Cited by 137Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Biochemistry and Molecular Biology of Amyloid β‐Protein and the Mechanism of Alzheimer's Disease

Dennis J. Selkoe·2008·Handbook of Clinical Neurology

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Crossref · 10.1016/s0072-9752(07)01223-7

Cites

124 of 124 references verified0 citation errors · 0 not checkable

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  • All high-penetrance AD genetic risk alleles (APOE ε4 allele, Down syndrome, APP mutations and duplications, PSEN1 and PSEN2 mutations) have been linked in various experimental systems with increased Aβ deposition and increased formation of putative toxic Aβ peptide species.

    “All high-penetrance AD genetic risk alleles (i.e. APOE ε4 allele, Down syndrome, APP mutations and duplications, PSEN1 and PSEN2 mutations) have been linked in various experimental systems with increased Aβ deposition and increased formation of putative toxic Aβ peptide species (46, 55-57).”
  • Abundant evidence from many independent studies indicates that Aβ peptides and other plaque substances (in their various molecular forms) may be neurotoxic, both directly and through secondary responses to stress, injury, and inflammation.

    “Abundant evidence from many independent studies indicates that Aβ peptides and other plaque substances (in their various molecular forms) may be neurotoxic, both directly and through secondary responses to stress, injury, and inflammation (46, 82, 83).”

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Authors
Selkoe, D. J.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Dennis J. Selkoe
Venue
Handbook of Clinical Neurology
Publisher
Elsevier
Published
2008
Volume
89
Pages
245-260
ISSN
0072-9752 (ISSN-L)
OpenAlex
W1575511938
Cited by
137
References
124
Citations by year
2026: 4 · 2025: 7 · 2024: 4 · 2023: 1 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 4 · 2018: 6 · 2017: 11 · 2016: 12 · 2015: 9 · 2014: 10 · 2013: 11 · 2012: 16
FWCI
29.29
Type
book chapter
Language
en
Open access
closed
Locations
  • Handbook of clinical neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, amyloid-beta, amyloid plaques, neurofibrillary tangles, amyloid fibrils, frontotemporal dementia, microglia, reactive astrocytes, risk assessment, mild cognitive impairment, disease pathobiology
MeSH terms
Alzheimer Disease, Biochemistry, Humans, Models, Biological, Molecular Biology, Amyloid beta-Peptides

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