Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models
Open accessAbstract
Rationale: Monocyte infiltration into the subintimal space and its intracellular lipid accumulation are the most prominent features of atherosclerosis. To understand the pathophysiology of atherosclerotic disease, we need to understand the characteristics of lipid-laden foamy macrophages in the subintimal space during atherosclerosis. Objective: We sought to examine the transcriptomic profiles of foamy and nonfoamy macrophages isolated from atherosclerotic intima. Methods and Results: Single-cell RNA sequencing analysis of CD45 + leukocytes from murine atherosclerotic aorta revealed that there are macrophage subpopulations with distinct differentially expressed genes involved in various functional pathways. To specifically characterize the intimal foamy macrophages of plaque, we developed a lipid staining–based flow cytometric method for analyzing the lipid-laden foam cells of atherosclerotic aortas. We used the fluorescent lipid probe BODIPY493/503 and assessed side-scattered light as an indication of cellular granularity. BODIPY hi SSC hi foamy macrophages were found residing in intima and expressing CD11c. Foamy macrophage accumulation determined by flow cytometry was positively correlated with the severity of atherosclerosis. Bulk RNA sequencing analysis showed that compared with nonfoamy macrophages, foamy macrophages expressed few inflammatory genes but many lipid-processing genes. Intimal nonfoamy macrophages formed the major population expressing IL (interleukin)-1β and many other inflammatory transcripts in atherosclerotic aorta. Conclusions: RNA sequencing analysis of intimal macrophages from atherosclerotic aorta revealed that lipid-loaded plaque macrophages are not likely the plaque macrophages that drive lesional inflammation.
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Lack of classical pro-inflammatory signaling has been previously found in MS lesions by mass cytometry of microglia and matches the lipid-induced lysosomal phenotype described in other diseases.
“This lack of classical pro-inflammatory signaling has been previously found in MS lesions by mass cytometry of microglia49 and matches the lipid-induced lysosomal phenotype described in other diseases14,18,50,51.”
From Foamy microglia link oxylipins to disease progression in multiple sclerosis (2026) · cites this paper as [51]
Overloading macrophages with cytoplasmic cholesteryl ester droplets shifts their phenotype from highly pro-inflammatory to fat-storing with less pro-inflammatory potential, as supported by murine atherosclerosis models.
“The concept that overloading macrophages with cytoplasmic cholesteryl ester droplets (that is, their transformation into foam cells) shifts the macrophage phenotype from highly pro-inflammatory to fat-storing with less pro-inflammatory potential has received strong support in the past year by elegant results obtained in murine models of atherosclerosis152.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [152]
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Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482 · see citing works
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703 · see citing works
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026 · see citing works
Macrophages in the Pathogenesis of Atherosclerosis
Moore, K. J., & Tabas, I. (2011) · Cell · doi:10.1016/j.cell.2011.04.005 · Cited by 2,669 · see citing works
The immune system in atherosclerosis
Hansson, G. K., & Hermansson, A. (2011) · Nature Immunology · doi:10.1038/ni.2001 · Cited by 2,331 · see citing works
Atherosclerosis: current pathogenesis and therapeutic options
Weber, C., & Noels, H. (2011) · Nature Medicine · doi:10.1038/nm.2538 · Cited by 2,203 · see citing works
The immune response in atherosclerosis: a double-edged sword
Hansson, G. K., & Libby, P. (2006) · Nature reviews. Immunology · doi:10.1038/nri1882 · Cited by 2,176 · see citing works
Tacke, F., Alvarez, D., Kaplan, T. J., Jakubzick, C., Spanbroek, R., Llodra, J., Garin, A., Liu, J., Mack, M., van Rooijen, N., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28549 · Cited by 1,323 · see citing works
Self-citationŚwirski, F. K., Libby, P., Aikawa, E. R., Alcaide, P., Luscinskas, F. W., Weissleder, R., & Pittet, M. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29950 · Cited by 1,258 · see citing works
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
Suzuki, H. I., Kurihara, Y., Takeya, M., Kamada, N., Kataoka, M., Jishage, K., Ueda, O., Sakaguchi, H., Higashi, T., Suzuki, T., et al. (1997) · Nature · doi:10.1038/386292a0 · Cited by 1,226 · see citing works
Macrophage Phenotype and Function in Different Stages of Atherosclerosis
Tabas, I., & Bornfeldt, K. E. (2016) · Circulation Research · doi:10.1161/circresaha.115.306256 · Cited by 1,121 · see citing works
