Common mechanisms of PIKK regulation

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466 · see citing works

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

Kim, D.-H., Sarbassov, D., Ali, S. M., King, J. E., Latek, R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,135 · see citing works

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773 · see citing works

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693 · see citing works

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665 · see citing works

ATR: an essential regulator of genome integrity

Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798 · see citing works

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424 · see citing works

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,248 · see citing works

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

Gottlieb, T. M., & Jackson, S. P. (1993) · Cell · doi:10.1016/0092-8674(93)90057-w · Cited by 1,233 · see citing works

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

Walker, J. R., Corpina, R. A., & Goldberg, J. D. (2001) · Nature · doi:10.1038/35088000 · Cited by 1,216 · see citing works

Requirement of the MRN complex for ATM activation by DNA damage

Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., & Shiloh, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg541 · Cited by 1,075 · see citing works

Rheb Binds and Regulates the mTOR Kinase

Long, X., Lin, Y., Ortiz-Vega, S., Yonezawa, K., & Avruch, J. (2005) · Current Biology · doi:10.1016/j.cub.2005.02.053 · Cited by 1,005 · see citing works

ATR and ATRIP: Partners in Checkpoint Signaling

Cortez, D., Guntuku, S., Qin, J., & Elledge, S. J. (2001) · Science · doi:10.1126/science.1065521 · Cited by 985 · see citing works

<i>ATR</i> disruption leads to chromosomal fragmentation and early embryonic lethality

Brown, E. J., & Baltimore, D. (2000) · Genes &amp; Development · doi:10.1101/gad.14.4.397 · Cited by 951 · see citing works

The DNA-dependent protein kinasePreprint

Smith, G. C. M., & Jackson, S. P. (1999) · Genes & Development · doi:10.1101/gad.13.8.916 · Cited by 883 · see citing works

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint

Byun, T. S., Pacek, M., Yee, M.-C., Walter, J. C., & Cimprich, K. A. (2005) · Genes &amp; Development · doi:10.1101/gad.1301205 · Cited by 767 · see citing works

TopBP1 Activates the ATR-ATRIP Complex

Kumagai, A., Lee, J., Yoo, H. Y., & Dunphy, W. G. (2006) · Cell · doi:10.1016/j.cell.2005.12.041 · Cited by 743 · see citing works

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.

Sekulić, A., Hudson, C. C., Homme, J. L., Yin, P., Otterness, D. M., Karnitz, L. M., & Abraham, R. T. (2000) · PubMed · Cited by 712 · see citing works

A dynamic model for replication protein A (RPA) function in DNA processing pathways

Fanning, E. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl550 · Cited by 565 · see citing works

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

Brown, E. J., & Baltimore, D. (2003) · Genes &amp; Development · doi:10.1101/gad.1067403 · Cited by 511 · see citing works

The Mre11 complex is required for ATM activation and the G2/M checkpoint

Carson, C. T., Schwartz, R. A., Stracker, T. H., Lilley, C. E., Lee, D. V., & Weitzman, M. D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg630 · Cited by 502 · see citing works

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaksPreprint

Chan, D. W., Chen, B. P.-C., Prithivirajsingh, S., Kurimasa, A., Story, M. D., Qin, J., & Chen, D. J. (2002) · Genes & Development · doi:10.1101/gad.1015202 · Cited by 479 · see citing works

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

Berkovich, E., Monnat, R. J., & Kastan, M. B. (2007) · Nature Cell Biology · doi:10.1038/ncb1599 · Cited by 477 · see citing works

The Rad9–Hus1–Rad1 (9–1–1) clamp activates checkpoint signaling via TopBP1Preprint

Delacroix, S., Wagner, J. M., Kobayashi, M., Yamamoto, K.-I., & Karnitz, L. M. (2007) · Genes & Development · doi:10.1101/gad.1547007 · Cited by 454 · see citing works

Replication protein A-mediated recruitment and activation of Rad17 complexes

Zou, L., Liu, D., & Elledge, S. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336100100 · Cited by 431 · see citing works

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.

