Cited by 33Treatment of Major DepressionStress Responses and CortisolTryptophan and brain disorders

Peripheral antioxidant markers are associated with total hippocampal and CA3/dentate gyrus volume in MDD and healthy controls—Preliminary findings

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Lindqvist, Daniel, Mueller, Susanne, Mellon, Synthia H., Su, Yali, Epel, Elissa S., Reus, Victor I., Rosser, Rebecca, Mahan, Laura +3 more·2014·Psychiatry Research: Neuroimaging

Abstract

Several psychiatric disorders, including major depressive disorder (MDD), are associated with increased blood markers of oxidative stress. The relevance of this to the oxidation-sensitive hippocampus (HC) is unknown. We investigated the relationship between peripheral oxidative stress markers and HC volume in unmedicated individuals with MDD (n=16) and healthy controls (n=19). To conserve power, our primary analysis was carried out in the combined group of subjects, and secondary analyses examined each group separately. Oxidative stress markers (oxidized glutathione (GSSG)) and antioxidants (reduced glutathione (GSH), glutathione peroxidase (Gpx), and Vitamin C) were assessed, and a "total net antioxidant score" was calculated. 4-T MRI estimated total HC volume and HC subfield (CA1, CA1-CA2 transition zone, subiculum and CA3/dentate gyrus [CA3&DG]) volumes. Across groups, the antioxidant score was significantly and positively correlated with total HC volume and CA3&DG subfield volume (normalized to total intracranial volume), adjusting for age and sex. Similar relationships were observed in each individual group but missed statistical significance, likely due to type II errors, with the exception of a significant correlation between the antioxidant score and CA3&DG volume in the MDD group. These preliminary data are consistent with oxidative stress being associated with smaller total HC and CA3&DG subfield volumes.

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Crossref · 10.1016/j.pscychresns.2014.09.002

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  1. Flohe L 1971 Glutathione peroxidase: enzymology and biological aspects Klinische Wochenschrift 49 669 683 4932493

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Authors
Lindqvist, D., Mueller, S., Mellon, S. H., Su, Y., Epel, E. S., Reus, V. I., Rosser, R., Mahan, L., Mackin, R. S., Yang, T. T., & Wolkowitz, O. M.
Affiliations
  • University of California, San Francisco (US)
  • San Francisco VA Medical Center (US)
Corresponding author
Lindqvist, Daniel
Venue
Psychiatry Research: Neuroimaging
Publisher
Elsevier BV
Published
2014-12
Volume
224
Issue
3
Pages
168-174
ISSN
0925-4927 (ISSN-L)
OpenAlex
W2035779474
Cited by
33
References
40
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 5 · 2018: 1 · 2017: 6 · 2016: 4 · 2015: 2
FWCI
2.91
Type
journal article
Language
en
Open access
Locations
  • Psychiatry Research Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Funders
  • NIMH (1 R01 MH083784)
  • O׳Shaughnessy Foundation
  • Tinberg family
  • Swedish Society of Medicine (SLS-244821)
  • Sjobring Foundation
  • OM Persson Foundation
  • ALF
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
major depressive disorder, oxidative stress, hippocampus, hippocampal subfields, antioxidant biomarkers, glutathione, glutathione peroxidase, vitamin C, blood biomarkers, hippocampal volume
MeSH terms
Adult, Major Depressive Disorder, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Biomarkers, Oxidative Stress, Dentate Gyrus, CA3 Region, Hippocampal

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