Local proliferation dominates lesional macrophage accumulation in atherosclerosis
Robbins, C. S., Hilgendorf, I., Weber, G. F., Theurl, I., Iwamoto, Y., Figueiredo, J.-L., Gorbatov, R., Sukhova, G. K., Gerhardt, L. M. S., Smyth, D., et al. (2013) · Nature Medicine · doi:10.1038/nm.3258 · Cited by 1,041 · see citing works
Quantitative assessment of atherosclerotic lesions in mice
Paigen, B. J., Morrow, A., Holmes, P. A., Mitchell, D., & Williams, R. A. (1987) · Atherosclerosis · doi:10.1016/0021-9150(87)90202-4 · Cited by 952 · see citing works
Cochain, C., Vafadarnejad, E., Arampatzi, P., Pelisek, J., Winkels, H., Ley, K., Wolf, D., Saliba, A.-E., & Zernecke, A. (2018) · Circulation Research · doi:10.1161/circresaha.117.312509 · Cited by 894 · see citing works
Allahverdian, S., Chehroudi, A. C., McManus, B. M., Abraham, T., & Francis, G. A. (2014) · Circulation · doi:10.1161/circulationaha.113.005015 · Cited by 748 · see citing works
Combadière, C., Potteaux, S., Rodero, M., Simon, T., Pézard, A., Esposito, B., Merval, R., Proudfoot, A., Tedgui, A., & Mallat, Z. (2008) · Circulation · doi:10.1161/circulationaha.107.745091 · Cited by 714 · see citing works
PCSK9: a convertase that coordinates LDL catabolism
Horton, J. D., Cohen, J. C., & Hobbs, H. H. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800091-jlr200 · Cited by 630 · see citing works
Spann, N. J., Garmire, L. X., McDonald, J. G., Myers, D. S., Milne, S. B., Shibata, N., Reichart, D. R., Fox, J. N., Shaked, I., Heudobler, D., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.054 · Cited by 605 · see citing works
Seidah (2014) · doi:10.1161/circresaha.114.301621 · Cited by 596 · see citing works
Self-citationMacrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo
Wang, X., Collins, H. L., Ranalletta, M., Fuki, I. V., Billheimer, J. T., Rothblat, G. H., Tall, A. R., & Rader, D. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32057 · Cited by 593 · see citing works
Rong, J. X., Shapiro, M., Trogan, E., & Fisher, E. A. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1735526100 · Cited by 551 · see citing works
Winkels, H., Ehinger, E., Vassallo, M., Buscher, K., Dinh, H. Q., Kobiyama, K., Hamers, A. A. J., Cochain, C., Vafadarnejad, E., Saliba, A.-E., et al. (2018) · Circulation Research · doi:10.1161/circresaha.117.312513 · Cited by 547 · see citing works
Llodrá, J., Angeli, V., Liu, J. J., Trogan, E., Fisher, E. A. A., & Randolph, G. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403259101 · Cited by 509 · see citing works
Self-citationExtramedullary Hematopoiesis Generates Ly-6C high Monocytes That Infiltrate Atherosclerotic Lesions
Robbins, C. S., Chudnovskiy, A., Rauch, P. J., Figueiredo, J., Iwamoto, Y., Gorbatov, R., Etzrodt, M., Weber, G. F., Ueno, T., van Rooijen, N., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.061986 · Cited by 483 · see citing works
Monocyte trafficking across the vessel wall
Gerhardt, T., & Ley, K. F. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv147 · Cited by 473 · see citing works
Galkina, E., Kadl, A., Sanders, J., Varughese, D., Sarembock, I. J., & Ley, K. F. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052205 · Cited by 451 · see citing works
Chappell, J., Harman, J. L., Narasimhan, V. M., Yu, H., Foote, K., Simons, B. D., Bennett, M. R., & Jørgensen, H. F. (2016) · Circulation Research · doi:10.1161/circresaha.116.309799 · Cited by 437 · see citing works
Ensan, S., Li, A., Besla, R., Degousee, N., Cosme, J., Roufaiel, M., Shikatani, E. A., El-Maklizi, M., Williams, J. W., Robins, L., et al. (2016) · Nature Immunology · doi:10.1038/ni.3343 · Cited by 372 · see citing works
Self-citationMonocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease
Swirski, F. K., Pittet, M. J., Kircher, M. F., Aikawa, E., Jaffer, F. A., Libby, P., & Weissleder, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604260103 · Cited by 367 · see citing works
Potteaux, S., Gautier, E. L., Hutchison, S. B., van Rooijen, N., Rader, D. J., Thomas, M. J., Sorci‐Thomas, M. G., & Randolph, G. J. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43802 · Cited by 335 · see citing works
Self-citationCyclodextrin promotes atherosclerosis regression via macrophage reprogramming
Zimmer, S., Grebe, A., Bakke, S. S., Bode, N., Halvorsen, B., Ulas, T., Skjelland, M., Nardo, D. D., Labzin, L. I., Kerksiek, A., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad6100 · Cited by 334 · see citing works
Paulson, K. E., Zhu, S.-N., Chen, M., Nurmohamed, S., Jongstra‐Bilen, J., & Cybulsky, M. I. (2009) · Circulation Research · doi:10.1161/circresaha.109.210781 · Cited by 316 · see citing works
Horton, H., Thomas, E. P., Stucky, J., Frank, I., Moodie, Z., Huang, Y., Chiu, Y.-L., McElrath, M. J., & Rosa, S. C. D. (2007) · Journal of Immunological Methods · doi:10.1016/j.jim.2007.03.002 · Cited by 260 · see citing works
ATP-binding cassette transporters, atherosclerosis, and inflammation.
