Entero-Insular Axis
Abstract
Evidence for an entero-insular axis is based upon studies showing that amino acids as well as glucose cause a greater and earlier release of islet cell hormones when administered via the gastrointestinal tract than occurs with comparable elevations in the plasma concentrations of the nutrients given intravenously. The ability of several gastrointestinal hormones to elicit immediate augmentation of insulin and glucagon secretion has been established. Gastrin, secretin, and pancreozymin in dogs all produce an immediate rise of insulin to a peak one minute after injection, but the response to gastrin is quantitatively trivial, while that to secretin is modest. However, pancreozymin elicits substantial release of both insulin and glucagon, and augments the insulinogenic and glucagonogenic effects of amino acids. The physiologic implications of such studies are considered.
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Immunoassay of endogenous plasma insulin in man
Yalow, R. S., & Berson, S. A. (1960) · Journal of Clinical Investigation · doi:10.1172/jci104130 · Cited by 3,041 · see citing works
Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*
Perley, M. J., & Kipnis, D. M. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105685 · Cited by 917 · see citing works
Plasma Insulin Response to Oral and Intravenous Glucose Administration1
ELRICK, H., STIMMLER, L., HLAD, C. J., & ARAI, Y. (1964) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-24-10-1076 · Cited by 857 · see citing works
New Interpretation of Oral Glucose Tolerance
Mcintyre, N., Holdsworth, C. D., & Turner, D. S. (1964) · The Lancet · doi:10.1016/s0140-6736(64)90011-x · Cited by 738 · see citing works
Unger, R. H., Ketterer, H., Dupré, J., & Eisentraut, A. M. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105565 · Cited by 337 · see citing works
Self-citationUnger, R. H., Ohneda, A., Valverde, I., Eisentraut, A. M., & Exton, J. H. (1968) · Journal of Clinical Investigation · doi:10.1172/jci105714 · Cited by 296 · see citing works
Self-citationGLUCAGON ANTIBODIES AND AN IMMUNOASSAY FOR GLUCAGON*
Unger, R. H., Eisentraut, A. M., McCall, M. S., & Madison, L. L. (1961) · Journal of Clinical Investigation · doi:10.1172/jci104357 · Cited by 285 · see citing works
Self-citationOn the treatment of <i>Diabetus mellitus</i> by acid extract of Duodenal Mucous Membrane
Moore, B., Edie, E. S., & Abram, J. H. (1906) · Biochemical Journal · doi:10.1042/bj0010028 · Cited by 279 · see citing works
Wang, C. C., & Grossman, M. I. (1951) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1951.164.2.527 · Cited by 230 · see citing works
Ohneda, A., Parada, E., Eisentraut, A. M., & Unger, R. H. (1968) · Journal of Clinical Investigation · doi:10.1172/jci105916 · Cited by 200 · see citing works
Self-citationSTIMULATION OF GLUCAGON SECRETION BY ORAL GLUCOSE
Samols, E., Tyler, J., Marri, G., & Marks, V. (1965) · The Lancet · doi:10.1016/s0140-6736(65)92278-6 · Cited by 145 · see citing works
EFFECTS OF SECRETIN ON INSULIN AND GLUCAGON IN PORTAL AND PERIPHERAL BLOOD IN MAN
Dupré, J., Rojas, L., White, J. J., Unger, R. H., & Beck, J. C. (1966) · The Lancet · doi:10.1016/s0140-6736(66)91750-8 · Cited by 114 · see citing works
Self-citationAN INTESTINAL HORMONE AFFECTING GLUCOSE DISPOSAL IN MAN
Dupré, J. (1964) · The Lancet · doi:10.1016/s0140-6736(64)92481-x · Cited by 110 · see citing works
Lawrence, A. M. (1966) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.55.2.316 · Cited by 91 · see citing works
Valverde, I., Rigopoulou, D., Exton, J. H., Ohneda, A., Eisentraut, A. M., & Unger, R. H. (1968) · The American Journal of the Medical Sciences · doi:10.1097/00000441-196806000-00007 · Cited by 89 · see citing works
Self-citationPlasma Insulin Activity after Glucose: An Index of Insulogenic Reserve in Normal and Diabetic Man
Seltzer, H. S., & Smith, W. L. (1959) · Diabetes · doi:10.2337/diab.8.6.417 · Cited by 87 · see citing works
Stimulation of Insulin Secretion by Pancreozymin
Meade, R. C., Kneubuhler, H. A., SCHULTE, W. J., & Barboriak, J. J. (1967) · Diabetes · doi:10.2337/diab.16.3.141 · Cited by 77 · see citing works
EFFECT OF SECRETIN ON INSULIN SECRETION
Unger, R. H., Ketterer, H., Eisentraut, A. M., & Dupré, J. (1966) · The Lancet · doi:10.1016/s0140-6736(66)91749-1 · Cited by 75 · see citing works
Self-citationIS A DUODENAL HORMONE INVOLVED IN CARBOHYDRATE METABOLISM?
