The Banting Memorial Lecture 1975: Diabetes and the Alpha Cell

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Regulatory Peptides of the Hypothalamus

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The pancreatic islets in diabetes

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Glucagon and the a Cell

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Assembly and secretion of hepatic very-low-density lipoprotein

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The glucose paradox. Is glucose a substrate for liver metabolism?

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The somatostatin-secreting pancreatic δ-cell in health and disease

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The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog.

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Medicinal Chemistry in the Golden Age of Biology: Lessons from Steroid and Peptide Research

Hirschmann, R. F. (1991) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199112781 · Cited by 227 · see citing works

Role of glucagon in the pathogenesis of diabetes: The status of the controversy

Unger, R. H. (1978) · Metabolism · doi:10.1016/0026-0495(78)90291-3 · Cited by 216 · see citing works

Amino acid transport in isolated rat hepatocytes

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Effect of glucagon on glucose production during insulin deficiency in the dog.

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Hyperglucagonemia and Its Suppression

Raskin, P., & Unger, R. H. (1978) · New England Journal of Medicine · doi:10.1056/nejm197808312990901 · Cited by 197 · see citing works

Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?

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Glucagon is the key factor in the development of diabetes

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Paradoxical Stimulation of Glucagon Secretion by High Glucose Concentrations

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2 Intra-islet insulin—glucagon—somatostatin relationships

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Metabolic manifestations of insulin deficiency do not occur without glucagon action

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The endocrine pancreas in chronic pancreatitis

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Hormonal Regulation of Cystathionine β-Synthase Expression in Liver

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Differential volumetry of A, B and D cells in the pancreatic islets of diabetic and nondiabetic subjects.

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Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice

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Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist

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Pathophysiology of Diabetes Mellitus

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Altered Tissue Content and Cytosol Distribution of Trace Metals in Experimental Diabetes

Failla, M. L., & Kiser, R. A. (1981) · Journal of Nutrition · doi:10.1093/jn/111.11.1900 · Cited by 111 · see citing works

Glucose homeostasis during prolonged suppression of glucagon and insulin secretion by somatostatin.

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KATP-channels and glucose-regulated glucagon secretion

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Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line.

Philippé, J. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114214 · Cited by 101 · see citing works

Pathogenesis of diabetic glomerulopathy: Hemodynamic considerations

Anderson, S., & Brenner, B. M. (1988) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610040206 · Cited by 103 · see citing works

Function and expression of somatostatin receptors of the endocrine pancreas

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Synthetic peptide antagonists of glucagon.

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Targeting the CNS to treat type 2 diabetes

Sandoval, D. A., Obici, S., & Seeley, R. J. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2874 · Cited by 100 · see citing works

Hormonal Control of Ketogenesis

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Hypoglycemia of Infancy and Nesidioblastosis

Hirsch, H. J., Loo, S., Evans, N., Crigler, J. F., Filler, R. M., & Gabbay, K. H. (1977) · New England Journal of Medicine · doi:10.1056/nejm197706092962305 · Cited by 96 · see citing works

Influence of Insulin in the Ventromedial Hypothalamus on Pancreatic Glucagon Secretion In Vivo

Paranjape, S., Chan, O. T. M., Zhu, W., Horblitt, A. M., McNay, E. C., Cresswell, J. A., Bogan, J. S., McCrimmon, R. J., & Sherwin, R. S. (2010) · Diabetes · doi:10.2337/db10-0014 · Cited by 94 · see citing works

Urinary Excretion of Zinc, Copper and Iron in the Streptozotocin-Diabetic Rat

Lau, A. L., & Failla, M. L. (1984) · Journal of Nutrition · doi:10.1093/jn/114.1.224 · Cited by 86 · see citing works

The milieu interieur and the islets of Langerhans

Unger, R. H. (1981) · Diabetologia · doi:10.1007/bf00253809 · Cited by 84 · see citing works

Synthesis and expression of a gene for the rat glucagon receptor. Replacement of an aspartic acid in the extracellular domain prevents glucagon binding.

