NOS1AP associates with Scribble and regulates dendritic spine development
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The formation and function of the neuronal synapse is dependent on the asymmetric distribution of proteins both presynaptically and postsynaptically. Recently, proteins important in establishing cellular polarity have been implicated in the synapse. We therefore performed a proteomic screen with known polarity proteins and identified novel complexes involved in synaptic function. Specifically, we show that the tumor suppressor protein, Scribble, associates with neuronal nitric oxide synthase (nNOS) adaptor protein (NOS1AP) [also known as C-terminal PDZ ligand of nNOS (CAPON)] and is found both presynaptically and postsynaptically. The Scribble–NOS1AP association is direct and is mediated through the phosphotyrosine-binding (PTB) domain of NOS1AP and the fourth PDZ domain of Scribble. Further, we show that Scribble bridges NOS1AP to a β-Pix [β-p21-activated kinase (PAK)-interacting exchange factor]/Git1 (G-protein-coupled receptor kinase-interacting protein)/PAK complex. The overexpression of NOS1AP leads to an increase in dendritic protrusions, in a fashion that depends on the NOS1AP PTB domain. Consistent with these observations, both full-length NOS1AP and the NOS1AP PTB domain influence Rac activity. Together these data suggest that NOS1AP plays an important role in the mammalian synapse.
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Nitric oxide synthase adaptor protein and NADPH oxidase bind directly to the fourth Scribble PDZ domain, a domain not required for binding either β-PIX or GUKh.
“Nitric oxide synthase adaptor protein and NADPH oxidase, on the other hand, bind directly to the fourth Scribble PDZ domain (Richier et al., 2010; Zheng et al., 2016), a domain not required for binding either β-PIX or GUKh.”
From Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation (2019) · cites this paper as Richier et al., 2010
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A statistical model for identifying proteins by tandem mass spectrometry.
Nesvizhskii, A., Keller, A., Kolker, E., & Aebersold, R. (2003) · Analytical Chemistry · doi:10.1021/ac0341261 · Cited by 4,902 · see citing works
Cooperative Regulation of Cell Polarity and Growth by Drosophila Tumor Suppressors
Bilder, D. H., Li, M., & Perrimon, N. (2000) · Science · doi:10.1126/science.289.5476.113 · Cited by 916 · see citing works
Rapid Actin-Based Plasticity in Dendritic Spines
Fischer, M., Kaech, S., Knutti, D., & Matus, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80467-5 · Cited by 905 · see citing works
PAK Kinases Are Directly Coupled to the PIX Family of Nucleotide Exchange Factors
Manser, E. J., Loo, T.-H., Koh, C.-G., Zhao, Z.-S., Chen, X., Tan, L. H.-P., Tan, I., Leung, T., & Lim, L. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80019-2 · Cited by 753 · see citing works
Schizophrenia as a Disorder of Developmentally Reduced Synaptic Connectivity
McGlashan, T. H. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.7.637 · Cited by 655 · see citing works
Neuronal polarity: from extracellular signals to intracellular mechanisms.
Arimura, N., & Kaibuchi, K. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2056 · Cited by 655 · see citing works
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization
Arking, D. E., Pfeufer, A., Post, W. S., Kao, W. H. L., Newton‐Cheh, C., Ikeda, M. A., West, K. M., Kashuk, C., Akyol, M., Perz, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1790 · Cited by 536 · see citing works
Establishment of axon-dendrite polarity in developing neurons.
