Peripheral circadian clocks mediate dietary restriction-dependent changes in lifespan and fat metabolism in Drosophila
Open accessAbstract
Endogenous circadian clocks orchestrate several metabolic and signaling pathways that are known to modulate lifespan, suggesting clocks as potential targets for manipulation of metabolism and lifespan. We report here that the core circadian clock genes, timeless (tim) and period (per), are required for the metabolic and lifespan responses to DR in Drosophila. Consistent with the involvement of a circadian mechanism, DR enhances the amplitude of cycling of most circadian clock genes, including tim, in peripheral tissues. Mass-spectrometry-based lipidomic analysis suggests a role of tim in cycling of specific medium chain triglycerides under DR. Furthermore, overexpression of tim in peripheral tissues improves its oscillatory amplitude and extends lifespan under ad libitum conditions. Importantly, effects of tim on lifespan appear to be mediated through enhanced fat turnover. These findings identify a critical role for specific clock genes in modulating the effects of nutrient manipulation on fat metabolism and aging.
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Caloric restriction's ability to extend Drosophila lifespan and improve fat metabolism depends on circadian regulation.
“the ability of caloric restriction to extend Drosophila lifespan and improve fat metabolism depends on circadian regulation (Katewa et al., 2016).”
From The Aging Epigenome (2016) · cites this paper as Katewa et al., 2016
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A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189 · see citing works
Obesity and Metabolic Syndrome in Circadian <i>Clock</i> Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485 · see citing works
Clock Mutants of Drosophila melanogaster
Konopka, R. J., & Benzer, S. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.9.2112 · Cited by 2,287 · see citing works
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,272 · see citing works
High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice
Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528 · see citing works
LMSD: LIPID MAPS structure database
Sud, M., Fahy, E., Cotter, D., Brown, A., Dennis, E. A., Glass, C. K., Merrill, A. H., Murphy, R. C., Raetz, C. R. H., Russell, D. W., et al. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl838 · Cited by 1,388 · see citing works
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.059 · Cited by 1,293 · see citing works
Self-citationLifespan and reproduction in <i>Drosophila</i> : New insights from nutritional geometry
Lee, K. P., Simpson, S. J., Clissold, F. J., Brooks, R., Ballard, J. W. O., Taylor, P. W., Soran, N., & Raubenheimer, D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710787105 · Cited by 1,032 · see citing works
Calorie restriction, SIRT1 and metabolism: understanding longevity
Bordone, L., & Guarente, L. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1616 · Cited by 1,021 · see citing works
LIPID MAPS online tools for lipid research
Fahy, E., Sud, M., Cotter, D., & Subramaniam, S. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm324 · Cited by 916 · see citing works
Solon-Biet, S. M., McMahon, A. C., Ballard, J. W. O., Ruohonen, K., Wu, L. E., Cogger, V. C., Warren, A., Huang, X., Pichaud, N., Melvin, R. G., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.009 · Cited by 904 · see citing works
Green, C. B., Takahashi, J. S., & Bass, J. (2008) · Cell · doi:10.1016/j.cell.2008.08.022 · Cited by 902 · cited 3× · see citing works
“Clocks Regulate Fat Metabolism under DR Circadian clocks are critical regulators of metabolism (Green et al., 2008; Kohsaka et al., 2007; Panda et al., 2002; Ramsey et al., 2007; Xu et al., 2011) and maintain temporal organization that optimizes various cellular functions (Kovac et al.”
A conditional tissue-specific transgene expression system using inducible GAL4
Osterwalder, T., Yoon, K. S., White, B. H., & Keshishian, H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221303298 · Cited by 770 · see citing works
Schibler, U., & Sassone‐Corsi, P. (2002) · Cell · doi:10.1016/s0092-8674(02)01225-4 · Cited by 752 · see citing works
Molecular components of the mammalian circadian clock
Buhr, E. D., & Takahashi, J. S. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_1 · Cited by 738 · see citing works
With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging
Kapahi, P., Chen, D., Rogers, A. N., Katewa, S. D., Li, P. W.-L., Thomas, E., & Kockel, L. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.001 · Cited by 663 · see citing works
Self-citationLoss of Circadian Behavioral Rhythms and per RNA Oscillations in the Drosophila Mutant timeless
Sehgal, A., Price, J. L., Man, B., & Young, M. W. (1994) · Science · doi:10.1126/science.8128246 · Cited by 651 · see citing works