Dvir, A., Peterson, S., Knuth, M. W., Lu, H., & Dynan, W. S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.11920 · Cited by 371 · see citing works

TopBP1 activates ATR through ATRIP and a PIKK regulatory domainPreprint

Mordes, D. A., Glick, G. G., Zhao, R., & Cortez, D. (2008) · Genes & Development · doi:10.1101/gad.1666208 · Cited by 368 · see citing works

Biochemical Characterization of DNA Damage Checkpoint Complexes: Clamp Loader and Clamp Complexes with Specificity for 5′ Recessed DNA

Ellison, V., & Stillman, B. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000033 · Cited by 363 · see citing works

Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex <i>in vitro</i>

Bermudez, V. P., Lindsey-Boltz, L. A., Cesare, A. J., Maniwa, Y., Griffith, J. D., Hurwitz, J., & Sancar, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437927100 · Cited by 324 · see citing works

Autophosphorylation of the Catalytic Subunit of the DNA-Dependent Protein Kinase Is Required for Efficient End Processing during DNA Double-Strand Break Repair

Ding, Q., Reddy, Y. V. R., Wang, W., Woods, T. L., Douglas, P., Ramsden, D. A., Lees‐Miller, S. P., & Meek, K. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5836-5848.2003 · Cited by 324 · see citing works

DNA Damage-Induced Acetylation of Lysine 3016 of ATM Activates ATM Kinase Activity

Sun, Y., Xu, Y., Roy, K., & Price, B. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01382-07 · Cited by 319 · see citing works

FAT: a novel domain in PIK-related kinases

Bosotti, R., Isacchi, A., & Sonnhammer, E. L. L. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01563-2 · Cited by 313 · see citing works

ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks

Lavin, M. F. (2007) · Oncogene · doi:10.1038/sj.onc.1210880 · Cited by 301 · see citing works

Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions

Soutoglou, E., & Misteli, T. (2008) · Science · doi:10.1126/science.1159051 · Cited by 299 · see citing works

Involvement of novel autophosphorylation sites in ATM activation

Kozlov, S., Graham, M. E., Peng, C., Chen, P., Robinson, P. J., & Lavin, M. F. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601231 · Cited by 283 · see citing works

The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR

Lee, J., Kumagai, A., & Dunphy, W. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704635200 · Cited by 281 · see citing works

Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair

Spagnolo, L., Rivera-Calzada, Á., Pearl, L. H., & Llorca, Ó. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.04.013 · Cited by 270 · see citing works

The ATRs, ATMs, and TORs Are Giant HEAT Repeat Proteins

Perry, J., & Kleckner, N. E. (2003) · Cell · doi:10.1016/s0092-8674(03)00033-3 · Cited by 268 · see citing works

ATRIP Binding to Replication Protein A-Single-stranded DNA Promotes ATR–ATRIP Localization but Is Dispensable for Chk1 Phosphorylation

Ball, H. L., Myers, J. S., & Cortez, D. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-11-1006 · Cited by 241 · see citing works

The structural determinants of checkpoint activation

MacDougall, C. A., Byun, T. S., Van, C., Yee, M.-C., & Cimprich, K. A. (2007) · Genes &amp; Development · doi:10.1101/gad.1522607 · Cited by 240 · see citing works

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

Pellegrini, M., Celeste, A., Difilippantonio, S., Guo, R., Wang, W., Feigenbaum, L., & Nussenzweig, A. (2006) · Nature · doi:10.1038/nature05112 · Cited by 207 · see citing works

Genetic Analysis of Yeast RPA1 Reveals Its Multiple Functions in DNA Metabolism

Umezu, K., Sugawara, N., Chen, C., Haber, J. E., & Kolodner, R. D. (1998) · Genetics · doi:10.1093/genetics/148.3.989 · Cited by 206 · see citing works

Replication Protein A Directs Loading of the DNA Damage Checkpoint Clamp to 5′-DNA Junctions

Majka, J., Binz, S. K., Wold, M. S., & Burgers, P. M. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605176200 · Cited by 205 · cited 1× · see citing works

Claspin Operates Downstream of TopBP1 To Direct ATR Signaling towards Chk1 Activation

Liu, S., Bekker‐Jensen, S., Mailand, N., Lukas, C., Bártek, J., & Lukas, J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00492-06 · Cited by 184 · see citing works

ATR signaling can drive cells into senescence in the absence of DNA breaks

Toledo, L. I., Murga, M., Gutierrez-Martinez, P., Soria, R., & Fernandez-Capetillo, O. (2008) · Genes &amp; Development · doi:10.1101/gad.452308 · Cited by 183 · see citing works

