Alzheimer's Disease Aβ Vaccine Reduces Central Nervous System Aβ Levels in a Non-Human Primate, the Caribbean Vervet
Open accessAbstract
Amyloid beta (Abeta) protein immunotherapy lowers cerebral Abeta and improves cognition in mouse models of Alzheimer's disease (AD). Here we show that Caribbean vervet monkeys (Chlorocebus aethiops, SK) develop cerebral Abeta plaques with aging and that these deposits are associated with gliosis and neuritic dystrophy. Five aged vervets were immunized with Abeta peptide over 10 months. Plasma and cerebral spinal fluid (CSF) samples were collected periodically from the immunized vervets and five aged controls; one monkey per group expired during the study. By Day 42, immunized animals generated plasma Abeta antibodies that labeled Abeta plaques in human, AD transgenic mouse and vervet brains; bound Abeta1-7; and recognized monomeric and oligomeric Abeta but not full-length amyloid precursor protein nor its C-terminal fragments. Low anti-Abeta titers were detected in CSF. Abetax-40 levels were elevated approximately 2- to 5-fold in plasma and decreased up to 64% in CSF in immunized vervets. Insoluble Abetax-42 was decreased by 66% in brain homogenates of the four immunized animals compared to archival tissues from 13 age-matched control vervets. Abeta42-immunoreactive plaques were detected in frontal cortex in 11 of the 13 control animals, but not in six brain regions examined in each of the four immunized vervets. No T cell response or inflammation was observed. Our study is the first to demonstrate age-related Abeta deposition in the vervet monkey as well as the lowering of cerebral Abeta by Abeta vaccination in a non-human primate. The findings further support Abeta immunotherapy as a potential prevention and treatment of AD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Neuritic plaques can be observed in vervets, some with phosphorylated tau immunoreactive dystrophic neurites.
“Neuritic plaques can be observed, some with phosphorylated tau immunoreactive dystrophic neurites [88].”
From Alzheimer's disease: experimental models and reality (2017) · cites this paper as [88]
Vervets have evidence of Aβ deposition, gliosis and neuronal dystrophy with age.
“Vervets live to approximately 30 years in captivity and have evidence of Aβ deposition, gliosis and neuronal dystrophy with age [72, 88, 89].”
From Alzheimer's disease: experimental models and reality (2017) · cites this paper as [88]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160 · see citing works
Bard, F., Cannon, C., Barbour, R., Burke, R.-L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., et al. (2000) · Nature Medicine · doi:10.1038/78682 · Cited by 2,012 · see citing works
Mucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856 · see citing works
Iwatsubo, T., Odaka, A., Suzuki, N., Mizusawa, H., Nukina, N., & Ihara, Y. (1994) · Neuron · doi:10.1016/0896-6273(94)90458-8 · Cited by 1,774 · see citing works
Translating cell biology into therapeutic advances in Alzheimer's disease
Selkoe, D. J. (1999) · Nature · doi:10.1038/399a023 · Cited by 1,588 · see citing works
Self-citationAβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C. A., Hardy, J., Duff, K., Jantzen, P. T., DiCarlo, G., Wilcock, D. M., et al. (2000) · Nature · doi:10.1038/35050116 · Cited by 1,488 · see citing works
Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., et al. (2000) · Nature · doi:10.1038/35050110 · Cited by 1,431 · see citing works
Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report
Nicoll, J. A. R., Wilkinson, D., Holmes, C., Steart, P., Markham, H., & Weller, R. O. (2003) · Nature Medicine · doi:10.1038/nm840 · Cited by 1,397 · see citing works
Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization
Orgogozo, J.-M., Gilman, S., Dartigues, J.-F., Laurent, B., Puel, M., Kirby, L. C., Jouanny, P., Dubois, B., Eisner, L., Flitman, S., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000073623.84147.a8 · Cited by 1,356 · see citing works
DeMattos, R. B., Bales, K. R., Cummins, D. J., Dodart, J.-C., Paul, S. M., & Holtzman, D. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151261398 · Cited by 1,298 · see citing works
Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model
Dodart, J.-C., Bales, K. R., Gannon, K. S., Greene, S. J., DeMattos, R. B., Mathis, C., DeLong, C. A., Wu, S., Wu, X., Holtzman, D. M., et al. (2002) · Nature Neuroscience · doi:10.1038/nn842 · Cited by 858 · see citing works
Antibodies against β-Amyloid Slow Cognitive Decline in Alzheimer's Disease
