Blood-Brain Barrier: A Dual Life of MFSD2A?
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Two recent papers in Nature, Ben-Zvi et al. (2014) and Nguyen et al. (2014), report a surprising dual role for the blood-brain barrier transporter MFSD2A in both establishing BBB integrity and in uptake of the fatty acid DHA.
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Knockout of murine Mfsd2a gene results in diminished brain uptake of docosahexaenoic acid (DHA) in the form of lysophosphatidylcholine and leads to dysregulated caveolae-mediated transcellular trafficking across the BBB causing BBB breakdown.
“whereas knockout of murine Mfsd2a gene results in not only diminished brain uptake of docosahexaenoic acid (DHA) in the form of lysophosphatidylcholine, but also leads to dysregulated caveolae-mediated transcellular trafficking across the BBB causing BBB breakdown (21, 62, 684).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [684]
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Cites
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“…shown in other models of a chronic BBB breakdown including pericyte-deficient mice (Bell et al., 2010), apolipoprotein E4-express- ing mice (Bell et al., 2012), and/or after experimentally induced BBB breakdown in a mouse model of amyotrophic lateral sclerosis (ALS) (Winkler et al., 2014).”
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Research works printed but not linked: 16
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Cited by
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Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works
Self-citationA blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity
Kadry, H., Noorani, B., & Cucullo, L. (2020) · Fluids and Barriers of the CNS · doi:10.1186/s12987-020-00230-3 · Cited by 1,853 · see citing works
Establishment and Dysfunction of the Blood-Brain Barrier
Zhao, Z., Nelson, A. R., Betsholtz, C., & Zlokovic, B. V. (2015) · Cell · doi:10.1016/j.cell.2015.10.067 · Cited by 1,670 · see citing works
Self-citationAlzheimer’s disease: A matter of blood–brain barrier dysfunction?
Montagne, A., Zhao, Z., & Zlokovic, B. V. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20171406 · Cited by 672 · see citing works
Self-citationGLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration
Winkler, E. A., Nishida, Y., Sagare, A. P., Rege, S. V., Bell, R. D., Perlmutter, D., Sengillo, J. D., Hillman, S., Kong, P., Nelson, A. R., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3966 · Cited by 689 · see citing works
Self-citationNeurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease
Nelson, A. R., Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.12.016 · Cited by 559 · see citing works
Self-citationNeuronal and vascular interactions
Andreone, B. J., Lacoste, B., & Gu, C. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033835 · Cited by 256 · see citing works
Blood–Brain Barrier Breakdown in Alzheimer’s Disease: Mechanisms and Targeted Strategies
Alkhalifa, A. E., Al-Ghraiybah, N. F., Odum, J., Shunnarah, J. G., Austin, N., & Kaddoumi, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216288 · Cited by 212 · see citing works
Cerebrospinal Fluid Biomarkers of Neurovascular Dysfunction in Mild Dementia and Alzheimer'S Disease
Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.76 · Cited by 122 · see citing works
- Authors
- Zhao, Z., & Zlokovic, B. V.
- Affiliations
- University of Southern California (US)
- ORCID
- Zhao, Zhen
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 82
- Issue
- 4
- Pages
- 728-730
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4114515
- OpenAlex
- W2073216243
- Cited by
- 59
- References
- 3
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 2 · 2020: 11 · 2019: 4 · 2018: 7 · 2017: 3 · 2015: 10 · 2014: 1
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Update notices
- erratum (2014-06-04)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG039452, R37AG023084, RF1AG039452)
- National Institute of Neurological Disorders and Stroke (R37NS034467)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- blood-brain barrier, MFSD2A, fatty acid uptake, docosahexaenoic acid, blood-brain barrier integrity, membrane transporters, lipid transport
- MeSH terms
- Animals, Blood-Brain Barrier, Brain, Docosahexaenoic Acids, Female, Male, Membrane Transport Proteins
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