Seidah, Nabil G.

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

Abifadel, M., Varret, M., Rabès, J.-P., Allard, D., Ouguerram, K., Devillers, M., Cruaud, C., Benjannet, S., Wickham, L., Erlich, D., et al. (2003) · Nature Genetics

Lipoproteins and Cardiovascular HealthLipid metabolism and disorders

Cited by 2,985

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

Seidah, N. G., Benjannet, S., Wickham, L., Marcinkiewicz, J., Jasmin, S. B., Stifani, S., Basak, A., Prat, A., & Chrétien, M. (2003) · Proceedings of the National Academy of Sciences

Protease and Inhibitor MechanismsLiver physiology and pathology

Cited by 1,191

Automated design of ligands to polypharmacological profiles

Besnard, J., Ruda, G. F., Setola, V., Abecassis, K., Rodriguiz, R. M., Huang, X.-P., Norval, S., Sassano, M. F., Shin, A. I., Webster, L. A., et al. (2012) · Nature

Computational Drug Discovery MethodsCholinesterase and Neurodegenerative Diseases

Cited by 832

The Proprotein Convertase PCSK9 Induces the Degradation of Low Density Lipoprotein Receptor (LDLR) and Its Closest Family Members VLDLR and ApoER2

Poirier, S., Mayer, G., Benjannet, S., Bergeron, E., Marcinkiewicz, J., Nassoury, N., Mayer, H., Nimpf, J., Prat, A., & Seidah, N. G. (2008) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 477

Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models

Kim, K., Shim, D., Lee, J. S., Zaitsev, K., Williams, J. W., Kim, K.-W., Jang, M.-Y., Seok Jang, H., Yun, T. J., Lee, S. H., et al. (2018) · Circulation Research

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 434

Proprotein convertase subtilisin/kexin type 9 (PCSK9): Hepatocyte‐specific low‐density lipoprotein receptor degradation and critical role in mouse liver regeneration†

Zaid, A., Roubtsova, A., Essalmani, R., Marcinkiewicz, J., Chamberland, A., Hamelin, J., Tremblay, M., Jacques, H., Jin, W., Davignon, J., et al. (2008) · Hepatology

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 404

Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction

Amiri, F., Virdis, A., Neves, M. F., Iglarz, M., Seidah, N. G., Touyz, R. M., Reudelhuber, T. L., & Schiffrin, E. L. (2004) · Circulation

Nitric Oxide and Endothelin EffectsCardiovascular, Neuropeptides, and Oxidative Stress Research

Cited by 346

The activation and physiological functions of the proprotein convertases

Seidah, N. G., Mayer, G., Zaid, A., Rousselet, E., Nassoury, N., Poirier, S., Essalmani, R., & Prat, A. (2008) · The International Journal of Biochemistry & Cell Biology

Protease and Inhibitor MechanismsBlood Coagulation and Thrombosis Mechanisms

Cited by 314

Post-translational Processing of β-Secretase (β-Amyloid-converting Enzyme) and Its Ectodomain Shedding

Benjannet, S., Elagoz, A., Wickham, L., Mamarbachi, M., Munzer, J. S., Basak, A., Lazure, C., Cromlish, J. A., Sisodia, S., Checler, F., et al. (2001) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsProtease and Inhibitor Mechanisms

Cited by 301

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

Nassoury, N., Blasiole, D. A., Tebon Oler, A., Benjannet, S., Hamelin, J., Poupon, V., McPherson, P. S., Attie, A. D., Prat, A., & Seidah, N. G. (2007) · Traffic

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 248

Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue

Roubtsova, A., Munkonda, M. N., Awan, Z., Marcinkiewicz, J., Chamberland, A., Lazure, C., Cianflone, K., Seidah, N. G., & Prat, A. (2011) · Arteriosclerosis, Thrombosis, and Vascular Biology

Lipid metabolism and disordersAdipokines, Inflammation, and Metabolic Diseases

Cited by 244

The Multifaceted Biology of PCSK9

Seidah, N. G., & Prat, A. (2022) · Endocrine Reviews

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 232

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Can Mediate Degradation of the Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1)

Canuel, M., Sun, X., Asselin, M.-C., Paramithiotis, E., Prat, A., & Seidah, N. G. (2013) · PLoS ONE

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 227

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

Bryleva, E. Y., Rogers, M. A., Chang, C. C. Y., Buen, F., Harris, B. T., Rousselet, E., Seidah, N. G., Oddo, S., LaFerla, F. M., Spencer, T. A., et al. (2010) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsCholesterol and Lipid Metabolism

Cited by 209

Alzheimer Disease Aβ Production in the Absence of S-Palmitoylation-dependent Targeting of BACE1 to Lipid Rafts

Vetrivel, K. S., Meckler, X., Chen, Y., Nguyen, P. D., Seidah, N. G., Vassar, R., Wong, P. C., Fukata, M., Kounnas, M. Z., & Thinakaran, G. (2009) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsLipid Membrane Structure and Behavior

Cited by 153

Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system

Poirier, S., Prat, A., Marcinkiewicz, E., Paquin, J., Chitramuthu, B. P., Baranowski, D., Cadieux, B., Bennett, H. P. J., & Seidah, N. G. (2006) · Journal of Neurochemistry

Developmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanisms

Cited by 121

Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture

Mayne, J., Dewpura, T., Raymond, A., Bernier, L., Cousins, M., Ooi, T. C., Davignon, J., Seidah, N. G., Mbikay, M., & Chrétien, M. (2011) · Clinical Chemistry

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 111

PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke

Rousselet, E., Marcinkiewicz, J., Kriz, J., Zhou, A., Hatten, M. E., Prat, A., & Seidah, N. G. (2011) · Journal of Lipid Research

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 107

Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells

Lalanne, F., Lambert, G., Amar, M. J. A., Chétiveaux, M., Zaïr, Y., Jarnoux, A.-L., Ouguerram, K., Friburg, J., Seidah, N. G., Brewer, H. B., et al. (2005) · Journal of Lipid Research

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 104

Expanding biology of PCSK9: roles in atherosclerosis and beyond

Seidah, N. G., & Garçon, D. (2022) · Current Atherosclerosis Reports

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 76

Post-transcriptional Regulation of PCSK9 by miR-191, miR-222, and miR-224

Naeli, P., Mirzadeh Azad, F., Malakootian, M., Seidah, N. G., & Mowla, S. J. (2017) · Frontiers in Genetics

MicroRNA in disease regulationLipoproteins and Cardiovascular Health

Cited by 58

Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other

Butkinaree, C., Canuel, M., Essalmani, R., Poirier, S., Benjannet, S., Asselin, M.-C., Roubtsova, A., Hamelin, J., Marcinkiewicz, J., Chamberland, A., et al. (2015) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 53

PCSK9 in metabolism and diseases

Ajoolabady, A., Pratico, D., Mazidi, M., Davies, I. G., Lip, G. Y. H., Seidah, N., Libby, P., Kroemer, G., & Ren, J. (2025) · Metabolism

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 49

Beyond LDL-C lowering: distinct molecular sphingolipids are good indicators of proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency

Jänis, M. T., Tarasov, K., Ta, H. X., Suoniemi, M., Ekroos, K., Hurme, R., Lehtimäki, T., Päivä, H., Kleber, M. E., März, W., et al. (2013) · Atherosclerosis

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 41