, A., Fragiadakis, G. K., Bjornson, Z. B., Nolan, G. P., Utz, P. J., & Khatri, P. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.019 · Cited by 115 · see citing works
Rheumatoid Arthritis, Immunosenescence and the Hallmarks of Aging
Chalan, P., van den Berg, A., Kroesen, B., Brouwer, L., & Boots, A. M. H. (2015) · Current Aging Science · doi:10.2174/1874609808666150727110744 · Cited by 114 · see citing works
Schulz, A. R., Mälzer, J. N., Domingo, C., Jürchott, K., Grützkau, A., Babel, N., Nienen, M., Jelinek, T., Niedrig, M., & Thiel, A. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500598 · Cited by 112 · see citing works
In Situ Tissue Engineering of Functional Small-Diameter Blood Vessels by Host Circulating Cells Only
Talacua, H., Smits, A. I. P. M., Muylaert, D. E. P., van Rijswijk, J. W., Vink, A., Verhaar, M. C., Driessen‐Mol, A., van Herwerden, L. A., Bouten, C. V. C., Kluin, J., et al. (2015) · Tissue Engineering Part A · doi:10.1089/ten.tea.2015.0066 · Cited by 106 · see citing works
Innate immunesenescence: underlying mechanisms and clinical relevance
Hazeldine, J., & Lord, J. M. (2015) · Biogerontology · doi:10.1007/s10522-014-9514-3 · Cited by 104 · see citing works
Advanced Age Alters Monocyte and Macrophage Responses
Albright, J. M., Dunn, R. C., Shults, J. A., Boe, D. M., Afshar, M., & Kovacs, E. J. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6691 · Cited by 104 · see citing works
Lay, M. K., Atmar, R. L., Guix, S., Bharadwaj, U., He, H., Neill, F. H., Sastry, K. J., Yao, Q. C., & Estes, M. K. (2010) · Virology · doi:10.1016/j.virol.2010.07.001 · Cited by 103 · see citing works
Groarke, E. M., & Young, N. S. (2019) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2019.03.001 · Cited by 103 · see citing works
Dysregulation of Systemic Immunity in Aging and Dementia
Lutshumba, J., Nikolajczyk, B. S., & Bachstetter, A. D. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.652111 · Cited by 103 · see citing works
Origins and diversity of macrophages in health and disease
Sreejit, G., Fleetwood, A. J., Murphy, A. J., & Nagareddy, P. R. (2020) · Clinical & Translational Immunology · doi:10.1002/cti2.1222 · Cited by 102 · see citing works
Overcoming immune dysfunction in the elderly: trained immunity as a novel approach
Bulut, O., Kilic, G., Domínguez-Andrés, J., & Netea, M. G. (2020) · International Immunology · doi:10.1093/intimm/dxaa052 · Cited by 99 · see citing works
Autophagy and Immune Senescence
Zhang, H., Puleston, D. J., & Simon, A. K. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.06.001 · Cited by 93 · see citing works
Melzer, S., Zachariae, S., Bocsi, J., Engel, C., Löffler, M., & Tárnok, A. (2015) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.21234 · Cited by 93 · see citing works
Tacke, F. (2012) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-5-s1-s27 · Cited by 92 · see citing works
Self-citationKeilich, S. R., Bartley, J. M., & Haynes, L. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2019.103992 · Cited by 88 · see citing works
Chemokines in Prediabetes and Type 2 Diabetes: A Meta-Analysis
Pan, X., Kaminga, A. C., Wen, S. W., & Liu, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.622438 · Cited by 87 · see citing works
Phenotypic and functional alterations of monocyte subsets with aging
Cao, Y., Fan, Y., Li, F., Hao, Y., Kong, Y., Chen, C., Hao, X., Han, D., Li, G., Wang, Z., et al. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00321-9 · Cited by 87 · see citing works
Zimmermann, H. W., Koch, A. H., Seidler, S., Trautwein, C., & Tacke, F. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02665.x · Cited by 87 · see citing works
Self-citationRondina, M. T., Carlisle, M., Fraughton, T., Brown, S. M., Miller, R. R., Harris, E. S., Weyrich, A. S., Zimmerman, G. A., Supiano, M. A., & Grissom, C. K. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu082 · Cited by 85 · see citing works
Host Resistance and Immune Aging
Bandaranayake, T., & Shaw, A. C. (2016) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2016.02.007 · Cited by 85 · see citing works
Asian diversity in human immune cells
Kock, K. H., Tan, L. M., Han, K. Y., Ando, Y., Jevapatarakul, D., Chatterjee, A., Lin, Q. X. X., Buyamin, E. V., Sonthalia, R., Rajagopalan, D., et al. (2025) · Cell · doi:10.1016/j.cell.2025.02.017 · Cited by 84 · see citing works
Krasselt, M., Baerwald, C., Wagner, U. G., & Rossol, M. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4321 · Cited by 84 · see citing works
