Li, En

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 6,143

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 3,984

Chromatin modification and epigenetic reprogramming in mammalian development

Li, E. (2002) · Nature Reviews Genetics

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 1,900

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

Gao, H., Korn, J. M., Ferretti, S., Monahan, J. E., Wang, Y., Singh, M., Zhang, C., Schnell, C., Yang, G., Zhang, Y., et al. (2015) · Nature Medicine

Cancer Cells and MetastasisCancer Genomics and Diagnostics

Cited by 1,393

Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons

Feng, J., Zhou, Y., Campbell, S. L., Le, T., Li, E., Sweatt, J. D., Silva, A. J., & Fan, G. (2010) · Nature Neuroscience

Epigenetics and DNA MethylationMemory and Neural Mechanisms

Cited by 1,019

De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells

Lei, H., Oh, S. P., Okano, M., Jüttermann, R., Goss, K. A., Jaenisch, R., & Li, E. (1996) · Development

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 816

Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b

Chen, T., Ueda, Y., Dodge, J. E., Wang, Z., & Li, E. (2003) · Molecular and Cellular Biology

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 751

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality.

Chae, T., Kwon, Y. T., Bronson, R., Dikkes, P., Li, E., & Tsai, L.-H. (1997) · Neuron

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 715

G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis

Feldman, N., Gerson, A., Fang, J., Li, E., Zhang, Y., Shinkai, Y., Cedar, H., & Bergman, Y. (2006) · Nature Cell Biology

Epigenetics and DNA MethylationPluripotent Stem Cells Research

Cited by 651

Dnmt3a-Dependent Nonpromoter DNA Methylation Facilitates Transcription of Neurogenic Genes

Wu, H., Coskun, V., Tao, J., Xie, W., Ge, W., Yoshikawa, K., Li, E., Zhang, Y., & Sun, Y. E. (2010) · Science

Epigenetics and DNA MethylationNeurogenesis and neuroplasticity mechanisms

Cited by 604

KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints

Ciccone, D. N., Su, H., Hevi, S., Gay, F., Lei, H., Bajko, J., Xu, G., Li, E., & Chen, T. (2009) · Nature

Genetic Syndromes and ImprintingEpigenetics and DNA Methylation

Cited by 514

Regulation of muscle growth by multiple ligands signaling through activin type II receptors

Lee, S.-J., Reed, L. A., Davies, M. V., Girgenrath, S., Goad, M. E. P., Tomkinson, K. N., Wright, J. F., Barker, C., Ehrmantraut, G., Holmstrom, J., et al. (2005) · Proceedings of the National Academy of Sciences

Muscle Physiology and DisordersTGF-β signaling in diseases

Cited by 501

STAT3 deletion during hematopoiesis causes Crohn’s disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity

Welte, T., Zhang, S. S. M., Wang, T., Zhang, Z., Hesslein, D. G. T., Yin, Z., Kano, A., Iwamoto, Y., Li, E., Craft, J. E., et al. (2003) · Proceedings of the National Academy of Sciences

Cytokine Signaling Pathways and InteractionsInflammatory Bowel Disease

Cited by 381

Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age

Jacoby, J. J., Kalinowski, A., Liu, M.-G., Zhang, S. S.-M., Gao, Q., Chai, G.-X., Ji, L., Iwamoto, Y., Li, E., Schneider, M., et al. (2003) · Proceedings of the National Academy of Sciences

Cardiac Fibrosis and RemodelingCytokine Signaling Pathways and Interactions

Cited by 357

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

Qi, W., Zhao, K., Gu, J., Huang, Y., Wang, Y., Zhang, H., Zhang, M., Zhang, J., Yu, Z., Li, L., et al. (2017) · Nature Chemical Biology

Epigenetics and DNA MethylationCancer-related gene regulation

Cited by 316

Activin receptor patterning of foregut organogenesis

Kim, S. K., Hebrok, M., Li, E., Oh, S. P., Schrewe, H., Harmon, E. B., Lee, J. S., & Melton, D. A. (2000) · Genes & Development

Developmental Biology and Gene RegulationPancreatic function and diabetes

Cited by 212

DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease

Jeziorska, D. M., Murray, R. J. S., De Gobbi, M., Gaentzsch, R., Garrick, D., Ayyub, H., Chen, T., Li, E., Telenius, J., Lynch, M., et al. (2017) · Proceedings of the National Academy of Sciences

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 166

Genetic evidence for Dnmt3a‐dependent imprinting during oocyte growth obtained by conditional knockout with Zp3‐Cre and complete exclusion of Dnmt3b by chimera formation

Kaneda, M., Hirasawa, R., Chiba, H., Okano, M., Li, E., & Sasaki, H. (2010) · Genes to Cells

Genetic Syndromes and ImprintingEpigenetics and DNA Methylation

Cited by 103

DNA Methylation Is Required for Silencing of Ant4 , an Adenine Nucleotide Translocase Selectively Expressed in Mouse Embryonic Stem Cells and Germ Cells

Rodić, N., Oka, M., Hamazaki, T., Murawski, M. R., Jorgensen, M., Maatouk, D. M., Resnick, J. L., Li, E., & Terada, N. (2005) · STEM CELLS

Epigenetics and DNA MethylationPluripotent Stem Cells Research

Cited by 89

Detecting S-adenosyl-l-methionine-induced conformational change of a histone methyltransferase using a homogeneous time-resolved fluorescence-based binding assay

Lin, Y., Fan, H., Frederiksen, M., Zhao, K., Jiang, L., Wang, Z., Zhou, S., Guo, W., Gao, J., Li, S., et al. (2012) · Analytical Biochemistry

Cancer-related gene regulationEpigenetics and DNA Methylation

Cited by 15