Pawson, Tony

Protein modules and signalling networks

Pawson, T. (1995) · Nature

Protein Kinase Regulation and GTPase SignalingBioinformatics and Genomic Networks

Cited by 2,420

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

Pawson, T., & Scott, J. D. (1997) · Science

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 2,256

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

Nott, T. J., Petsalaki, E., Farber, P., Jervis, D., Fussner, E., Plochowietz, A., Craggs, T. D., Bazett-Jones, D. P., Pawson, T., Forman-Kay, J. D., et al. (2015) · Molecular Cell

RNA Research and SplicingProtein Structure and Dynamics

Cited by 1,803

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

Mellacheruvu, D., Wright, Z., Couzens, A. L., Lambert, J.-P., St-Denis, N. A., Li, T., Miteva, Y. V., Hauri, S., Sardiu, M. E., Low, T. Y., et al. (2013) · Nature Methods

Advanced Proteomics Techniques and ApplicationsBioinformatics and Genomic Networks

Cited by 1,686

The Discoidin Domain Receptor Tyrosine Kinases Are Activated by Collagen

Vogel, W., Gish, G. D., Alves, F., & Pawson, T. (1997) · Molecular Cell

Protease and Inhibitor MechanismsCell Adhesion Molecules Research

Cited by 1,002

Early Lineage Segregation between Epiblast and Primitive Endoderm in Mouse Blastocysts through the Grb2-MAPK Pathway

Chazaud, C., Yamanaka, Y., Pawson, T., & Rossant, J. (2006) · Developmental Cell

Developmental Biology and Gene RegulationPluripotent Stem Cells Research

Cited by 898

Post-translational modifications in signal integration

Deribe, Y. L., Pawson, T., & Dikic, I. (2010) · Nature Structural & Molecular Biology

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Cited by 876

A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

Lin, D., Edwards, A. S., Fawcett, J. P., Mbamalu, G., Scott, J. D., & Pawson, T. (2000) · Nature Cell Biology

Protein Kinase Regulation and GTPase SignalingDevelopmental Biology and Gene Regulation

Cited by 743

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring

Shi, Y., Gao, W., Lytle, N. K., Huang, P., Yuan, X., Dann, A. M., Ridinger-Saison, M., DelGiorno, K. E., Antal, C. E., Liang, G., et al. (2019) · Nature

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

Cited by 431

The Syk protein tyrosine kinase is essential for Fcγ receptor signaling in macrophages and neutrophils

Kiefer, F., Brumell, J., Al-Alawi, N., Latour, S., Cheng, A., Veillette, A., Grinstein, S., & Pawson, T. (1998) · Molecular and Cellular Biology

Monoclonal and Polyclonal Antibodies ResearchNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 376

Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition

Lambert, J.-P., Ivosev, G., Couzens, A. L., Larsen, B., Taipale, M., Lin, Z.-Y., Zhong, Q., Lindquist, S., Vidal, M., Aebersold, R., et al. (2013) · Nature Methods

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 318

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions

Müller, P. M., Rademacher, J., Bagshaw, R. D., Wortmann, C., Barth, C., van Unen, J., Alp, K. M., Giudice, G., Eccles, R. L., Heinrich, L. E., et al. (2020) · Nature Cell Biology

Protein Kinase Regulation and GTPase SignalingCellular Mechanics and Interactions

Cited by 253

Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity

Borg, M., Mittag, T., Pawson, T., Tyers, M., Forman-Kay, J. D., & Chan, H. S. (2007) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsElectrostatics and Colloid Interactions

Cited by 245

ProHits: integrated software for mass spectrometry–based interaction proteomics

Liu, G., Zhang, J., Larsen, B., Stark, C., Breitkreutz, A., Lin, Z.-Y., Breitkreutz, B.-J., Ding, Y., Colwill, K., Pasculescu, A., et al. (2010) · Nature Biotechnology

Advanced Proteomics Techniques and ApplicationsBioinformatics and Genomic Networks

Cited by 243

Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice.

Kozlowski, M., Mlinaric-Rascan, I., Feng, G. S., Shen, R., Pawson, T., & Siminovitch, K. A. (1993) · The Journal of experimental medicine

Protein Tyrosine PhosphatasesImmunodeficiency and Autoimmune Disorders

Cited by 235

Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration.

Schmoranzer, J., Fawcett, J. P., Segura, M., Tan, S., Vallee, R. B., Pawson, T., & Gundersen, G. G. (2009) · Current Biology

Microtubule and mitosis dynamicsCellular Mechanics and Interactions

Cited by 192

Structure and mutagenesis of the Dbl homology domain

Aghazadeh, B., Zhu, K., Kubiseski, T. J., Liu, G. A., Pawson, T., Zheng, Y., & Rosen, M. K. (1998) · Nature Structural Biology

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 145

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

Ivarsson, Y., Arnold, R., McLaughlin, M., Nim, S., Joshi, R., Ray, D., Liu, B., Teyra, J., Pawson, T., Moffat, J., et al. (2014) · Proceedings of the National Academy of Sciences

Chemical Synthesis and AnalysisAdvanced Proteomics Techniques and Applications

Cited by 135

NOS1AP associates with Scribble and regulates dendritic spine development

Richier, L., Williton, K., Clattenburg, L., Colwill, K., O'Brien, M., Tsang, C., Kolar, A., Zinck, N., Metalnikov, P., Trimble, W. S., et al. (2010) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 81

MERTK interactions with SH2-domain proteins in the retinal pigment epithelium

Shelby, S. J., Colwill, K., Dhe-Paganon, S., Pawson, T., & Thompson, D. A. (2013) · PLoS ONE

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 35