Self-citationAging and Survival: The Genetics of Life Span Extension by Dietary Restriction
Mair, W. B., & Dillin, A. G. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061206.171059 · Cited by 600 · see citing works
Effects of experience and social context on prospective caching strategies by scrub jays
Emery, N. J., & Clayton, N. S. (2001) · Nature · doi:10.1038/35106560 · Cited by 565 · see citing works
4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila
Zid, B. M., Rogers, A. N., Katewa, S. D., Vargas, M. A., Kolipinski, M., Lu, T. A., Benzer, S., & Kapahi, P. (2009) · Cell · doi:10.1016/j.cell.2009.07.034 · Cited by 541 · see citing works
Self-citationPHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
Panowski, S. H., Wolff, S., Aguilaniu, H., Durieux, J., & Dillin, A. G. (2007) · Nature · doi:10.1038/nature05837 · Cited by 538 · see citing works
Demography of Dietary Restriction and Death in Drosophila
Mair, W. B., Goymer, P., Pletcher, S. D., & Partridge, L. (2003) · Science · doi:10.1126/science.1086016 · Cited by 526 · see citing works
Calories Do Not Explain Extension of Life Span by Dietary Restriction in Drosophila
Mair, W. B., Piper, M. D. W., & Partridge, L. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030223 · Cited by 522 · see citing works
PGRP-SC2 Promotes Gut Immune Homeostasis to Limit Commensal Dysbiosis and Extend Lifespan
Guo, L., Karpac, J., Tran, S. L., & Jasper, H. (2014) · Cell · doi:10.1016/j.cell.2013.12.018 · Cited by 463 · see citing works
Genetic links between diet and lifespan: shared mechanisms from yeast to humans
Bishop, N. A., & Guarente, L. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2188 · Cited by 421 · see citing works
P{Switch}, a system for spatial and temporal control of gene expression in Drosophila melanogaster
Roman, G., Endo, K., Zong, L., & Davis, R. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221303998 · Cited by 406 · see citing works
Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB
Mair, W., Morantte, I., Rodrigues, A. P. C., Manning, G., Montminy, M., Shaw, R. J., & Dillin, A. (2011) · Nature · doi:10.1038/nature09706 · Cited by 393 · see citing works
Chippindale, A. K., Leroi, A. M., Saing, H., Borash, D. J., & Rose, M. R. (1997) · Journal of Evolutionary Biology · doi:10.1046/j.1420-9101.1997.10030269.x · Cited by 385 · see citing works
Chippindale, A. K., Leroi, A. M., Kim, S. B., & Rose, M. R. (1993) · Journal of Evolutionary Biology · doi:10.1046/j.1420-9101.1993.6020171.x · Cited by 372 · see citing works
Physiological Effects of Medium-Chain Triglycerides: Potential Agents in the Prevention of Obesity
St‐Onge, M., & Jones, P. J. H. (2002) · Journal of Nutrition · doi:10.1093/jn/132.3.329 · Cited by 369 · see citing works
A Drosophila model for age-associated changes in sleep:wake cycles
Koh, K., Evans, J. M., Hendricks, J. C., & Sehgal, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605903103 · Cited by 341 · see citing works
Self-citationInterplay of Circadian Clocks and Metabolic Rhythms
Wijnen, H., & Young, M. W. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090603 · Cited by 335 · see citing works
Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates
Bruss, M. D., Khambatta, C. F., Ruby, M. A., Aggarwal, I., & Hellerstein, M. K. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00524.2009 · Cited by 321 · see citing works
Effects of aging on central and peripheral mammalian clocks
Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., Menaker, M., & Block, G. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152318499 · Cited by 317 · see citing works
Behavior in Light-Dark Cycles of Drosophila Mutants That Are Arrhythmic, Blind, or Both
Wheeler, D. A., Hamblen, M. J., Dushay, M. S., & Hall, J. C. (1993) · Journal of Biological Rhythms · doi:10.1177/074873049300800106 · Cited by 302 · see citing works
Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism
Masri, S., Rigor, P., Cervantes, M., Ceglia, N., Sebastian, C., Xiao, C., Roqueta-Rivera, M., Deng, C., Osborne, T. F., Mostoslavsky, R., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.050 · Cited by 292 · see citing works
The Significance of Circadian Organization for Longevity in the Golden Hamster
Hurd, M. W., & Ralph, M. R. (1998) · Journal of Biological Rhythms · doi:10.1177/074873098129000255 · Cited by 275 · see citing works
Positional Cloning and Sequence Analysis of the Drosophila Clock Gene, timeless
Myers, M. P., Wager‐Smith, K., Wesley, C. S., Young, M. W., & Sehgal, A. (1995) · Science · doi:10.1126/science.270.5237.805 · Cited by 270 · see citing works
Self-citationMasoro, E. J. (1993) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1993.tb06767.x · Cited by 242 · see citing works
The Drosophila Circadian Network Is a Seasonal Timer
Stoleru, D., Nawathean, P., Fernandez, M. P., Menet, J. S., Ceriani, M. F., & Rosbash, M. (2007) · Cell · doi:10.1016/j.cell.2007.02.038 · Cited by 241 · see citing works
