Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation?

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The glamour and gloom of glycogen synthase kinase-3

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GSK3 takes centre stage more than 20 years after its discovery

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The many faces of CREB

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Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

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Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus

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Toll-like receptor–mediated cytokine production is differentially regulated by glycogen synthase kinase 3

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GSK3 takes centre stage more than 20 years after its discovery

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Decreased nuclear β‐catenin, tau hyperphosphorylation and neurodegeneration in GSK‐3β conditional transgenic mice

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Glycogen Synthase Kinase‐3 from Rabbit Skeletal Muscle

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Cell Proliferation in Adult Hippocampus is Decreased by Inescapable Stress: Reversal by Fluoxetine Treatment

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Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade

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GSK3 inhibitors: development and therapeutic potential

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Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

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Hippocampal Neurogenesis: Regulation by Stress and Antidepressants

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The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior

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Activation of the Wnt Signaling Pathway: A Molecular Mechanism for Lithium Action

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Enhancement of Hippocampal Neurogenesis by Lithium

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Pharmacological inhibitors of glycogen synthase kinase 3

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The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways

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Lithium Inhibits Glycogen Synthase Kinase-3 by Competition for Magnesium

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Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3β Inactivation

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The Mood‐Stabilizing Agent Valproate Inhibits the Activity of Glycogen Synthase Kinase‐3

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VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants

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CREB DNA binding activity is inhibited by glycogen synthase kinase‐3β and facilitated by lithium

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Glycogen Synthase Kinase-3β Haploinsufficiency Mimics the Behavioral and Molecular Effects of Lithium

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GSK-3 is a master regulator of neural progenitor homeostasis

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Sequential Phosphorylation by Mitogen-activated Protein Kinase and Glycogen Synthase Kinase 3 Represses Transcriptional Activation by Heat Shock Factor-1

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Role of GSK3β in behavioral abnormalities induced by serotonin deficiency

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Cyclic AMP Promotes Neuronal Survival by Phosphorylation of Glycogen Synthase Kinase 3β

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A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior

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Transgenic Mice Overexpressing Glycogen Synthase Kinase 3β: A Putative Model of Hyperactivity and Mania

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The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity

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Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event

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Glycogen Synthase Kinase-3β Phosphorylates Protein Tau and Rescues the Axonopathy in the Central Nervous System of Human Four-repeat Tau Transgenic Mice

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The role of dopamine in bipolar disorder

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Direct, activating interaction between glycogen synthase kinase-3β and p53 after DNA damage

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Central Role of Glycogen Synthase Kinase-3β in Endoplasmic Reticulum Stress-induced Caspase-3 Activation

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Insulin Transiently Increases Tau Phosphorylation

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Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity

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The α‐isoform of glycogen synthase kinase‐3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase‐activated protein kinase‐1 in vitro

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Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3

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Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain

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Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances

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Alteration in Kinase Activity But Not in Protein Levels of Protein Kinase B and Glycogen Synthase Kinase-3β in Ventral Prefrontal Cortex of Depressed Suicide Victims

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Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model

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The Antiapoptotic Actions of Mood Stabilizers: Molecular Mechanisms and Therapeutic Potentials

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BDNF‐mediated signal transduction is modulated by GSK3β and mood stabilizing agents

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A glycogen synthase kinase 3-β promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression

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Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation

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Antipsychotics alter the protein expression levels of β-catenin and GSK-3 in the rat medial prefrontal cortex and striatum

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WNT-1 and HGF Regulate GSK3β Activity and β-Catenin Signaling in Mammary Epithelial Cells

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Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-β −50 T/C SNP

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Lithium Increases Transcription Factor Binding to AP‐1 and Cyclic AMP‐Responsive Element in Cultured Neurons and Rat Brain

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Valproate Regulates GSK-3-Mediated Axonal Remodeling and Synapsin I Clustering in Developing Neurons

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Phosphorylation of the cAMP Response Element Binding Protein CREB by cAMP-Dependent Protein Kinase A and Glycogen Synthase Kinase-3 Alters DNA-Binding Affinity, Conformation, and Increases Net Charge

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Low GSK-3β Immunoreactivity in Postmortem Frontal Cortex of Schizophrenic Patients

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A single nucleotide polymorphism in glycogen synthase kinase 3-β promoter gene influences onset of illness in patients affected by bipolar disorder

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Opposing Actions of Phosphatidylinositol 3‐Kinase and Glycogen Synthase Kinase‐3β in the Regulation of HSF‐1 Activity

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Unique and Overlapping Functions of GSK-3 Isoforms in Cell Differentiation and Proliferation and Cardiovascular Development

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β-Catenin Overexpression in the Mouse Brain Phenocopies Lithium-Sensitive Behaviors

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Risk for Depression During Interferon-Alpha Treatment Is Affected by the Serotonin Transporter Polymorphism

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Regulation and Function of Glycogen Synthase Kinase-3 Isoforms in Neuronal Survival

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Differential Roles of Glycogen Synthase Kinase-3 Isoforms in the Regulation of Transcriptional Activation

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Forkhead Box, Class O Transcription Factors in Brain: Regulation and Behavioral Manifestation

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Differential Modulation of Long-Term Depression by Acute Stress in the Rat Dorsal and Ventral Hippocampus

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Blocked Inhibitory Serine-Phosphorylation of Glycogen Synthase Kinase-3α/β Impairs In Vivo Neural Precursor Cell Proliferation

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Lithium Regulates Glycogen Synthase Kinase-3β in Human Peripheral Blood Mononuclear Cells: Implication in the Treatment of Bipolar Disorder

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Neonatal neuronal overexpression of glycogen synthase kinase-3β reduces brain size in transgenic mice

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