Westerterp, M., Bochem, A., Yvan-Charvet, L., Murphy, A., Wang, N., & Tall, A. (2014) · Circulation Research · doi:10.1161/circresaha.114.300738 · Cited by 250 · see citing works
Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves
Choi, J., Do, Y., Cheong, C., Koh, H., Boscardin, S. B., Oh, Y., Bozzacco, L., Trumpfheller, C., Park, C. G., & Steinman, R. M. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082129 · Cited by 239 · see citing works
Self-citationFlt3 Signaling-Dependent Dendritic Cells Protect against Atherosclerosis
Choi, J., Cheong, C., Dandamudi, D. B., Park, C. G., Rodriguez, A. B., Mehandru, S., Velinzon, K., Jung, I., Yoo, J.-Y., Oh, G. T., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.014 · Cited by 203 · see citing works
Self-citationMacrophagic CD146 promotes foam cell formation and retention during atherosclerosis
Luo, Y., Duan, H., Qian, Y., Feng, L., Wu, Z., Wang, F., Feng, J., Yang, D., Qin, Z., & Yan, X. (2017) · Cell Research · doi:10.1038/cr.2017.8 · Cited by 191 · see citing works
Feig, J. E., Pineda‐Torra, I., Sanson, M., Bradley, M. N., Vengrenyuk, Y., Bogunovic, D., Gautier, E. L., Rubinstein, D., Hong, C., Liu, J., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci38911 · Cited by 185 · see citing works
Macrophages in vascular inflammation and atherosclerosis
Cochain, C., & Zernecke, A. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1941-y · Cited by 164 · see citing works
Gold, E. S., Ramsey, S. A., Sartain, M. J., Selinummi, J., Podolsky, I., Rodriguez, D. J., Moritz, R. L., & Aderem, A. A. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111202 · Cited by 154 · see citing works
Yun, T. J., Lee, J. S., Machmach, K., Shim, D., Choi, J., Wi, Y. J., Jang, H. S., Jung, I.-H., Kim, K., Yoon, W. K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.010 · Cited by 116 · see citing works
Self-citationHerbert, B. R., Patel, D., Waddington, S. N., Eden, E. R., McAleenan, A., Sun, X.-M., & Soutar, A. K. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.204040 · Cited by 82 · see citing works
A Macrophage Sterol-Responsive Network Linked to Atherogenesis
Becker, L., Gharib, S. A., Irwin, A. D., Wijsman, E. M., Vaisar, T., Oram, J. F., & Heinecke, J. W. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.01.003 · Cited by 79 · see citing works
Development and Function of Arterial and Cardiac Macrophages
Świrski, F. K., Robbins, C. S., & Nahrendorf, M. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.11.004 · Cited by 73 · see citing works
Hydroxypropyl-β-cyclodextrin-mediated Efflux of 7-Ketocholesterol from Macrophage Foam Cells
Kritharides, L., Kus, M. L., Brown, A. J., Jessup, W., & Dean, R. T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27450 · Cited by 66 · see citing works
Foam Cell Formation In Vivo Converts Macrophages to a Pro-Fibrotic Phenotype
Thomas, A. C., Eijgelaar, W. J., Daemen, M. J. A. P., & Newby, A. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128163 · Cited by 56 · see citing works
Characterization of Proliferating Lesion‐Resident Cells During All Stages of Atherosclerotic Growth
Lhoták, Š., Gyulay, G., Cutz, J., Al‐Hashimi, A., Trigatti, B. L., Richards, C. D., Igdoura, S. A., Steinberg, G. R., Bramson, J. L., Ask, K., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003945 · Cited by 45 · see citing works
Liu, S. M., Cogny, A., Kockx, M., Dean, R. T., Gaus, K., Jessup, W., & Kritharides, L. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200464-jlr200 · Cited by 35 · see citing works
The Rationale for Using HMG-CoA Reductase Inhibitors (‘Statins’) in Peripheral Arterial Disease
Erez, G., & Leitersdorf, E. (2006) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2006.11.020 · Cited by 26 · see citing works
Goo, Y., Son, S., Yechoor, V. K., & Paul, A. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002663 · Cited by 25 · see citing works
Walenbergh, S. M. A., Houben, T., Hendrikx, T., Jeurissen, M. L. J., van Gorp, P. J., Vaes, N., Damink, S. W. M. O., Verheyen, F., Koek, G. H., Lütjohann, D., et al. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160921056 · Cited by 22 · see citing works
Microarray gene profiling of laser-captured cells: A new tool to study atherosclerosis in mice
Paul, A., Yechoor, V. K., Raja, R. G., Li, L., & Chan, L. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.12.056 · Cited by 14 · see citing works
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Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341 · see citing works
Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases
Kapellos, T. S., Bonaguro, L., Gemünd, I. D., Reusch, N., Saglam, A., Hinkley, E. R., & Schultze, J. L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02035 · Cited by 887 · see citing works
T cell subsets and functions in atherosclerosis
Saigusa, R., Winkels, H., & Ley, K. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0352-5 · Cited by 742 · see citing works
Macrophages in Atherosclerosis Regression
Barrett, T. J. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312802 · Cited by 633 · see citing works
Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics
Depuydt, M. A. C., Prange, K. H. M., Slenders, L., Örd, T., Elbersen, D., Boltjes, A., de Jager, S. C. A., Asselbergs, F. W., de Borst, G. J., Aavik, E., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.316770 · Cited by 590 · see citing works
How the immune system shapes atherosclerosis: roles of innate and adaptive immunity
Roy, P., Orecchioni, M., & Ley, K. F. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00584-1 · Cited by 584 · see citing works
Metabolism of tissue macrophages in homeostasis and pathology
Wculek, S. K., Dunphy, G., Heras-Murillo, I., Mastrangelo, A., & Sancho, D. (2022) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00791-9 · Cited by 501 · see citing works
Inflammation in atherosclerosis: pathophysiology and mechanisms
Ajoolabady, A., Praticò, D., Lin, L., Mantzoros, C. S., Bahijri, S., Tuomilehto, J. O., & Ren, J. T. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07166-8 · Cited by 510 · see citing works
Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?