Role of Molecular Oscillations in Generating Behavioral Rhythms in Drosophila
Yang, Z., & Sehgal, A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00218-5 · Cited by 240 · see citing works
Self-citationA new role for cryptochrome in a Drosophila circadian oscillator
Krishnan, B., Levine, J. D., Lynch, M. K. S., Dowse, H. B., Funes, P., Hall, J. C., Hardin, P. E., & Dryer, S. E. (2001) · Nature · doi:10.1038/35077094 · Cited by 239 · see citing works
Vargas, M. A., Luo, N., Yamaguchi, A., & Kapahi, P. (2010) · Current Biology · doi:10.1016/j.cub.2010.04.009 · Cited by 200 · see citing works
Self-citationThe circadian rhythm of core temperature: Effects of physical activity and aging
Weinert, D., & Waterhouse, J. M. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.09.003 · Cited by 194 · see citing works
The Circadian Clock Interacts with Metabolic Physiology to Influence Reproductive Fitness
Xu, K., DiAngelo, J. R., Hughes, M. E., Hogenesch, J. B., & Sehgal, A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.001 · Cited by 181 · see citing works
Self-citationFontana, L., Klein, S., & Holloszy, J. O. (2009) · AGE · doi:10.1007/s11357-009-9118-z · Cited by 178 · see citing works
Mumme, K., & Stonehouse, W. (2015) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2014.10.022 · Cited by 170 · see citing works
ALTERATIONS WITH AGING OF THE ENDOCRINE AND NEUROENDOCRINE CIRCADIAN SYSTEM IN HUMANS
Touitou, Y., & Haus, E. L. (2000) · Chronobiology International · doi:10.1081/cbi-100101052 · Cited by 169 · see citing works
Katewa, S. D., Demontis, F., Kolipinski, M., Hubbard, A., Gill, M. S., Perrimon, N., Melov, S., & Kapahi, P. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.005 · Cited by 162 · see citing works
Self-citationAsai, M., Yoshinobu, Y., Kaneko, S., Mori, A., Nikaido, T., Moriya, T., Akiyama, M., & Shibata, S. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.10010 · Cited by 151 · see citing works
A role of the circadian system and circadian proteins in aging
KONDRATOV, R. (2007) · Ageing Research Reviews · doi:10.1016/j.arr.2007.02.003 · Cited by 149 · see citing works
Zhdanova, I. V., Yu, L., López‐Patiño, M. A., Shang, E. H. H., Kishi, S., & Guélin, E. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.10.053 · Cited by 148 · see citing works
AKT and TOR Signaling Set the Pace of the Circadian Pacemaker
Zheng, X., & Sehgal, A. (2010) · Current Biology · doi:10.1016/j.cub.2010.05.027 · Cited by 145 · see citing works
Self-citationRestriction of amino acids extends lifespan in Drosophila melanogaster
Min, K., & Tatar, M. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.02.005 · Cited by 137 · see citing works
Role of TOR signaling in aging and related biological processes in Drosophila melanogaster
Katewa, S. D., & Kapahi, P. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.11.036 · Cited by 134 · see citing works
Self-citationHigh carbohydrate–low protein consumption maximizes Drosophila lifespan
Bruce, K. D., Hoxha, S., Carvalho, G. B., Yamada, R., Wang, H., Karayan, P., He, S., Brummel, T., Kapahi, P., & Ja, W. W. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.003 · Cited by 125 · see citing works
Self-citationIt’s All in the Timing: Many Clocks, Many Outputs
Panda, S., & Hogenesch, J. B. (2004) · Journal of Biological Rhythms · doi:10.1177/0748730404269008 · Cited by 125 · see citing works
Diurnal variation of the human adipose transcriptome and the link to metabolic disease
Loboda, A., Kraft, W. K., Fine, B., Joseph, J., Nebozhyn, M., Zhang, C., He, Y., Yang, X., Wright, C., Morris, M., et al. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-7 · Cited by 124 · see citing works
Ramsey, K. M., Marcheva, B., Kohsaka, A., & Bass, J. T. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093546 · Cited by 122 · see citing works
FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress
Zheng, X., Yang, Z., Yue, Z., Alvarez, J. D., & Sehgal, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701599104 · Cited by 120 · see citing works
Self-citationProbing the Relative Importance of Molecular Oscillations in the Circadian Clock
Zheng, X., & Sehgal, A. (2008) · Genetics · doi:10.1534/genetics.107.088658 · Cited by 112 · see citing works
Self-citationLuo, W., Chen, W., Yue, Z., Chen, D., Sowcik, M., Sehgal, A., & Zheng, X. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00800.x · Cited by 102 · see citing works
Self-citationA Time to Fast, a Time to Feast: The Crosstalk between Metabolism and the Circadian Clock
Kovac, J., Husse, J., & Oster, H. (2009) · Molecules and Cells · doi:10.1007/s10059-009-0113-0 · Cited by 100 · see citing works
Geng, S., Zhu, W., Xie, C., Li, X., Wu, J., Liang, Z., Xie, W., Zhu, J., Huang, C. X., Zhu, M., et al. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0907-0 · Cited by 92 · see citing works