Barnes, A. P., & Polleux, F. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125536 · Cited by 523 · see citing works
A Specificity Map for the PDZ Domain Family
Tonikian, R., Zhang, Y., Sazinsky, S. L., Currell, B., Yeh, J.-H., Reva, B., Held, H. A., Appleton, B. A., Evangelista, M., Wu, Y., et al. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060239 · Cited by 476 · see citing works
Zhan, L., Rosenberg, A., Bergami, K. C., Yu, M., Xuan, Z., Jaffe, A. B., Allred, C., & Muthuswamy, S. K. (2008) · Cell · doi:10.1016/j.cell.2008.09.045 · Cited by 436 · see citing works
Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density
Feng, W., & Zhang, M. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2540 · Cited by 387 · see citing works
The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans
Zhen, M., & Jin, Y. (1999) · Nature · doi:10.1038/43886 · Cited by 374 · see citing works
Jaffrey, S. R., Snowman, A. M., Eliasson, M. J. L., Cohen, N. A., & Snyder, S. H. (1998) · Neuron · doi:10.1016/s0896-6273(00)80439-0 · Cited by 374 · see citing works
Linhoff, M. W., Laurén, J., Cassidy, R. M., Dobie, F. A., Takahashi, H., Nygaard, H. B., Airaksinen, M. S., Strittmatter, S. M., & Craig, A. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.017 · Cited by 358 · see citing works
A GIT1/PIX/Rac/PAK Signaling Module Regulates Spine Morphogenesis and Synapse Formation through MLC
Zhang, H., Webb, D. J., Asmussen, H., Niu, S., & Horwitz, A. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3553-04.2005 · Cited by 354 · see citing works
Molecular organization of the presynaptic active zone
Schoch, S., & Gundelfinger, E. D. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0244-y · Cited by 334 · see citing works
Fang, M., Jaffrey, S. R., Sawa, A., Ye, K., Luo, X., & Snyder, S. H. (2000) · Neuron · doi:10.1016/s0896-6273(00)00095-7 · Cited by 316 · see citing works
A Novel Regulator of p21-activated Kinases
Bagrodia, S., Taylor, S. J., Jordon, K. A., Aelst, L. V., & Cerione, R. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.37.23633 · Cited by 311 · see citing works
Interaction between GRIP and Liprin-α/SYD2 Is Required for AMPA Receptor Targeting
Wyszynski, M. W., Kim, E., Dunah, A. W., Passafaro, M., Valtschanoff, J. G., Serra‐Pages, C., Streuli, M., Weinberg, R. J., & Sheng, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00640-2 · Cited by 255 · see citing works
Colocalization of synapsin and actin during synaptic vesicle recycling
Bloom, O., Evergren, E., Tomilin, N. V., Kjærulff, O., Löw, P., Brodin, L., Pieribone, V. A., Greengard, P., & Shupliakov, O. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200212140 · Cited by 241 · see citing works
Osmani, N., Vitale, N., Borg, J.-P., & Etienne-Manneville, S. (2006) · Current Biology · doi:10.1016/j.cub.2006.10.026 · Cited by 239 · see citing works
Saneyoshi, T., Wayman, G. A., Fortin, D. A., Davare, M. A., Hoshi, N., Nozaki, N., Natsume, T., & Soderling, T. R. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.016 · Cited by 228 · see citing works
Mammalian Scribble Forms a Tight Complex with the βPIX Exchange Factor
Audebert, S., Navarro, C., Nourry, C., Chasserot-Golaz, S., Lécine, P., Bellaiche, Y., Dupont, J.-L., Premont, R. T., Sempéré, C., Strub, J.-M., et al. (2004) · Current Biology · doi:10.1016/j.cub.2004.05.051 · Cited by 218 · see citing works
SYD-2 Liprin-α organizes presynaptic active zone formation through ELKS
Dai, Y., Taru, H., Deken, S. L., Grill, B., Ackley, B., Nonet, M. L., & Jin, Y. (2006) · Nature Neuroscience · doi:10.1038/nn1808 · Cited by 218 · see citing works
The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis
Zhang, H., & Macara, I. G. (2006) · Nature Cell Biology · doi:10.1038/ncb1368 · Cited by 213 · see citing works
Synapse formation is regulated by the signaling adaptor GIT1
Zhang, H., Webb, D. J., Asmussen, H., & Horwitz, A. F. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211002 · Cited by 211 · see citing works
Ko, J., Na, M., Kim, S.-H., Lee, J.-R., & Kim, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307561200 · Cited by 185 · see citing works
PSD-95 promotes synaptogenesis and multiinnervated spine formation through nitric oxide signaling
