Cited by 161Calpain Protease Function and RegulationAlzheimer's disease research and treatmentsS100 Proteins and Annexins

Proteolysis of tau by calpain

Johnson, Gail V.W., Jope, Richard S., Binder, Lester I.·1989·Biochemical and Biophysical Research Communications

Abstract

The calpain-induced proteolysis of tau associated with twice-cycled microtubules or from a total brain heat-stable fraction was studied. Twice-cycled microtubule tau was rapidly hydrolyzed by calpain. In contrast, tau purified from the total brain heat-stable fraction was very resistant to degradation by calpain. These results clearly demonstrate that there are at least 2 populations of tau in the brain based on calpain-sensitivity, a calpain-sensitive form that is associated with microtubules and a calpain-resistant form that may represent another population of tau in the brain.

Integrity signals

Registry

Crossref · 10.1016/0006-291x(89)91150-9

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Johnson, G. V. W., Jope, R. S., & Binder, L. I.
Affiliations
University of Alabama at Birmingham (US)
Corresponding author
Johnson, Gail V.W.
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
1989-09
Volume
163
Issue
3
Pages
1505-1511
ISSN
0006-291X (ISSN-L)
OpenAlex
W2026101249
Cited by
161
References
18
Citations by year
2025: 2 · 2021: 1 · 2020: 4 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 5 · 2012: 8
FWCI
2.90
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p01ag006569-13)
  • National Institute on Aging (P01 AG06569)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Calpain Protease Function and Regulation
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
Keywords
tau protein, calpain, proteolysis, microtubules, tau isoforms
MeSH terms
Animals, Brain, Calpain, Cattle, Kinetics, Microtubule-Associated Proteins, Microtubules, Nerve Tissue Proteins, Immunoblotting, tau Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review