Höck, C., Konietzko, U., Streffer, J. R., Tracy, J., Signorell, A., Müller-Tillmanns, B., Lemke, U., Henke, K., Moritz, E., Garcia, E., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00294-0 · Cited by 777 · see citing works
The Pathogenesis of Senile Plaques
DICKSON, D. W. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199704000-00001 · Cited by 753 · see citing works
Johnson‐Wood, K., Lee, M., Motter, R. N., Hu, K., Gordon, G., Barbour, R., Khan, K., Gordon, M. N., Tan, H. T., Games, D., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1550 · Cited by 634 · see citing works
Lemere, C. A., Blusztajn, J. K., Yamaguchi, H., Wisniewski, T., Saido, T. C., & Selkoe, D. J. (1996) · Neurobiology of Disease · doi:10.1006/nbdi.1996.0003 · Cited by 584 · see citing works
Self-citationDeMattos, R. B., Bales, K. R., Cummins, D. J., Paul, S. M., & Holtzman, D. M. (2002) · Science · doi:10.1126/science.1067568 · Cited by 563 · see citing works
Cerebral Hemorrhage After Passive Anti-Aβ Immunotherapy
Pfeifer, M., Boncristiano, S., Bondolfi, L., Stalder, A., Deller, T., Staufenbiel, M., Mathews, P. M., & Jucker, M. (2002) · Science · doi:10.1126/science.1078259 · Cited by 511 · see citing works
Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease.
Selkoe, D. J., Bell, D., Podlisny, M., Price, D. L., & Cork, L. (1987) · Science · doi:10.1126/science.3544219 · Cited by 471 · see citing works
Self-citationReversible memory loss in a mouse transgenic model of Alzheimer’s disease
Kotilinek, L. A., Bacskai, B., Westerman, M., Kawarabayashi, T., Younkin, L., Hyman, B. T., Younkin, S., & Ashe, K. H. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06331.2002 · Cited by 420 · see citing works
Disaggregation of Alzheimer β-amyloid by site-directed mAb
Solomon, B., Koppel, R., Frankel, D., & Hanan, E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4109 · Cited by 420 · see citing works
McLaurin, J., Cecal, R., Kierstead, M. E., Tian, X., Phinney, A. L., Manea, M., French, J. E., Lambermon, M. H. L., Darabie, A. A., Brown, M. E., et al. (2002) · Nature Medicine · doi:10.1038/nm790 · Cited by 412 · see citing works
Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in down Syndrome
Iwatsubo, T., Mann, D. M. A., Odaka, A., Suzuki, N., & Ihara, Y. (1995) · Annals of Neurology · doi:10.1002/ana.410370305 · Cited by 380 · see citing works
Increased T cell reactivity to amyloid β protein in older humans and patients with Alzheimer disease
Monsonego, A., Zota, V., Karni, A., Krieger, J. I., Bar-Or, A., Bitan, G., Budson, A. E., Sperling, R., Selkoe, D. J., & Weiner, H. L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318104 · Cited by 367 · see citing works
Self-citationMonoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide.
Solomon, B., Koppel, R., Hanan, E., & Katzav-Gozansky, T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.452 · Cited by 314 · see citing works
Weiner, H. L., Lemere, C. A., Maron, R., Spooner, E. T., Grenfell, T. J., Mori, C., Issazadeh‐Navikas, S., Hancock, W. W., & Selkoe, D. J. (2000) · PubMed · Cited by 310 · see citing works
Self-citationGeneration of antibodies specific for β-amyloid by vaccination of patients with Alzheimer disease
Höck, C., Konietzko, U., Papassotiropoulos, A., Wollmer, A., Streffer, J. R., von Rotz, R. C., Davey, G. E., Moritz, E., & Nitsch, R. M. (2002) · Nature Medicine · doi:10.1038/nm783 · Cited by 281 · see citing works
Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid
Cribbs, D. H. (2003) · International Immunology · doi:10.1093/intimm/dxg049 · Cited by 280 · see citing works
Neuritic (Senile) Plaques and Filamentous Changes in Aged Rhesus Monkeys
Wiśniewski, H. M., Ghetti, B., & Terry, R. D. (1973) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197310000-00007 · Cited by 272 · cited 1× · see citing works
“NFTs have not been observed in most non-human primates, but degenerating neurites stained by silver or immunoreactive with antibodies to APP or phosphorylated neurofilament proteins have been associated with a subset of cerebral A plaques in non-human primates.(28,36,37,40,41,48) In our initial studies to characterize…”
BackgroundSigurdsson, E. M., Scholtzova, H., Mehta, P. D., Frangione, B., & Wısnıewskı, T. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61715-4 · Cited by 258 · see citing works
Wilcock, D. M., DiCarlo, G., Henderson, D., Jackson, J., Clarke, K., Ugen, K. E., Gordon, M. N., & Morgan, D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03745.2003 · Cited by 232 · see citing works
Podlisny, M. B., Tolan, D. R., & Selkoe, D. J. (1991) · PubMed Central · Cited by 217 · see citing works
Self-citationSenile plaques in cortex of aged normal monkeys.