The Basic Cleft of RPA70N Binds Multiple Checkpoint Proteins, Including RAD9, To Regulate ATR Signaling

Xu, X., Vaithiyalingam, S., Glick, G. G., Mordes, D. A., Chazin, W., & Cortez, D. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01079-08 · Cited by 166 · see citing works

Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage

Bonilla, C. Y., Melo, J. A., & Toczyski, D. P. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.023 · Cited by 161 · see citing works

Identification and functional analysis of TopBP1 and its homologs

Garcia, V., Furuya, K., & Carr, A. M. (2005) · DNA Repair · doi:10.1016/j.dnarep.2005.04.001 · Cited by 158 · see citing works

Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4 TOPBP1Preprint

Furuya, K., Poitelea, M., Guo, L., Caspari, T., & Carr, A. M. (2004) · Genes & Development · doi:10.1101/gad.291104 · Cited by 155 · see citing works

Function of a Conserved Checkpoint Recruitment Domain in ATRIP Proteins

Ball, H. L., Ehrhardt, M. R., Mordes, D. A., Glick, G. G., Chazin, W., & Cortez, D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02238-06 · Cited by 135 · see citing works

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

Stracker, T. H., Morales, M., Couto, S. S., Hussein, H., & Petrini, J. H. J. (2007) · Nature · doi:10.1038/nature05740 · Cited by 127 · see citing works

Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

Hořejšı́, Z., Falck, J., Bakkenist, C. J., Kastan, M. B., Lukas, J., & Bártek, J. (2004) · Oncogene · doi:10.1038/sj.onc.1207447 · Cited by 125 · see citing works

DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?

Weterings, E., & Chen, D. J. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200705106 · Cited by 116 · see citing works

Rapid activation of ATM on DNA flanking double-strand breaks

You, Z., Bailis, J. M., Johnson, S. A., Dilworth, S. M., & Hunter, T. R. (2007) · Nature Cell Biology · doi:10.1038/ncb1651 · Cited by 100 · see citing works

A Role for the Phosphorylation of hRad9 in Checkpoint Signaling

St.Onge, R. P., Besley, B. D. A., Pelley, J. L., & Davey, S. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303134200 · Cited by 99 · see citing works

The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast

Longhese, M. P. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.18.3533 · Cited by 96 · see citing works

ATMIN defines an NBS1‐independent pathway of ATM signalling

Kanu, N., & Behrens, A. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601733 · Cited by 84 · see citing works

Activation of ATR and related PIKKs

Mordes, D. A., & Cortez, D. (2008) · Cell Cycle · doi:10.4161/cc.7.18.6689 · Cited by 82 · see citing works

ATRIP Oligomerization Is Required for ATR-dependent Checkpoint Signaling

Ball, H. L., & Cortez, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504961200 · Cited by 77 · see citing works

hRad9 rapidly binds DNA containing double-strand breaks and is required for damage-dependent topoisomerase II beta binding protein 1 focus formation.

Greer, D. A., Besley, B. D. A., Kennedy, K. B., & Davey, S. K. (2003) · PubMed · Cited by 73 · see citing works

Cyclin-Dependent Kinase 2–Dependent Phosphorylation of ATRIP Regulates the G2-M Checkpoint Response to DNA Damage

Myers, J. S., Zhao, R., Xu, X., Ham, A. L., & Cortez, D. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0495 · Cited by 66 · see citing works

Aven-Dependent Activation of ATM Following DNA Damage

Guo, J. Y., Yamada, A., Kajino, T., Wu, J. Q., Tang, W., Freel, C. D., Feng, J., Chau, B. N., Wang, M. Z., Margolis, S. S., et al. (2008) · Current Biology · doi:10.1016/j.cub.2008.05.045 · Cited by 51 · see citing works

Single-Strand DNA Gaps Trigger an ATR- and Cdc7-Dependent Checkpoint

Costanzo, V., & Gautier, J. (2003) · Cell Cycle · doi:10.4161/cc.2.1.290 · Cited by 38 · see citing works

Phosphorylation of ATR-Interacting Protein on Ser239 Mediates an Interaction with Breast-Ovarian Cancer Susceptibility 1 and Checkpoint Function

Venere, M., Snyder, A. R., Zgheib, O., & Halazonetis, T. D. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0369 · Cited by 25 · see citing works

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

Shiloh, Y., & Ziv, Y. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3546 · Cited by 1,649 · see citing works