Nikonenko, I., Boda, B., Steen, S., Knott, G. W., Welker, E., & Müller, D. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200805132 · Cited by 173 · see citing works
Nitric Oxide Is a Volume Transmitter Regulating Postsynaptic Excitability at a Glutamatergic Synapse
Steinert, J. R., Kopp‐Scheinpflug, C., Baker, C., Challiss, R. A. J., Mistry, R., Haustein, M. D., Griffin, S. J., Tong, H., Graham, B. P., & Forsythe, I. D. (2008) · Neuron · doi:10.1016/j.neuron.2008.08.025 · Cited by 172 · see citing works
Krueger, S., Kolar, A., & Fitzsimonds, R. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00729-3 · Cited by 161 · see citing works
Self-citationInteraction between Liprin-α and GIT1 Is Required for AMPA Receptor Targeting
Ko, J., Kim, S.-H., Valtschanoff, J. G., Shin, H., Lee, J.-R., Sheng, M., Premont, R. T., Weinberg, R. J., & Kim, E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01667.2003 · Cited by 160 · see citing works
Zhang, H., & Macara, I. G. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.11.020 · Cited by 159 · see citing works
Scribble associates with two polarity proteins, Lgl2 and Vangl2, via distinct molecular domains
Kallay, L. M., McNickle, A., Brennwald, P. J., Hubbard, A. L., & Braiterman, L. T. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20992 · Cited by 156 · see citing works
Brzustowicz, L. M., Simone, J., Mohseni, P., Hayter, J. E., Hodgkinson, K. A., Chow, E. W. C., & Bassett, A. S. (2004) · The American Journal of Human Genetics · doi:10.1086/420774 · Cited by 150 · see citing works
Kim, S.-H., Ko, J., Shin, H., Lee, J.-R., Lim, C., Han, J., Altrock, W. D., Garner, C. C., Gundelfinger, E. D., Premont, R. T., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212287200 · Cited by 139 · see citing works
Polarity Proteins in Axon Specification and Synaptogenesis
Wiggin, G. R., Fawcett, J. P., & Pawson, T. J. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.05.007 · Cited by 131 · see citing works
Self-citationNeuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON
Jaffrey, S. R., Benfenati, F., Snowman, A. M., Czernik, A. J., & Snyder, S. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261705799 · Cited by 115 · see citing works
Xu, B., Wratten, N. S., Charych, E. I., Buyske, S. G., Firestein, B. L., & Brzustowicz, L. M. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020263 · Cited by 111 · see citing works
The NGL family of leucine-rich repeat-containing synaptic adhesion molecules
Woo, J., Kwon, S., & Kim, E. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.05.008 · Cited by 109 · see citing works
Scrib regulates PAK activity during the cell migration process
Nola, S., Sebbagh, M., Marchetto, S., Osmani, N., Nourry, C., Audebert, S., Navarro, C., Rachel, R. A., Montcouquiol, M., Sans, N., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn248 · Cited by 108 · see citing works
Smith, M. J., Hardy, W. R., Murphy, J. M., Jones, N., & Pawson, T. J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01491-06 · Cited by 108 · see citing works
Self-citationRegulation of Synaptic Plasticity and Synaptic Vesicle Dynamics by the PDZ Protein Scribble
Roche, J. P., Packard, M. C., Moeckel‐Cole, S., & Budnik, V. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06471.2002 · Cited by 100 · see citing works
Scribble Interacts with β-Catenin to Localize Synaptic Vesicles to Synapses
Sun, Y., Aiga, M., Yoshida, E., Humbert, P. O., & Bamji, S. X. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1172 · Cited by 93 · see citing works
Carrel, D., Du, Y., Komlos, D., Hadzimichalis, N. M., Kwon, M., Wang, B., Brzustowicz, L. M., & Firestein, B. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5287-08.2009 · Cited by 66 · see citing works
Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration
Eijgelsheim, M., Aarnoudse, A. L. H. J., Rivadeneira, F., Kors, J. A., Witteman, J. C. M., Hofman, A., van Duijn, C. M., Uitterlinden, A. G., & Stricker, B. H. C. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn341 · Cited by 64 · see citing works
Watanabe, Y., Song, T., Sugimoto, K., Horii, M., Araki, N., Tokumitsu, H., Tezuka, T., Yamamoto, T. S., & Tokuda, M. (2003) · Biochemical Journal · doi:10.1042/bj20030380 · Cited by 62 · see citing works