FORD, D., Hoe, N., Landis, G. N., Tozer, K. R., Luu, A., Bhole, D., Badrinath, A., & Tower, J. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.01.004 · Cited by 90 · see citing works
Insulin-FOXO3 Signaling Modulates Circadian Rhythms via Regulation of Clock Transcription
Chaves, I., van der Horst, G. T. J., Schellevis, R. D., Nijman, R., Koerkamp, M. J. A. G., Holstege, F. C. P., Smidt, M. P., & Hoekman, M. F. M. (2014) · Current Biology · doi:10.1016/j.cub.2014.04.018 · Cited by 89 · see citing works
Effects of Aging on the Molecular Circadian Oscillations inDrosophila
Rakshit, K., Krishnan, N., Guzik, E. M., Pyza, E., & Giebultowicz, J. M. (2012) · Chronobiology International · doi:10.3109/07420528.2011.635237 · Cited by 88 · see citing works
Self-citationCircadian Regulation of Glutathione Levels and Biosynthesis in Drosophila melanogaster
Beaver, L. M., Klichko, V. I., Chow, E. S., Kotwica‐Rolinska, J., Williamson, M., Orr, W. C., Radyuk, S. N., & Giebultowicz, J. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050454 · Cited by 87 · see citing works
Self-citationDietary restriction and aging, 2009
Katewa, S. D., & Kapahi, P. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00552.x · Cited by 76 · see citing works
Self-citationThe Circadian Clock, Light, and Cryptochrome Regulate Feeding and Metabolism in Drosophila
Seay, D. J., & Thummel, C. S. (2011) · Journal of Biological Rhythms · doi:10.1177/0748730411420080 · Cited by 70 · see citing works
Cryptochromerestores dampened circadian rhythms and promotes healthspan in agingDrosophila
Rakshit, K., & Giebultowicz, J. M. (2013) · Aging Cell · doi:10.1111/acel.12100 · Cited by 65 · see citing works
Self-citationAging of Intrinsic Circadian Rhythms and Sleep in a Diurnal Nonhuman Primate, Macaca mulatta
Zhdanova, I. V., Masuda, K., Quasarano-Kourkoulis, C., Rosene, D. L., Killiany, R., & Wang, S. (2011) · Journal of Biological Rhythms · doi:10.1177/0748730410395849 · Cited by 63 · see citing works
Ronis, M. J. J., Baumgardner, J. N., Sharma, N., Vantrease, J., Ferguson, M. E., Tong, Y., Wu, X., Cleves, M. A., & Badger, T. M. (2013) · Experimental Biology and Medicine · doi:10.1258/ebm.2012.012303 · Cited by 63 · see citing works
Diet Restriction in Drosophila melanogaster
Tatar, M. (2006) · KARGER eBooks · doi:10.1159/000096559 · Cited by 55 · see citing works
Hammad, L. A., Cooper, B. S., Fisher, N. P., Montooth, K. L., & Karty, J. A. (2011) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.5187 · Cited by 49 · see citing works
Lipidomic Profiling of Di- and Tri-Acylglycerol Species in Weight-Controlled Mice
King, B. S., Lu, L., Yu, M., Jiang, Y., Standard, J., Su, X., Zhao, Z., & Wang, W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116398 · Cited by 46 · see citing works
The Central Clock Neurons Regulate Lipid Storage in Drosophila
DiAngelo, J. R., Erion, R., Crocker, A. J., & Sehgal, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019921 · Cited by 35 · see citing works
Self-citationAbsorption of Dietary Fat: Use of Medium-Chain Triglycerides in Malabsorption
Scheig, R. (1968) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/21.4.300 · Cited by 13 · see citing works
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Self-citationMolecular mechanisms and physiological importance of circadian rhythms
Patke, A., Young, M. W., & Axelrod, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0179-2 · Cited by 1,388 · see citing works
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López-Otín, C., Galluzzi, L., Freije, J. M. P., Madeo, F., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.07.031 · Cited by 753 · see citing works
Circadian time signatures of fitness and disease
Bass, J. T., & Lazar, M. A. (2016) · Science · doi:10.1126/science.aah4965 · Cited by 616 · see citing works
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Hood, S., & Amir, S. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90328 · Cited by 621 · see citing works
Booth, L. N., & Brunet, A. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.013 · Cited by 499 · see citing works
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Self-citationCircadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice
Acosta-Rodríguez, V. A., Rijo‐Ferreira, F., Izumo, M., Xu, P., Wight‐Carter, M., Green, C. B., & Takahashi, J. S. (2022) · Science · doi:10.1126/science.abk0297 · Cited by 361 · see citing works
Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging
Sato, S., Solanas, G., Peixoto, F. O., Bee, L., Symeonidi, A., Schmidt, M. S., Brenner, C., Masri, S., Benitah, S. A., & Sassone‐Corsi, P. (2017) · Cell · doi:10.1016/j.cell.2017.07.042 · Cited by 359 · see citing works
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Li, S., Yu, X., & Feng, Q. (2018) · Annual Review of Entomology · doi:10.1146/annurev-ento-011118-112007 · Cited by 338 · see citing works
