Luo, Hongbo R.

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

Hu, J. J., Liu, X., Xia, S., Zhang, Z., Zhang, Y., Zhao, J., Ruan, J., Luo, X., Lou, X., Bai, Y., et al. (2020) · Nature Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 1,145

The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke

Wu, L.-J., Wu, G., Sharif, M. R. A., Baker, A., Jia, Y., Fahey, F. H., Luo, H. R., Feener, E. P., & Clapham, D. E. (2012) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsNeuroprotection in Cerebral Ischemia

Cited by 252

A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect

Liu, X., Chan, C.-B., Jang, S.-W., Pradoldej, S., Huang, J., He, K., Phun, L. H., France, S., Xiao, G., Jia, Y., et al. (2010) · Journal of Medicinal Chemistry

Synthesis of Organic CompoundsTreatment of Major Depression

Cited by 208

Stem Cell Factor SALL4 Represses the Transcriptions of PTEN and SALL1 through an Epigenetic Repressor Complex

Lu, J., Jeong, H., Kong, N., Yang, Y., Carroll, J., Luo, H. R., Silberstein, L. E., YupoMa, & Chai, L. (2009) · PLoS ONE

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 168

Proteinase 3–dependent caspase-3 cleavage modulates neutrophil death and inflammation

Loison, F., Zhu, H., Karatepe, K., Kasorn, A., Liu, P., Ye, K., Zhou, J., Cao, S., Gong, H., Jenne, D. E., et al. (2014) · Journal of Clinical Investigation

Cell death mechanisms and regulationNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 145

Single-cell transcriptomic landscape of human blood cells

Xie, X., Liu, M., Zhang, Y., Wang, B., Zhu, C., Wang, C., Li, Q., Huo, Y., Guo, J., Xu, C., et al. (2021) · National Science Review

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 145

Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages

Ding, X., Kambara, H., Guo, R., Kanneganti, A., Acosta-Zaldívar, M., Li, J., Liu, F., Bei, T., Qi, W., Xie, X., et al. (2021) · Nature Communications

Inflammasome and immune disordersAntifungal resistance and susceptibility

Cited by 115

Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate

Saiardi, A., Nagata, E., Luo, H. R., Sawa, A., Luo, X., Snowman, A. M., & Snyder, S. H. (2001) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingCalcium signaling and nucleotide metabolism

Cited by 110

Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology

Stygelbout, V., Leroy, K., Pouillon, V., Ando, K., D’Amico, E., Jia, Y., Luo, H. R., Duyckaerts, C., Erneux, C., Schurmans, S., et al. (2014) · Brain

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 85

Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex

Gao, C., Dimitrov, T., Yong, K. J., Tatetsu, H., Jeong, H.-W., Luo, H. R., Bradner, J. E., Tenen, D. G., & Chai, L. (2013) · Blood

Acute Myeloid Leukemia ResearchHistone Deacetylase Inhibitors Research

Cited by 65

Optimization of a Small Tropomyosin-Related Kinase B (TrkB) Agonist 7,8-Dihydroxyflavone Active in Mouse Models of Depression

Liu, X., Chan, C.-B., Qi, Q., Xiao, G., Luo, H. R., He, X., & Ye, K. (2012) · Journal of Medicinal Chemistry

Treatment of Major DepressionSynthesis of Organic Compounds

Cited by 60

Zinc finger protein SALL4 functions through an AT-rich motif to regulate gene expression

Kong, N. R., Bassal, M. A., Tan, H. K., Kurland, J. V., Yong, K. J., Young, J. J., Yang, Y., Li, F., Lee, J. D., Liu, Y., et al. (2021) · Cell Reports

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 56

Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion

Fan, Y., Teng, Y., Loison, F., Pang, A., Kasorn, A., Shao, X., Zhang, C., Ren, Q., Yu, H., Zheng, Y., et al. (2021) · Science Translational Medicine

Cell death mechanisms and regulationBlood transfusion and management

Cited by 36