Leucine‐rich repeat proteins of synapses
Ko, J., & Kim, E. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21306 · Cited by 59 · see citing works
A Novel PTB-PDZ Domain Interaction Mediates Isoform-specific Ubiquitylation of Mammalian Numb
Nie, J., Li, S. S. ‐., & McGlade, C. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311396200 · Cited by 39 · see citing works
Bilder, D. H. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00599-2 · Cited by 17 · see citing works
Le complexe GIT-PIX : Une plate-forme de régulation des GTPases ARF et Rac/Cdc42
Zeniou, M., Borg, J., & Vitale, N. (2005) · médecine/sciences · doi:10.1051/medsci/20052110849 · Cited by 8 · see citing works
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Halaoui, R., & McCaffrey, L. M. (2014) · Oncogene · doi:10.1038/onc.2014.59 · Cited by 176 · see citing works
Recent advances in the modeling of Alzheimer’s disease
Sasaguri, H., Hashimoto, S., Watamura, N., Sato, K., Takamura, R., Nagata, K., Tsubuki, S., Ohshima, T., Yoshiki, A., Sato, K., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.807473 · Cited by 157 · see citing works
Feigin, M. E., Akshinthala, S. D., Araki, K., Rosenberg, A. Z., Muthuswamy, L. B., Martin, B., Lehmann, B. D., Berman, H. K., Pietenpol, J. A., Cardiff, R. D., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3415 · Cited by 135 · see citing works
Anastas, J. N., Biechele, T. L., Robitaille, M., Muster, J., Allison, K. H., Angers, S., & Moon, R. T. (2011) · Oncogene · doi:10.1038/onc.2011.528 · Cited by 126 · see citing works
Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation
Bonello, T. T., & Peifer, M. (2019) · Journal of Cell Biology · doi:10.1083/jcb.201810103 · Cited by 127 · see citing works
“Nitric oxide synthase adaptor protein and NAD PH oxidase, on the other hand, bind directly to the fourth Scribble PDZ domain (Richier et al., 2010; Zheng et al., 2016), a domain not required for binding either β-PIX or GUKh.”
BackgroundZhou, W., Li, X., & Premont, R. T. (2016) · Journal of Cell Science · doi:10.1242/jcs.179465 · Cited by 118 · see citing works
Tau binding protein CAPON induces tau aggregation and neurodegeneration
Hashimoto, S., Matsuba, Y., Kamano, N., Mihira, N., Sahara, N., Takano, J., Muramatsu, S.-I., Saido, T. C., & Saito, T. (2019) · Nature Communications · doi:10.1038/s41467-019-10278-x · Cited by 111 · see citing works
CAPON-nNOS coupling can serve as a target for developing new anxiolytics
Zhu, L., Li, T., Luo, C., Jiang, N., Chang, L., Lin, Y., Zhou, H.-H., Chen, C., Zhang, Y., Lü, W., et al. (2014) · Nature Medicine · doi:10.1038/nm.3644 · Cited by 106 · see citing works
Crosstalk between Rac1-mediated actin regulation and ROS production
Acevedo, A., & González-Billault, C. E. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.008 · Cited by 96 · see citing works
O’Connell, K. S., McGregor, N. W., Löchner, C., Emsley, R. A., & Warnich, L. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.02.010 · Cited by 86 · see citing works
The planar polarity protein Scribble1 is essential for neuronal plasticity and brain function
Moreau, M. M., Piguel, N., Papouin, T., Koehl, M., Durand, C. M., Rubio, M. E., Loll, F., Richard, E. M., Mazzocco, C., Racca, C., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6007-09.2010 · Cited by 69 · see citing works
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Lawford, B. R., Morris, C. P., Swagell, C. D., Hughes, I. P., Young, R. M., & Voisey, J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.10.013 · Cited by 44 · see citing works
Shi, H., Wu, D., Chen, R., Li, N., & Zhu, L. (2022) · Theranostics · doi:10.7150/thno.70370 · Cited by 40 · see citing works
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Zhang, Y., Zhu, Z., Liang, H., Zhang, L., Zhou, Q., Ni, H., Luo, C., & Zhu, D. (2018) · Aging Cell · doi:10.1111/acel.12754 · Cited by 39 · see citing works
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Wang, J., Jin, L., Zhu, Y., Zhou, X., Yu, R., & Gao, S. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.05.014 · Cited by 41 · see citing works
Li, L., de Mera, R. M. M.-F., Chen, J., Ba, W., Kasri, N. N., Zhang, M., & Courtney, M. J. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0037-15.2015 · Cited by 38 · see citing works
