Chien, Kenneth R.

Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart

Zhou, B., Ma, Q., Rajagopal, S., Wu, S. M., Domian, I., Rivera-Feliciano, J., Jiang, D., von Gise, A., Ikeda, S., Chien, K. R., et al. (2008) · Nature

Congenital heart defects researchPluripotent Stem Cells Research

Cited by 1,019

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

Wang, G., McCain, M. L., Yang, L., He, A., Pasqualini, F. S., Agarwal, A., Yuan, H., Jiang, D., Zhang, D., Zangi, L., et al. (2014) · Nature Medicine

Pluripotent Stem Cells ResearchMitochondrial Function and Pathology

Cited by 837

The Cardiac Mechanical Stretch Sensor Machinery Involves a Z Disc Complex that Is Defective in a Subset of Human Dilated Cardiomyopathy

Knöll, R., Hoshijima, M., Hoffman, H. M., Person, V., Lorenzen-Schmidt, I., Bang, M.-L., Hayashi, T., Shiga, N., Yasukawa, H., Schaper, W., et al. (2002) · Cell

Cardiomyopathy and Myosin StudiesMuscle Physiology and Disorders

Cited by 786

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

Yasukawa, H., Ohishi, M., Mori, H., Murakami, M., Chinen, T., Aki, D., Hanada, T., Takeda, K., Akira, S., Hoshijima, M., et al. (2003) · Nature Immunology

Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic Diseases

Cited by 771

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

Zangi, L., Lui, K. O., von Gise, A., Ma, Q., Ebina, W., Ptaszek, L. M., Später, D., Xu, H., Tabebordbar, M., Gorbatov, R., et al. (2013) · Nature Biotechnology

Congenital heart defects researchMesenchymal stem cell research

Cited by 646

Unlocking the promise of mRNA therapeutics

Rohner, E., Yang, R., Foo, K. S., Goedel, A., & Chien, K. R. (2022) · Nature Biotechnology

RNA Interference and Gene DeliveryRNA and protein synthesis mechanisms

Cited by 612

Essential Role for Mitochondrial Thioredoxin Reductase in Hematopoiesis, Heart Development, and Heart Function

Conrad, M., Jakupoglu, C., Moreno, S. G., Lippl, S., Banjac, A., Schneider, M., Beck, H., Hatzopoulos, A. K., Just, U., Sinowatz, F., et al. (2004) · Molecular and Cellular Biology

Redox biology and oxidative stressSelenium in Biological Systems

Cited by 485

Fli-1 Is Required for Murine Vascular and Megakaryocytic Development and Is Hemizygously Deleted in Patients with Thrombocytopenia

Hart, A., Melet, F., Grossfeld, P., Chien, K., Jones, C., Tunnacliffe, A., Favier, R., & Bernstein, A. (2000) · Immunity

Platelet Disorders and TreatmentsAngiogenesis and VEGF in Cancer

Cited by 369

Embryonic Heart Progenitors and Cardiogenesis

Brade, T., Pane, L. S., Moretti, A., Chien, K. R., & Laugwitz, K.-L. (2013) · Cold Spring Harbor Perspectives in Medicine

Congenital heart defects researchDevelopmental Biology and Gene Regulation

Cited by 254

Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells

Drawnel, F. M., Boccardo, S., Prummer, M., Delobel, F., Graff, A., Weber, M., Gérard, R., Badi, L., Kam-Thong, T., Bu, L., et al. (2014) · Cell Reports

Pluripotent Stem Cells ResearchCongenital heart defects research

Cited by 247

Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo

Hirai, M., Ohbayashi, T., Horiguchi, M., Okawa, K., Hagiwara, A., Chien, K. R., Kita, T., & Nakamura, T. (2007) · The Journal of Cell Biology

Connective tissue disorders researchDermatological and Skeletal Disorders

Cited by 165

How to make a cardiomyocyte

Später, D., Hansson, E. M., Zangi, L., & Chien, K. R. (2014) · Development

Congenital heart defects researchPluripotent Stem Cells Research

Cited by 143

SOCS3 Is a Physiological Negative Regulator for Granulopoiesis and Granulocyte Colony-stimulating Factor Receptor Signaling

Kimura, A., Kinjyo, I., Matsumura, Y., Mori, H., Mashima, R., Harada, M., Chien, K. R., Yasukawa, H., & Yoshimura, A. (2004) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsBlood disorders and treatments

Cited by 119

Left ventricular volumes and function in the embryonic mouse heart

Tanaka, N., Mao, L., DeLano, F. A., Sentianin, E. M., Chien, K. R., Schmid-Schonbein, G. W., & Ross, J. (1997) · American Journal of Physiology-Heart and Circulatory Physiology

Cardiovascular Function and Risk FactorsCardiac Imaging and Diagnostics

Cited by 13