Carruthers, C. J., Unson, C. G., Kim, H. N., et al. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)62047-8 · Cited by 80 · see citing works

Early glycosilation products induce glomerular hyperfiltration in normal rats

Sabbatini, M., Sansone, G., Uccello, F., et al. (1992) · Kidney International · doi:10.1038/ki.1992.363 · Cited by 78 · see citing works

Glucose, insulin, and somatostatin infusion for the determination of insulin sensitivity in vivo

Harano, Y., Hidaka, H., Takatsuki, K., et al. (1978) · Metabolism · doi:10.1016/0026-0495(78)90091-4 · Cited by 74 · see citing works

Glucagon and the A Cells

UNGER, R. H., Raskin, P., Srikant, C. B., & Orci, L. (1977) · Elsevier eBooks · doi:10.1016/b978-0-12-571133-3.50018-0 · Cited by 76 · see citing works

Compartmental modeling of glucagon kinetics in the conscious dog

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Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients

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Effect of Diabetes, Insulin, Starvation, and Refeeding on the Level of Rat Hepatic Fructose 2,6-Bisphosphate

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Clinical evaluation of somatostatin as a potential adjunct to insulin in the management of diabetes mellitus

Gerich, J. E., Schultz, T. A., Lewis, S. B., et al. (1977) · Diabetologia · doi:10.1007/bf01234510 · Cited by 66 · see citing works

Human Genetic Disorders That Feature Premature Onset and Accelerated Progression of Biological Aging

Goldstein, S. (1978) · Springer eBooks · doi:10.1007/978-1-4684-2445-4_8 · Cited by 64 · see citing works

Hyperglucagonemia in Rats Results in Decreased Plasma Homocysteine and Increased Flux through the Transsulfuration Pathway in Liver

Jacobs, R. L., Stead, L. M., Brosnan, M. E., & Brosnan, J. T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107553200 · Cited by 62 · see citing works

Absence of Glucagon and Insulin Action Reveals a Role for the GLP-1 Receptor in Endogenous Glucose Production

Jun, L. S., Millican, R. L., Hawkins, E. D., Konkol, D. L., Showalter, A. D., Christe, M. E., Michael, M. D., & Sloop, K. W. (2015) · Diabetes · doi:10.2337/db14-1052 · Cited by 60 · see citing works

Hormonal Interactions in the Regulation of Blood Glucose

Felig, P., Sherwin, R. S., Soman, V., Wahren, J., Hendler, R., Saccà, L., Eigler, N., GOLDBERG, D., & Walesky, M. (1979) · Elsevier eBooks · doi:10.1016/b978-0-12-571135-7.50016-3 · Cited by 64 · see citing works

Extraction, gel filtration pattern, and receptor binding of porcine gastrointestinal glucagon-like immunoreactivity

Holst, J. J. (1977) · Diabetologia · doi:10.1007/bf00745145 · Cited by 61 · see citing works

Short‐term hormonal control of hepatic carbohydrate and lipid catabolism

HEMS, D. A. (1977) · FEBS Letters · doi:10.1016/0014-5793(77)80449-3 · Cited by 59 · see citing works

Die Medizinische Chemie im Goldenen Zeitalter der Biologie: Lehren aus der Steroid‐ und Peptidforschung

Hirschmann, R. F. (1991) · Angewandte Chemie · doi:10.1002/ange.19911031008 · Cited by 58 · see citing works

Identification of an essential serine residue in glucagon: implication for an active site triad.

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Insulin, glucagon, and amino acids during glycemic control by the artificial pancreas in diabetic man

Hanna, A., Zinman, B., NAKHOODA, A. F., Minuk, H. L., Stokes, E. F., Albisser, A. M., LEIBEL, B. S., & Marliss, E. B. (1980) · Metabolism · doi:10.1016/0026-0495(80)90005-0 · Cited by 58 · see citing works

Role of Glucagon and Its Receptor in the Pathogenesis of Diabetes

Jia, Y., Liu, Y., Feng, L., Sun, S., & Sun, G. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.928016 · Cited by 56 · see citing works

Treatment of Type 1 Diabetic Patients with Glucagon-Like Peptide-1 (GLP-1) and GLP-1R Agonists