Rui, M., Qian, J., Liu, L., Cai, Y., Lv, H., Han, J., Jia, Z., & Xie, W. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.794040 · Cited by 37 · see citing works
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Clattenburg, L., Wigerius, M., Qi, J., Rainey, J. K., Rourke, J. L., Muruganandan, S., Sinal, C. J., & Fawcett, J. P. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00062-15 · Cited by 36 · see citing works
Self-citationRecessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice
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Carrel, D., Hernandez, K. O., Kwon, M., Mau, C. Y., Trivedi, M. P., Brzustowicz, L. M., & Firestein, B. L. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.016 · Cited by 33 · see citing works
Hernandez, K. O., Swiatkowski, P., Patel, M. V., Chen, L., Dudzinski, N. R., Brzustowicz, L. M., & Firestein, B. L. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00006 · Cited by 31 · see citing works
Candemir, E., Kollert, L., Weißflog, L., Geis, M., Müller, A., Post, A. M., O’Leary, A., Harro, J., Reif, A., & Freudenberg, F. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.01.008 · Cited by 30 · see citing works
Alzahrani, F., Clattenburg, L., Muruganandan, S., Bullock, M. J., MacIsaac, K., Wigerius, M., Williams, B., Graham, M. E., Rigby, M. H., Trites, J. R. B., et al. (2017) · Journal of Otolaryngology - Head and Neck Surgery · doi:10.1186/s40463-017-0187-1 · Cited by 27 · see citing works
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How, J. Y., Caria, S., Humbert, P. O., & Kvansakul, M. (2019) · FEBS Letters · doi:10.1002/1873-3468.13329 · Cited by 19 · see citing works
Hilal, M. L., Moreau, M. M., Racca, C., Pinheiro, V. L., Piguel, N. H., Santoni, M.-J., Dos Santos Carvalho, S., Blanc, J.-M., Abada, Y.-S. K., Peyroutou, R., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhw333 · Cited by 20 · see citing works
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Mapping the Polarity Interactome
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Sun, S. D., Purdy, A. M., & Walsh, G. S. (2016) · BMC Neuroscience · doi:10.1186/s12868-016-0318-z · Cited by 17 · see citing works
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Janezic, E. M., Harris, D.-A., Dinh, D., Lee, K.-S., Stewart, A., Hinds, T. R., Hsu, P. L., Zheng, N., & Hague, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-50671-6 · Cited by 15 · see citing works
Sans, N., Ezan, J., Moreau, M. M., & Montcouquiol, M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800109-7.00013-3 · Cited by 15 · see citing works
The polarity protein Angiomotin p130 controls dendritic spine maturation
Wigerius, M., Quinn, D. P., Diab, A. M., Clattenburg, L., Kolar, A., Qi, J., Krueger, S., & Fawcett, J. P. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201705184 · Cited by 15 · see citing works
Self-citationGIT1 enhances neurite outgrowth by stimulating microtubule assembly
Shen, H., Gao, W., Li, Y., Qin, L.-X., Liu, J., Xia, W., & Li, J. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.179054 · Cited by 14 · see citing works
Roles of Rac1-Dependent Intrinsic Forgetting in Memory-Related Brain Disorders: Demon or Angel
Wang, W., Wang, Z., Cao, J., Dong, Y., & Chen, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310736 · Cited by 11 · see citing works
Mu, K., Sun, Y. W., Zhao, Y., Zhao, T., Li, Q., Zhang, M., Li, H., Zhang, R., Hu, C., Wang, C., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.033 · Cited by 14 · see citing works
Polarity proteins: Shaping dendritic spines and memory
Voglewede, M. M., & Zhang, H. (2022) · Developmental Biology · doi:10.1016/j.ydbio.2022.05.007 · Cited by 13 · see citing works
The Physiological Function of nNOS-Associated CAPON Proteins and the Roles of CAPON in Diseases
Xie, W., Xing, N., Qu, J., Liu, D., & Pang, Q. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115808 · Cited by 12 · see citing works
“NO” Time in Fear Response: Possible Implication of Nitric-Oxide-Related Mechanisms in PTSD
Fronza, M. G., Ferreira, B. F., Pavan-Silva, I., Guimarães, F. S., & Lisboa, S. F. D. S. (2023) · Molecules · doi:10.3390/molecules29010089 · Cited by 11 · see citing works