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Acosta-Rodríguez, V. A., Rijo‐Ferreira, F., Green, C. B., & Takahashi, J. S. (2021) · Nature Communications · doi:10.1038/s41467-021-22922-6 · Cited by 249 · see citing works
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Gelino, S., Chang, J. T., Kumsta, C., She, X., Davis, A. E. M., Nguyen, C. N., Panowski, S. H., & Hansen, M. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006135 · Cited by 203 · see citing works
Nohara, K., Mallampalli, V. K. P. S., Nemkov, T. G., Wirianto, M., Yang, J., Ye, Y., Sun, Y., Han, L., Esser, K. A., Mileykovskaya, E., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11926-y · Cited by 190 · see citing works
Dietary regulation in health and disease
Wu, Q., Gao, Z., Yu, X., & Wang, P. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01104-w · Cited by 182 · see citing works
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Lee, Y., Field, J. M., & Sehgal, A. (2021) · Journal of Biological Rhythms · doi:10.1177/07487304211044301 · Cited by 166 · see citing works
Self-citationInterconnections between circadian clocks and metabolism
Guan, D., & Lazar, M. A. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148278 · Cited by 166 · see citing works
Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms
Hwangbo, D., Lee, H., Abozaid, L. S., & Min, K. (2020) · Nutrients · doi:10.3390/nu12041194 · Cited by 164 · see citing works
Development and Therapeutic Potential of Small-Molecule Modulators of Circadian Systems
Chen, Z., Yoo, S. H., & Takahashi, J. S. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-052645 · Cited by 153 · see citing works
Patel, S. A., Velingkaar, N., Makwana, K., Chaudhari, A., & Kondratov, R. V. (2016) · Scientific Reports · doi:10.1038/srep25970 · Cited by 99 · see citing works
Obesity and Aging in the Drosophila Model
Gáliková, M., & Klepsatel, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071896 · Cited by 99 · see citing works
Visible light reduces C. elegans longevity
Filho, C. D. D. M., Henriquez, B., Seah, N., Evans, R. M., Lapierre, L. R., & Dillin, A. G. (2018) · Nature Communications · doi:10.1038/s41467-018-02934-5 · Cited by 100 · see citing works
Muscle Directs Diurnal Energy Homeostasis through a Myokine-Dependent Hormone Module in Drosophila
Zhao, X. L., & Karpac, J. (2017) · Current Biology · doi:10.1016/j.cub.2017.06.004 · Cited by 98 · see citing works
Meal timing, aging, and metabolic health
Kessler, K., & Pivovarova-Ramich, O. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081911 · Cited by 95 · see citing works
Circadian blueprint of metabolic pathways in the brain
Greco, C. M., & Sassone‐Corsi, P. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0096-y · Cited by 93 · see citing works
Zanco, B., Mirth, C. K., Sgrò, C. M., & Piper, M. D. W. (2021) · eLife · doi:10.7554/elife.62335 · Cited by 85 · see citing works
Circadian regulation of mitochondrial uncoupling and lifespan
Ulgherait, M., Chen, A., McAllister, S. F., Kim, H. X., Delventhal, R., Wayne, C. R., Garcia, C., Recinos, Y., Oliva, M. K., Canman, J. C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15617-x · Cited by 89 · see citing works
Nutrition and Inflammation: Are Centenarians Similar to Individuals on Calorie-Restricted Diets?
Franceschi, C., Ostan, R., & Santoro, A. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082117-051637 · Cited by 81 · see citing works
Circadian Clocks and Metabolism: Implications for Microbiome and Aging
Paschos, G. K., & FitzGerald, G. A. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.07.010 · Cited by 77 · see citing works
Clock-Enhancing Small Molecules and Potential Applications in Chronic Diseases and Aging
Gloston, G. F., Yoo, S. H., & Chen, Z. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00100 · Cited by 73 · see citing works
Das, J. K., Banskota, N., Candia, J., Griswold, M., Orenduff, M. C., de Cabo, R., Corcoran, D. L., Das, S. K., De, S., Huffman, K. M., et al. (2023) · Aging Cell · doi:10.1111/acel.13963 · Cited by 70 · see citing works
Vaccaro, A., Issa, A.-R., Seugnet, L., Birman, S., & Klarsfeld, A. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006507 · Cited by 69 · see citing works
Jin, K., Wilson, K. A., Beck, J. N., Nelson, C. S., Brownridge, G. W., Harrison, B. R., Djukovic, D., Raftery, D., Brem, R. B., Yu, S., et al. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008835 · Cited by 66 · see citing works
Self-citationChaudhari, A. B., Gupta, R., Patel, S. A., Velingkaar, N., & Kondratov, R. V. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-08-0624 · Cited by 64 · see citing works
Effects of light on aging and longevity
Shen, J., & Tower, J. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100913 · Cited by 59 · see citing works
Wilson, K. A., Beck, J. N., Nelson, C. S., Hilsabeck, T. A. U., Promislow, D., Brem, R. B., & Kapahi, P. (2020) · Current Biology · doi:10.1016/j.cub.2020.05.020 · Cited by 60 · see citing works