Müller, L., & Benedetto, S. D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020753 · Cited by 82 · see citing works
Inflammatory Co-morbidities in HIV+ Individuals: Learning Lessons from Healthy Ageing
Hearps, A. C., Martin, G. E., Rajasuriar, R., & Crowe, S. M. (2014) · Current HIV/AIDS Reports · doi:10.1007/s11904-013-0190-8 · Cited by 82 · see citing works
Nutritional modulation of age-related changes in the immune system and risk of infection
Pae, M., & Wu, D. (2017) · Nutrition Research · doi:10.1016/j.nutres.2017.02.001 · Cited by 80 · see citing works
Mohebali, D., Kaplan, D., Carlisle, M., Supiano, M. A., & Rondina, M. T. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12700 · Cited by 78 · see citing works
Alterations in Monocyte CD16 in Association with Diabetes Complications
Min, D., Brooks, B. A., Wong, J., Salomon, R., Bao, W., Harrisberg, B. P., Twigg, S. M., Yue, D. K., & McLennan, S. V. (2012) · Mediators of Inflammation · doi:10.1155/2012/649083 · Cited by 76 · see citing works
Epigenomic drivers of immune dysfunction in aging
Keenan, C. R., & Allan, R. S. (2018) · Aging Cell · doi:10.1111/acel.12878 · Cited by 76 · see citing works
Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs
Moss, C. E., Johnston, S. A., Kimble, J. V., Clements, M., Codd, V., Hamby, S. E., Goodall, A. H., Deshmukh, S., Sudbery, I. M., Coca, D., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114073 · Cited by 71 · see citing works
Verschoor, C. P., Johnstone, J., Millar, J., Parsons, R., Lelic, A., Loeb, M. B., Bramson, J. L., & Bowdish, D. M. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104522 · Cited by 71 · see citing works
Kapétanovic, R., Bokil, N. J., & Sweet, M. J. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.02.005 · Cited by 69 · see citing works
Rizzo, A. M., Corsetto, P. A., Montorfano, G., Opizzi, A., Faliva, M. A., Giacosa, A., Ricevuti, G., Pelucchi, C., Berra, B., & Rondanelli, M. (2012) · Nutrition Journal · doi:10.1186/1475-2891-11-82 · Cited by 69 · see citing works
CCL3/CCR1 mediates CD14+CD16− circulating monocyte recruitment in knee osteoarthritis progression
Zhao, X., Gu, M., Xu, X., Wen, X., Yang, G., Li, L., Sheng, P., & Meng, F. (2020) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2020.01.009 · Cited by 66 · see citing works
Aging and chronic kidney disease: epidemiology, therapy, management and the role of immunity
Tang, Y., Jiang, J., Zhao, Y., & Du, D. (2024) · Clinical Kidney Journal · doi:10.1093/ckj/sfae235 · Cited by 65 · see citing works
Assessing immune aging in HIV-infected patients
Appay, V., & Sauce, D. (2016) · Virulence · doi:10.1080/21505594.2016.1195536 · Cited by 65 · see citing works
Age-related changes in the immune system and challenges for the development of age-specific vaccines
Doherty, M. T., Weinberger, B., Didierlaurent, A. M., & Lambert, P. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2477300 · Cited by 63 · see citing works
Production of MHCII ‐expressing classical monocytes increases during aging in mice and humans
Barman, P. K., Shin, J. E., Lewis, S. A., Kang, S., Wu, D., Wang, Y., Yang, X., Nagarkatti, P. S., Nagarkatti, M., Messaoudi, I., et al. (2022) · Aging Cell · doi:10.1111/acel.13701 · Cited by 62 · see citing works
Immunosenescence and inflamm-ageing in COVID-19
Zinatizadeh, M. R., Zarandi, P. K., Ghiasi, M., Kooshki, H., Mohammadi, M., Amani, J., & Rezaei, N. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101818 · Cited by 62 · see citing works
Cheng, N., Chen, X., Kim, J., Shi, A., Nguyen, C., Wersto, R. P., & Weng, N. (2015) · Aging Cell · doi:10.1111/acel.12294 · Cited by 62 · see citing works
Seidler, S., Zimmermann, H. W., Weiskirchen, R., Trautwein, C., & Tacke, F. (2012) · BMC Gastroenterology · doi:10.1186/1471-230x-12-38 · Cited by 60 · see citing works
Self-citationPerdaens, O., & Pesch, V. V. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.811518 · Cited by 59 · see citing works
Biomarkers of ageing: Current state‐of‐art, challenges, and opportunities
Chen, R., Wang, Y., Zhang, S., Bulloch, G., Zhang, J., Liao, H., Shang, X., Clark, M., Peng, Q., Ge, Z., et al. (2023) · MedComm – Future Medicine · doi:10.1002/mef2.50 · Cited by 59 · see citing works
Effects of aging on human leukocytes (part I): immunophenotyping of innate immune cells
Stervbo, U., Meier, S., Mälzer, J. N., Baron, U., Bozzetti, C., Jürchott, K., Nienen, M., Olek, S., Rachwalik, D., Schulz, A. R., et al. (2015) · AGE · doi:10.1007/s11357-015-9828-3 · Cited by 59 · see citing works
