Yang, Jian

Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits.

Porcu, E., Rüeger, S., Lepik, K., eQTLGen Consortium, Agbessi, M., Ahsan, H., Alves, I., Andiappan, A., Arindrarto, W., Awadalla, P., et al. (2019) · Nature Communications

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

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Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture

Zhang, Q., Sidorenko, J., Couvy-Duchesne, B., Marioni, R. E., Wright, M. J., Goate, A. M., Marcora, E., Huang, K.-L., Porter, T., Laws, S. M., et al. (2020) · Nature Communications

Alzheimer's disease research and treatmentsGenetic Associations and Epidemiology

Cited by 272

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

Wang, Y., Guo, J., Ni, G., Yang, J., Visscher, P. M., & Yengo, L. (2020) · Nature Communications

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

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Genetic correlates of social stratification in Great Britain

Abdellaoui, A., Hugh-Jones, D., Yengo, L., Kemper, K. E., Nivard, M. G., Veul, L., Holtz, Y., Zietsch, B. P., Frayling, T. M., Wray, N. R., et al. (2019) · Nature Human Behaviour

Genetic Associations and EpidemiologyForensic and Genetic Research

Cited by 261

Genome-wide association study of medication-use and associated disease in the UK Biobank

Wu, Y., Byrne, E. M., Zheng, Z., Kemper, K. E., Yengo, L., Mallett, A. J., Yang, J., Visscher, P. M., & Wray, N. R. (2019) · Nature Communications

Genetic Associations and EpidemiologyPharmacogenetics and Drug Metabolism

Cited by 243

Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits

Haplotype Reference Consortium, Evans, L. M., Tahmasbi, R., Vrieze, S. I., Abecasis, G. R., Das, S., Gazal, S., Bjelland, D. W., de Candia, T. R., Goddard, M. E., et al. (2018) · Nature Genetics

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

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Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Mullins, N., Kang, J., Campos, A. I., Coleman, J. R. I., Edwards, A. C., Galfalvy, H., Levey, D. F., Lori, A., Shabalin, A., Starnawska, A., et al. (2022) · Biological Psychiatry

Suicide and Self-Harm StudiesGenetic Associations and Epidemiology

Cited by 238

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Pairo-Castineira, E., Rawlik, K., Bretherick, A. D., Qi, T., Wu, Y., Nassiri, I., McConkey, G. A., Zechner, M., Klaric, L., Griffiths, F., et al. (2023) · Nature

Genetic Associations and EpidemiologyCOVID-19 Clinical Research Studies

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Dominance Genetic Variation Contributes Little to the Missing Heritability for Human Complex Traits

Zhu, Z., Bakshi, A., Vinkhuyzen, A. A. E., Hemani, G., Lee, S. H., Nolte, I. M., van Vliet-Ostaptchouk, J. V., Snieder, H., Esko, T., Milani, L., et al. (2015) · The American Journal of Human Genetics

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

Cited by 224

An epigenome-wide association study of sex-specific chronological ageing

McCartney, D. L., Zhang, F., Hillary, R. F., Zhang, Q., Stevenson, A. J., Walker, R. M., Bermingham, M. L., Boutin, T., Morris, S. W., Campbell, A., et al. (2020) · Genome Medicine

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 152

Imprint of assortative mating on the human genome

Yengo, L., Robinson, M. R., Keller, M. C., Kemper, K. E., Yang, Y., Trzaskowski, M., Gratten, J., Turley, P., Cesarini, D., Benjamin, D. J., et al. (2018) · Nature Human Behaviour

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

Cited by 148

Widespread signatures of natural selection across human complex traits and functional genomic categories

Zeng, J., Xue, A., Jiang, L., Lloyd-Jones, L. R., Wu, Y., Wang, H., Zheng, Z., Yengo, L., Kemper, K. E., Goddard, M. E., et al. (2021) · Nature Communications