Loew, E. R., Gray, J. S., & Ivy, A. C. (1940) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1940.129.3.659 · Cited by 48 · see citing works
Augmentation De L’Insuline Tissulaire Et De L’Insuline Circulante Apres Ingestion De Glucose
Bastenie, P. A., Conard, V., Franckson, J. R. M., Bellens, R., & Christophe, J. (1958) · Acta Clinica Belgica · doi:10.1080/17843286.1958.11717487 · Cited by 2 · see citing works
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Reduced incretin effect in Type 2 (non-insulin dependent) diabetes
Nauck, M., Stöckmann, F., Ebert, R., & Creutzfeldt, W. (1986) · Diabetologia · doi:10.1007/bf02427280 · Cited by 1,307 · see citing works
Kieffer, T. J., McIntosh, C. H., & Pederson, R. A. (1995) · Endocrinology · doi:10.1210/endo.136.8.7628397 · Cited by 1,124 · see citing works
Kieffer, T. J., & Habener, J. F. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.6.0385 · Cited by 1,056 · see citing works
Thorens, B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.18.8641 · Cited by 906 · see citing works
Mojsov, S., Weir, G. C., & Habener, J. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112855 · Cited by 882 · see citing works
NAUCK, M. A., HOMBERGER, E., SIEGEL, E. G., ALLEN, R. C., EATON, R. P., EBERT, R., & CREUTZFELDT, W. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-63-2-492 · Cited by 874 · see citing works
Creutzfeldt, W. (1979) · Diabetologia · doi:10.1007/bf01225454 · Cited by 731 · see citing works
Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans
Holst, J. J., & Gromada, J. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00545.2003 · Cited by 611 · see citing works
Johnston, K. L., Clifford, M. N., & Morgan, L. M. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.4.728 · Cited by 590 · see citing works
Steinert, R. E., Feinle-Bisset, C., Asarian, L., Horowitz, M., Beglinger, C., & Geary, N. (2017) · Physiological Reviews · doi:10.1152/physrev.00031.2014 · Cited by 578 · see citing works
Thorens, B., Porret, A., Bühler, L. H., Deng, S., Morel, P., & Widmann, C. (1993) · Diabetes · doi:10.2337/diab.42.11.1678 · Cited by 552 · see citing works
Fehmann, H. C., Göke, R., & Göke, B. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-3-390 · Cited by 527 · see citing works
International Union of Pharmacology. XXXV. The Glucagon Receptor Family
Mayo, K. E., Miller, L. J., BATAILLE, D., Dalle, S., Göke, B., Thorens, B., & Drucker, D. J. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.1.6 · Cited by 507 · see citing works
Nauck, M. A., & Meier, J. J. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00482-9 · Cited by 503 · see citing works
Miyawaki, K., Yamada, Y., Yano, H., Niwa, H., Ban, N., Ihara, Y., Kubota, A., Fujimoto, S., Kajikawa, M., Kuroe, A., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14843 · Cited by 454 · see citing works
Wei, Y., & Mojsov, S. (1995) · FEBS Letters · doi:10.1016/0014-5793(94)01430-9 · Cited by 450 · see citing works
Fehmann, H. C., & Habener, J. F. (1992) · Endocrinology · doi:10.1210/endo.130.1.1309325 · Cited by 337 · see citing works
Identification and Actions of Gastric Inhibitory Polypeptide
Brown, J. C., Dryburgh, J. R., ROSS, S. A., & DUPRÉ, J. (1975) · Elsevier eBooks · doi:10.1016/b978-0-12-571131-9.50017-7 · Cited by 333 · see citing works
Hansotia, T., Baggio, L. L., Delmeire, D., Hinke, S. A., Yamada, Y., Tsukiyama, K., Seino, Y., Holst, J. J., Schuit, F., & Drucker, D. J. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1326 · Cited by 309 · see citing works
Elahi, D., McAloon-Dyke, M., Fukagawa, N. K., Meneilly, G. S., Sclater, A. L., Minaker, K. L., Habener, J. F., & Andersen, D. K. (1994) · Regulatory Peptides · doi:10.1016/0167-0115(94)90136-8 · Cited by 308 · see citing works
Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure
Hansotia, T., Maida, A., Flock, G., Yamada, Y., Tsukiyama, K., Seino, Y., & Drucker, D. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci25483 · Cited by 290 · see citing works