Struble, R., Price, D. L., & Cork, L. (1985) · Brain Research · doi:10.1016/0006-8993(85)91298-3 · Cited by 182 · see citing works
Immunization against Alzheimer's β-amyloid plaques via EFRH phage administration
Frenkel, D., Katz, O., & Solomon, B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11455 · Cited by 166 · see citing works
Das, P., Murphy, M. P., Younkin, L. H., Younkin, S. G., & Golde, T. E. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00245-7 · Cited by 150 · see citing works
Amyloid precursor protein in aged nonhuman primates.
Martin, L. J., Sisodia, S. S., Koo, E. H., Cork, L. C., Dellovade, T., Weidemann, A., Beyreuther, K. T., Masters, C. L., & Price, D. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.4.1461 · Cited by 146 · see citing works
Lemere, C. A. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00044-5 · Cited by 138 · see citing works
Self-citationPearlson, G. D. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200010)48:4 · Cited by 133 · see citing works
β-Amyloid (Aβ) Deposition in the Brains of Aged Orangutans
Gearing, M., Tigges, J., Mori, H., & Mirra, S. S. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00012-2 · Cited by 130 · see citing works
Geula, C., Nagykery, N. G., & Wu, C. (2001) · Acta Neuropathologica · doi:10.1007/s004010100429 · Cited by 128 · see citing works
Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice
Furlan, R. (2003) · Brain · doi:10.1093/brain/awg031 · Cited by 116 · see citing works
Aβ40 is a major form of β-amyloid in nonhuman primates
Gearing, M., Tigges, J., Mori, H., & Mirra, S. S. (1996) · Neurobiology of Aging · doi:10.1016/s0197-4580(96)00164-9 · Cited by 114 · see citing works
Bons, N., Mestre‐Francés, N., & Petter, A. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90016-q · Cited by 113 · see citing works
Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits.
Cork, L. C., Masters, C. L., Beyreuther, K. T., & Price, D. L. (1990) · Europe PMC (PubMed Central) · Cited by 112 · see citing works
Zhang, J., Wu, X., Qin, C., Jin, Q., Ma, S., Zhang, H., Kong, Q., Chen, D., Ba, D., & He, W. (2003) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.07.005 · Cited by 102 · see citing works
Lemere, C. A., Maron, R., SPOONER, E. T., Grenfell, T. J., Mori, C., Desai, R. V., Hancock, W. W., Weiner, H. L., & Selkoe, D. J. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06943.x · Cited by 101 · see citing works
Self-citationSenile plaques in aged squirrel monkeys
Walker, L. C., Kitt, C. A., Schwam, E., Buckwald, B., Garcia, F., Sepinwall, J., & Price, D. L. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90067-4 · Cited by 94 · see citing works
Wilcock, D. M., Gordon, M. N., Ugen, K. E., Gottschall, P. E., DiCarlo, G., Dickey, C. A., Boyett, K. W., Jantzen, P. T., Connor, K. E., Melachrino, J., et al. (2001) · DNA and Cell Biology · doi:10.1089/10445490152717596 · Cited by 87 · see citing works