DNA Damage Sensing by the ATM and ATR Kinases

Marechal, A., & Zou, L. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012716 · Cited by 1,514 · see citing works

mTOR kinase structure, mechanism and regulation

Yang, H., Rudge, D. G., Koos, J. D., Vaidialingam, B., Yang, H. J., & Pavletich, N. P. (2013) · Nature · doi:10.1038/nature12122 · Cited by 1,075 · see citing works

Mechanisms of ATM Activation

Paull, T. T. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034335 · Cited by 458 · see citing works

Replication stress induces 53BP1-containing OPT domains in G1 cells

Harrigan, J. A., Belotserkovskaya, R., Coates, J., Dimitrova, D. S., Polo, S. E., Bradshaw, C. R., Fraser, P., & Jackson, S. P. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201011083 · Cited by 344 · see citing works

ATR signalling: more than meeting at the fork

Nam, E. A., & Cortez, D. (2011) · Biochemical Journal · doi:10.1042/bj20102162 · Cited by 316 · see citing works

DNA mismatch repair and the DNA damage response

Li, Z., Pearlman, A. H., & Hsieh, P. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.11.019 · Cited by 311 · see citing works

Platinum Resistance in Ovarian Cancer: Role of DNA Repair

Damia, G. L. M., & Broggini, M. (2019) · Cancers · doi:10.3390/cancers11010119 · Cited by 297 · see citing works

Cellular functions of the protein kinase ATM and their relevance to human disease

Lee, J., & Paull, T. T. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00394-2 · Cited by 290 · see citing works

ATM and ATR signaling at a glance

Awasthi, P., Foiani, M., & Kumar, A. (2015) · Journal of Cell Science · doi:10.1242/jcs.169730 · Cited by 277 · see citing works

ATM-Dependent and -Independent Dynamics of the Nuclear Phosphoproteome After DNA Damage

Bensimon, A., Schmidt, A., Ziv, Y., Elkon, R., Wang, S., Chen, D. J., Aebersold, R. H., & Shiloh, Y. (2010) · Science Signaling · doi:10.1126/scisignal.2001034 · Cited by 275 · see citing works

The Ku heterodimer: Function in DNA repair and beyond

Fell, V. L., & Schild‐Poulter, C. (2014) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2014.06.002 · Cited by 272 · see citing works

DNA Damage Response: Three Levels of DNA Repair Regulation

Sirbu, B. M., & Cortez, D. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012724 · Cited by 272 · see citing works

Multiple roles of ATM in monitoring and maintaining DNA integrity

Derheimer, F. A., & Kastan, M. B. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.05.031 · Cited by 256 · see citing works

Inositol pyrophosphates: between signalling and metabolism

Wilson, M. S. C., Livermore, T. M., & Saiardi, A. (2013) · Biochemical Journal · doi:10.1042/bj20130118 · Cited by 256 · see citing works

Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly

Kaizuka, T., Hara, T., Oshiro, N., Kikkawa, U., Yonezawa, K., Takehana, K., Iemura, S.-I., Natsume, T., & Mizushima, N. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.121699 · Cited by 255 · see citing works

The ubiquitous role of ubiquitin in the DNA damage response

Al-Hakim, A., Escribano‐Diaz, C., Landry, M.-C., O’Donnell, L., Panier, S., Szilard, R. K., & Durocher, D. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.09.011 · Cited by 224 · see citing works

Quantitative Phosphoproteomics of the Ataxia Telangiectasia-Mutated (ATM) and Ataxia Telangiectasia-Mutated and Rad3-related (ATR) Dependent DNA Damage Response in Arabidopsis thaliana*

Roitinger, E., Hofer, M., Köcher, T., Pichler, P., Novatchkova, M., Yang, J., Schlögelhofer, P., & Mechtler, K. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.040352 · Cited by 216 · see citing works

Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response

Salton, M., Lerenthal, Y., Wang, S., Chen, D. J., & Shiloh, Y. (2010) · Cell Cycle · doi:10.4161/cc.9.8.11298 · Cited by 209 · see citing works

Beyond ATM: The protein kinase landscape of the DNA damage response

Bensimon, A., Aebersold, R. H., & Shiloh, Y. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.013 · Cited by 206 · see citing works