Engelen, S. E., Robinson, A., Zurke, Y.-X., & Monaco, C. G. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00668-4 · Cited by 442 · see citing works
Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation
Srinivasan, K., Friedman, B. A., Etxeberria, A., Huntley, M. A., van der Brug, M. P., Foreman, O., Paw, J. S., Modrusan, Z., Beach, T. G., Serrano, G. E., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107843 · Cited by 427 · see citing works
Alencar, G. F., Owsiany, K. M., Karnewar, S., Sukhavasi, K., Mocci, G., Nguyen, A. T., Williams, C. M., Shamsuzzaman, S., Mokrý, M., Henderson, C. A., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.046672 · Cited by 393 · see citing works
Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas
Zernecke, A., Winkels, H., Cochain, C., Williams, J. W., Wolf, D., Soehnlein, O., Robbins, C. S., Monaco, C. G., Park, I., McNamara, C. A., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.316903 · Cited by 373 · see citing works
Self-citationTissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371 · see citing works
Wang, Y., Dubland, J. A., Allahverdian, S., Asonye, E., Sahin, B., Jaw, J. E., Sin, D. D., Seidman, M. A., Leeper, N. J., & Francis, G. A. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312434 · Cited by 369 · see citing works
Transcriptional and epigenetic regulation of macrophages in atherosclerosis
Kuznetsova, T., Prange, K. H. M., Glass, C. K., & de Winther, M. P. J. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0265-3 · Cited by 364 · see citing works
Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets
Chen, R., Zhang, H., Tang, B., Luo, Y., Yang, Y., Zhong, X., Chen, S., Xu, X., Huang, S., & Liu, C. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01840-1 · Cited by 387 · see citing works
Macrophage polarization and metabolism in atherosclerosis
Hou, P., Fang, J., Liu, Z., Shi, Y., Agostini, M., Bernassola, F., Bove, P., Candi, E., Rovella, V., Sica, G. S., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06206-z · Cited by 360 · see citing works
Lin, J.-D., Nishi, H., Poles, J., Niu, X., McCauley, C., Rahman, K., Brown, E. J., Yeung, S. T., Vozhilla, N., Weinstock, A., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.124574 · Cited by 301 · see citing works
Triacylglycerol synthesis enhances macrophage inflammatory function
Castoldi, Â., Monteiro, L. D. B., Bakker, N. V. T., Sanin, D. E., Rana, N., Corrado, M., Cameron, A. M., Hässler, F., Matsushita, M., Caputa, G., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17881-3 · Cited by 299 · see citing works
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Liu, M., & Gomez, D. A. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312131 · Cited by 284 · see citing works
Gui, Y., Zheng, H., & Cao, R. Y. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.845942 · Cited by 258 · see citing works
Dynamics of Cardiac Neutrophil Diversity in Murine Myocardial Infarction
Vafadarnejad, E., Rizzo, G., Krampert, L., Arampatzi, P., Arias-Loza, P.-A., Nazzal, Y., Rizakou, A., Knochenhauer, T., Bandi, S. R., Nugroho, V. A., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.317200 · Cited by 257 · see citing works
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Tabas, I. A., & Bornfeldt, K. (2020) · Circulation Research · doi:10.1161/circresaha.119.315939 · Cited by 249 · see citing works
A subset of Kupffer cells regulates metabolism through the expression of CD36
Blériot, C., Barreby, E., Dunsmore, G., Ballaire, R., Chakarov, S., Ficht, X., De Simone, G., Andreata, F., Fumagalli, V., Guo, W., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.08.006 · Cited by 236 · see citing works
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Macrophage subsets in atherosclerosis as defined by single‐cell technologies
Willemsen, L., & de Winther, M. P. J. (2020) · The Journal of Pathology · doi:10.1002/path.5392 · Cited by 228 · see citing works
Robichaud, S., Fairman, G., Vijithakumar, V., Mak, E., Cook, D. P., Pelletier, A. R., Huard, S., Vanderhyden, B. C., Figeys, D., Lavallée‐Adam, M., et al. (2021) · Autophagy · doi:10.1080/15548627.2021.1886839 · Cited by 228 · see citing works
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Jinnouchi, H., Guo, L., Sakamoto, A., Torii, S., Sato, Y., Cornelissen, A., Kuntz, S. H., Paek, K. H., Fernandez, R., Fuller, D. T., et al. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03371-3 · Cited by 219 · see citing works
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Lutgens, E., Atzler, D., Döring, Y., Duchene, J., Steffens, S., & Weber, C. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz283 · Cited by 192 · see citing works