Jetton, T. L., Liang, Y. T., Pettepher, C. C., Zimmerman, E. C., Cox, F., Horvath, K., Matschinsky, F. M., & Magnuson, M. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41910-7 · Cited by 279 · see citing works
New developments in the incretin concept
Creutzfeldt, W., & Ebert, R. (1985) · Diabetologia · doi:10.1007/bf00281990 · Cited by 277 · see citing works
Glucose metabolism and hyperglycemia
Giugliano, D., Ceriello, A., & Esposito, K. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.217s · Cited by 278 · see citing works
Prato, S. D., & Tiengo, A. (2001) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.198 · Cited by 237 · see citing works
Harder, H., Nielsen, L., Thi, T. D. T., & Astrup, A. V. (2004) · Diabetes Care · doi:10.2337/diacare.27.8.1915 · Cited by 232 · see citing works
Pospisilik, J. A., Stafford, S. G., Demuth, H.-U., Brownsey, R. W., Parkhouse, W. S., Finegood, D. T., McIntosh, C. H. S., & Pederson, R. A. (2002) · Diabetes · doi:10.2337/diabetes.51.4.943 · Cited by 232 · see citing works
Initial splanchnic extraction of ingested glucose in normal man
Radziuk, J., McDonald, T. J., Rubenstein, D., & Dupre, J. (1978) · Metabolism · doi:10.1016/0026-0495(78)90003-3 · Cited by 207 · see citing works
Vagal hepatopancreatic reflex effect evoked by intraportal appearance of tGLP-1
Nakabayashi, H., NISHIZAWA, M., Nakagawa, A., Takeda, R., & Niijima, A. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.5.e808 · Cited by 203 · see citing works
Narrative Review: Effect of Bariatric Surgery on Type 2 Diabetes Mellitus
Vetter, M. L., Cardillo, S., Rickels, M. R., & Iqbal, N. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-2-200901200-00007 · Cited by 192 · see citing works
Glucagon-like peptide-1 is a physiological incretin in rat.
Wang, Z., Wang, R. M., Owji, A. A., Smith, D. M., Ghatei, M. A., & Bloom, S. R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117671 · Cited by 190 · see citing works
Gumbs, A. A., Modlin, I. M., & Ballantyne, G. H. (2005) · Obesity Surgery · doi:10.1381/0960892053723367 · Cited by 188 · see citing works
Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes
Gautier, J. F., Choukem, S. P., & Girard, J. R. (2008) · Diabetes & Metabolism · doi:10.1016/s1262-3636(08)73397-4 · Cited by 181 · see citing works
GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice
Hansotia, T., & Drucker, D. J. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.07.019 · Cited by 182 · see citing works
Gut hormones and diabetes mellitus
Creutzfeldt, W., & Nauck, M. (1992) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610080206 · Cited by 176 · see citing works
First-phase insulin secretion: does it exist in real life? Considerations on shape and function
Caumo, A., & Luzi, L. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00139.2003 · Cited by 174 · see citing works
Receptors and effects of gut hormones in three osteoblastic cell lines
Pacheco-Pantoja, E. L., Ranganath, L. R., Gallagher, J. A., Wilson, P. J., & Fraser, W. D. (2011) · BMC Physiology · doi:10.1186/1472-6793-11-12 · Cited by 173 · see citing works
Chapter 15 Glucose‐Dependent Insulinotropic Polypeptide (Gastric Inhibitory Polypeptide; GIP)
McIntosh, C. H. S., Widenmaier, S. B., & Kim, S. (2009) · Vitamins and hormones · doi:10.1016/s0083-6729(08)00615-8 · Cited by 172 · see citing works
The Effect of Gastrin on Basal- and Glucose-Stimulated Insulin Secretion in Man
Rehfeld, J. F., & STADIL, F. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107315 · Cited by 165 · see citing works
Gautier, J. F., Fetita, S., Sobngwi, E., & Salaun-Martin, C. (2005) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70190-8 · Cited by 163 · see citing works
Physiologic relevance of heterogeneity in the pancreatic beta-cell population
PIPELEERS, D. G., Kiekens, R., Ling, Z., Wilikens, A., & Schuit, F. C. (1994) · Diabetologia · doi:10.1007/bf00400827 · Cited by 152 · see citing works