Autophosphorylation and ATM Activation

Kozlov, S., Graham, M. E., Jakob, B., Tobias, F., Kijas, A. W., Tanuji, M., Chen, P., Robinson, P. J., Taucher-Scholz, G., Suzuki, K., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.204065 · Cited by 203 · see citing works

Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay

McIlwain, D. R., Pan, Q., Reilly, P. T., Elia, A., McCracken, S. A., Wakeham, A. C., Itie-YouTen, A., Blencowe, B. J., & Mak, T. W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007336107 · Cited by 197 · see citing works

The Meiotic Checkpoint Network: Step-by-Step through Meiotic ProphasePreprint

Subramanian, V. V., & Hochwagen, A. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016675 · Cited by 189 · see citing works

DNA damage response in cisplatin-induced nephrotoxicity

Zhu, S., Pabla, N., Tang, C., He, L., & Dong, Z. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1633-3 · Cited by 183 · see citing works

Senescence in Post-Mitotic Cells: A Driver of Aging?

von Zglinicki, T., Wan, T., & Miwa, S. (2021) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2020.8048 · Cited by 170 · see citing works

Interactions between polycyclic aromatic hydrocarbons in complex mixtures and implications for cancer risk assessment

Jarvis, I. W. H., Dreij, K., Mattsson, Å., Jernström, B., & Stenius, U. (2014) · Toxicology · doi:10.1016/j.tox.2014.03.012 · Cited by 163 · see citing works

The R2TP complex: Discovery and functions

Kakihara, Y., & Houry, W. A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.08.016 · Cited by 157 · see citing works

Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question

Hwang, J., & Maquat, L. E. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2011.03.008 · Cited by 149 · see citing works

Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy

Manic, G., Obrist, F., Sistigu, A., & Vitale, I. (2015) · Molecular & Cellular Oncology · doi:10.1080/23723556.2015.1012976 · Cited by 147 · see citing works

Targeting DNA Damage Response and Repair to Enhance Therapeutic Index in Cisplatin-Based Cancer Treatment

Kiss, R. C., Xia, F., & Acklin, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158199 · Cited by 145 · see citing works

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

Tong, A. S., Stern, J. L., Sfeir, A. J., Kartawinata, M., de Lange, T., Zhu, X., & Bryan, T. M. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.041 · Cited by 136 · see citing works

Functions of SMARCAL1, ZRANB3, and HLTF in maintaining genome stability

Poole, L. A., & Cortez, D. (2017) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2017.1380597 · Cited by 142 · see citing works

The ATR barrier to replication-born DNA damage

Lopez-Contreras, A. J., & Fernández-Capetillo, Ó. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.09.012 · Cited by 138 · see citing works

The DNA Damage Response: A Common Pathway in the Regulation of NKG2D and DNAM-1 Ligand Expression in Normal, Infected, and Cancer Cells

Cerboni, C., Fionda, C., Soriani, A., Zingoni, A., Doria, M., Cippitelli, M., & Santoni, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00508 · Cited by 135 · see citing works

Inositol Pyrophosphates Mediate the DNA-PK/ATM-p53 Cell Death Pathway by Regulating CK2 Phosphorylation of Tti1/Tel2

Rao, F., Cha, J., Xu, J., Xu, R., Vandiver, M. S., Tyagi, R., Tokhunts, R. A., Koldobskiy, M. A., Fu, C., Barrow, R. K., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.02.020 · Cited by 124 · see citing works

Thr-1989 Phosphorylation Is a Marker of Active Ataxia Telangiectasia-mutated and Rad3-related (ATR) Kinase

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Eukaryotic DNA damage checkpoint activation in response to double-strand breaks

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Structures of closed and open conformations of dimeric human ATM

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ATM, ATR, CHK1, CHK2 and WEE1 inhibitors in cancer and cancer stem cells

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Checkpoint mechanisms: the puppet masters of meiotic prophase

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A wheat PI4K gene whose product possesses threonine autophophorylation activity confers tolerance to drought and salt in Arabidopsis

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Systemic DNA damage responses in aging and diseases

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ATM protein kinase: the linchpin of cellular defenses to stress

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Oxidative stress, mitochondrial abnormalities and antioxidant defense in Ataxia-telangiectasia, Bloom syndrome and Nijmegen breakage syndrome

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Dealing with DNA damage: Relationships between checkpoint and repair pathways

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Ataxia-telangiectasia (A-T): An emerging dimension of premature ageing

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ATM: Expanding roles as a chief guardian of genome stability