Williams, J. W., Zaitsev, K., Kim, K.-W., Ivanov, S., Saunders, B. T., Schrank, P. R., Kim, K., Elvington, A., Kim, S. H., Tucker, C., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0768-4 · Cited by 196 · see citing works
Self-citationZernecke, A., Erhard, F., Weinberger, T., Schulz, C., Ley, K. F., Saliba, A., & Cochain, C. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac161 · Cited by 195 · see citing works
Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis
Patterson, M. T., Firulyova, M. M., Xu, Y., Hillman, H., Bishop, C., Zhu, A., Hickok, G. H., Schrank, P. R., Ronayne, C. E., Caillot, Z., et al. (2023) · Nature Cardiovascular Research · doi:10.1038/s44161-023-00354-3 · Cited by 190 · see citing works
Self-citationLysosomal Acid Lipase in Lipid Metabolism and Beyond
Li, F., & Zhang, H. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312136 · Cited by 185 · see citing works
He, Z., Chen, W., Hu, K., Luo, Y., Zeng, W., He, X., Li, T., Ouyang, J., Li, Y., Xie, L., et al. (2024) · Nature Nanotechnology · doi:10.1038/s41565-024-01687-1 · Cited by 190 · see citing works
Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.092 · Cited by 175 · see citing works
Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation
Gioia, M. D., Spreafico, R., Springstead, J. R., Mendelson, M., Joehanes, R., Levy, D. A., & Zanoni, I. (2019) · Nature Immunology · doi:10.1038/s41590-019-0539-2 · Cited by 174 · see citing works
Cytokine Circuits in Cardiovascular Disease
Williams, J. W., Huang, L.-H., & Randolph, G. J. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.007 · Cited by 166 · see citing works
Self-citationMacrophage Plasticity and Atherosclerosis Therapy
Lin, P. C., Ji, H., Li, Y., & Guo, S. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.679797 · Cited by 166 · see citing works
Cholesterol efflux pathways, inflammation, and atherosclerosis
Groenen, A. G., Halmos, B., Tall, A. R., & Westerterp, M. (2021) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2021.1925217 · Cited by 164 · see citing works
Foam Cells: One Size Doesn’t Fit All
Guerrini, V., & Gennaro, M. L. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.10.002 · Cited by 155 · see citing works
The Dynamics of B Cell Aging in Health and Disease
de Mol, J., Kuiper, J., Tsiantoulas, D., & Foks, A. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.733566 · Cited by 155 · see citing works
Addressing dyslipidemic risk beyond LDL-cholesterol
Tall, A. R., Thomas, D. G., Gonzalez-Cabodevilla, A. G., & Goldberg, I. J. (2022) · Journal of Clinical Investigation · doi:10.1172/jci148559 · Cited by 150 · see citing works
Autoimmune diseases and atherosclerotic cardiovascular disease
Porsch, F., & Binder, C. J. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01045-7 · Cited by 151 · see citing works
Dib, L. H., Koneva, L. A., Edsfeldt, A., Zurke, Y.-X., Sun, J., Nitulescu, M., Attar, M., Lutgens, E., Schmidt, S., Lindholm, M., et al. (2023) · Nature Cardiovascular Research · doi:10.1038/s44161-023-00295-x · Cited by 150 · see citing works
The Pathophysiology of Myocardial Ischemia and Perioperative Myocardial Infarction
Smit, M., Coetzee, A., & Lochner, A. (2019) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2019.10.005 · Cited by 148 · see citing works
Single Cell RNA Sequencing in Atherosclerosis Research
Williams, J. W., Winkels, H., Durant, C. P., Zaitsev, K., Ghosheh, Y., & Ley, K. F. (2020) · Circulation Research · doi:10.1161/circresaha.119.315940 · Cited by 139 · see citing works
Self-citationDisruption of USP9X in macrophages promotes foam cell formation and atherosclerosis
Wang, B., Tang, X., Liu, Y., Wang, Y., Chen, Z., Li, M., Wu, N., Wu, D., Dai, X., Jiang, H., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci154217 · Cited by 141 · see citing works
Heterogeneity of immune cells in human atherosclerosis revealed by scRNA-Seq
Vallejo, J., Cochain, C., Zernecke, A., & Ley, K. F. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab260 · Cited by 140 · see citing works
Monocyte Recruitment, Specification, and Function in Atherosclerosis
Kim, K.-W., Ivanov, S., & Williams, J. W. (2020) · Cells · doi:10.3390/cells10010015 · Cited by 137 · see citing works
Self-citationZhang, X., McDonald, J. G., Aryal, B. K., Canfrán‐Duque, A., Goldberg, E. L., Araldi, E., Ding, W., Fan, Y., Thompson, B. M., Singh, A. K., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2107682118 · Cited by 135 · see citing works
Canfrán‐Duque, A., Rotllán, N., Zhang, X., Andrés‐Blasco, I., Thompson, B. M., Sun, J., Price, N. L., Fernández‐Fuertes, M., Fowler, J. W., Gómez‐Coronado, D., et al. (2022) · Circulation · doi:10.1161/circulationaha.122.059062 · Cited by 127 · see citing works
Dyslipidemia, Diabetes and Atherosclerosis: Role of Inflammation and ROS-Redox-Sensitive Factors
Hasheminasabgorji, E., & Jha, J. C. (2021) · Biomedicines · doi:10.3390/biomedicines9111602 · Cited by 126 · see citing works
SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels
Eberhardt, N., Noval, M. G., Kaur, R., Amadori, L., Gildea, M. A., Sajja, S., Das, D., Cılhoroz, B., Stewart, O., Fernandez, D. M., et al. (2023) · Nature Cardiovascular Research · doi:10.1038/s44161-023-00336-5 · Cited by 127 · see citing works
Immune cell profiling in atherosclerosis: role in research and precision medicine
Fernandez, D. M., & Giannarelli, C. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00589-2 · Cited by 124 · see citing works
Type-I interferons in atherosclerosis
Chen, H., Tas, S. W., & de Winther, M. P. J. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190459 · Cited by 121 · see citing works
High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis
Bashore, A. C., Yan, H., Xue, C., Zhu, L. Y., Kim, E., Mawson, T. L., Coronel, J., Chung, A. Y., Sachs, N., Ho, S., et al. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.320524 · Cited by 121 · see citing works
Lipid Metabolism in Macrophages: Focus on Atherosclerosis
Sukhorukov, V. N., Khotina, V. A., Chegodaev, Y. S., Ivanova, E. A., Sobenin, I. A., & Orekhov, A. N. (2020) · Biomedicines · doi:10.3390/biomedicines8080262 · Cited by 115 · see citing works
Gu, W., Ni, Z., Tan, Y.-Q., Deng, J., Zhang, S.-J., Lv, Z.-C., Wang, X.-J., Chen, T., Zhang, Z., Hu, Y., et al. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312399 · Cited by 111 · see citing works
Huggins, D. N., LaRue, R. S., Wang, Y., Knutson, T. P., Xu, Y., Williams, J. W., & Schwertfeger, K. L. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0101 · Cited by 110 · see citing works
Self-citationRoles of Macrophages in Atherogenesis
Farahi, L., Sinha, S. K., & Lusis, A. J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.785220 · Cited by 112 · see citing works
Inflammation in atherosclerosis: Lessons and therapeutic implications
Libby, P., & Soehnlein, O. (2025) · Immunity · doi:10.1016/j.immuni.2025.09.012 · Cited by 115 · see citing works
Zuo, W., Sun, R., Ji, Z., & Ma, G. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00491-4 · Cited by 107 · see citing works
Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis
Takaoka, M., Zhao, X., Lim, H. Y., Magnussen, C. G., Ang, O., Suffee, N., Schrank, P. R., Ong, W. S., Tsiantoulas, D., Sommer, F., et al. (2024) · Nature · doi:10.1038/s41586-024-07993-x · Cited by 109 · see citing works
Self-citationInflammatory Cells in Atherosclerosis
Mehu, M., Narasimhulu, C. A., & Singla, D. K. (2022) · Antioxidants · doi:10.3390/antiox11020233 · Cited by 105 · see citing works
Lipid-associated macrophages between aggravation and alleviation of metabolic diseases
Xu, R., Vujić, N., Bianco, V., Reinisch, I., Kratky, D., Krstić, J., & Prokesch, A. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.04.009 · Cited by 102 · see citing works
Macrophage profiling in atherosclerosis: understanding the unstable plaque
Gianopoulos, I., & Daskalopoulou, S. S. (2024) · Basic Research in Cardiology · doi:10.1007/s00395-023-01023-z · Cited by 99 · see citing works
Ketelhuth, D. F. J., Lutgens, E., Bäck, M., Binder, C. J., den Bossche, J. V., Daniel, C., Dumitriu, I. E., Hoefer, I. E., Libby, P., O'Neill, L. A. J., et al. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz166 · Cited by 101 · see citing works
Translational opportunities of single-cell biology in atherosclerosis
de Winther, M. P. J., Bäck, M., Evans, P. C., Gomez, D. A., Gonçalves, I., Jørgensen, H. F., Koenen, R. R., Lutgens, E., Norata, G. D., Osto, E., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac686 · Cited by 96 · see citing works
TREM2 promotes cholesterol uptake and foam cell formation in atherosclerosis
Guo, X. Q., Li, B., Wen, C., Zhang, F. S., Xiang, X., Nie, L., Chen, J., & Mao, L. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04786-9 · Cited by 96 · see citing works
Osteopontin in Cardiovascular Diseases
Shirakawa, K., & Sano, M. (2021) · Biomolecules · doi:10.3390/biom11071047 · Cited by 94 · see citing works
Jin, H., Goossens, P., Juhász, P., Eijgelaar, W. J., Manca, M., Karel, J. M. H., Smirnov, E. N., Sikkink, C. J. J. M., Mees, B., Waring, O. J., et al. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.458 · Cited by 93 · see citing works
Lipid scavenging macrophages and inflammation
Vogel, A., Brunner, J. S., Hajto, A., Sharif, O., & Schabbauer, G. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.159066 · Cited by 85 · see citing works
Immunometabolic function of cholesterol in cardiovascular disease and beyond
Yvan‐Charvet, L., Bonacina, F., Guinamard, R., & Norata, G. D. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz127 · Cited by 86 · see citing works
NLRP3 inflammasome and IL-1β pathway in type 2 diabetes and atherosclerosis: Friend or foe?
