Pearson, Ewan R.

The mechanisms of action of metformin

Rena, G., Hardie, D. G., & Pearson, E. R. (2017) · Diabetologia

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 2,287

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): A double-blind, randomised placebo-controlled trial

Hernandez, A. F., Green, J. B., Janmohamed, S., D'Agostino, R. B., Granger, C. B., Jones, N. P., Leiter, L. A., Rosenberg, A. E., Sigmon, K. N., Somerville, M. C., et al. (2018) · The Lancet

Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 1,829

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

Gloyn, A. L., Pearson, E. R., Antcliff, J. F., Proks, P., Bruining, G. J., Slingerland, A. S., Howard, N., Srinivasan, S., Silva, J. M. C. L., Molnes, J., et al. (2004) · New England Journal of Medicine

Pancreatic function and diabetesIon channel regulation and function

Cited by 1,137

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations

Pearson, E. R., Flechtner, I., Njølstad, P. R., Malecki, M. T., Flanagan, S. E., Larkin, B., Ashcroft, F. M., Klimes, I., Codner, E., Iotova, V., et al. (2006) · New England Journal of Medicine

Pancreatic function and diabetesIon channel regulation and function

Cited by 988

Using machine learning approaches for multi-omics data analysis: A review

Reel, P. S., Reel, S., Pearson, E., Trucco, E., & Jefferson, E. (2021) · Biotechnology Advances

Bioinformatics and Genomic NetworksGene expression and cancer classification

Cited by 903

Metformin and the gastrointestinal tract

McCreight, L. J., Bailey, C. J., & Pearson, E. R. (2016) · Diabetologia

Diabetes Treatment and ManagementMetabolism, Diabetes, and Cancer

Cited by 733

Genetic cause of hyperglycaemia and response to treatment in diabetes

Pearson, E. R., Starkey, B. J., Powell, R. J., Gribble, F. M., Clark, P. M., & Hattersley, A. T. (2003) · The Lancet

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 607

Molecular mechanism of action of metformin: old or new insights?

Rena, G., Pearson, E. R., & Sakamoto, K. (2013) · Diabetologia

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 479

Precision medicine in diabetes: a consensus report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Chung, W. K., Erion, K., Florez, J. C., Hattersley, A. T., Hivert, M.-F., Lee, C. G., McCarthy, M. I., Nolan, J. J., Norris, J. M., Pearson, E. R., et al. (2020) · Diabetes Care

Diabetes Management and ResearchDiabetes and associated disorders

Cited by 400

Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes: An Individual-Participant Data Meta-Analysis

Writing Group for the CKD Prognosis Consortium, Appel, L. J., Grams, M., Woodward, M., Harris, K., Arima, H., Chalmers, J., Yatsuya, H., Tamakoshi, K., Li, Y., et al. (2023) · JAMA

Chronic Kidney Disease and DiabetesAcute Kidney Injury Research

Cited by 396

Sensitivity to sulphonylureas in patients with hepatocyte nuclear factor‐1α gene mutations: evidence for pharmacogenetics in diabetes

Pearson, E. R., Liddell, W. G., Shepherd, M., Corrall, R. J., & Hattersley, A. T. (2000) · Diabetic Medicine

Pancreatic function and diabetesPharmacogenetics and Drug Metabolism

Cited by 259

Systematic population screening, using biomarkers and genetic testing, identifies 2.5% of the U.K. pediatric diabetes population with monogenic diabetes

Shepherd, M., Shields, B., Hammersley, S., Hudson, M., McDonald, T. J., Colclough, K., Oram, R. A., Knight, B., Hyde, C., Cox, J., et al. (2016) · Diabetes Care

Diabetes and associated disordersPancreatic function and diabetes

Cited by 236

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

Perry, J. R. B., Weedon, M. N., Langenberg, C., Jackson, A. U., Lyssenko, V., Sparsø, T., Thorleifsson, G., Grallert, H., Ferrucci, L., Maggio, M., et al. (2010) · Human Molecular Genetics

