Selkoe, Dennis J.

Alzheimer's Disease Aβ Vaccine Reduces Central Nervous System Aβ Levels in a Non-Human Primate, the Caribbean Vervet

Lemere, C. A., Beierschmitt, A., Iglesias, M., Spooner, E. T., Bloom, J. K., Leverone, J. F., Zheng, J. B., Seabrook, T. J., Louard, D., Li, D., et al. (2004) · The American Journal of Pathology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 230

In Vivo Cross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells

Dettmer, U., Newman, A. J., Luth, E. S., Bartels, T., & Selkoe, D. (2013) · Journal of Biological Chemistry

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 221

Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes

Hong, S., Ostaszewski, B. L., Yang, T., O’Malley, T. T., Jin, M., Yanagisawa, K., Li, S., Bartels, T., & Selkoe, D. J. (2014) · Neuron

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 213

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1

Young-Pearse, T. L., Chen, A. C., Chang, R., Marquez, C., & Selkoe, D. J. (2008) · Neural Development

Alzheimer's disease research and treatmentsAxon Guidance and Neuronal Signaling

Cited by 210

Alzheimer disease and aducanumab: adjusting our approach

Selkoe, D. J. (2019) · Nature Reviews Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 208

Temporal Accrual of Complement Proteins in Amyloid Plaques in Down's Syndrome with Alzheimer's Disease

Stoltzner, S. E., Grenfell, T. J., Mori, C., Wisniewski, K. E., Wisniewski, T. M., Selkoe, D. J., & Lemere, C. A. (2000) · The American Journal of Pathology

Alzheimer's disease research and treatmentsComplement system in diseases

Cited by 187

Protein chemical and immunocytochemical studies of meningovascular β-amyloid protein in Alzheimer's disease and normal aging

Joachim, C. L., Duffy, L. K., Morris, J. H., & Selkoe, D. J. (1988) · Brain Research

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 180

α‐Synuclein and Polyunsaturated Fatty Acids Promote Clathrin‐Mediated Endocytosis and Synaptic Vesicle Recycling

Ben Gedalya, T., Loeb, V., Israeli, E., Altschuler, Y., Selkoe, D. J., & Sharon, R. (2009) · Traffic

Cellular transport and secretionParkinson's Disease Mechanisms and Treatments

Cited by 169

Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors

Lagomarsino, V. N., Pearse, R. V., Liu, L., Hsieh, Y.-C., Fernandez, M. A., Vinton, E. A., Paull, D., Felsky, D., Tasaki, S., Gaiteri, C., et al. (2021) · Neuron

Alzheimer's disease research and treatmentsPluripotent Stem Cells Research

Cited by 151

If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline?

Haass, C., & Selkoe, D. (2022) · PLOS Biology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 145

Biochemistry and Molecular Biology of Amyloid β‐Protein and the Mechanism of Alzheimer's Disease

Selkoe, D. J. (2008) · Handbook of Clinical Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 137

Treatments for Alzheimer's disease emerge

Selkoe, D. J. (2021) · Science

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 117

Inhibition of Receptor-mediated Endocytosis Demonstrates Generation of Amyloid β-Protein at the Cell Surface

Chyung, J. H., & Selkoe, D. J. (2003) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 111

Dynamic Analysis of Amyloid β-Protein in Behaving Mice Reveals Opposing Changes in ISF versus Parenchymal Aβ during Age-Related Plaque Formation

Hong, S., Quintero-Monzon, O., Ostaszewski, B. L., Podlisny, D. R., Cavanaugh, W. T., Yang, T., Holtzman, D. M., Cirrito, J. R., & Selkoe, D. J. (2011) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 111

Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid -Protein Oligomers

Xu, H., Gelyana, E., Rajsombath, M., Yang, T., Li, S., & Selkoe, D. (2016) · Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 109

Target engagement in an Alzheimer trial: crenezumab lowers amyloid β oligomers in cerebrospinal fluid

Yang, T., Dang, Y., Ostaszewski, B., Mengel, D., Steffen, V., Rabe, C., Bittner, T., Walsh, D. M., & Selkoe, D. J. (2019) · Annals of Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 91

Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer’s disease brains

Stern, A. M., Yang, Y., Jin, S., Yamashita, K., Meunier, A. L., Liu, W., Cai, Y., Ericsson, M., Liu, L., Goedert, M., et al. (2023) · Neuron

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 91

Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease

Kimura, K., Subramanian, A., Yin, Z., Khalilnezhad, A., Wu, Y., He, D., Dixon, K. O., Chitta, U. K., Ding, X., Adhikari, N., et al. (2025) · Nature

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 85

Aβ oligomers inhibit synapse remodelling necessary for memory consolidation

Freir, D. B., Fedriani, R., Scully, D., Smith, I. M., Selkoe, D. J., Walsh, D. M., & Regan, C. M. (2011) · Neurobiology of Aging

Alzheimer's disease research and treatmentsMemory and Neural Mechanisms

Cited by 85

Impaired glutamate recycling and GluN2B‐mediated neuronal calcium overload in mice lacking TGF‐β1 in the CNS

Koeglsperger, T., Li, S., Brenneis, C., Saulnier, J. L., Mayo, L., Carrier, Y., Selkoe, D. J., & Weiner, H. L. (2013) · Glia

Neuroscience and Neuropharmacology ResearchAmino Acid Enzymes and Metabolism

Cited by 73

Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals

Chhatwal, J. P., Schultz, A. P., Dang, Y., Ostaszewski, B., Liu, L., Yang, H.-S., Johnson, K. A., Sperling, R. A., & Selkoe, D. J. (2020) · Nature Communications

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 60

Presenilin‐1 Exists in Both Pre‐ and Post‐Golgi Compartments and Recycles Via COPI‐Coated Membranes

Réchards, M., Xia, W., Oorschot, V. M. J., Selkoe, D. J., & Klumperman, J. (2003) · Traffic

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 55

Co-expression of β-amyloid precursor protein (βAPP) and apolipoprotein E in cell culture: analysis of βAPP processing

Biere, A. L., Ostaszewski, B., Zhao, H., Gillespie, S., Younkin, S. G., & Selkoe, D. J. (1995) · Neurobiology of Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 52

SnapShot: Pathobiology of Alzheimer's Disease

Selkoe, D. J. (2013) · Cell

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 46