Tseng, C., Kieffer, T. J., Jarboe, L. A., Usdin, T. B., & Wolfe, M. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119060 · Cited by 149 · see citing works
Meier, J. J., Kemmeries, G., Holst, J. J., & Nauck, M. A. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2212 · Cited by 146 · see citing works
Glucagon-like peptide-1: a major regulator of pancreatic beta-cell function
Perfetti, R., & Merkel, P. A. (2000) · European Journal of Endocrinology · doi:10.1530/eje.0.1430717 · Cited by 143 · see citing works
Targeting the glucagon receptor family for diabetes and obesity therapy
Cho, Y. M., Merchant, C. E., & Kieffer, T. J. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.05.009 · Cited by 142 · see citing works
Carbohydrate Metabolism and Its Disorders
Kaneko, J. J. (1980) · Elsevier eBooks · doi:10.1016/b978-0-12-396350-5.50006-1 · Cited by 142 · see citing works
The Enteroinsular Axis and the Recovery from Type 2 Diabetes after Bariatric Surgery
Patriti, A., Facchiano, E., Sanna, A., Gullà, N., & Donini, A. (2004) · Obesity Surgery · doi:10.1381/0960892041590818 · Cited by 139 · see citing works
Ballantyne, G. H., Gumbs, A. A., & Modlin, I. M. (2005) · Obesity Surgery · doi:10.1381/0960892053923789 · Cited by 131 · see citing works
Masoro, E. J. (1977) · Annual Review of Physiology · doi:10.1146/annurev.ph.39.030177.001505 · Cited by 130 · see citing works
Pamir, N., Lynn, F. C., Buchan, A. M. J., Ehses, J., Hinke, S. A., Pospisilik, J. A., Miyawaki, K., Yamada, Y., Seino, Y., McIntosh, C. H. S., et al. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00270.2002 · Cited by 126 · see citing works
Ebert, R., Unger, H., & Creutzfeldt, W. (1983) · Diabetologia · doi:10.1007/bf00257346 · Cited by 120 · see citing works
Pathophysiology of Diabetes Mellitus
Sherwin, R., & Felig, P. (1978) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)31766-7 · Cited by 120 · see citing works
Incretin hormone mimetics and analogues in diabetes therapeutics
Green, B. D., & Flatt, P. R. (2007) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2007.09.003 · Cited by 113 · see citing works
Levine, R., & Haft, D. E. (1970) · New England Journal of Medicine · doi:10.1056/nejm197007232830405 · Cited by 114 · see citing works
Green, B., Gault, V., O'Harte, F., & Flatt, P. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043382774 · Cited by 111 · see citing works
Neural regulation of the endocrine pancreas
Brunicardi, F., Shavelle, D., & Andersen, D. (1995) · International Journal of Pancreatology · doi:10.1007/bf02784941 · Cited by 106 · see citing works
Therapeutic potential for GIP receptor agonists and antagonists
Irwin, N., & Flatt, P. R. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2009.03.001 · Cited by 105 · see citing works
Metformin Effects on Dipeptidylpeptidase IV Degradation of Glucagon-like Peptide-1
Hinke, S. A., Kühn‐Wache, K., Hoffmann, T., Pederson, R. A., McIntosh, C. H. S., & Demuth, H. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6607 · Cited by 105 · see citing works
Effects of oral fructose and glucose on plasma GLP-1 and appetite in normal subjects
Kong, M., Chapman, I. M., Goble, E., Wishart, J. M., Wittert, G., Morris, H. A., & Horowitz, M. (1999) · Peptides · doi:10.1016/s0196-9781(99)00006-6 · Cited by 104 · see citing works
The [pre-] history of the incretin concept
Creutzfeldt, W. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.08.004 · Cited by 104 · see citing works
Pauly, R. P., Demuth, H., Rosche, F., Schmidt, J., White, H. A., Lynn, F. C., McIntosh, C. H. S., & Pederson, R. A. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90090-2 · Cited by 103 · see citing works
The Origin and Understanding of the Incretin Concept
Rehfeld, J. F. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00387 · Cited by 102 · see citing works
Kakei, M., Yada, T., Nakagawa, A., & Nakabayashi, H. (2002) · Autonomic Neuroscience · doi:10.1016/s1566-0702(02)00182-0 · Cited by 102 · see citing works