Chen, X., Zhang, D., Li, Y., Wang, W., Bei, W., & Guo, J. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105885 · Cited by 84 · see citing works
Macrophage Biology in Cardiovascular Diseases
Khoury, M. K., Yang, H., & Liu, B. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.313584 · Cited by 79 · see citing works
Monocytes and macrophages as protagonists in vascular complications of diabetes
Kanter, J. E., Hsu, C.-C., & Bornfeldt, K. E. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00010 · Cited by 76 · see citing works
Endo-Umeda, K., Kim, E., Thomas, D. G., Liu, W.-L., Dou, H., Yalçınkaya, M., Abramowicz, S., Xiao, T., Antonson, P., Gustafsson, J.-Å., et al. (2022) · Arteriosclerosis, Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.317583 · Cited by 66 · see citing works
Migratory and Dancing Macrophage Subsets in Atherosclerotic Lesions
McArdle, S., Buscher, K., Ghosheh, Y., Pramod, A. B., Miller, J. F., Winkels, H., Wolf, D., & Ley, K. F. (2019) · Circulation Research · doi:10.1161/circresaha.119.315175 · Cited by 78 · see citing works
Pharmacological targets of metabolism in disease: Opportunities from macrophages
Castegna, A., Gissi, R., Menga, A., Montopoli, M., Favia, M., Viola, A., & Canton, M. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107521 · Cited by 75 · see citing works
Expanding biology of PCSK9: roles in atherosclerosis and beyond
Seidah, N. G., & Garçon, D. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-01057-z · Cited by 76 · see citing works
Self-citationSingle-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis
Mocci, G., Sukhavasi, K., Örd, T., Bankier, S., Singha, P., Arasu, U. T., Agbabiaje, O. O., Mäkinen, P. I., Ma, L., Hodonsky, C. J., et al. (2024) · Circulation Research · doi:10.1161/circresaha.123.323184 · Cited by 76 · see citing works
Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability—Brief Report
Patterson, M. T., Xu, Y., Hillman, H., Osinski, V., Schrank, P. R., Kennedy, A. E., Barrow, F., Zhu, A., Tollison, S., Shekhar, S., et al. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.320797 · Cited by 76 · see citing works
Self-citationMacrophage Responses to Environmental Stimuli During Homeostasis and Disease
Rasheed, A., & Rayner, K. J. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab004 · Cited by 79 · see citing works
The Ontogeny and Function of Placental Macrophages
Thomas, J. R., Naidu, P., Appios, A., & McGovern, N. N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.771054 · Cited by 73 · see citing works
Single-cell profiling reveals age-associated immunity in atherosclerosis
Smit, V., de Mol, J., Schaftenaar, F. H., Depuydt, M. A. C., Postel, R. J., Smeets, D., Verheijen, F. W., Bogers, L., van Duijn, J., Verwilligen, R. A. F., et al. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad099 · Cited by 73 · see citing works
Modification of lipoprotein metabolism and function driving atherogenesis in diabetes
Luciani, L., Pedrelli, M., & Parini, P. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.117545 · Cited by 72 · see citing works
Lee, S. H., Kim, N., Kim, M., Woo, S.-H., Han, I., Park, J., Kim, K., Park, K. S., Kim, K., Shim, D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33202-2 · Cited by 70 · see citing works
Self-citationDysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities
Stroope, C., Nettersheim, F. S., Coon, B. G., Finney, A. C., Schwartz, M. A., Ley, K. F., Rom, O., & Yurdagul, A. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01015-w · Cited by 72 · see citing works
Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis
Jeon, S., Kim, T. K., Jeong, S., Jung, I., Kim, N., Lee, M.-N., Sonn, S., Seo, S., Jin, J., Kweon, H. Y., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.046907 · Cited by 69 · see citing works
Self-citationWinkels, H., & Wolf, D. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.312137 · Cited by 69 · see citing works
Androvic, P., Schifferer, M., Perez Anderson, K., Cantuti-Castelvetri, L., Jiang, H., Ji, H., Liu, L., Gouna, G., Berghoff, S. A., Besson-Girard, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39447-9 · Cited by 67 · see citing works
