Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors
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Key Points: Gpx4 is essential for preventing anemia in mice via inhibiting RIP3-dependent necroptosis in erythroid precursor cells. ROS accumulation and lipid peroxidation in erythroid precursor cells trigger receptor-independent activation of necroptosis.
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GPx4 KO mice show impaired hematopoiesis without hemolysis.
“GPx4 KO mice show impaired hematopoiesis without hemolysis (28), indicating that erythroid cells rather than adult RBCs are affected by deficient redox detoxification by GPx4.”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [28]
Erythroid cells rather than adult RBCs are affected by deficient redox detoxification by GPx4.
“GPx4 KO mice show impaired hematopoiesis without hemolysis (28), indicating that erythroid cells rather than adult RBCs are affected by deficient redox detoxification by GPx4.”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [28]
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- Authors
- Canli, Ö., Alankuş, Y. B., Grootjans, S., Vegi, N., Hültner, L., Hoppe, P. S., Schroeder, T., Vandenabeele, P., Bornkamm, G. W., & Greten, F. R.
- Affiliations
- Georg Speyer Haus (DE)
- TUM Klinikum (DE)
- Ghent University (BE)
- Institute of Experimental Cancer Research, Comprehensive Cancer Center and University Hospital Ulm, Ulm, Germany;
- Helmholtz Munich (DE)
- ETH Zurich (CH)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2016-01-07
- Volume
- 127
- Issue
- 1
- Pages
- 139-148
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC4705604
- OpenAlex
- W2285203836
- Cited by
- 247
- References
- 53
- Citations by year
- 2026: 15 · 2025: 18 · 2024: 29 · 2023: 35 · 2022: 35 · 2021: 37 · 2020: 21 · 2019: 21 · 2018: 8 · 2017: 10 · 2016: 18
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Site cant be reached (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Keywords
- GPX4, necroptosis, erythroid precursors, RIPK3, caspase-8, glutathionylation, oxidative stress, reactive oxygen species, lipid peroxidation, lipid hydroperoxides, reticulocyte maturation, anemia, hematopoietic cells, redox homeostasis
- MeSH terms
- Phospholipid Hydroperoxide Glutathione Peroxidase, Animals, Cell Differentiation, Cells, Cultured, Flow Cytometry, Glutathione Peroxidase, Humans, Immunoenzyme Techniques, Necrosis, Blotting, Western, Apoptosis, Reactive Oxygen Species, Mice, Knockout, Oxidative Stress, Erythroid Cells, Cell Proliferation, Mice, Receptor-Interacting Protein Serine-Threonine Kinases
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