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Glucose Dependence of the Regulated Secretory Pathway in αTC1-6 Cells

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Role of Glucagon in Diabetes

Unger, R. H. (1977) · Archives of Internal Medicine · doi:10.1001/archinte.1977.03630160050012 · Cited by 55 · see citing works

Improvement of Glucose Tolerance by Verapamil in Patients with Non‐Insulin‐Dependent Diabetes Mellitus

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Suppression of Ca2+ oscillations in glucagon-producing α2-cells by insulin/glucose and amino acids

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Hepatic and renal metabolism of copper and zinc in the diabetic rat

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GLUCOSE-INDUCED HYPERKALÆMIA: A HAZARD FOR DIABETICS?

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Excessive Islet NO Generation in Type 2 Diabetic GK Rats Coincides with Abnormal Hormone Secretion and Is Counteracted by GLP-1

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Zinc, iron, and copper absorption in the streptozotocin-diabetic rat

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Glucagon‐like peptide‐1 receptor agonists for type 2 diabetes: A rational drug development

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Factors controlling gastric-glucagon release.

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Chemically and Hormonally Induced Diabetes

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Hepatic Glucose Production Oscillates in Synchrony with the Islet Secretory Cycle in Fasting Rhesus Monkeys

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The Role of Glucagon in the Endogenous Hyperglycemia of Diabetes Mellitus

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Glucagon-stimulable adenylyl cyclase in rat liver. The impact of streptozotocin-induced diabetes mellitus.

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Multiple-site replacement analogs of glucagon. A molecular basis for antagonist design.

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Hormone secretion and glucose metabolism in islets of Langerhans of the isolated perfused pancreas from normal and streptozotocin diabetic rats.

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Extrapancreatic Glucagon and Glucagonlike Immunoreactivity in Depancreatized Dogs

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Endocrine pancreatic response of children with onset of insulin-requiring diabetes before age 3 and after age 5

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Somatostatin. Its possible role in carbohydrate homeostasis and the treatment of diabetes mellitus

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Endothelial dysfunction in the early- and late-stage type-2 diabetic Goto-Kakizaki rat aorta

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Insights from a Successful Case of Intrahepatic Islet Transplantation into a Type 1 Diabetic Patient

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Intraislet Insulin-Glucagon-Somatostatin Relationships

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Hormonal regulation of hepatic amino acid transport

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Localization of four polypeptide hormones in the saurian pancreas

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Four hormones in the pancreas of the lizard, Anolis carolinensis

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Regulation of very-low-density-lipoprotein lipid secretion in hepatocyte cultures derived from diabetic animals

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A New Biology of Diabetes Revealed by Leptin

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Long-term survival in a case of functional pancreatic agenesis

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Tributyltin in male mice disrupts glucose homeostasis as well as recovery after exposure: mechanism analysis

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Effect of glucose on plasma glucagon and free fatty acids during prolonged exercise

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Early-Morning Hyperglycemia in Diabetic Individuals Treated with Continuous Subcutaneous Insulin Infusion

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Islet Changes in Human Diabetes

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The effect of chronic insulin therapy on phosphate metabolism in diabetes mellitus

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Glucagon therapeutics: Dawn of a new era for diabetes care

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Effect of sodium dichromate on carbohydrate metabolism

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Antidiabetic Activity of a Highly Potent and Selective Nonpeptide Somatostatin Receptor Subtype-2 Agonist

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Adaptations of alpha2- and beta-cells of rat and mouse pancreatic islets to starvation, to refeeding after starvation, and to obesity.

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Effects of glucagon and insulin on fatty acid synthesis and glycogen degradation in the perfused liver of normal and genetically obese (ob/ob) mice

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CNS Regulation of Glucagon Secretion

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Protamine Insulin

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Somatostatin: A metabolic regulator

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DETERMINING QUALITY REQUIREMENTS AT THE UNIVERSITIES TO IMPROVE THE QUALITY OF EDUCATION

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Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

Genentech taps Affimed’s antibodies

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Enxerto livre de arteria epigastrica inferior: avaliacao hemodinamica e angiografica pre e pos-operatoria

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Interleucinas na encefalopatia hipóxico-isquêmica

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