Salera, M., Giacomoni, P., Pironi, L., Cornia, G. L., Capelli, M., Marini, A. M., Benfenati, F., Miglioli, M., & Barbara, L. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-55-2-329 · Cited by 101 · see citing works
Glucose-dependent insulinotropic polypeptide (GIP)
Müller, T. D., Adriaenssens, A. E., Ahrén, B., Blüher, M., Birkenfeld, A. L., Campbell, J. E., Coghlan, M. P., D’Alessio, D. D., Deacon, C. F., DelPrato, S., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102118 · Cited by 99 · see citing works
K-cells and Glucose-Dependent Insulinotropic Polypeptide in Health and Disease
Cho, Y. M., & Kieffer, T. J. (2010) · Vitamins and hormones · doi:10.1016/b978-0-12-381517-0.00004-7 · Cited by 93 · see citing works
Oral glucose is the prime elicitor of preabsorptive insulin secretion
Grill, H. J., Berridge, K. C., & Ganster, D. J. (1984) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1984.246.1.r88 · Cited by 92 · see citing works
Gastrointestinal peptides and insulin secretion
Ebert, R., & Creutzfeldt, W. (1987) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610030101 · Cited by 90 · see citing works
Glucagon‐like peptide‐1(7–36) amide is a new incretin/enterogastrone candidate
Göke, R., Fehmann, H. C., & Göke, B. (1991) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1991.tb01802.x · Cited by 90 · see citing works
Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes
Flatt, P. R. (2008) · Frontiers in bioscience · doi:10.2741/2956 · Cited by 85 · see citing works
Lewis, J. T., Dayanandan, B., Habener, J. F., & Kieffer, T. J. (2000) · Endocrinology · doi:10.1210/endo.141.10.7750 · Cited by 85 · see citing works
The milieu interieur and the islets of Langerhans
Unger, R. H. (1981) · Diabetologia · doi:10.1007/bf00253809 · Cited by 84 · see citing works
Self-citationPhysiology and Emerging Biochemistry of the Glucagon-Like Peptide-1 Receptor
Willard, F. S., & Sloop, K. W. (2012) · Experimental Diabetes Research · doi:10.1155/2012/470851 · Cited by 81 · see citing works
Baggio, L. L., Kieffer, T. J., & Drucker, D. J. (2000) · Endocrinology · doi:10.1210/endo.141.10.7720 · Cited by 79 · see citing works
Metabolic Regulation of Plasma Insulin Levels in Cattle
McAtee, J. W., & Trenkle, A. H. (1971) · Journal of Animal Science · doi:10.2527/jas1971.332438x · Cited by 79 · see citing works
Damholt, A. B., Kofod, H., & Buchan, A. M. J. (1999) · Cell and Tissue Research · doi:10.1007/s004419900093 · Cited by 78 · see citing works
Meier, J. J., Gallwitz, B., Askenas, M., Vollmer, K., Deacon, C. F., Holst, J. J., Schmidt, W. E., & Nauck, M. A. (2005) · Diabetologia · doi:10.1007/s00125-005-1863-7 · Cited by 77 · see citing works
Myint, K. S., Greenfield, J. R., Farooqi, I. S., Henning, E., Holst, J. J., & Finer, N. (2012) · European Journal of Endocrinology · doi:10.1530/eje-11-1065 · Cited by 77 · see citing works
Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action
Zhou, H., Yamada, Y., Tsukiyama, K., Miyawaki, K., Hosokawa, M., Nagashima, K., Toyoda, K., Naitoh, R., Mizunoya, W., Fushiki, T., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.164 · Cited by 76 · see citing works
Holst, J. J., & Ørskov, C. (2001) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/clb.61.234.75.85 · Cited by 76 · see citing works
Friesen, S. R., Hermreck, A. S., & Mantz, F. A. (1974) · The American Journal of Surgery · doi:10.1016/0002-9610(74)90017-8 · Cited by 71 · see citing works
The Insulinotropic Effect of Endogenous Gastric Inhibitory Polypeptide in Normal Subjects
Crockett, S. E., Cataland, S., Falko, J. M., & Mazzaferri, E. L. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-42-6-1098 · Cited by 70 · see citing works
Metabolic Mechanisms in Obesity and Type 2 Diabetes: Insights from Bariatric/Metabolic Surgery
Cătoi, A. F., Pârvu, A. E., Mureșan, A., & Busetto, L. (2015) · Obesity Facts · doi:10.1159/000441259 · Cited by 68 · see citing works