Self-citationWilson, K. A., Chamoli, M., Hilsabeck, T. A. U., Pandey, M., Bansal, S., Chawla, G., & Kapahi, P. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.08.018 · Cited by 56 · see citing works
Self-citationMarelja, Z., Leimkühler, S., & Missirlis, F. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00050 · Cited by 57 · see citing works
Akagi, K., Wilson, K. A., Katewa, S. D., Ortega, M., Simons, J., Hilsabeck, T. A. U., Kapuria, S., Sharma, A., Jasper, H., & Kapahi, P. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007777 · Cited by 55 · see citing works
Self-citationCircadian and Sleep Metabolomics Across Species
Malik, D. M., Paschos, G. K., Sehgal, A., & Weljie, A. M. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.04.027 · Cited by 52 · see citing works
Self-citationCircadian clocks, diets and aging
Chaudhari, A., Gupta, R., Makwana, K., & Kondratov, R. V. (2016) · Nutrition and Healthy Aging · doi:10.3233/nha-160006 · Cited by 52 · see citing works
Aging and the clock: Perspective from flies to humans
Nobrega, A. K. D., & Lyons, L. C. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14176 · Cited by 49 · see citing works
Calorie restriction effects on circadian rhythms in gene expression are sex dependent
Astaf’ev, A. A., Patel, S. A., & Kondratov, R. V. (2017) · Scientific Reports · doi:10.1038/s41598-017-09289-9 · Cited by 47 · see citing works
Glial control of sphingolipid levels sculpts diurnal remodeling in a circadian circuit
Vaughen, J. P., Theisen, E. K., Rivas‐Serna, I. M., Berger, A. B., Kalakuntla, P. R., Anreiter, I., Mazurak, V. C., Rodriguez, T. P., Mast, J. D., Hartl, T. A., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.07.016 · Cited by 46 · see citing works
Good Ol’ Fat: Links between Lipid Signaling and Longevity
Bustos, V., & Partridge, L. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.07.001 · Cited by 45 · see citing works
The functional changes of the circadian system organization in aging
Zhao, J., Warman, G. R., & Cheeseman, J. F. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.04.006 · Cited by 44 · see citing works
Hunt, L. C., Jiao, J., Wang, Y., Finkelstein, D., Rao, D., Curley, M., Robles‐Murguia, M., Shirinifard, A., Pagala, V., Peng, J., et al. (2019) · Genome Research · doi:10.1101/gr.246884.118 · Cited by 42 · see citing works
Aging circadian rhythms and cannabinoids
Hodges, E. L., & Ashpole, N. M. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.03.008 · Cited by 43 · see citing works
Circadian- and Light-driven Metabolic Rhythms in Drosophila melanogaster
Rhoades, S. D., Nayak, K., Zhang, S., Sehgal, A., & Weljie, A. M. (2018) · Journal of Biological Rhythms · doi:10.1177/0748730417753003 · Cited by 39 · see citing works
Self-citationVelingkaar, N., Mezhnina, V., Poe, A., Makwana, K., Tulsian, R., & Kondratov, R. V. (2020) · Aging Cell · doi:10.1111/acel.13138 · Cited by 40 · see citing works
The Janus-Faced Role of Lipid Droplets in Aging: Insights from the Cellular Perspective
Bresgen, N., Kovacs, M., Lahnsteiner, A., Felder, T. K., & Rinnerthaler, M. (2023) · Biomolecules · doi:10.3390/biom13060912 · Cited by 39 · see citing works
Circadian regulation of metabolism and healthspan in Drosophila
Giebultowicz, J. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.12.025 · Cited by 39 · see citing works
Self-citationBeck, B. R., Park, G.-S., Jeong, D. Y., Lee, Y. H., Im, S., Song, W. H., & Kang, J. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00269 · Cited by 38 · see citing works
Hodge, B. A., Meyerhof, G. T., Katewa, S. D., Lian, T., Lau, C., Bar, S., Leung, N. Y., Li, M., Li‐Kroeger, D., Melov, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30975-4 · Cited by 38 · see citing works
Self-citationDuszka, K., & Wahli, W. (2020) · Nutrients · doi:10.3390/nu12113476 · Cited by 37 · see citing works
Caloric restriction effects on liver mTOR signaling are time-of-day dependent
Tulsian, R., Velingkaar, N., & Kondratov, R. (2018) · Aging · doi:10.18632/aging.101498 · Cited by 36 · see citing works
Schäbler, S., Amatobi, K. M., Horn, M., Rieger, D., Helfrich‐Förster, C., Mueller, M. J., Wegener, C., & Fekete, Á. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03441-6 · Cited by 31 · see citing works
Mezhnina, V., Pearce, R. W., Poe, A., Velingkaar, N., Astaf’ev, A. A., Ebeigbe, O. P., Makwana, K., Sandlers, Y. I., & Kondratov, R. V. (2020) · Aging Cell · doi:10.1111/acel.13266 · Cited by 31 · see citing works
Yin, S., Wang, J., Bai, Y., Yang, Z., Cui, J., & Wang, J. H. (2022) · Sleep Health · doi:10.1016/j.sleh.2022.08.003 · Cited by 31 · see citing works
Serra, M., Marongiu, F., Pisu, M. G., Serra, M., & Laconi, E. (2019) · Aging · doi:10.18632/aging.102021 · Cited by 30 · see citing works
Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers
Curcio, R., Lunetti, P., Zara, V., Ferramosca, A., Marra, F., Fiermonte, G., Cappello, A. R., Leonardis, F. D., Capobianco, L., & Dolce, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176052 · Cited by 28 · see citing works