Maclean, C. J., Baker, H. F., Ridley, R. M., & Mori, H. (2000) · Journal of Neural Transmission · doi:10.1007/s007020070060 · Cited by 86 · see citing works
Histopathological studies of senile plaques and cerebral amyloidosis in cynomolgus monkeys
Nakamura, S., Nakayama, H., Naoaki, G. O. T. O., Ono, F., Sakakibara, I., & Yoshikawa, Y. (1998) · Journal of Medical Primatology · doi:10.1111/j.1600-0684.1998.tb00244.x · Cited by 83 · see citing works
Cerebral amyloid angiopathy and plaques, and visceral amyloidosis in aged macaques
Uno, H., Alsum, P. B., Dong, S., Richardson, R., Zimbric, M. L., Thieme, C. S., & Houser†, W. D. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(95)02063-2 · Cited by 72 · see citing works
Lemere, C. A., Spooner, E. T., Leverone, J. F., Mori, C., & Clements, J. D. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00127-6 · Cited by 71 · see citing works
Self-citationSpooner, E. T., Desai, R. V., Mori, C., Leverone, J. F., & Lemere, C. A. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00464-4 · Cited by 49 · see citing works
Self-citationOf Monkeys and Men: Vervets and the Genetics of Human-Like Behaviors
Palmour, R. M., Mulligan, J. T., Howbert, J. J., et al. (1997) · The American Journal of Human Genetics · doi:10.1086/515526 · Cited by 46 · see citing works
Self-citationNakamura, S., Tamaoka, A., Sawamura, N., Shoji, S., Nakayama, H., Ono, F., Sakakibara, I., Yoshikawa, Y., Mori, H., Naoaki, G. O. T. O., et al. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12160-9 · Cited by 42 · see citing works
The St. Kitts Vervet (Cercopithecus aethiops)
McGuire, M. T. (1974) · Journal of Medical Primatology · doi:10.1159/000460030 · Cited by 32 · see citing works
Comparable amyloid β-protein (Aβ) 42(43) and Aβ40 deposition in the aged monkey brain
Kanemaru, K., Iwatsubo, T., & Ihara, Y. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12893-7 · Cited by 27 · see citing works
Brayden, D. J., Templeton, L., McClean, S., Barbour, R., Huang, J., Nguyen, M., Ahern, D., Motter, R. N., Johnson‐Wood, K., Vasquez, N. J., et al. (2001) · Vaccine · doi:10.1016/s0264-410x(01)00162-1 · Cited by 23 · see citing works
INSIGHTS FROM MODEL SYSTEMS Of Monkeys and Men: Vervets and the Genetics of Human-Like Behaviors
Palmour, R. M., Mulligan, J. T., Howbert, J. J., et al. (1997) · DigitalGeorgetown (Georgetown University Library) · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Lemere CA, Khan K, Saido TC, Haass C, Masliah E, Selkoe DJ, Games D. Temporal sequence of deposition of Aβ peptides bearing heterogeneous N-termini and APO J in PD-APP transgenic mice. Soc Neurosci. 1997;23:534. [209.535] [Google Scholar]
Cited by
Sorted by citations
Alzheimer's disease: experimental models and reality
Drummond, E., & Wisniewski, T. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1662-x · Cited by 810 · see citing works
Does neuroinflammation fan the flame in neurodegenerative diseases?
