Denton, Christopher P.

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

Simonneau, G., Montani, D., Celermajer, D. S., Denton, C. P., Gatzoulis, M. A., Krowka, M., Williams, P. G., & Souza, R. (2019) · European Respiratory Journal

Pulmonary Hypertension Research and TreatmentsVascular Anomalies and Treatments

Cited by 3,813

Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database

Tyndall, A. J., Bannert, B., Vonk, M., Airò, P., Cozzi, F., Carreira, P. E., Bancel, D. F., Allanore, Y., Müller-Ladner, U., Distler, O., et al. (2010) · Annals of the Rheumatic Diseases

Systemic Sclerosis and Related DiseasesPulmonary Hypertension Research and Treatments

Cited by 1,443

Update of EULAR recommendations for the treatment of systemic sclerosis

Kowal-Bielecka, O., Fransen, J., Avouac, J., Becker, M., Kulak, A., Allanore, Y., Distler, O., Clements, P., Cutolo, M., Czirjak, L., et al. (2017) · Annals of the Rheumatic Diseases

Systemic Sclerosis and Related DiseasesPulmonary Hypertension Research and Treatments

Cited by 1,104

A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma

Hoyles, R. K., Ellis, R. W., Wellsbury, J., Lees, B., Newlands, P., Goh, N. S. L., Roberts, C., Desai, S., Herrick, A. L., McHugh, N. J., et al. (2006) · Arthritis & Rheumatism

Systemic Sclerosis and Related DiseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 732

Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial

Khanna, D., Denton, C. P., Jahreis, A., van Laar, J. M., Frech, T. M., Anderson, M. E., Baron, M., Chung, L., Fierlbeck, G., Lakshminarayanan, S., et al. (2016) · The Lancet

Systemic Sclerosis and Related DiseasesRheumatoid Arthritis Research and Therapies

Cited by 683

Endothelial to mesenchymal transition contributes to endothelial dysfunction in pulmonary arterial hypertension

Good, R. B., Gilbane, A. J., Trinder, S. L., Denton, C. P., Coghlan, G., Abraham, D. J., & Holmes, A. M. (2015) · The American Journal of Pathology

Pulmonary Hypertension Research and TreatmentsSystemic Sclerosis and Related Diseases

Cited by 349

Safety and efficacy of subcutaneous tocilizumab in systemic sclerosis: results from the open-label period of a phase II randomised controlled trial (faSScinate)

Khanna, D., Denton, C. P., Lin, C. J. F., van Laar, J. M., Frech, T. M., Anderson, M. E., Baron, M., Chung, L., Fierlbeck, G., Lakshminarayanan, S., et al. (2018) · Annals of the Rheumatic Diseases

Systemic Sclerosis and Related DiseasesConnective tissue disorders research

Cited by 265

Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1

Shi-wen, X., Denton, C. P., Holmes, A. M., Black, C. M., Abraham, D. J., Dashwood, M. R., Bou-Gharios, G., & Pearson, J. D. (2001) · Journal of Investigative Dermatology

Systemic Sclerosis and Related DiseasesNitric Oxide and Endothelin Effects

Cited by 243

Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis

Rajkumar, V. S., Howell, K., Csiszar, K., Denton, C. P., Black, C. M., & Abraham, D. J. (2005) · Arthritis Research & Therapy

Systemic Sclerosis and Related DiseasesDupuytren's Contracture and Treatments

Cited by 242

Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy

Gorlova, O., Martin, J.-E., Rueda, B., Koeleman, B. P. C., Ying, J., Teruel, M., Diaz-Gallo, L.-M., Broen, J. C., Vonk, M. C., Simeon, C. P., et al. (2011) · PLoS Genetics

Systemic Sclerosis and Related DiseasesGenetic Associations and Epidemiology

Cited by 231

Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells

Gilbane, A. J., Denton, C. P., & Holmes, A. M. (2013) · Arthritis Research & Therapy

Systemic Sclerosis and Related DiseasesDupuytren's Contracture and Treatments

Cited by 196

Clinical features and prognosis of primary biliary cirrhosis associated with systemic sclerosis

Rigamonti, C., Shand, L. M., Feudjo, M., Bunn, C. C., Black, C. M., Denton, C. P., & Burroughs, A. K. (2006) · Gut

Liver Diseases and ImmunitySystemic Sclerosis and Related Diseases

Cited by 194

Therapeutic interleukin-6 blockade reverses transforming growth factor-beta pathway activation in dermal fibroblasts: insights from the faSScinate clinical trial in systemic sclerosis

Denton, C. P., Ong, V. H., Xu, S., Chen-Harris, H., Modrusan, Z., Lafyatis, R., Khanna, D., Jahreis, A., Siegel, J., & Sornasse, T. (2018) · Annals of the Rheumatic Diseases

Systemic Sclerosis and Related DiseasesTGF-β signaling in diseases

Cited by 166

Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk

Moreno-Moral, A., Bagnati, M., Koturan, S., Ko, J.-H., Fonseca, C., Harmston, N., Game, L., Martin, J., Ong, V., Abraham, D. J., et al. (2018) · Annals of the Rheumatic Diseases

Systemic Sclerosis and Related DiseasesDupuytren's Contracture and Treatments

Cited by 78

Partially Evoked Epithelial-Mesenchymal Transition (EMT) Is Associated with Increased TGFβ Signaling within Lesional Scleroderma Skin

Nikitorowicz-Buniak, J., Denton, C. P., Abraham, D., & Stratton, R. (2015) · PLOS ONE

Systemic Sclerosis and Related DiseasesTGF-β signaling in diseases

Cited by 73

STAT3 controls COL1A2 enhancer activation cooperatively with JunB, regulates type I collagen synthesis posttranscriptionally, and is essential for lung myofibroblast differentiation

Papaioannou, I., Xu, S., Denton, C. P., Abraham, D. J., & Ponticos, M. (2018) · Molecular Biology of the Cell

Cytokine Signaling Pathways and InteractionsSystemic Sclerosis and Related Diseases

Cited by 64

Multidisciplinary Evaluation in Patients with Lung Disease Associated with Connective Tissue Disease

Wells, A., Devaraj, A., Renzoni, E. A., & Denton, C. P. (2019) · Seminars in Respiratory and Critical Care Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisSystemic Sclerosis and Related Diseases

Cited by 36