A Crucial Role for CDC42 in Senescence-Associated Inflammation and Atherosclerosis
Ito, T. K., Yokoyama, M., Yoshida, Y., Nojima, A., Kassai, H., Oishi, K., Okada, S., Kinoshita, D., Kobayashi, Y., Fruttiger, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102186 · Cited by 58 · see citing works
Differential Modulation of Retinal Degeneration by Ccl2 and Cx3cr1 Chemokine Signalling
Luhmann, U. F. O., Lange, C., Robbie, S. J., Munro, P., Cowing, J. A., Armer, H. E. J., Luong, V., Carvalho, L. S., MacLaren, R. E., Fitzke, F. W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035551 · Cited by 58 · see citing works
Haschka, D., Tymoszuk, P., Bsteh, G., Petzer, V., Berek, K., Theurl, I., Berger, T., & Weiß, G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00594 · Cited by 58 · see citing works
Neutrophils are a main source of circulating suPAR predicting outcome in critical illness
Gussen, H., Hohlstein, P., Bartneck, M., Warzecha, K. T., Buendgens, L., Luedde, T., Trautwein, C., Koch, A. H., & Tacke, F. (2019) · Journal of Intensive Care · doi:10.1186/s40560-019-0381-5 · Cited by 57 · see citing works
Self-citationAging and Options to Halt Declining Immunity to Virus Infections
Palacios-Pedrero, M. Á., Osterhaus, A. D. M. E., Becker, T., Elbahesh, H., Rimmelzwaan, G. F., & Saletti, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.681449 · Cited by 55 · see citing works
Głuchowska, A., Cysewski, D., Baj‐Krzyworzeka, M., Szatanek, R., Węglarczyk, K., Podszywalow‐Bartnicka, P., Sunderland, P., Kozłowska, E., Śliwińska, M. A., Dąbrowski, M., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00625-0 · Cited by 55 · see citing works
Macromolecular Degradation Systems and Cardiovascular Aging
Nakayama, H., Nishida, K., & Otsu, K. (2016) · Circulation Research · doi:10.1161/circresaha.115.307495 · Cited by 55 · see citing works
How Immunosenescence and Inflammaging May Contribute to Hyperinflammatory Syndrome in COVID-19
Müller, L., & Benedetto, S. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212539 · Cited by 55 · see citing works
Brown, B. N., Haschak, M. J., Lopresti, S. T., & Stahl, E. C. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.05.001 · Cited by 55 · see citing works
Aging enhances liver fibrotic response in mice through hampering extracellular matrix remodeling
Delire, B., Lebrun, V., Selvais, C., Henriet, P., Bertrand, A., Horsmans, Y., & Leclercq, I. A. (2016) · Aging · doi:10.18632/aging.101124 · Cited by 54 · see citing works
Immunesenescence: A Predisposing Risk Factor for the Development of COVID-19?
Hazeldine, J., & Lord, J. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.573662 · Cited by 53 · see citing works
An immunologist’s guide to immunosenescence and its treatment
Caruso, C., Ligotti, M. E., Accardi, G., Aiello, A., & Candore, G. (2022) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2022.2106217 · Cited by 53 · see citing works
- Authors
- Seidler, S., Zimmermann, H. W., Bartneck, M., Trautwein, C., & Tacke, F.
- Affiliations
- Universitätsklinikum Aachen (DE)
- Corresponding author
- Tacke, Frank
- Venue
- BMC Immunology
- Published
- 2010-06-21
- Volume
- 11
- Issue
- 1
- Pages
- 30-30
- ISSN
- 1471-2172 (ISSN-L)
- PMC
- PMC2910032
- OpenAlex
- W2058743791
- Cited by
- 390
- References
- 35
- Citations by year
- 2026: 17 · 2025: 23 · 2024: 32 · 2023: 32 · 2022: 30 · 2021: 40 · 2020: 33 · 2019: 27 · 2018: 21 · 2017: 17 · 2016: 22 · 2015: 26 · 2014: 20 · 2013: 22 · 2012: 16
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- RWTH Publications (RWTH Aachen) (submittedVersion, cc-by)
- RWTH Publications (RWTH Aachen)
- Funders
- Deutsche Forschungsgemeinschaft (GRK 1035, DFG Ta434/2–1, SFB‐TRR57, Ta434/2-1, DFG: SFB/TRR57)
- RWTH Aachen University
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- monocyte subsets, aging, immunosenescence, CD14+CD16+ monocytes, classical monocytes, CX3CR1, HLA-DR, chemokine receptors, MCP-1, monocyte-derived macrophages, cytokine production, lipopolysaccharide stimulation, healthy adults
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Cell Movement, Female, Health, HLA-DR Antigens, Humans, Macrophages, Male, Middle Aged, Monocytes, Cohort Studies, Signal Transduction, Receptors, IgG, Chemokines, Chemokine CCL2, Lipopolysaccharide Receptors, Receptors, Chemokine, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