Genetic Associations and EpidemiologyEvolution and Genetic Dynamics

Cited by 144

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Czamara, D., Eraslan, G., Page, C. M., Lahti, J., Lahti-Pulkkinen, M., Hämäläinen, E., Kajantie, E., Laivuori, H., Villa, P. M., Reynolds, R. M., et al. (2019) · Nature Communications

Epigenetics and DNA MethylationBirth, Development, and Health

Cited by 143

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

Hivert, V., Sidorenko, J., Rohart, F., Goddard, M. E., Yang, J., Wray, N. R., Yengo, L., & Visscher, P. M. (2021) · The American Journal of Human Genetics

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

Cited by 136

Dissection of genetic variation and evidence for pleiotropy in male pattern baldness

Yap, C. X., Sidorenko, J., Wu, Y., Kemper, K. E., Yang, J., Wray, N. R., Robinson, M. R., & Visscher, P. M. (2018) · Nature Communications

Hair Growth and DisordersGenetic Associations and Epidemiology

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Predicting gene targets from integrative analyses of summary data from GWAS and eQTL studies for 28 human complex traits

Pavlides, J. M. W., Zhu, Z., Gratten, J., McRae, A. F., Wray, N. R., & Yang, J. (2016) · Genome Medicine

Genetic Associations and EpidemiologyBioinformatics and Genomic Networks

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Whole-genome sequence-based analysis of thyroid function

Taylor, P. N., Porcu, E., Chew, S., Campbell, P. J., Traglia, M., Brown, S. J., Mullin, B. H., Shihab, H. A., Min, J., Walter, K., et al. (2015) · Nature Communications

Genetic Associations and EpidemiologyThyroid Disorders and Treatments

Cited by 104

Quantifying the mapping precision of genome-wide association studies using whole-genome sequencing data

Wu, Y., Zheng, Z., Visscher, P. M., & Yang, J. (2017) · Genome biology

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 100

Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

study, T. A. I. B. A. L., Nabais, M. F., Initiative, T. A. D. N., Laws, S. M., Lin, T., Vallerga, C. L., Armstrong, N. J., Blair, I. P., Kwok, J. B., Mather, K. A., et al. (2021) · Genome Biology

Epigenetics and DNA MethylationDementia and Cognitive Impairment Research

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Genotype-free demultiplexing of pooled single-cell RNA-seq

Xu, J., Falconer, C., Nguyen, Q., Crawford, J., McKinnon, B. D., Mortlock, S., Senabouth, A., Andersen, S., Chiu, H. S., Jiang, L., et al. (2019) · Genome Biology

Single-cell and spatial transcriptomicsGenomics and Phylogenetic Studies

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The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects

Peyrot, W. J., Lee, S. H., Milaneschi, Y., Abdellaoui, A., Byrne, E. M., Esko, T., de Geus, E. J. C., Hemani, G., Hottenga, J. J., Kloiber, S., et al. (2015) · Molecular Psychiatry

Genetic Associations and EpidemiologyNeurotransmitter Receptor Influence on Behavior

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The effect of X-linked dosage compensation on complex trait variation

Sidorenko, J., Kassam, I., Kemper, K. E., Zeng, J., Lloyd-Jones, L. R., Montgomery, G. W., Gibson, G., Metspalu, A., Esko, T., Yang, J., et al. (2019) · Nature Communications

Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesGenetic Associations and Epidemiology

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Phenotypic covariance across the entire spectrum of relatedness for 86 billion pairs of individuals

Kemper, K. E., Yengo, L., Zheng, Z., Abdellaoui, A., Keller, M. C., Goddard, M. E., Wray, N. R., Yang, J., & Visscher, P. M. (2021) · Nature Communications

Genetic and phenotypic traits in livestockGenetic Associations and Epidemiology

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Response to browning and browning

Goddard, M. E., Lee, S. H., Yang, J., Wray, N. R., & Visscher, P. M. (2011) · The American Journal of Human Genetics

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

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