Vousden, Karen H.

C-terminal modifications regulate MDM2 dissociation and nuclear export of p53

Carter, S., Bischof, O., Dejean, A., & Vousden, K. H. (2007) · Nature Cell Biology

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 225

Ubiquitination and Degradation of Mutant p53

Lukashchuk, N., & Vousden, K. H. (2007) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 223

p53, ROS and senescence in the control of aging

Vigneron, A., & Vousden, K. H. (2010) · Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 221

Mdm2 binds p73α without targeting degradation

Bálint, E., Bates, S., & Vousden, K. H. (1999) · Oncogene

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 212

Oncogenic KRAS induces NIX-mediated mitophagy to promote pancreatic cancer

Humpton, T. J., Alagesan, B., DeNicola, G. M., Lu, D., Yordanov, G. N., Leonhardt, C. S., Yao, M. A., Alagesan, P., Zaatari, M. N., Park, Y., et al. (2019) · Cancer Discovery

Autophagy in Disease and TherapyPancreatic and Hepatic Oncology Research

Cited by 198

Phosphorylation of HDM2 by Akt

Ashcroft, M., Ludwig, R. L., Woods, D. B., Copeland, T. D., Weber, H. O., MacRae, E. J., & Vousden, K. H. (2002) · Oncogene

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 197

Serine one-carbon catabolism with formate overflow

Meiser, J., Tumanov, S., Maddocks, O., Labuschagne, C. F., Athineos, D., Van Den Broek, N., Mackay, G. M., Gottlieb, E., Blyth, K., Vousden, K., et al. (2016) · Science Advances

Cancer, Hypoxia, and MetabolismFolate and B Vitamins Research

Cited by 174

An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

Uldrijan, S., Pannekoek, W., & Vousden, K. H. (2007) · The EMBO Journal

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 170

The role of ubiquitin modification in the regulation of p53

Hock, A. K., & Vousden, K. H. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 168

The ERBB network facilitates KRAS-driven lung tumorigenesis

Kruspig, B., Monteverde, T., Neidler, S., Hock, A., Kerr, E., Nixon, C., Clark, W., Hedley, A., Laing, S., Coffelt, S. B., et al. (2018) · Science Translational Medicine

Lung Cancer Treatments and MutationsProtein Kinase Regulation and GTPase Signaling

Cited by 111

p53‐mediated adaptation to serine starvation is retained by a common tumour‐derived mutant

Humpton, T. J., Hock, A. K., Maddocks, O. D. K., & Vousden, K. H. (2018) · Cancer & Metabolism

Cancer-related Molecular PathwaysCancer, Hypoxia, and Metabolism

Cited by 58

Small molecules that bind the Mdm2 RING stabilize and activate p53

Roxburgh, P., Hock, A. K., Dickens, M. P., Mezna, M., Fischer, P. M., & Vousden, K. H. (2012) · Carcinogenesis

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 43