Genetic Associations and EpidemiologyHormonal and reproductive studies

Cited by 217

Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Chung, W. K., Erion, K., Florez, J. C., Hattersley, A. T., Hivert, M.-F., Lee, C. G., McCarthy, M. I., Nolan, J. J., Norris, J. M., Pearson, E. R., et al. (2020) · Diabetologia

Diabetes Management and ResearchDiabetes and associated disorders

Cited by 203

Population-based assessment of a biomarker-based screening pathway to aid diagnosis of monogenic diabetes in young-onset patients

Shields, B. M., Shepherd, M., Hudson, M., McDonald, T. J., Colclough, K., Peters, J., Knight, B., Hyde, C., Ellard, S., Pearson, E. R., et al. (2017) · Diabetes Care

Diabetes and associated disordersPancreatic function and diabetes

Cited by 151

Most people with long-duration type 1 diabetes in a large population-based study are insulin microsecretors

Oram, R. A., McDonald, T. J., Shields, B. M., Hudson, M. M., Shepherd, M. H., Hammersley, S., Pearson, E. R., Hattersley, A. T., & on behalf of the UNITED Team (2015) · Diabetes Care

Diabetes and associated disordersDiabetes Management and Research

Cited by 133

Increased all-cause and cardiovascular mortality in monogenic diabetes as a result of mutations in the HNF1A gene

Steele, A. M., Shields, B. M., Shepherd, M., Ellard, S., Hattersley, A. T., & Pearson, E. R. (2010) · Diabetic Medicine

Diabetes and associated disordersDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 130

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

Wood, A. R., Jonsson, A., Jackson, A. U., Wang, N., van Leewen, N., Palmer, N. D., Kobes, S., Deelen, J., Boquete-Vilarino, L., Paananen, J., et al. (2017) · Diabetes

Genetic Associations and EpidemiologyPancreatic function and diabetes

Cited by 117

Monogenic Diabetes: From Genetic Insights to Population-Based Precision in Care. Reflections From a Diabetes Care Editors’ Expert Forum

Riddle, M. C., Philipson, L. H., Rich, S. S., Carlsson, A., Franks, P. W., Greeley, S. A. W., Nolan, J. J., Pearson, E. R., Zeitler, P. S., & Hattersley, A. T. (2020) · Diabetes Care

Diabetes and associated disordersDiabetes Management and Research

Cited by 117

Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models

Allesøe, R. L., Lundgaard, A. T., Hernández Medina, R., Aguayo-Orozco, A., Johansen, J., Nissen, J. N., Brorsson, C., Mazzoni, G., Niu, L., Biel, J. H., et al. (2023) · Nature Biotechnology

Bioinformatics and Genomic NetworksComputational Drug Discovery Methods

Cited by 111

Predicting and elucidating the etiology of fatty liver disease: a machine learning modeling and validation study in the IMI DIRECT cohorts

Atabaki-Pasdar, N., Ohlsson, M., Viñuela, A., Frau, F., Pomares-Millan, H., Haid, M., Jones, A. G., Thomas, E. L., Koivula, R. W., Kurbasic, A., et al. (2020) · PLOS Medicine

Liver Disease Diagnosis and TreatmentAlcohol Consumption and Health Effects

Cited by 97

The effect of obesity on glycaemic response to metformin or sulphonylureas in Type 2 diabetes

Donnelly, L. A., Doney, A. S. F., Hattersley, A. T., Morris, A. D., & Pearson, E. R. (2006) · Diabetic Medicine

Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 88

Adherence in patients transferred from immediate release metformin to a sustained release formulation: a population‐based study

Donnelly, L. A., Morris, A. D., & Pearson, E. R. (2009) · Diabetes, Obesity and Metabolism

Medication Adherence and ComplianceDiabetes Treatment and Management

Cited by 78

Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18-50 years

Lynam, A., McDonald, T., Hill, A., Dennis, J., Oram, R., Pearson, E., Weedon, M., Hattersley, A., Owen, K., Shields, B., et al. (2019) · BMJ Open

Diabetes and associated disordersDiabetes Management and Research

Cited by 72