Impaired Sleep, Circadian Rhythms and Neurogenesis in Diet-Induced Premature Aging
Stankiewicz, A. J., McGowan, E., Yu, L., & Zhdanova, I. V. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112243 · Cited by 28 · see citing works
Time‐restricted eating for chronodisruption‐related chronic diseases
Cheng, W.-Y., Desmet, L., & Depoortere, I. (2023) · Acta Physiologica · doi:10.1111/apha.14027 · Cited by 27 · see citing works
Lipidome remodeling in aging normal and genetically obese Drosophila males
Hofbauer, H. F., Heier, C., Saji, A. K. S., & Kühnlein, R. P. (2020) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2020.103498 · Cited by 23 · see citing works
Roles of peripheral clocks: lessons from the fly
Yildirim, E., Curtis, R., & Hwangbo, D. (2021) · FEBS Letters · doi:10.1002/1873-3468.14251 · Cited by 25 · see citing works
Regulation of feeding and energy homeostasis by clock-mediated Gart in Drosophila
He, L., Wu, B., Shi, J., Du, J., & Zhao, Z. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112912 · Cited by 25 · see citing works
Cardiolipin Synthesis in Skeletal Muscle Is Rhythmic and Modifiable by Age and Diet
Nohara, K., Kim, E., Wirianto, M., Mileykovskaya, E., Dowhan, W., Chen, Z., & Yoo, S. H. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5304768 · Cited by 24 · see citing works
Krittika, S., & Yadav, P. (2020) · Scientific Reports · doi:10.1038/s41598-020-66372-4 · Cited by 23 · see citing works
Circadian regulation of caterpillar feeding and growth
Suszczyńska, A., Kaniewska, M. M., Bębas, P., Giebultowicz, J. M., & Kotwica‐Rolinska, J. (2017) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2017.07.009 · Cited by 23 · see citing works
Self-citationDietary Restriction Extends the Lifespan of Circadian Mutants tim and per
Ulgherait, M., Chen, A., Oliva, M. K., Kim, H. X., Canman, J. C., Ja, W. W., & Shirasu‐Hiza, M. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.11.002 · Cited by 23 · see citing works
Multiple sclerosis and circadian rhythms: Can diet act as a treatment?
Pivovarova‐Ramich, O., Zimmermann, H. G., & Paul, F. (2023) · Acta Physiologica · doi:10.1111/apha.13939 · Cited by 21 · see citing works
Melkani, G. C., Bhide, S., Han, A., Vyas, J., Livelo, C. R., Bodmer, R., & Bernstein, S. I. (2017) · FEBS Letters · doi:10.1002/1873-3468.12860 · Cited by 21 · see citing works
Drosophila melanogaster females prioritise dietary sterols for producing viable eggs
Zanco, B., Rapley, L., Johnstone, J. N., Dedman, A., Mirth, C. K., Sgrò, C. M., & Piper, M. D. W. (2022) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2022.104472 · Cited by 18 · see citing works
Circadian Rhythm of Lipid Metabolism in Health and Disease
Zhang, Z., Xin, H., & Li, M. (2020) · Small Methods · doi:10.1002/smtd.201900601 · Cited by 21 · see citing works
Bar, S., Wilson, K. A., Hilsabeck, T. A. U., Alderfer, S. A., Dammer, E. B., Burton, J. B., Shah, S., Holtz, A. N., Carrera, E. M., Beck, J. N., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01314-w · Cited by 19 · see citing works
Self-citationMolecular crosstalk between circadian clock and cancer and therapeutic implications
Qu, M. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1143001 · Cited by 19 · see citing works
OXR1 maintains the retromer to delay brain aging under dietary restriction
Wilson, K. A., Bar, S., Dammer, E. B., Carrera, E. M., Hodge, B. A., Hilsabeck, T. A. U., Bons, J., Brownridge, G. W., Beck, J. N., Rose, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44343-3 · Cited by 17 · see citing works
Self-citationTao, H., Li, X., Qiu, J., Cui, W., Sima, Y., & Xu, S. (2017) · Scientific Reports · doi:10.1038/srep46258 · Cited by 19 · see citing works
Circadian clock genes’ overexpression in Drosophila alters diet impact on lifespan
Solovev, I. A., Shchegoleva, E., Fedintsev, A., Shaposhnikov, M. V., & Moskalev, A. (2018) · Biogerontology · doi:10.1007/s10522-018-9784-2 · Cited by 19 · see citing works
Landis, G. N., Hilsabeck, T. A. U., Bell, H. S., Ronnen-Oron, T., Wang, L., Doherty, D. V., Tejawinata, F., Erickson, K., Vu, W., Promislow, D., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.751647 · Cited by 18 · see citing works
Self-citationCalorie restriction reprograms diurnal rhythms in protein translation to regulate metabolism
Makwana, K., Gosai, N., Poe, A., & Kondratov, R. V. (2018) · The FASEB Journal · doi:10.1096/fj.201802167r · Cited by 18 · see citing works
Circadian rhythm in prostate cancer: time to take notice of the clock
Zhu, W., He, Q., Feng, D., Wei, Q., & Yang, L. (2022) · Asian Journal of Andrology · doi:10.4103/aja202255 · Cited by 18 · see citing works
An overview of two decades of diet restriction studies using Drosophila
Krittika, S., & Yadav, P. (2019) · Biogerontology · doi:10.1007/s10522-019-09827-0 · Cited by 18 · see citing works
