PreprintCited by 272DNA Repair MechanismsEffects of Radiation ExposurePARP inhibition in cancer therapy

DNA Damage Response: Three Levels of DNA Repair Regulation

Open access
Sirbu, B. M., Cortez, D.·2013·Cold Spring Harbor Perspectives in Biology

Abstract

Genome integrity is challenged by DNA damage from both endogenous and environmental sources. This damage must be repaired to allow both RNA and DNA polymerases to accurately read and duplicate the information in the genome. Multiple repair enzymes scan the DNA for problems, remove the offending damage, and restore the DNA duplex. These repair mechanisms are regulated by DNA damage response kinases including DNA-PKcs, ATM, and ATR that are activated at DNA lesions. These kinases improve the efficiency of DNA repair by phosphorylating repair proteins to modify their activities, by initiating a complex series of changes in the local chromatin structure near the damage site, and by altering the overall cellular environment to make it more conducive to repair. In this review, we focus on these three levels of regulation to illustrate how the DNA damage kinases promote efficient repair to maintain genome integrity and prevent disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1101/cshperspect.a012724

Cites

149 of 149 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Goodarzi AA Noon AT Deckbar D Ziv Y Shiloh Y Löbrich M Jeggo PA ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin Molecular cell 2008b 31 167 177 18657500

Cited by

Sorted by citations

Authors
Sirbu, B. M., & Cortez, D.
Affiliations
Vanderbilt University (US)
Corresponding author
Cortez, D.
Venue
Cold Spring Harbor Perspectives in Biology
Published
2013-06-28
Volume
5
Issue
8
Pages
a012724-a012724
ISSN
1943-0264 (ISSN-L)
OpenAlex
W2128552624
Cited by
272
References
149
Citations by year
2026: 12 · 2025: 11 · 2024: 17 · 2023: 15 · 2022: 22 · 2021: 25 · 2020: 32 · 2019: 30 · 2018: 12 · 2017: 23 · 2016: 25 · 2015: 19 · 2014: 20 · 2013: 7 · 2012: 1
Type
posted content
Language
en
Open access
Locations
  • Cold Spring Harbor Perspectives in Biology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Defense (W81XWH)
  • Swim Across America
  • National Institutes of Health (W81XWH)
  • National Cancer Institute (R01CA102729, R01CA136933)
  • National Institute of Environmental Health Sciences (P30ES000267, T32ES007028)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords
DNA damage response, DNA repair regulation, DNA-PKcs, ATM kinase, ATR kinase, genome stability, chromatin structure, protein phosphorylation, DNA replication fidelity
MeSH terms
Chromatin, DNA Damage, DNA Repair, Models, Genetic, Phosphorylation, Genomic Instability, DNA-Activated Protein Kinase, Ataxia Telangiectasia Mutated Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review