Glucagon-like peptide-1(7–37)/(7–36)amide is a new incretin
Fehmann, H. C., Göke, R., & Göke, B. (1992) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(92)90118-p · Cited by 66 · see citing works
Nishizawa, M., Nakabayashi, H., Uehara, K., Nakagawa, A., Uchida, K., & Koya, D. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00565.2012 · Cited by 64 · see citing works
Fushiki, T., Kojima, A., Imoto, T., Inoue, K., & Sugimoto, E. (1992) · Journal of NutriLife · doi:10.1093/jn/122.12.2367 · Cited by 73 · see citing works
Svendsen, P. F., Nilas, L., Madsbad, S., & Holst, J. J. (2009) · Metabolism · doi:10.1016/j.metabol.2008.11.009 · Cited by 64 · see citing works
Immune recognition and response to the intestinal microbiome in type 1 diabetes
Paun, A., Yau, C., & Danska, J. S. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2016.02.004 · Cited by 62 · see citing works
The gastrointestinal stimulus to insulin release
Kraegen, E. W., Chisholm, D. J., Young, J. D., & Lazarus, L. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106262 · Cited by 61 · see citing works
Suppressive effect of secretin upon pancreatic alpha cell function
Santeusanio, F., Faloona, G. R., & Unger, R. H. (1972) · Journal of Clinical Investigation · doi:10.1172/jci106975 · Cited by 60 · see citing works
Self-citationRadioimmunoassay of Plasma Hormones: Review of Plasma Insulin in Ruminants
Trenkle, A. H. (1972) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(72)85648-0 · Cited by 59 · see citing works
Rossetti, L., Shulman, G. I., & Zawalich, W. S. (1987) · Diabetes · doi:10.2337/diab.36.10.1212 · Cited by 57 · see citing works
Theodorakis, M. J., Carlson, O. D., Muller, D. C., & Egan, J. M. (2004) · Diabetes Care · doi:10.2337/diacare.27.7.1692 · Cited by 55 · see citing works
Metabolic control in diabetic pregnancy
Persson, B., & Lunell, N. (1975) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(75)90580-3 · Cited by 55 · see citing works
The role of the Wnt signaling pathway in incretin hormone production and function
Chiang, Y., Ip, W., & Jin, T. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00273 · Cited by 56 · see citing works
Applications of dipeptidyl peptidase IV inhibitors in diabetes mellitus
McIntosh, C. H. S., Demuth, H., Kim, S.-J., Pospisilik, J. A., & Pederson, R. A. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.12.013 · Cited by 54 · see citing works
Glucagon-like Peptide-1 (GLP-1) and the Control of Glucose Metabolism in Mammals and Teleost Fish1
Mojsov, S. (2000) · American Zoologist · doi:10.1668/0003-1569(2000)040[0246:glpgat]2.0.co;2 · Cited by 51 · see citing works
Lauritsen, K. B., Christensen, K. C., & Stokholm, K. H. (1980) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528009181506 · Cited by 51 · see citing works
Stimulation of adenylate cyclase from isolated hepatocytes and Kupffer cells.
Wincek, T. J., Hupka, A. L., & Sweat, F. W. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40753-9 · Cited by 51 · see citing works
Hofeldt, F. D. (1975) · Metabolism · doi:10.1016/0026-0495(75)90156-0 · Cited by 50 · see citing works
- Authors
- Unger, R. H.
- Corresponding author
- Unger, Roger H.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1969-03-01
- Volume
- 123
- Issue
- 3
- Pages
- 261
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2097717126
- Cited by
- 371
- References
- 20
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 6
- FWCI
- 30.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- enteroinsular axis, gut-brain axis, gastrointestinal hormones, insulin secretion, glucagon secretion, amino acids, glucose, gastrin, secretin, cholecystokinin, enteroendocrine cells
- MeSH terms
- Insulin Secretion, Amino Acids, Animals, Blood Glucose, Cholecystokinin, Dogs, Gastrins, Gastrointestinal Hormones, Glucagon, Glucose, Injections, Intravenous, Insulin, Intestinal Absorption, Pancreas, Secretin
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