Babon, Jeffrey J.

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

Murphy, J. M., Czabotar, P. E., Hildebrand, J. M., Lucet, I. S., Zhang, J.-G., Alvarez-Diaz, S., Lewis, R., Lalaoui, N., Metcalf, D., Webb, A. I., et al. (2013) · Immunity

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 1,220

The molecular details of cytokine signaling via the JAK/STAT pathway

Morris, R., Kershaw, N. J., & Babon, J. J. (2018) · Protein Science

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 943

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Hildebrand, J. M., Tanzer, M. C., Lucet, I. S., Young, S. N., Spall, S. K., Sharma, P., Pierotti, C., Garnier, J.-M., Dobson, R. C. J., Webb, A. I., et al. (2014) · Proceedings of the National Academy of Sciences

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 598

TLR7 gain-of-function genetic variation causes human lupus

Brown, G. J., Cañete, P. F., Wang, H., Medhavy, A., Bones, J., Roco, J. A., He, Y., Qin, Y., Cappello, J., Ellyard, J. I., et al. (2022) · Nature

Systemic Lupus Erythematosus ResearchImmune Response and Inflammation

Cited by 596

Leukemia inhibitory factor (LIF)

Nicola, N. A., & Babon, J. J. (2015) · Cytokine & Growth Factor Reviews

Cytokine Signaling Pathways and InteractionsPluripotent Stem Cells Research

Cited by 478

The molecular basis of JAK/STAT inhibition by SOCS1

Liau, N. P. D., Laktyushin, A., Lucet, I. S., Murphy, J. M., Yao, S., Whitlock, E., Callaghan, K., Nicola, N. A., Kershaw, N. J., & Babon, J. J. (2018) · Nature Communications

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 456

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

Kershaw, N. J., Murphy, J. M., Liau, N. P. D., Varghese, L. N., Laktyushin, A., Whitlock, E. L., Lucet, I. S., Nicola, N. A., & Babon, J. J. (2013) · Nature Structural & Molecular Biology

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 301

Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity

Babon, J. J., Kershaw, N. J., Murphy, J. M., Varghese, L. N., Laktyushin, A., Young, S. N., Lucet, I. S., Norton, R. S., & Nicola, N. A. (2012) · Immunity

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 279

The Structure of SOCS3 Reveals the Basis of the Extended SH2 Domain Function and Identifies an Unstructured Insertion That Regulates Stability

Babon, J. J., McManus, E. J., Yao, S., DeSouza, D. P., Mielke, L. A., Sprigg, N. S., Willson, T. A., Hilton, D. J., Nicola, N. A., Baca, M., et al. (2006) · Molecular Cell

Cytokine Signaling Pathways and InteractionsProtein Structure and Dynamics

Cited by 163

Stabilization of Neurotoxic Soluble β-Sheet-Rich Conformations of the Alzheimer's Disease Amyloid-β Peptide

Tew, D. J., Bottomley, S. P., Smith, D. P., Ciccotosto, G. D., Babon, J., Hinds, M. G., Masters, C. L., Cappai, R., & Barnham, K. J. (2008) · Biophysical Journal

Alzheimer's disease research and treatmentsProtein Structure and Dynamics

Cited by 93

Molecular Architecture of the Ankyrin SOCS Box Family of Cul5-Dependent E3 Ubiquitin Ligases

Muniz, J. R. C., Guo, K., Kershaw, N. J., Ayinampudi, V., von Delft, F., Babon, J. J., & Bullock, A. N. (2013) · Journal of Molecular Biology

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 34

ARAP2 regulates responses to interferon-gamma by restricting SOCS1

Keating, N., Doggett, K., Bidgood, G. M., Meza Guzman, L. G., Dagley, L. F., Li, K., Gabrielyan, A., Alvarado, C., Williams, B. E., Broomfield, B. J., et al. (2025) · Cell Reports

Cytokine Signaling Pathways and Interactionsinterferon and immune responses

Cited by 1

ARAP2 regulates responses to interferon-gamma by restricting SOCS1

Keating, N., Doggett, K., Bidgood, G. M., Meza Guzman, L. G., Dagley, L. F., Li, K., Williams, B. E., Gabrielyan, A., Alvarado, C., Broomfield, B. J., et al. (2025) · Cell Reports

Cytokine Signaling Pathways and Interactionsinterferon and immune responses

Cited by 1