Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
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Dnmt1 and Dnmt3a are important DNA methyltransferases that are expressed in postmitotic neurons, but their function in the CNS is unclear. We generated conditional mutant mice that lack Dnmt1, Dnmt3a or both exclusively in forebrain excitatory neurons and found that only double knockout (DKO) mice showed abnormal long-term plasticity in the hippocampal CA1 region together with deficits in learning and memory. Although we found no neuronal loss, hippocampal neurons in DKO mice were smaller than in the wild type; furthermore, DKO neurons showed deregulated expression of genes, including the class I MHC genes and Stat1, that are known to contribute to synaptic plasticity. In addition, we observed a significant decrease in DNA methylation in DKO neurons. We conclude that Dnmt1 and Dnmt3a are required for synaptic plasticity, learning and memory through their overlapping roles in maintaining DNA methylation and modulating neuronal gene expression in adult CNS neurons.
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The development of the brain and the functional abilities of the brain such as memory formation, learning, motivation and reward are all regulated by epigenetic regulation of gene expression.
“Recent animal studies have demonstrated that the development of the brain and the functional abilities of the brain such as memory formation, learning, motivation and reward are all regulated by epigenetic regulation of gene expression 16, 17.”
From Resilience in mental health: linking psychological and neurobiological perspectives. (2013) · cites this paper as [17]
Mice lacking Dnmt1 and Dnmt3a in postmitotic neurons show abnormal long-term plasticity in CA1 hippocampal neurons along with deficits in learning and memory.
“Mice lacking Dnmt1 and Dnmt3a in postmitotic neurons show abnormal long-term plasticity in CA1 hippocampal neurons along with deficits in learning and memory [ 75 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [75]
STAT1 and STAT3 have roles in hippocampal plasticity.
“STAT1 and STAT3 have roles in hippocampal plasticity178,179.”
From Immune mediators in the brain and peripheral tissues in autism spectrum disorder (2015) · cites this paper as [179]
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DNA methylation regulates neuronal glutamatergic synaptic scaling
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Self-citationEpigenetic memory: The Lamarckian brain
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Global DNA Hypermethylation in Down Syndrome Placenta
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Retracted
- Authors
- Feng, J., Zhou, Y., Campbell, S. L., Le, T., Li, E., Sweatt, J. D., Silva, A. J., & Fan, G.
- Affiliations
- University of California, Los Angeles (US)
- Qingdao University (CN)
- University of Alabama at Birmingham (US)
- Corresponding author
- Fan, Guoping
- Venue
- Nature Neuroscience
- Published
- 2010-03-14
- Volume
- 13
- Issue
- 4
- Pages
- 423-430
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3060772
- OpenAlex
- W2115818350
- Cited by
- 1,019
- References
- 66
- Citations by year
- 2026: 23 · 2025: 51 · 2024: 37 · 2023: 38 · 2022: 52 · 2021: 63 · 2020: 58 · 2019: 69 · 2018: 54 · 2017: 79 · 2016: 84 · 2015: 72 · 2014: 83 · 2013: 84 · 2012: 75
- FWCI
- 33.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG031722, R37AG013622, R01AG013622, R01AG031722)
- National Institute of Mental Health (P50-MH0779720, MH 57014, R01MH057014, P50MH077972)
- National Institute of Neurological Disorders and Stroke (NS 057098, R01NS051411, R56NS051411, P30NS057098)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- DNMT1, DNMT3A, DNA methylation, synaptic plasticity, learning and memory, hippocampal CA1, excitatory neurons, postmitotic neurons, conditional knockout mice, neuronal gene expression, MHC class I, STAT1, epigenetics
- MeSH terms
- DNA (Cytosine-5-)-Methyltransferase 1, DNA Methyltransferase 3A, Age Factors, Animals, Cells, Cultured, DNA (Cytosine-5-)-Methyltransferases, Female, Learning, Male, Memory, Mice, Transgenic, Neuronal Plasticity, Neurons, Synapses, Prosencephalon, Mice, Knockout, Gene Expression Regulation, Developmental, DNA Methylation, Mice
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