Leukocyte Heterogeneity in Adipose Tissue, Including in Obesity
Weinstock, A., Silva, H. M., Moore, K. J., Schmidt, A. M., & Fisher, E. A. A. (2020) · Circulation Research · doi:10.1161/circresaha.120.316203 · Cited by 67 · see citing works
Härdtner, C., Kornemann, J., Krebs, K., Ehlert, C. A., Jander, A., Zou, J., Starz, C., Rauterberg, S., Sharipova, D., Dufner, B., et al. (2020) · Basic Research in Cardiology · doi:10.1007/s00395-020-00838-4 · Cited by 66 · see citing works
Xue, Y., Luo, M., Hu, X., Li, X., Shen, J., Zhu, W., Huang, L., Hu, Y., Guo, Y., Liu, L., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-04255-2 · Cited by 66 · see citing works
The Unique Phenotype of Lipid-Laden Macrophages
van Eijk, M., & Aerts, J. M. F. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084039 · Cited by 63 · see citing works
Low-density lipoprotein nanomedicines: mechanisms of targeting, biology, and theranostic potential
Di, L., & Maiseyeu, A. (2021) · Drug Delivery · doi:10.1080/10717544.2021.1886199 · Cited by 63 · see citing works
Revealing the Origins of Foam Cells in Atherosclerotic Lesions
Owsiany, K. M., Alencar, G. F., & Owens, G. K. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312557 · Cited by 61 · see citing works
Dubland, J. A., Allahverdian, S., Besler, K. J., Ortega, C., Wang, Y., Pryma, C. S., Boukais, K., Chan, T., Seidman, M. A., & Francis, G. A. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.316063 · Cited by 60 · see citing works
Breaking tolerance: the autoimmune aspect of atherosclerosis
Khan, A. S., Roy, P., & Ley, K. F. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01010-y · Cited by 60 · see citing works
Immune Mechanisms of Plaque Instability
Gerhardt, T., Haghikia, A., Stapmanns, P., & Leistner, D. M. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.797046 · Cited by 63 · see citing works
- Authors
- Kim, K., Shim, D., Lee, J. S., Zaitsev, K., Williams, J. W., Kim, K.-W., Jang, M.-Y., Seok Jang, H., Yun, T. J., Lee, S. H., Yoon, W. K., Prat, A., Seidah, N. G., Choi, J., Lee, S.-P., Yoon, S.-H., Nam, J. W., Seong, J. K., Oh, G. T., Randolph, G. J., Artyomov, M. N., Cheong, C., & Choi, J.-H.
- Affiliations
- Washington University in St. Louis (US)
- Hanyang University (KR)
- Montreal Clinical Research Institute (CA)
- ITMO University (RU)
- From the Department of Life Sciences (K.K., D.S., M.-Y.J., H.S.J., S.H.L., S.-H.Y., J.W.N., J.-H.C.), College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, Republic of Korea
- Seoul National University (KR)
- Korea Research Institute of Bioscience and Biotechnology (KR)
- Ewha Womans University (KR)
- Corresponding author
- Kim, Kyeongdae
- Shim, Dahee
- Lee, Jun Seong
- Zaitsev, Konstantin
- Randolph, Gwendalyn J.
- Artyomov, Maxim N.
- Cheong, Cheolho
- Choi, Jae-Hoon
- ORCID
- Venue
- Circulation Research
- Published
- 2018-10-26
- Volume
- 123
- Issue
- 10
- Pages
- 1127-1142
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC6945121
- OpenAlex
- W2891644675
- Cited by
- 434
- References
- 52
- Citations by year
- 2026: 36 · 2025: 57 · 2024: 69 · 2023: 60 · 2022: 71 · 2021: 57 · 2020: 42 · 2019: 37 · 2018: 5
- FWCI
- 15.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- KRIBB Repository (submittedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- Hanyang University
- National Institutes of Health (UL1TR002345)
- Canadian Institutes of Health Research (125933_1, 148363)
- National Heart, Lung, and Blood Institute (K99HL138163)
- National Cancer Institute (P30CA091842)
- National Institute of Allergy and Infectious Diseases (U01AI025903, R37AI049653)
- National Institute of Diabetes and Digestive and Kidney Diseases (DP1DK109668)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
- Keywords
- atherosclerosis, plaque macrophages, foam cells, macrophage heterogeneity, IL-1β, aortic intima, BODIPY staining, single-cell RNA sequencing
- MeSH terms
- Animals, Aorta, Cells, Cultured, Humans, Macrophages, Male, Mice, Inbred C57BL, Mice, Plaque, Atherosclerotic, Transcriptome
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