Frank-Cannon, T. C., Alto, L. T., McAlpine, F. E., & Tansey, M. G. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-47 · Cited by 751 · see citing works
Bohrmann, B., Baumann, K., Benz, J., Gerber, F., Huber, W., Knoflach, F., Messer, J., Oroszlan, K., Rauchenberger, R., Richter, W. F., et al. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-110977 · Cited by 448 · see citing works
Klyubin, I., Betts, V., Welzel, A. T., Blennow, K., Zetterberg, H., Wallin, A., Lemere, C. A., Cullen, W. K., Peng, Y., Wisniewski, T., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5161-07.2008 · Cited by 321 · see citing works
Self-citationCox, P. A., Davis, D. A., Mash, D. C., Metcalf, J. S., & Banack, S. A. (2016) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2015.2397 · Cited by 256 · see citing works
Bates, K. A., Verdile, G., Li, Q.-X., Ames, D., Hudson, P., Masters, C. L., & Martins, R. N. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.96 · Cited by 247 · see citing works
Immunotherapy for Alzheimer’s disease: Key Symposium: Immunotherapy for Alzheimer’s disease
Morgan, D. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02315.x · Cited by 225 · see citing works
Mouse Models of Alzheimer’s Disease
Yokoyama, M., Kobayashi, H., Tatsumi, L., & Tomita, T. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.912995 · Cited by 213 · see citing works
Britschgi, M., Olin, C. E., Johns, H. T., Takeda-Uchimura, Y., LeMieux, M. C., Rufibach, K., Rajadas, J., Zhang, H., Tomooka, B., Robinson, W. H., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904866106 · Cited by 201 · see citing works
Self-citationKitazawa, M., Medeiros, R., & M. LaFerla, F. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799315786 · Cited by 178 · see citing works
Nonhuman Primate Models of Alzheimer-Like Cerebral Proteopathy
Heuer, E., F. Rosen, R., Cintron, A., & C. Walker, L. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799315885 · Cited by 169 · see citing works
Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review
Edler, M. K., Mhatre-Winters, I., & Richardson, J. R. (2021) · Cells · doi:10.3390/cells10051138 · Cited by 126 · see citing works
Aerobic glycolysis in the primate brain: Reconsidering the implications for growth and maintenance
Bauernfeind, A. L., Barks, S. K., Duka, T., Grossman, L. I., Hof, P. R., & Sherwood, C. C. (2014) · Brain Structure and Function · doi:10.1007/s00429-013-0662-z · Cited by 105 · see citing works
Perez, S. E., Raghanti, M. A., Hof, P. R., Kramer, L., Ikonomovic, M. D., Lacor, P. N., Erwin, J. M., Sherwood, C. C., & Mufson, E. J. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23428 · Cited by 95 · see citing works
Perez, S. E., Sherwood, C. C., Cranfield, M. R., Erwin, J. M., Mudakikwa, A., Hof, P. R., & Mufson, E. J. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.12.017 · Cited by 50 · see citing works
Comparative pathobiology of β-amyloid and the unique susceptibility of humans to Alzheimer's disease
Rosen, R. F., Tomidokoro, Y., Farberg, A. S., Dooyema, J., Ciliax, B., Preuss, T. M., Neubert, T. A., Ghiso, J. A., LeVine, H., & Walker, L. C. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.04.019 · Cited by 46 · see citing works
Development of amyloid burden in African Green monkeys
Kalinin, S., Willard, S. L., Shively, C. A., Kaplan, J. R., Register, T. C., Jorgensen, M. J., Polak, P. E., Rubinstein, I., & Feinstein, D. L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.023 · Cited by 32 · see citing works
Lambert, M., Velasco, P., Viola, K., & Klein, W. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709787601876 · Cited by 29 · see citing works
Alzheimer's disease biomarkers: correspondence between human studies and animal models
Sabbagh, J. J., Kinney, J. W., & Cummings, J. L. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.04.010 · Cited by 27 · see citing works
AD Vaccines: Conclusions and Future Directions
Wisniewski, T. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709787847289 · Cited by 14 · see citing works
- Authors
- Lemere, C. A., Beierschmitt, A., Iglesias, M., Spooner, E. T., Bloom, J. K., Leverone, J. F., Zheng, J. B., Seabrook, T. J., Louard, D., Li, D., Selkoe, D. J., Palmour, R. M., & Ervin, F. R.
- Affiliations
- Brigham and Women's Hospital (US)
- McGill University (CA)
- ORCID
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2004-07
- Volume
- 165
- Issue
- 1
- Pages
- 283-297
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC1618542
- OpenAlex
- W1967777458
- Cited by
- 230
- References
- 59
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 4 · 2023: 4 · 2022: 9 · 2021: 6 · 2020: 9 · 2019: 2 · 2018: 5 · 2017: 18 · 2016: 10 · 2015: 9 · 2014: 5 · 2013: 18 · 2012: 13
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal Of Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Foundation for Neurologic Diseases
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, amyloid-beta immunotherapy, Chlorocebus aethiops, anti-amyloid antibodies, amyloid-beta 42, Aβ40, cerebrospinal fluid, gliosis, nonhuman primate model
- MeSH terms
- Age Factors, Alzheimer Disease, Animals, Central Nervous System, Chlorocebus aethiops, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Female, Humans, Image Processing, Computer-Assisted, Immunohistochemistry, Male, Mice, Transgenic, Peptide Fragments, Time Factors, Blotting, Western, Amyloid beta-Peptides, Neocortex, Alzheimer Vaccines, Mice, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
