Kapahi, Pankaj

From discoveries in ageing research to therapeutics for healthy ageing

Campisi, J., Kapahi, P., Lithgow, G. J., Melov, S., Newman, J. C., & Verdin, E. (2019) · Nature

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 1,389

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004) · Current Biology

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

Cited by 1,293

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

Laberge, R.-M., Sun, Y., Orjalo, A. V., Patil, C. K., Freund, A., Zhou, L., Curran, S. C., Davalos, A. R., Wilson-Edell, K. A., Liu, S., et al. (2015) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,160

The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality

Chaudhuri, J., Bains, Y., Guha, S., Kahn, A., Hall, D., Bose, N., Gugliucci, A., & Kapahi, P. (2018) · Cell Metabolism

Advanced Glycation End Products researchGenetics, Aging, and Longevity in Model Organisms

Cited by 669

Cellular senescence: a link between cancer and age-related degenerative disease?

Campisi, J., Andersen, J. K., Kapahi, P., & Melov, S. (2011) · Seminars in Cancer Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 421

Dietary restriction and lifespan: lessons from invertebrate models

Kapahi, P., Kaeberlein, M., & Hansen, M. (2017) · Ageing Research Reviews

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 340

SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease

Shin, J., He, M., Liu, Y., Paredes, S., Villanova, L., Brown, K., Qiu, X., Nabavi, N., Mohrin, M., Wojnoonski, K., et al. (2013) · Cell Reports

Sirtuins and Resveratrol in MedicineLiver Disease Diagnosis and Treatment

Cited by 287

HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans

Chen, D., Thomas, E. L., & Kapahi, P. (2009) · PLoS Genetics

Genetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy

Cited by 250

Glucocorticoids suppress selected components of the senescence‐associated secretory phenotype

Laberge, R., Zhou, L., Sarantos, M. R., Rodier, F., Freund, A., de Keizer, P. L. J., Liu, S., Demaria, M., Cong, Y., Kapahi, P., et al. (2012) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 229

Peripheral circadian clocks mediate dietary restriction-dependent changes in lifespan and fat metabolism in Drosophila

Katewa, S. D., Akagi, K., Bose, N., Rakshit, K., Camarella, T., Zheng, X., Hall, D., Davis, S., Nelson, C. S., Brem, R. B., et al. (2016) · Cell Metabolism

Circadian rhythm and melatoninGenetics, Aging, and Longevity in Model Organisms

Cited by 173

Oxidative stress and gene expression: The AP‐1 and NF‐κB connections

Karin, M., Takahashi, T., Kapahi, P., Delhase, M., Chen, Y., Makris, C., Rothwarf, D., Baud, V., Natoli, G., Guido, F., et al. (2001) · BioFactors

NF-κB Signaling PathwaysRedox biology and oxidative stress

Cited by 151

SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells

Wiley, C. D., Liu, S., Limbad, C., Zawadzka, A. M., Beck, J., Demaria, M., Artwood, R., Alimirah, F., Lopez-Dominguez, J.-A., Kuehnemann, C., et al. (2019) · Cell Reports

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 137

Simvastatin suppresses breast cancer cell proliferation induced by senescent cells

Liu, S., Uppal, H., Demaria, M., Desprez, P.-Y., Campisi, J., & Kapahi, P. (2015) · Scientific Reports

Telomeres, Telomerase, and SenescenceCancer, Lipids, and Metabolism

Cited by 124

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.

SenNet Consortium, Writing Group, Lee, P. J., Benz, C. C., Blood, P., Börner, K., Campisi, J., Chen, F., Daldrup-Link, H., De Jager, P., et al. (2022) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 122

Dietary restriction induces post-transcriptional regulation of longevity genes

Rollins, J. A., Snow, S. S., Kapahi, P., & Rogers, A. N. (2019) · Life Science Alliance

Genetics, Aging, and Longevity in Model OrganismsRNA Research and Splicing

Cited by 44

Inhibition of the metalloprotease ADAM19 as a novel senomorphic strategy to ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP)

Bar, S., Hilsabeck, T. A. U., Pattavina, B., López-Domínguez, J. A., Basisty, N., Bons, J., Watson, M., Schilling, B., Campisi, J., Kapahi, P., et al. (2025) · Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 3