Schroeder, Timm

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

Pietras, E. M., Mirantes-Barbeito, C., Fong, S., Loeffler, D., Kovtonyuk, L. V., Zhang, S., Lakshminarasimhan, R., Chin, C. P., Techner, J.-M., Will, B., et al. (2016) · Nature Cell Biology

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

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Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

Walter, D., Lier, A., Geiselhart, A., Thalheimer, F. B., Huntscha, S., Sobotta, M. C., Moehrle, B., Brocks, D., Bayindir, I., Kaschutnig, P., et al. (2015) · Nature

Hematopoietic Stem Cell TransplantationDNA Repair Mechanisms

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Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors

Haas, S., Hansson, J., Klimmeck, D., Loeffler, D., Velten, L., Uckelmann, H., Wurzer, S., Prendergast, Á. M., Schnell, A., Hexel, K., et al. (2015) · Cell Stem Cell

Platelet Disorders and TreatmentsHematopoietic Stem Cell Transplantation

Cited by 471

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy

Cabezas-Wallscheid, N., Buettner, F., Sommerkamp, P., Klimmeck, D., Ladel, L., Thalheimer, F. B., Pastor-Flores, D., Roma, L. P., Renders, S., Zeisberger, P., et al. (2017) · Cell

Hematopoietic Stem Cell TransplantationRetinoids in leukemia and cellular processes

Cited by 454

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

Canli, Ö., Alankuş, Y. B., Grootjans, S., Vegi, N., Hültner, L., Hoppe, P. S., Schroeder, T., Vandenabeele, P., Bornkamm, G. W., & Greten, F. R. (2016) · Blood

Cell death mechanisms and regulationRedox biology and oxidative stress

Cited by 247

Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling

Ortega, F., Gascón, S., Masserdotti, G., Deshpande, A., Simon, C., Fischer, J., Dimou, L., Chichung Lie, D., Schroeder, T., & Berninger, B. (2013) · Nature Cell Biology

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 247

Notch Signaling Induces Multilineage Myeloid Differentiation and Up-Regulates PU.1 Expression

Schroeder, T., Kohlhof, H., Rieber, N., & Just, U. (2003) · The Journal of Immunology

Developmental Biology and Gene RegulationHematopoietic Stem Cell Transplantation

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Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia

McKenzie, M. D., Ghisi, M., Oxley, E. P., Ngo, S., Cimmino, L., Esnault, C., Liu, R., Salmon, J. M., Bell, C. C., Ahmed, N., et al. (2019) · Cell Stem Cell

Acute Myeloid Leukemia ResearchCancer Cells and Metastasis

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PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

Chavez, J. S., Rabe, J. L., Loeffler, D., Higa, K. C., Hernandez, G., Mills, T. S., Ahmed, N., Gessner, R. L., Ke, Z., Idler, B. M., et al. (2021) · Journal of Experimental Medicine

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 91

JAK2-V617F and interferon-α induce megakaryocyte-biased stem cells characterized by decreased long-term functionality

Rao, T. N., Hansen, N., Stetka, J., Luque Paz, D., Kalmer, M., Hilfiker, J., Endele, M., Ahmed, N., Kubovcakova, L., Rybarikova, M., et al. (2021) · Blood

Myeloproliferative Neoplasms: Diagnosis and TreatmentHematopoietic Stem Cell Transplantation

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Inflammatory signals directly instruct PU.1 in HSCs via TNF

Etzrodt, M., Ahmed, N., Hoppe, P. S., Loeffler, D., Skylaki, S., Hilsenbeck, O., Kokkaliaris, K. D., Kaltenbach, H.-M., Stelling, J., Nerlov, C., et al. (2019) · Blood

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 67

Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm

Strasser, M. K., Hoppe, P. S., Loeffler, D., Kokkaliaris, K. D., Schroeder, T., Theis, F. J., & Marr, C. (2018) · Nature Communications

Gene Regulatory Network AnalysisHematopoietic Stem Cell Transplantation

Cited by 26

Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation

Ahmed, N., Etzrodt, M., Dettinger, P., Kull, T., Loeffler, D., Hoppe, P. S., Chavez, J. S., Zhang, Y., Camargo Ortega, G., Hilsenbeck, O., et al. (2022) · Journal of Experimental Medicine

Hematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

Cited by 9

PU.1 Enforces Hematopoietic Stem Cell Quiescence during Chronic Inflammation

Chavez, J., Rabe, J. L., Higa, K., Loeffler, D., Nouraiz, A., Mills, T., Idler, B. M., Stevens, B. M., Fleenor, C., Nerlov, C., et al. (2019) · Blood

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

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