Scribble controls NGF-mediated neurite outgrowth in PC12 cells
Wigerius, M., Asghar, N., Melik, W., & Johansson, M. (2013) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2013.07.002 · Cited by 11 · see citing works
Roles of mammalian Scribble in polarity signaling, virus offense and cell-fate determination
Wigerius, M. (2010) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 11 · see citing works
Role of the glycoprotein thorns in anxious effects of rabies virus: Evidence from an animal study
Ghassemi, S., Pourbadie, H. G., Prehaud, C. J. N., Lafon, M., & Sayyah, M. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.05.001 · Cited by 10 · see citing works
A Localized Scaffold for cGMP Increase Is Required for Apical Dendrite Development
Szczurkowska, J., Lee, S.-I., Guo, A., Cwetsch, A. W., Khan, T., Rao, S. B., Walz, G., Huber, T. B., Cancedda, L., Pautot, S., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.083 · Cited by 10 · see citing works
Candemir, E., Fattakhov, N. S., O’Leary, A., Slattery, D. A., Courtney, M. J., Reif, A., & Freudenberg, F. (2022) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2022.11.006 · Cited by 8 · see citing works
Saito, A., Taniguchi, Y., Kim, S.-H., Selvakumar, B., Perez, G., Ballinger, M. D., Zhu, X., Sabra, J., Jallow, M., Yan, P., et al. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw201 · Cited by 8 · see citing works
Diab, A. M., Qi, J., Shahin, I., Milligan, C., & Fawcett, J. P. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.09.026 · Cited by 8 · see citing works
Self-citationPolarity Determinants in Dendritic Spine Development and Plasticity
Zhang, H. (2015) · Neural Plasticity · doi:10.1155/2016/3145019 · Cited by 7 · see citing works
Structural analysis of human papillomavirus E6 interactions with Scribble PDZ domains
Stewart, B. Z., Caria, S., Humbert, P. O., & Kvansakul, M. (2023) · FEBS Journal · doi:10.1111/febs.16718 · Cited by 6 · see citing works
Nitric oxide and sex differences in dendritic branching and arborization
Richards, L. A., & Schonhoff, C. M. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24789 · Cited by 6 · see citing works
KANK1 promotes breast cancer development by compromising Scribble-mediated Hippo activation
Guo, S. S., Liu, Z., Wang, G., Sun, Z., Yu, K., Fawcett, J. P., Büttner, R., Gao, B., & Faessler, R. (2024) · Nature Communications · doi:10.1038/s41467-024-54645-9 · Cited by 5 · see citing works
Self-citationBuerger, F., Salmanullah, D., Liang, L., Gauntner, V. C., Krueger, K., Qi, J., Normand, J., Sharma, V., Ranga, A., Rubin, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65663-6 · Cited by 5 · see citing works
Self-citationCai, P., Mu, Y., Piao, X., Hou, N., Liu, S., Gao, Y., Wang, H., & Chen, Q. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002837 · Cited by 5 · see citing works
Wang, Y., Wang, Z., Li, Y., Cao, M., Zhang, S., Ding, S., Chen, S., Jin, Y., Zhang, Y., Gao, J., et al. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01797-5 · Cited by 4 · see citing works
Genetic heterogeneity in familial forms of genetic generalized epilepsy: from mono- to oligogenism
Dahawi, M., Agathe, J. D. S., Elmagzoub, M. S., Ahmed, E. A. A., Buratti, J., Courtin, T., Noé, E., Bogoin, J., Copin, B., Elmugadam, F. A., et al. (2024) · Human Genomics · doi:10.1186/s40246-024-00659-9 · Cited by 4 · see citing works
Generation of a cre recombinase-conditional Nos1ap over-expression transgenic mouse
Auer, D. R., Sysa‐Shah, P., Bedja, D., Simmers, J. L., Pak, E. D., Dutra, A., Cohn, R. D., Gabrielson, K. L., Chakravarti, A., & Kapoor, A. (2014) · Biotechnology Letters · doi:10.1007/s10529-014-1473-x · Cited by 4 · see citing works
Szczurkowska, J., Guo, A., Martin, J., Lee, S.-I., Martinez, E. A., Chien, C. T., Khan, T. A., Singh, R., Dadson, D., Tran, T. S., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110483 · Cited by 4 · see citing works
Directed mechanisms for apical dendrite development during neuronal polarization
Khan, T. A., Guo, A., Martin, J., Chien, C. T., Liu, T., Szczurkowska, J., & Shelly, M. (2022) · Developmental Biology · doi:10.1016/j.ydbio.2022.07.002 · Cited by 3 · see citing works
An Unconventional Ligand for Scribble PDZ-4 Domain Mediates Its Interaction with Dusp26