Shiloh, Y. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.09.002 · Cited by 107 · see citing works

Parvovirus Minute Virus of Mice Induces a DNA Damage Response That Facilitates Viral Replication

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The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses

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ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development

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Suppression of nonsense mutations as a therapeutic approach to treat genetic diseases

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Identification of pyrimidine derivatives as hSMG-1 inhibitors

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Wild-type p53-induced Phosphatase 1 Dephosphorylates Histone Variant γ-H2AX and Suppresses DNA Double Strand Break Repair

Moon, S.-H., Lin, L., Zhang, X., Nguyen, T., Darlington, Y. F., Waldman, A. S., Lu, X., & Donehower, L. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.071696 · Cited by 105 · see citing works

Chaperone-like activity of the AAA+ proteins Rvb1 and Rvb2 in the assembly of various complexes

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Clinical Candidates Targeting the ATR–CHK1–WEE1 Axis in Cancer

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Consensus, debate, and prospective on pancreatic cancer treatments

Wang, J., Yang, J., Narang, A. K., He, J., Wolfgang, C. L., Li, K., & Zheng, L. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01613-x · Cited by 99 · see citing works

AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation

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TORC2 Signaling Pathway Guarantees Genome Stability in the Face of DNA Strand Breaks

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New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress

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DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response

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Unraveling the Guardian: p53’s Multifaceted Role in the DNA Damage Response and Tumor Treatment Strategies

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Metformin and the ATM DNA damage response (DDR): Accelerating the onset of stress-induced senescence to boost protection against cancer

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Making the best of the loose ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection

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FOXOs: masters of the equilibrium

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The kinomes of apicomplexan parasites

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The DNA damage checkpoint response to replication stress: A Game of Forks

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PIKKs — the solenoid nest where partners and kinases meet

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Mammalian TOR signaling to the AGC kinases

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DNA damage, metabolism and aging in pro-inflammatory T cells

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ATM and ATR signaling at a glance

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RNF20–RNF40: A ubiquitin‐driven link between gene expression and the DNA damage response

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Targeting ATM and ATR for cancer therapeutics: Inhibitors in clinic

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Compromised genomic integrity impedes muscle growth after Atrx inactivation

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Molecular basis of human ATM kinase inhibition

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Chromatin: Receiver and Quarterback for Cellular Signals

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Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex

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DNA repair as a shared hallmark in cancer and ageing

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Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks

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Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations

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Structure of the intact ATM/Tel1 kinase

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The activating transcription factor 2: an influencer of cancer progression

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Ataxia-telangiectasia: future prospects

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Elevated Cyclin G2 Expression Intersects with DNA Damage Checkpoint Signaling and Is Required for a Potent G2/M Checkpoint Arrest Response to Doxorubicin

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Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation

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ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression

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Structure of the human ATM kinase and mechanism of Nbs1 binding

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Structure of the human dimeric ATM kinase

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ATR inhibition enables complete tumour regression in ALK-driven NB mouse models

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DNA damage‐induced CHK1 autophosphorylation at Ser296 is regulated by an intramolecular mechanism

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The Intersection of DNA Damage Response and Ferroptosis—A Rationale for Combination Therapeutics

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DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis

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Relationship of DNA damage signaling to DNA replication following treatment with DNA topoisomerase inhibitors camptothecin/topotecan, mitoxantrone, or etoposide

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ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation

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Oxidative stress and cell senescence as drivers of ageing: Chicken and egg

von Zglinicki, T. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102558 · Cited by 52 · see citing works

Phosphoproteomics reveals novel modes of function and inter‐relationships among PIKKs in response to genotoxic stress

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Aquarius is required for proper CtIP expression and homologous recombination repair

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Take your PIKK: tumour viruses and DNA damage response pathways

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Rare Genetic Diseases with Defects in DNA Repair: Opportunities and Challenges in Orphan Drug Development for Targeted Cancer Therapy

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ATR-mediated regulation of nuclear and cellular plasticity

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Mind the gap: keeping UV lesions in check

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PI 3-kinase related kinases: ?big? players in stress-induced signaling pathways

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The PIKK Family of Protein Kinases

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It takes three to the DNA damage response tango

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DNA Damage Checkpoint Response

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Phosphoproteomics reveals novel modes of function and inter‐relationships among PIKKs in response to genotoxic stress

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