Chin, Lynda

Melanoma: from mutations to medicine

Tsao, H., Chin, L., Garraway, L. A., & Fisher, D. E. (2012) · Genes & Development

Melanoma and MAPK PathwaysCutaneous Melanoma Detection and Management

Cited by 496

FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis

Paik, J.-H., Ding, Z., Narurkar, R., Ramkissoon, S., Muller, F., Kamoun, W. S., Chae, S.-S., Zheng, H., Ying, H., Mahoney, J., et al. (2009) · Cell Stem Cell

FOXO transcription factor regulationNeurogenesis and neuroplasticity mechanisms

Cited by 459

Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution

Kim, H., Zheng, S., Amini, S. S., Virk, S. M., Mikkelsen, T., Brat, D. J., Grimsby, J., Sougnez, C., Muller, F., Hu, J., et al. (2015) · Genome Research

Glioma Diagnosis and TreatmentCancer Genomics and Diagnostics

Cited by 411

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

Maser, R. S., Choudhury, B., Campbell, P. J., Feng, B., Wong, K.-K., Protopopov, A., O’Neil, J., Gutierrez, A., Ivanova, E., Perna, I., et al. (2007) · Nature

Cancer Genomics and DiagnosticsGenomic variations and chromosomal abnormalities

Cited by 377

Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse

Greenberg, R. A., Chin, L., Femino, A., Lee, K.-H., Gottlieb, G. J., Singer, R. H., Greider, C. W., & DePinho, R. A. (1999) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 367

Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma

Kwong, L. N., Costello, J. C., Liu, H., Jiang, S., Helms, T. L., Langsdorf, A. E., Jakubosky, D., Genovese, G., Muller, F. L., Jeong, J. H., et al. (2012) · Nature Medicine

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 358

Passenger deletions generate therapeutic vulnerabilities in cancer

Muller, F. L., Colla, S., Aquilanti, E., Manzo, V. E., Genovese, G., Lee, J., Eisenson, D., Narurkar, R., Deng, P., Nezi, L., et al. (2012) · Nature

Cancer Genomics and DiagnosticsGlioma Diagnosis and Treatment

Cited by 339

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

Wong, K.-K., Chang, S., Weiler, S. R., Ganesan, S., Chaudhuri, J., Zhu, C., Artandi, S. E., Rudolph, K. L., Gottlieb, G. J., Chin, L., et al. (2000) · Nature Genetics

Telomeres, Telomerase, and SenescenceEffects of Radiation Exposure

Cited by 309

Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

Akdemir, K. C., Le, V. T., Chandran, S., Li, Y., Verhaak, R. G., Beroukhim, R., Campbell, P. J., Chin, L., Dixon, J. R., Futreal, P. A., et al. (2020) · Nature Genetics

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 283

Telomere dysfunction provokes regional amplification and deletion in cancer genomes

O'Hagan, R. C., Chang, S., Maser, R. S., Mohan, R., Artandi, S. E., Chin, L., & DePinho, R. A. (2002) · Cancer Cell

Telomeres, Telomerase, and SenescenceGenomic variations and chromosomal abnormalities

Cited by 246

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival

Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2015) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchTGF-β signaling in diseases

Cited by 245

Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM

Wiedemeyer, W. R., Dunn, I. F., Quayle, S. N., Zhang, J., Chheda, M. G., Dunn, G. P., Zhuang, L., Rosenbluh, J., Chen, S., Xiao, Y., et al. (2010) · Proceedings of the National Academy of Sciences

Glioma Diagnosis and TreatmentCancer Genomics and Diagnostics

Cited by 223

Telomerase Reactivation following Telomere Dysfunction Yields Murine Prostate Tumors with Bone Metastases

Ding, Z., Wu, C.-J., Jaskelioff, M., Ivanova, E., Kost-Alimova, M., Protopopov, A., Chu, G. C., Wang, G., Lu, X., Labrot, E. S., et al. (2012) · Cell

Telomeres, Telomerase, and SenescenceProstate Cancer Treatment and Research

Cited by 220

Dual Inactivation of RB and p53 Pathways in RAS-Induced Melanomas

Bardeesy, N., Bastian, B. C., Hezel, A., Pinkel, D., DePinho, R. A., & Chin, L. (2001) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysMelanoma and MAPK Pathways

Cited by 166

Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma

Reuben, A., Spencer, C. N., Prieto, P. A., Gopalakrishnan, V., Reddy, S. M., Miller, J. P., Mao, X., De Macedo, M. P., Chen, J., Song, X., et al. (2017) · npj Genomic Medicine

Cancer Immunotherapy and BiomarkersCutaneous Melanoma Detection and Management

Cited by 166

Comprehensive pan-genomic characterization of adrenocortical carcinoma

Zheng, S., Cherniack, A. D., Dewal, N., Moffitt, R. A., Danilova, L., Murray, B. A., Lerario, A. M., Else, T., Knijnenburg, T. A., Ciriello, G., et al. (2016) · Cancer Cell

Adrenal and Paraganglionic TumorsChromatin Remodeling and Cancer

Cited by 165

Telomere Dysfunction Triggers Developmentally Regulated Germ Cell Apoptosis

Hemann, M. T., Rudolph, K. L., Strong, M. A., DePinho, R. A., Chin, L., & Greider, C. W. (2001) · Molecular Biology of the Cell

Telomeres, Telomerase, and SenescenceMicrotubule and mitosis dynamics

Cited by 162

Amplification of CDK4 and MDM2 in malignant melanoma

Muthusamy, V., Hobbs, C., Nogueira, C., Cordon‐Cardo, C., McKee, P. H., Chin, L., & Bosenberg, M. W. (2006) · Genes Chromosomes and Cancer

Cancer-related Molecular PathwaysCutaneous Melanoma Detection and Management

Cited by 148

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer

Genovese, G., Carugo, A., Tepper, J., Robinson, F. S., Li, L., Svelto, M., Nezi, L., Corti, D., Minelli, R., Pettazzoni, P., et al. (2017) · Nature

Pancreatic and Hepatic Oncology ResearchCancer Cells and Metastasis

Cited by 131

Telomere Dysfunction Drives Aberrant Hematopoietic Differentiation and Myelodysplastic Syndrome

Colla, S., Ong, D. S. T., Ogoti, Y., Marchesini, M., Mistry, N. A., Clise-Dwyer, K., Ang, S. A., Storti, P., Viale, A., Giuliani, N., et al. (2015) · Cancer Cell

Telomeres, Telomerase, and SenescenceAcute Myeloid Leukemia Research

Cited by 105

PRKCI promotes immune suppression in ovarian cancer

Sarkar, S., Bristow, C. A., Dey, P., Rai, K., Perets, R., Ramirez-Cardenas, A., Malasi, S., Huang-Hobbs, E., Haemmerle, M., Wu, S. Y., et al. (2017) · Genes & Development

Ovarian cancer diagnosis and treatmentHippo pathway signaling and YAP/TAZ

Cited by 93

Neutralization of terminal differentiation in gliomagenesis

Hu, J., Ho, A. L., Yuan, L., Hu, B., Hua, S., Hwang, S. S., Zhang, J., Hu, T., Zheng, H., Gan, B., et al. (2013) · Proceedings of the National Academy of Sciences

Glioma Diagnosis and TreatmentCancer Cells and Metastasis

Cited by 76