Amatobi, K. M., Ozbek-Unal, A. G., Schäbler, S., Deppisch, P., Helfrich‐Förster, C., Mueller, M. J., Wegener, C., & Fekete, Á. (2023) · Journal of Lipid Research · doi:10.1016/j.jlr.2023.100417 · Cited by 17 · see citing works
Biological clock regulation by the PER gene family: a new perspective on tumor development
Chen, K., Wang, Y., Li, D., Wu, R., Wang, J., Wei, W., Zhu, W., Xie, W., Feng, D., & He, Y. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1332506 · Cited by 16 · see citing works
Solovev, I. A., Dobrovolskaya, E., Shaposhnikov, M. V., Sheptyakov, M. A., & Moskalev, A. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.11.005 · Cited by 16 · see citing works
ACS-20/FATP4 mediates the anti-ageing effect of dietary restriction in C. elegans
Wang, Z., Zou, L., Zhang, Y., Zhu, M., Zhang, S., Wu, D., Lan, J., Zang, X., Wang, Q., Zhang, H., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43613-4 · Cited by 15 · see citing works
Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan
Lian, T., Wu, Q., Hodge, B. A., Wilson, K. A., Yu, G., & Yang, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123810 · Cited by 16 · see citing works
Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception
Gendron, C. M., Chakraborty, T. S., Chung, B. Y., Harvanek, Z. M., Holme, K. J., Johnson, J. C., Lyu, Y., Munneke, A. S., & Pletcher, S. D. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034440 · Cited by 16 · see citing works
Pak, H. H., Grossberg, A. N., Sanderfoot, R. R., Babygirija, R., Green, C. L., Koller, M., Dzieciątkowska, M., Paredes, D., & Lamming, D. W. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114663 · Cited by 13 · see citing works
Sex specific effects of capsaicin on longevity regulation
Shen, J., Shan, J., Zhu, X., Yang, P., Zhang, D., Liang, B., Li, M., Zang, X., & Dai, Z. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110788 · Cited by 14 · see citing works
Cha, S., Lee, S.-M., Wang, J., Zhao, Q. S., & Bai, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910632 · Cited by 13 · see citing works
Goh, G. H., Mark, P. J., Blache, D., Binks, D., Parsons, R., Rawashdeh, O., & Maloney, S. K. (2021) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2021.102983 · Cited by 13 · see citing works
Jiang, P., & Turek, F. W. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.04.017 · Cited by 12 · see citing works
Protein malnutrition after weaning disrupts peripheral clock and daily insulin secretion in mice
Borck, P. C., Batista, T. M., Vettorazzi, J. F., Camargo, R. L., Boschero, A. C., Vieira, E. C., & Carneiro, E. M. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.08.013 · Cited by 13 · see citing works
Neurogenetics of Drosophila circadian clock: expect the unexpected
Jarabo, P., & Martín, F. A. (2017) · Journal of Neurogenetics · doi:10.1080/01677063.2017.1370466 · Cited by 11 · see citing works
Sun, Y., Zhong, M., Wang, J., Feng, M., Shen, C., Han, Z., Cao, X., & Zhang, Q. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177388 · Cited by 11 · see citing works
Chronic jet lag impairs startle-induced locomotion in Drosophila
Vaccaro, A., Birman, S., & Klarsfeld, A. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.09.012 · Cited by 11 · see citing works
Goh, G. H., Blache, D., Mark, P. J., Kennington, W. J., & Maloney, S. K. (2021) · Journal of Experimental Biology · doi:10.1242/jeb.233213 · Cited by 11 · see citing works
- Authors
- Katewa, S. D., Akagi, K., Bose, N., Rakshit, K., Camarella, T., Zheng, X., Hall, D., Davis, S., Nelson, C. S., Brem, R. B., Ramanathan, A., Sehgal, A., Giebultowicz, J. M., & Kapahi, P.
- Affiliations
- Buck Institute for Research on Aging (US)
- Oregon State University (US)
- University of Pennsylvania (US)
- Corresponding author
- Katewa, Subhash D.
- Kapahi, Pankaj
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 23
- Issue
- 1
- Pages
- 143-154
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC4715572
- OpenAlex
- W2175005753
- Cited by
- 173
- References
- 78
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 14 · 2023: 20 · 2022: 12 · 2021: 18 · 2020: 17 · 2019: 14 · 2018: 18 · 2017: 23 · 2016: 13
- FWCI
- 9.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 377 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Ellison Medical Foundation
- American Federation for Aging Research
- Larry L. Hillblom Foundation
- National Institutes of Health (AG038012, AG045835, R01 AG045830, R01AG038688)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- circadian clock, dietary restriction, lifespan extension, TIMELESS, period, peripheral tissues, fat metabolism, lipid metabolism, medium-chain triglycerides, aging, Drosophila
- MeSH terms
- Animals, Drosophila melanogaster, Female, Gene Expression Regulation, Longevity, Male, Signal Transduction, Gene Expression, Drosophila Proteins, Caloric Restriction, Lipid Metabolism, CLOCK Proteins, Circadian Clocks
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