Gallo, R., Sensi, E. D., Storino, F., & Panni, S. (2022) · BioChem · doi:10.3390/biochem2010006 · Cited by 2 · see citing works
Kuznetsova, L. A., & Basova, N. E. (2023) · Сибирский научный медицинский журнал · doi:10.18699/ssmj20230504 · Cited by 2 · see citing works
Spatially resolved m6A profiling using m6A-ARTR-DBiT
Xiao, Y., Bai, Z., Zou, Z., Ye, C., Tao, B., Zheng, Z., Chen, Y.-M., Zou, Z., Jiang, L., Zhao, L., et al. (2026) · Nature Methods · doi:10.1038/s41592-026-03123-9 · Cited by 2 · see citing works
Hippocampal overexpression of Nos1ap promotes endophenotypes related to mental disordersPreprint
Freudenberg, F., Candemir, E., Chen, X., Li, L., Esen-Sehir, D., Schenk, N., Kinoshita, M., Grünewald, L., Frerichs, V., Fattakhov, N. S., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-289893/v1 · Cited by 2 · see citing works
Generation of sophisticated Alzheimer’s disease mouse models and research advances utilizing them
Hashimoto, S., & Saido, T. C. (2023) · Translational and Regulatory Sciences · doi:10.33611/trs.2023-003 · Cited by 1 · see citing works
Identification and characterization of NOS1APc interacting proteins
Clattenburg, L. (2013) · Library and Archives Canada (Government of Canada)
Self-citationFuruta, S. (2017) · Open Access Journal of Cancer & Oncology · doi:10.23880/oajco-16000101
Rôle de Scribble1 dans la formation des synapses glutamatergiques et le trafic des récepteurs NMDA
Piguel, N. H. (2010) · theses.fr (ABES) · doi:10.70675/df9c39f9zd4f5z42c6z9dcfzb990c91e9dee
The Scrib1 Interactome and its relevance for synaptic plasticity & neurodevelopmental disorders
Pinheiro, V. L. M. (2014) · theses.fr (ABES) · doi:10.70675/b1c2e418zac9cz44c5zb050z72f9b6a47586
Identification and functional characterization of a novel Scribble phosphorylation site
Wagner, M. S. (2019) · theses.fr (ABES) · doi:10.70675/4042eb4fz7dbfz4465za1bez63d3149b21d5
The TDP-43-NOS1AP connection can regulate lipid-droplet homeostasis in neuronal cellsPreprint
Zangrando, L., Lombardi, S., & Buratti, E. (2026) · Research Square · doi:10.21203/rs.3.rs-11031579/v1
Kaur, B., Abdo, A., Cho, S., & Gabr, M. T. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.12.758423
LATS2 modulates synaptic organization and function by regulating actin dynamicsPreprint
Wigerius, M., Labana, P. K., Diab, A. M., Krueger, S., & Fawcett, J. P. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.16.758881
Self-citation
- Authors
- Richier, L., Williton, K., Clattenburg, L., Colwill, K., O'Brien, M., Tsang, C., Kolar, A., Zinck, N., Metalnikov, P., Trimble, W. S., Krueger, S. R., Pawson, T., & Fawcett, J. P.
- Affiliations
- Dalhousie University (CA)
- Lunenfeld-Tanenbaum Research Institute (CA)
- Hospital for Sick Children (CA)
- University of Toronto (CA)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-03-31
- Volume
- 30
- Issue
- 13
- Pages
- 4796-4805
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC5123869
- OpenAlex
- W2043884153
- Cited by
- 81
- References
- 50
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 9 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 4 · 2016: 9 · 2015: 4 · 2014: 7 · 2013: 4 · 2012: 1
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vanderbilt University
- Genome Canada
- Ontario Genomics
- Ontario Genomics Institute
- Dalhousie University
- Canadian Institutes of Health Research (97950)
- Natural Sciences and Engineering Research Council of Canada
- National Cancer Institute
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- NOS1AP, Scribble, neuronal nitric oxide synthase, dendritic spine development, neuronal polarity, synaptic protein complexes, PDZ domain, phosphotyrosine binding domain, betaPIX, GIT1, PAK, dendritic protrusions, synaptogenesis
- MeSH terms
- Amino Acid Sequence, Animals, Binding Sites, Cell Line, Humans, Molecular Sequence Data, Protein Structure, Tertiary, Cell Cycle Proteins, Phosphotyrosine, Protein Isoforms, Guanine Nucleotide Exchange Factors, rac GTP-Binding Proteins, Tumor Suppressor Proteins, Multiprotein Complexes, Adaptor Proteins, Signal Transducing, Dendritic Spines, Rats, p21-Activated Kinases, Rho Guanine Nucleotide Exchange Factors
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