Zhao, Zhen

Blood-Brain Barrier: From Physiology to Disease and Back

Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews

Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 2,294

Blood-brain barrier breakdown in the aging human hippocampus

Montagne, A., Barnes, S. R., Sweeney, M. D., Halliday, M. R., Sagare, A. P., Zhao, Z., Toga, A. W., Jacobs, R. E., Liu, C. Y., Amezcua, L., et al. (2015) · Neuron

Barrier Structure and Function StudiesCerebrospinal fluid and hydrocephalus

Cited by 2,102

Establishment and Dysfunction of the Blood-Brain Barrier

Zhao, Z., Nelson, A. R., Betsholtz, C., & Zlokovic, B. V. (2015) · Cell

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 1,670

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

Winkler, E. A., Nishida, Y., Sagare, A. P., Rege, S. V., Bell, R. D., Perlmutter, D., Sengillo, J. D., Hillman, S., Kong, P., Nelson, A. R., et al. (2015) · Nature Neuroscience

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 689

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

Montagne, A., Zhao, Z., & Zlokovic, B. V. (2017) · Journal of Experimental Medicine

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 672

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

Halliday, M. R., Rege, S. V., Ma, Q., Zhao, Z., Miller, C. A., Winkler, E. A., & Zlokovic, B. V. (2016) · Journal of Cerebral Blood Flow & Metabolism

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 649

RETRACTED ARTICLE: Pericyte loss influences Alzheimer-like neurodegeneration in mice

Sagare, A. P., Bell, R. D., Zhao, Z., Ma, Q., Winkler, E. A., Ramanathan, A., & Zlokovic, B. V. (2013) · Nature Communications

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 589

A Genome-Wide Association Study Identifies Novel Alleles Associated with Hair Color and Skin Pigmentation

Han, J., Kraft, P., Nan, H., Guo, Q., Chen, C., Qureshi, A., Hankinson, S. E., Hu, F. B., Duffy, D. L., Zhao, Z. Z., et al. (2008) · PLoS Genetics

melanin and skin pigmentationGenetic Associations and Epidemiology

Cited by 499

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain

Kisler, K., Nelson, A. R., Rege, S. V., Ramanathan, A., Wang, Y., Ahuja, A., Lazic, D., Tsai, P. S., Zhao, Z., Zhou, Y., et al. (2017) · Nature Neuroscience

Barrier Structure and Function StudiesNeurological Disease Mechanisms and Treatments

Cited by 497

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

Zhao, Z., Sagare, A. P., Ma, Q., Halliday, M. R., Kong, P., Kisler, K., Winkler, E. A., Ramanathan, A., Kanekiyo, T., Bu, G., et al. (2015) · Nature Neuroscience

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 410

A Single SNP in an Evolutionary Conserved Region within Intron 86 of the HERC2 Gene Determines Human Blue-Brown Eye Color

Sturm, R. A., Duffy, D. L., Zhao, Z. Z., Leite, F. P. N., Stark, M. S., Hayward, N. K., Martin, N. G., & Montgomery, G. W. (2008) · The American Journal of Human Genetics

melanin and skin pigmentationGenetic Associations and Epidemiology

Cited by 378

RETRACTED ARTICLE: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system

Montagne, A., Nikolakopoulou, A. M., Zhao, Z., Sagare, A. P., Si, G., Lazic, D., Barnes, S. R., Daianu, M., Ramanathan, A., Go, A., et al. (2018) · Nature Medicine

Cerebrovascular and genetic disordersBarrier Structure and Function Studies

Cited by 344

Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis

Painter, J. N., Anderson, C. A., Nyholt, D. R., Macgregor, S., Lin, J., Lee, S. H., Lambert, A., Zhao, Z. Z., Roseman, F., Guo, Q., et al. (2011) · Nature Genetics

Endometriosis Research and TreatmentGenetic Associations and Epidemiology

Cited by 308

Activation of innate immune cGAS-STING pathway contributes to Alzheimer’s pathogenesis in 5×FAD mice

Xie, X., Ma, G., Li, X., Zhao, J., Zhao, Z., & Zeng, J. (2023) · Nature Aging

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 292

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism

Ma, Q., Zhao, Z., Sagare, A. P., Wu, Y., Wang, M., Owens, N. C., Verghese, P. B., Herz, J., Holtzman, D. M., & Zlokovic, B. V. (2018) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 281

A three-single-nucleotide polymorphism haplotype in intron 1 of OCA2 explains most human eye-color variation

Duffy, D. L., Montgomery, G. W., Chen, W., Zhao, Z. Z., Le, L., James, M. R., Hayward, N. K., Martin, N. G., & Sturm, R. A. (2007) · The American Journal of Human Genetics

melanin and skin pigmentationGenetic Associations and Epidemiology

Cited by 240

Blood–spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

Winkler, E. A., Sengillo, J. D., Sagare, A. P., Zhao, Z., Ma, Q., Zuniga, E., Wang, Y., Zhong, Z., Sullivan, J. S., Griffin, J. H., et al. (2014) · Proceedings of the National Academy of Sciences

Amyotrophic Lateral Sclerosis ResearchBarrier Structure and Function Studies

Cited by 238

The search for genes contributing to endometriosis risk

Montgomery, G. W., Nyholt, D. R., Zhao, Z. Z., Treloar, S. A., Painter, J. N., Missmer, S. A., Kennedy, S. H., & Zondervan, K. T. (2008) · Human Reproduction Update

Endometriosis Research and TreatmentGenetic Associations and Epidemiology

Cited by 211

Regulation of Kiss1 and Dynorphin Gene Expression in the Murine Brain by Classical and Nonclassical Estrogen Receptor Pathways

Gottsch, M. L., Navarro, V. M., Zhao, Z., Glidewell-Kenney, C., Weiss, J., Jameson, J. L., Clifton, D. K., Levine, J. E., & Steiner, R. A. (2009) · The Journal of Neuroscience

Hypothalamic control of reproductive hormonesEstrogen and related hormone effects

Cited by 195

Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice

Park, C. J., Zhao, Z., Glidewell-Kenney, C., Lazic, M., Chambon, P., Krust, A., Weiss, J., Clegg, D. J., Dunaif, A., Jameson, J. L., et al. (2011) · Journal of Clinical Investigation

Estrogen and related hormone effectsRegulation of Appetite and Obesity

Cited by 162

Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-β signaling

Nikolakopoulou, A. M., Zhao, Z., Montagne, A., & Zlokovic, B. V. (2017) · PLOS ONE

Barrier Structure and Function StudiesAngiogenesis and VEGF in Cancer

Cited by 109

Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo

Nelson, A. R., Sagare, M. A., Wang, Y., Kisler, K., Zhao, Z., & Zlokovic, B. V. (2020) · Frontiers in Aging Neuroscience

Barrier Structure and Function StudiesTraumatic Brain Injury and Neurovascular Disturbances

Cited by 73

Remote control of BBB: A tale of exosomes and microRNA

Zhao, Z., & Zlokovic, B. V. (2017) · Cell Research

Extracellular vesicles in diseaseBarrier Structure and Function Studies

Cited by 70

Blood-Brain Barrier: A Dual Life of MFSD2A?

Zhao, Z., & Zlokovic, B. V. (2014) · Neuron

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 59